BR9907980A - Isolated nucleic acid fragment, chimeric gene, transformed host cell, polypeptide lcb2 subunit, method of altering the expression level of an lcb2 subunit, method of obtaining a nucleic acid fragment, product and method of evaluation of the ability of at least one compound to inhibit the activity of an lcb2 subunit - Google Patents
Isolated nucleic acid fragment, chimeric gene, transformed host cell, polypeptide lcb2 subunit, method of altering the expression level of an lcb2 subunit, method of obtaining a nucleic acid fragment, product and method of evaluation of the ability of at least one compound to inhibit the activity of an lcb2 subunitInfo
- Publication number
- BR9907980A BR9907980A BR9907980-1A BR9907980A BR9907980A BR 9907980 A BR9907980 A BR 9907980A BR 9907980 A BR9907980 A BR 9907980A BR 9907980 A BR9907980 A BR 9907980A
- Authority
- BR
- Brazil
- Prior art keywords
- lcb2
- nucleic acid
- acid fragment
- lcb2 subunit
- subunit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
''FRAGMENTO DE áCIDO NUCLéICO ISOLADO, GENE QUIMéRICO, CéLULA HOSPEDEIRA TRANSFORMADA, SUB-UNIDADE DE Lcb2 DE POLIPEPTìDEO, MéTODO DE ALTERAçãO DO NìVEL DE EXPRESSãO DE UMA SUB-UNIDADE Lcb2, MéTODO DE OBTENçãO DE UM FRAGMENTO DE áCIDO NUCLéICO, PRODUTO E MéTODO DE AVALIAçãO DA CAPACIDADE DE PELO MENOS UM COMPOSTO EM INIBIR A ATIVIDADE DE UMA SUB-UNIDADE Lcb2" A presente invenção refere-se a um fragmento de ácido nucléico isolado codificador de uma sub-unidade Lcb2 de palmitoiltransferase de serina. A presente invenção também se refere à construção de um gene quimérico que codifique a sub-unidade Lcb2 de palmitoiltransferase de serina, no todo ou em parte, em orientação de mesmo sentido ou sentido contrário, em que a expressão do gene quimérico resulte na produção de níveis alterados da sub-unidade Lcb2 de palmitoiltransferase de serina em uma célula hospedeira transformada.'' ISOLATED NUCLEIC ACID FRAGMENT, CHIMERIC GENE, TRANSFORMED HOST CELL, POLYPEPTIDE Lcb2 SUB-UNIT, METHOD OF ALTERING THE EXPRESSION LEVEL OF A Lcb SUB-UNIT, METHOD OF METHOD, OF EVALUATION OF THE CAPACITY OF AT LEAST ONE COMPOUND IN INHIBITING THE ACTIVITY OF AN Lcb2 SUB-UNIT "The present invention relates to an isolated nucleic acid fragment encoding an Lcb2 sub-unit of serine palmitoyltransferase. The present invention also refers to the construction of a chimeric gene encoding the Lcb2 subunit of serine palmitoyltransferase, in whole or in part, in the same or opposite direction, in which the expression of the chimeric gene results in the production of altered levels of the sub- Lcb2 unit of serine palmitoyltransferase in a transformed host cell.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7946298P | 1998-03-26 | 1998-03-26 | |
PCT/US1999/006587 WO1999049021A1 (en) | 1998-03-26 | 1999-03-22 | Lcb2 subunit of serine palmitoyltransferase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907980A true BR9907980A (en) | 2000-11-28 |
Family
ID=22150719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907980-1A BR9907980A (en) | 1998-03-26 | 1999-03-22 | Isolated nucleic acid fragment, chimeric gene, transformed host cell, polypeptide lcb2 subunit, method of altering the expression level of an lcb2 subunit, method of obtaining a nucleic acid fragment, product and method of evaluation of the ability of at least one compound to inhibit the activity of an lcb2 subunit |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1064361A1 (en) |
AU (1) | AU3204799A (en) |
BR (1) | BR9907980A (en) |
WO (1) | WO1999049021A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902620A (en) * | 1985-04-25 | 1990-02-20 | Eli Lilly And Company | Novel DNA for expression of delta-aminolevulinic acid synthetase and related method |
US5583030A (en) * | 1992-06-30 | 1996-12-10 | The University Of Kentucky Research Foundation | Method for obtaining antifungal and herbicidal compounds that target the first committed step in shingolipid long-chain base biosynthesis |
DE19650216A1 (en) * | 1996-12-04 | 1998-06-10 | Inst Pflanzengenetik & Kultur | Process for influencing chlorophyll biosynthesis in plants |
-
1999
- 1999-03-22 BR BR9907980-1A patent/BR9907980A/en not_active Application Discontinuation
- 1999-03-22 EP EP99914145A patent/EP1064361A1/en not_active Withdrawn
- 1999-03-22 WO PCT/US1999/006587 patent/WO1999049021A1/en not_active Application Discontinuation
- 1999-03-22 AU AU32047/99A patent/AU3204799A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3204799A (en) | 1999-10-18 |
WO1999049021A1 (en) | 1999-09-30 |
EP1064361A1 (en) | 2001-01-03 |
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