BR9912719A - Processo para propagar um vìrus do herpes mutante, uso de uma linhagem de célula, linhagem de célula, vìrus, e, composição farmacêutica - Google Patents

Processo para propagar um vìrus do herpes mutante, uso de uma linhagem de célula, linhagem de célula, vìrus, e, composição farmacêutica

Info

Publication number
BR9912719A
BR9912719A BR9912719-9A BR9912719A BR9912719A BR 9912719 A BR9912719 A BR 9912719A BR 9912719 A BR9912719 A BR 9912719A BR 9912719 A BR9912719 A BR 9912719A
Authority
BR
Brazil
Prior art keywords
cell line
virus
mutant herpes
homologue
propagating
Prior art date
Application number
BR9912719-9A
Other languages
English (en)
Inventor
Robert Stuart Coffin
David Seymour Latchman
Original Assignee
Biovex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovex Ltd filed Critical Biovex Ltd
Publication of BR9912719A publication Critical patent/BR9912719A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"PROCESSO PARA PROPAGAR UM VìRUS DO HERPES MUTANTE, USO DE UMA LINHAGEM DE CéLULA, LINHAGEM DE CéLULA, VìRUS, E, COMPOSIçãO FARMACêUTICA" Processo para a propagação de um vírus do herpes mutante, tendo uma mutação em seu gene VP16 HSV endógeno ou um seu homólogo, processo este compreendendo infectar uma linhagem de célula com o vírus do herpes mutante e cultivar a linhagem de célula, em que a linhagem de célula compreende uma seq³ência de ácido nucleico codificando um polipeptídeo VP16 do vírus do herpes simples funcional, ou um seu homólogo, operavelmente ligado a uma seq³ência de controle permitindo a expressão do polipeptídeo em dita linhagem de célula; a seq³ência de ácido nucleico sendo (i) capaz de complementar o gene endógeno e (ii) incapaz de sofrer recombinação homóloga com o gene endógeno. Além disso, a presente invenção fornece linhagens de células que podem ser usadas para o crescimento dos vírus do herpes mutante que têm defeitos em certos genes prematuros imediatos junto com mutação em VP16 ou seu homólogo.
BR9912719-9A 1998-08-03 1999-08-03 Processo para propagar um vìrus do herpes mutante, uso de uma linhagem de célula, linhagem de célula, vìrus, e, composição farmacêutica BR9912719A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9816856.0A GB9816856D0 (en) 1998-08-03 1998-08-03 Cell lines for virus growth
PCT/GB1999/002547 WO2000008194A2 (en) 1998-08-03 1999-08-03 Cell lines for the propagation of mutated herpes viruses

Publications (1)

Publication Number Publication Date
BR9912719A true BR9912719A (pt) 2001-05-02

Family

ID=10836609

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912719-9A BR9912719A (pt) 1998-08-03 1999-08-03 Processo para propagar um vìrus do herpes mutante, uso de uma linhagem de célula, linhagem de célula, vìrus, e, composição farmacêutica

Country Status (14)

Country Link
US (1) US7262033B1 (pt)
EP (1) EP1102858B1 (pt)
JP (1) JP2002526039A (pt)
KR (1) KR20010072236A (pt)
CN (1) CN1187453C (pt)
AT (1) ATE279526T1 (pt)
AU (1) AU766267B2 (pt)
BR (1) BR9912719A (pt)
CA (1) CA2336592A1 (pt)
DE (1) DE69921148T2 (pt)
GB (2) GB9816856D0 (pt)
HK (1) HK1037213A1 (pt)
IL (1) IL141127A0 (pt)
WO (1) WO2000008194A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1346036B1 (en) 2000-11-29 2010-04-28 University of Rochester Helper virus-free herpes virus amplicon particles and uses thereof
US8092791B2 (en) 2001-05-23 2012-01-10 University Of Rochester Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
EP1592455A4 (en) * 2003-01-23 2006-06-28 Univ Rochester AMPLICON PARTICLES OF THE HERPES VIRUS
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
WO2006050211A2 (en) * 2004-10-28 2006-05-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain
TWI608102B (zh) * 2013-01-08 2017-12-11 健臻公司 iNOS抑制劑於病毒培養中增加病毒產量之用途
EP4288140A1 (en) 2021-02-05 2023-12-13 Iovance Biotherapeutics, Inc. Adjuvant therapy for cancer
CN114107230B (zh) * 2021-11-29 2023-08-11 东北农业大学 一种牛疱疹病毒1型ul41缺失毒株及其获取方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804413A (en) * 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
GB9415369D0 (en) 1994-07-29 1994-09-21 Lynxvale Ltd Mutant virus
US6200811B1 (en) 1996-04-02 2001-03-13 The Regents Of The University Of California Cell transformation vector comprising an HIV-2 packaging site nucleic acid and an HIV-1 GAG protein
GB9615794D0 (en) 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof

Also Published As

Publication number Publication date
IL141127A0 (en) 2002-02-10
AU5183799A (en) 2000-02-28
GB0104403D0 (en) 2001-04-11
AU766267B2 (en) 2003-10-09
WO2000008194A3 (en) 2000-05-25
KR20010072236A (ko) 2001-07-31
DE69921148T2 (de) 2006-02-16
JP2002526039A (ja) 2002-08-20
ATE279526T1 (de) 2004-10-15
US7262033B1 (en) 2007-08-28
GB2361243A (en) 2001-10-17
EP1102858A2 (en) 2001-05-30
WO2000008194A2 (en) 2000-02-17
GB2361243B (en) 2003-09-03
GB9816856D0 (en) 1998-09-30
EP1102858B1 (en) 2004-10-13
CA2336592A1 (en) 2000-02-17
HK1037213A1 (en) 2002-02-01
CN1187453C (zh) 2005-02-02
DE69921148D1 (de) 2004-11-18
CN1321199A (zh) 2001-11-07

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.