BR9816177B1 - processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina. - Google Patents

processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.

Info

Publication number
BR9816177B1
BR9816177B1 BRPI9816177-6A BR9816177A BR9816177B1 BR 9816177 B1 BR9816177 B1 BR 9816177B1 BR 9816177 A BR9816177 A BR 9816177A BR 9816177 B1 BR9816177 B1 BR 9816177B1
Authority
BR
Brazil
Prior art keywords
preparing
vinflunine
difluorovinblastine
deoxy
formula
Prior art date
Application number
BRPI9816177-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Bridget Hill
Jacques Fahy
Alain Duflos
Boulay Valerie Thillaye Du
Jean-Marc Barret
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9816177B1 publication Critical patent/BR9816177B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI9816177-6A 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina. BR9816177B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9704398A FR2761990B1 (fr) 1997-04-10 1997-04-10 Derives halogenes antimitotiques d'alcaloides de vinca

Publications (1)

Publication Number Publication Date
BR9816177B1 true BR9816177B1 (pt) 2010-08-24

Family

ID=9505731

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9816177-6A BR9816177B1 (pt) 1997-04-10 1998-04-10 processo para preparar a 4'-desàxi-20', 20'-difluorovinblastina, e, processo para preparar a vinflunina.
BRPI9807944-1A BR9807944B1 (pt) 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI9807944-1A BR9807944B1 (pt) 1997-04-10 1998-04-10 derivados antimitóticos dos alcalóides da vinca, processo para preparar os mesmos e uso dos derivados.

Country Status (15)

Country Link
US (1) US6127377A (enExample)
EP (3) EP1764368B1 (enExample)
JP (3) JP4401440B2 (enExample)
AT (2) ATE473987T1 (enExample)
AU (1) AU737549C (enExample)
BR (2) BR9816177B1 (enExample)
CA (3) CA2665949C (enExample)
CY (2) CY1111476T1 (enExample)
DE (3) DE69824840T2 (enExample)
DK (2) DK0975640T3 (enExample)
ES (2) ES2222588T3 (enExample)
FR (2) FR2761990B1 (enExample)
LU (1) LU91769I2 (enExample)
PT (2) PT1764368E (enExample)
WO (1) WO1998045301A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
EP1694330A4 (en) * 2003-12-04 2009-06-24 Amr Technology Inc DERIVATIVES OF VINORELBINE
NZ547370A (en) * 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
FR2905949B1 (fr) * 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
FR2910812B1 (fr) 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
DE102010020994B4 (de) * 2010-01-27 2022-01-27 Interpane Entwicklungs-Und Beratungsgesellschaft Mbh Verfahren zur Herstellung eines beschichteten Gegenstands mit Texturätzen
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
US8940754B2 (en) 2010-02-22 2015-01-27 The Scripps Research Institute 10′-fluorinated Vinca alkaloids provide enhanced biological activity against MDR cancer cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca

Also Published As

Publication number Publication date
ATE270297T1 (de) 2004-07-15
CA2665949C (fr) 2013-06-11
JP2009167196A (ja) 2009-07-30
AU737549B2 (en) 2001-08-23
DE69824840T2 (de) 2005-07-21
DE69824840D1 (de) 2004-08-05
EP1357125A2 (fr) 2003-10-29
JP2001518892A (ja) 2001-10-16
CA2455416A1 (fr) 1998-10-15
DE69841766D1 (de) 2010-08-26
PT1764368E (pt) 2010-09-16
JP4401440B2 (ja) 2010-01-20
FR2761990A1 (fr) 1998-10-16
US6127377A (en) 2000-10-03
BR9807944B1 (pt) 2011-02-08
CA2286560C (fr) 2009-09-08
WO1998045301A1 (fr) 1998-10-15
CY2010019I2 (el) 2012-01-25
JP4307292B2 (ja) 2009-08-05
LU91769I2 (fr) 2011-02-22
FR2761990B1 (fr) 1999-06-25
ES2222588T3 (es) 2005-02-01
PT975640E (pt) 2004-11-30
CY1111476T1 (el) 2012-01-25
CA2286560A1 (fr) 1998-10-15
AU737549C (en) 2002-03-28
EP0975640B1 (fr) 2004-06-30
DE122010000054I1 (de) 2011-05-05
FR10C0045I2 (fr) 2011-04-29
ES2347878T3 (es) 2010-11-22
EP1357125A3 (fr) 2003-11-26
DK1764368T3 (da) 2010-10-18
AU7340898A (en) 1998-10-30
EP0975640A1 (fr) 2000-02-02
EP1764368B1 (fr) 2010-07-14
CA2665949A1 (fr) 1998-10-15
CA2455416C (fr) 2010-11-02
CY2010019I1 (el) 2012-01-25
FR10C0045I1 (enExample) 2010-10-29
ATE473987T1 (de) 2010-07-15
JP2004277418A (ja) 2004-10-07
BR9807944A (pt) 2000-03-08
EP1764368A1 (fr) 2007-03-21
DK0975640T3 (da) 2004-11-01

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 24.08.2020