BR9908765A - Process for the preparation of the tetrapeptide h-tyr-d-ala-phe (f) -phe-nh2, peptide, and peptide derivative - Google Patents
Process for the preparation of the tetrapeptide h-tyr-d-ala-phe (f) -phe-nh2, peptide, and peptide derivativeInfo
- Publication number
- BR9908765A BR9908765A BR9908765-0A BR9908765A BR9908765A BR 9908765 A BR9908765 A BR 9908765A BR 9908765 A BR9908765 A BR 9908765A BR 9908765 A BR9908765 A BR 9908765A
- Authority
- BR
- Brazil
- Prior art keywords
- phe
- peptide
- preparation
- ala
- tetrapeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DO TETRAPEPTìDEO H-TYR-D-ALA-PHE(F)-PHE-NH~ 2~, PEPTìDEO, E DERIVADO DE PEPTìDEO" A presente invenção expõe um processo novo e aperfeiçoado para a preparação do tetrapeptídeo H-Tyr-D-Ala-Phe(F)-Phe-NH~ 2~, que é um peptídeo de fórmula (I): ou um sal farmaceuticamente aceitável do mesmo, assim como novos intermediários na preparação dos mesmos. O novo processo é adequado para a produção em larga escala."PROCESS FOR THE PREPARATION OF THE H-TYR-D-ALA-PHE (F) -PHE-NH ~ 2 ~, PEPTIDE, AND PEPTIDE DERIVATIVE TETRAPEPTIDE" The present invention exposes a new and improved process for the preparation of the H- tetrapeptide Tyr-D-Ala-Phe (F) -Phe-NH ~ 2 ~, which is a peptide of formula (I): or a pharmaceutically acceptable salt thereof, as well as new intermediates in the preparation thereof. The new process is suitable for large-scale production.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800865A SE9800865D0 (en) | 1998-03-16 | 1998-03-16 | New Process |
| PCT/SE1999/000414 WO1999047548A1 (en) | 1998-03-16 | 1999-03-16 | Process for the preparation of a tetrapeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908765A true BR9908765A (en) | 2000-11-07 |
Family
ID=20410566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908765-0A BR9908765A (en) | 1998-03-16 | 1999-03-16 | Process for the preparation of the tetrapeptide h-tyr-d-ala-phe (f) -phe-nh2, peptide, and peptide derivative |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1062231A1 (en) |
| JP (1) | JP2002506880A (en) |
| KR (1) | KR20010041888A (en) |
| CN (1) | CN1300293A (en) |
| AU (1) | AU2968899A (en) |
| BR (1) | BR9908765A (en) |
| CA (1) | CA2323678A1 (en) |
| EE (1) | EE200000540A (en) |
| HU (1) | HUP0102877A3 (en) |
| ID (1) | ID26938A (en) |
| IL (1) | IL138244A0 (en) |
| IS (1) | IS5612A (en) |
| NO (1) | NO20004613L (en) |
| PL (1) | PL343277A1 (en) |
| SE (1) | SE9800865D0 (en) |
| SK (1) | SK13442000A3 (en) |
| TR (1) | TR200002652T2 (en) |
| WO (1) | WO1999047548A1 (en) |
| ZA (1) | ZA200004376B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903291D0 (en) * | 1999-09-15 | 1999-09-15 | Astra Ab | New process |
| ES2550604T3 (en) * | 2007-12-13 | 2015-11-11 | Cytogel Pharma, Llc | Advantageous salts of opioid receptor peptides mu |
| CN103319568B (en) * | 2013-06-20 | 2015-01-21 | 重庆理工大学 | Non-protein amino acid antibacterial peptide and application for same |
| CN104371002B (en) * | 2013-06-20 | 2017-10-10 | 重庆理工大学 | A kind of non-protein amino acid antibacterial peptide and its application |
| CN104478993B (en) * | 2013-06-20 | 2017-10-10 | 重庆理工大学 | A kind of non-protein amino acid antibacterial peptide and its application |
| CN104783298A (en) * | 2015-03-24 | 2015-07-22 | 湖州珍贝羊绒制品有限公司 | Preparation and application of biological sterilizing composition and nanoemulsion thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9503924D0 (en) * | 1995-08-18 | 1995-11-07 | Astra Ab | Novel opioid peptides |
| GB9516994D0 (en) * | 1995-08-18 | 1995-10-18 | Iaf Biochem Int | Solution synthesis of peripheral acting analgestic opioid tetrapeptides |
-
1998
- 1998-03-16 SE SE9800865A patent/SE9800865D0/en unknown
-
1999
- 1999-03-16 JP JP2000536740A patent/JP2002506880A/en active Pending
- 1999-03-16 CN CN99806071A patent/CN1300293A/en active Pending
- 1999-03-16 PL PL99343277A patent/PL343277A1/en not_active Application Discontinuation
- 1999-03-16 EP EP99910934A patent/EP1062231A1/en not_active Withdrawn
- 1999-03-16 WO PCT/SE1999/000414 patent/WO1999047548A1/en not_active Application Discontinuation
- 1999-03-16 HU HU0102877A patent/HUP0102877A3/en unknown
- 1999-03-16 TR TR2000/02652T patent/TR200002652T2/en unknown
- 1999-03-16 IL IL13824499A patent/IL138244A0/en unknown
- 1999-03-16 KR KR1020007010189A patent/KR20010041888A/en not_active Application Discontinuation
- 1999-03-16 ID IDW20001952A patent/ID26938A/en unknown
- 1999-03-16 AU AU29688/99A patent/AU2968899A/en not_active Abandoned
- 1999-03-16 BR BR9908765-0A patent/BR9908765A/en not_active IP Right Cessation
- 1999-03-16 SK SK1344-2000A patent/SK13442000A3/en unknown
- 1999-03-16 EE EEP200000540A patent/EE200000540A/en unknown
- 1999-03-16 CA CA002323678A patent/CA2323678A1/en not_active Abandoned
-
2000
- 2000-08-24 ZA ZA200004376A patent/ZA200004376B/en unknown
- 2000-08-30 IS IS5612A patent/IS5612A/en unknown
- 2000-09-15 NO NO20004613A patent/NO20004613L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999047548A1 (en) | 1999-09-23 |
| EP1062231A1 (en) | 2000-12-27 |
| EE200000540A (en) | 2002-02-15 |
| ZA200004376B (en) | 2001-10-31 |
| SE9800865D0 (en) | 1998-03-16 |
| ID26938A (en) | 2001-02-22 |
| HUP0102877A2 (en) | 2002-01-28 |
| IS5612A (en) | 2000-08-30 |
| IL138244A0 (en) | 2001-10-31 |
| NO20004613L (en) | 2000-10-30 |
| SK13442000A3 (en) | 2001-04-09 |
| AU2968899A (en) | 1999-10-11 |
| CN1300293A (en) | 2001-06-20 |
| PL343277A1 (en) | 2001-08-13 |
| KR20010041888A (en) | 2001-05-25 |
| CA2323678A1 (en) | 1999-09-23 |
| JP2002506880A (en) | 2002-03-05 |
| HUP0102877A3 (en) | 2002-02-28 |
| TR200002652T2 (en) | 2000-11-21 |
| NO20004613D0 (en) | 2000-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTA A 6O, 7O E 8O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |