BR9810649A - "sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue" - Google Patents

"sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue"

Info

Publication number
BR9810649A
BR9810649A BR9810649-0A BR9810649A BR9810649A BR 9810649 A BR9810649 A BR 9810649A BR 9810649 A BR9810649 A BR 9810649A BR 9810649 A BR9810649 A BR 9810649A
Authority
BR
Brazil
Prior art keywords
red blood
cells
blood cells
interface
mononuclear cells
Prior art date
Application number
BR9810649-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Kyungyoon Min
Richard I Brown
Daniel F Bischof
William H Cork
Robert J Cantu
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of BR9810649A publication Critical patent/BR9810649A/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/302—Active control mechanisms with external energy, e.g. with solenoid valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222—Details related to the interface between cassette and machine
    • A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362261—Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265—Details of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362266—Means for adding solutions or substances to the blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B04B2013/006—Interface detection or monitoring of separated components

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
BR9810649-0A 1997-07-01 1998-06-22 "sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue" BR9810649A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/886,780 US5980760A (en) 1997-07-01 1997-07-01 System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
PCT/US1998/012172 WO1999001225A1 (en) 1997-07-01 1998-06-22 Systems and methods for harvesting mononuclear cells by recirculation of packed red blood cells

Publications (1)

Publication Number Publication Date
BR9810649A true BR9810649A (pt) 2000-10-03

Family

ID=25389755

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810649-0A BR9810649A (pt) 1997-07-01 1998-06-22 "sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue"

Country Status (9)

Country Link
US (1) US5980760A (enExample)
EP (1) EP1003609B1 (enExample)
JP (1) JP4076588B2 (enExample)
CN (1) CN1113702C (enExample)
BR (1) BR9810649A (enExample)
CA (1) CA2293298A1 (enExample)
DE (1) DE69836586T2 (enExample)
ES (1) ES2278414T3 (enExample)
WO (1) WO1999001225A1 (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US6312607B1 (en) 1995-06-07 2001-11-06 Baxter International Inc. Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
US6254784B1 (en) * 1997-10-30 2001-07-03 Baxter International Inc. Optical interface detection system for centrifugal blood processing
JP3196838B2 (ja) * 1998-09-11 2001-08-06 ヘモネティクス・コーポレーション アフェレーシス装置及び血液製剤の製造方法
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6315707B1 (en) 1999-09-03 2001-11-13 Baxter International Inc. Systems and methods for seperating blood in a rotating field
US6294094B1 (en) 1999-09-03 2001-09-25 Baxter International Inc. Systems and methods for sensing red blood cell hematocrit
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US6322488B1 (en) * 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6860846B2 (en) * 1999-09-03 2005-03-01 Baxter International Inc. Blood processing systems and methods with umbilicus-driven blood processing chambers
US6284142B1 (en) 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US7011761B2 (en) * 1999-09-03 2006-03-14 Baxter International Inc. Red blood cell processing systems and methods which control red blood cell hematocrit
US20020077241A1 (en) * 1999-09-03 2002-06-20 Baxter International Inc. Blood processing systems and methods with quick attachment of a blood separation chamber to a centrifuge rotor
US6730054B2 (en) * 1999-10-16 2004-05-04 Baxter International Inc. Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit
US6466879B1 (en) * 2000-07-13 2002-10-15 Baxter International Inc. Systems and methods for monitoring introduction of a processing fluid during a fluid processing procedure
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
US6808503B2 (en) 2001-03-06 2004-10-26 Baxter International Inc. Automated system and method for pre-surgical blood donation and fluid replacement
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6878105B2 (en) 2001-08-16 2005-04-12 Baxter International Inc. Red blood cell processing systems and methods with deliberate under spill of red blood cells
JP3997890B2 (ja) * 2001-11-13 2007-10-24 松下電器産業株式会社 送信方法及び送信装置
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
WO2003089926A2 (en) 2002-04-19 2003-10-30 Mission Medical, Inc. Integrated automatic blood processing unit
US6982038B2 (en) 2002-06-14 2006-01-03 Medtronic, Inc. Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma
US6849039B2 (en) * 2002-10-24 2005-02-01 Baxter International Inc. Blood processing systems and methods for collecting plasma free or essentially free of cellular blood components
US7297272B2 (en) * 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US7476209B2 (en) 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US8628489B2 (en) 2008-04-14 2014-01-14 Haemonetics Corporation Three-line apheresis system and method
US8454548B2 (en) 2008-04-14 2013-06-04 Haemonetics Corporation System and method for plasma reduced platelet collection
US8702637B2 (en) 2008-04-14 2014-04-22 Haemonetics Corporation System and method for optimized apheresis draw and return
US8834402B2 (en) 2009-03-12 2014-09-16 Haemonetics Corporation System and method for the re-anticoagulation of platelet rich plasma
FI123500B (fi) 2009-09-25 2013-06-14 Metso Paper Inc Järjestely kuiturainan kiinnirullaimen yhteydessä
JP5490966B2 (ja) 2010-11-05 2014-05-14 ヘモネティクス・コーポレーション 自動化された血小板洗浄のためのシステムおよび方法
US20220031925A1 (en) 2010-11-19 2022-02-03 Dsm Ip Assets B.V. Centrifuge
US8317672B2 (en) 2010-11-19 2012-11-27 Kensey Nash Corporation Centrifuge method and apparatus
US8394006B2 (en) 2010-11-19 2013-03-12 Kensey Nash Corporation Centrifuge
US8870733B2 (en) 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US8556794B2 (en) 2010-11-19 2013-10-15 Kensey Nash Corporation Centrifuge
US8469871B2 (en) 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US9302042B2 (en) 2010-12-30 2016-04-05 Haemonetics Corporation System and method for collecting platelets and anticipating plasma return
US11386993B2 (en) 2011-05-18 2022-07-12 Fenwal, Inc. Plasma collection with remote programming
US9347540B2 (en) * 2011-09-22 2016-05-24 Fenwal, Inc. Flexible shaft drive system for centrifuge with pivoting arms
CN111494743B (zh) 2012-09-04 2023-08-22 汾沃有限公司 血液处理系统和在血液处理系统内监测流体的方法
EP3660140A1 (en) 2014-01-31 2020-06-03 DSM IP Assets B.V. Adipose tissue processing centrifuge and methods of use
US9833557B2 (en) 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
US11383015B2 (en) * 2016-01-11 2022-07-12 Fenwal, Inc. System and method for plasma purification prior to mononuclear cell collection
EP3354300B1 (en) 2017-01-30 2020-08-05 Fenwal, Inc. Systems for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis
CN106890373A (zh) * 2017-02-10 2017-06-27 广州上诺生物技术有限公司 一种用于数字化管理血浆过滤白细胞的方法及系统
EP3372259B1 (en) 2017-03-07 2022-11-23 Fenwal, Inc. System and methods for separating blood under conditions of reduced plasma clarity
US10792416B2 (en) 2017-05-30 2020-10-06 Haemonetics Corporation System and method for collecting plasma
US10758652B2 (en) 2017-05-30 2020-09-01 Haemonetics Corporation System and method for collecting plasma
US10561784B2 (en) 2017-05-31 2020-02-18 Fenwal, Inc. Stationary optical monitoring system for blood processing system
EP3501562B1 (en) 2017-12-22 2025-02-05 Fenwal, Inc. Convertible fluid processing assemblies
CA3088016A1 (en) 2018-01-22 2019-07-25 Scinogy Products Pty Ltd System, method and controller for recovery of concentrated particles suspended in fluid
EP3553498B1 (en) 2018-04-13 2021-06-02 Fenwal, Inc. Optical detection and measurement of hematocrit and free hemoglobin concentration
US12033750B2 (en) 2018-05-21 2024-07-09 Fenwal, Inc. Plasma collection
CN112105403B (zh) 2018-05-21 2022-08-09 汾沃有限公司 用于对血浆采集体积进行优化的系统和方法
US11412967B2 (en) 2018-05-21 2022-08-16 Fenwal, Inc. Systems and methods for plasma collection
US10890524B2 (en) 2018-06-05 2021-01-12 Fenwal, Inc. Discerning between the presence of red blood cells and free hemoglobin in a biological fluid
US11137344B2 (en) 2018-11-28 2021-10-05 Fenwal, Inc. Optical mixing of fluids
EP3705147B1 (en) 2019-03-05 2024-11-06 Fenwal, Inc. Collection, genome editing, and washing of t-cell lymphocytes
EP4483917A3 (en) 2019-03-05 2025-03-19 Fenwal, Inc. Collection of mononuclear cells and peripheral blood stem cells
EP3741460B1 (en) 2019-05-23 2023-09-27 Fenwal, Inc. Adjustment of target interface location between separated fluid components in a centrifuge
EP4035700B1 (en) 2021-01-29 2025-03-05 Fenwal, Inc. Automated splitting of a fluid into uneven volumes
US11898967B2 (en) 2021-02-02 2024-02-13 Fenwal, Inc. Predicting malfunction and failure of centrifuge umbilicus
US12235208B2 (en) 2021-04-15 2025-02-25 Fenwal, Inc. Adjustment of the thickness of a biological fluid being monitored by an optical detection assembly

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145713A (en) * 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US3655123A (en) * 1966-08-08 1972-04-11 Us Health Education & Welfare Continuous flow blood separator
US3519201A (en) * 1968-05-07 1970-07-07 Us Health Education & Welfare Seal means for blood separator and the like
BE794220A (fr) * 1972-01-28 1973-05-16 Ibm Reservoir destine notamment au traitement du sang
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US4113173A (en) * 1975-03-27 1978-09-12 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus
US3957197A (en) * 1975-04-25 1976-05-18 The United States Of America As Represented By The United States Energy Research And Development Administration Centrifuge apparatus
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4425112A (en) * 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
US4636193A (en) * 1976-05-14 1987-01-13 Baxter Travenol Laboratories, Inc. Disposable centrifugal blood processing system
US4430072A (en) * 1977-06-03 1984-02-07 International Business Machines Corporation Centrifuge assembly
US4094461A (en) * 1977-06-27 1978-06-13 International Business Machines Corporation Centrifuge collecting chamber
US4419089A (en) * 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4164318A (en) * 1977-10-12 1979-08-14 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus with reduced-load tubing
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US4386730A (en) * 1978-07-21 1983-06-07 International Business Machines Corporation Centrifuge assembly
SE412528B (sv) * 1978-07-25 1980-03-10 Separex Sa Centrifugrotor och kollaberbar separationsbehallare
US4283004A (en) * 1979-08-15 1981-08-11 Baxter Travenol Laboratories, Inc. Vibration attenuation support assembly for a centrifugal liquid processing apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4447221A (en) * 1982-06-15 1984-05-08 International Business Machines Corporation Continuous flow centrifuge assembly
SE8302215D0 (sv) * 1983-04-20 1983-04-20 Alfa Laval Marine Power Eng Centrifugalseparator
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
FR2548541B1 (fr) * 1983-07-07 1986-09-12 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
FR2548907B1 (fr) * 1983-07-13 1985-11-08 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4776964A (en) * 1984-08-24 1988-10-11 William F. McLaughlin Closed hemapheresis system and method
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
US4647279A (en) * 1985-10-18 1987-03-03 Cobe Laboratories, Inc. Centrifugal separator
US4724317A (en) * 1985-12-05 1988-02-09 Baxter Travenol Laboratories, Inc. Optical data collection apparatus and method used with moving members
US4670002A (en) * 1985-12-09 1987-06-02 Hitachi Koki Company, Ltd. Centrifugal elutriator rotor
US4708710A (en) * 1986-03-27 1987-11-24 E. I. Du Pont De Nemours And Company Particle separation process
US4708712A (en) * 1986-03-28 1987-11-24 Cobe Laboratories, Inc. Continuous-loop centrifugal separator
US5076911A (en) * 1987-01-30 1991-12-31 Baxter International Inc. Centrifugation chamber having an interface detection surface
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US4940543A (en) * 1987-01-30 1990-07-10 Baxter International Inc. Plasma collection set
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US5078671A (en) * 1988-10-07 1992-01-07 Baxter International Inc. Centrifugal fluid processing system and method
US4936820A (en) * 1988-10-07 1990-06-26 Baxter International Inc. High volume centrifugal fluid processing system and method for cultured cell suspensions and the like
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
US5224921A (en) * 1990-05-31 1993-07-06 Baxter International Inc. Small volume collection chamber
AU663160B2 (en) * 1991-12-23 1995-09-28 Baxter International Inc. Centrifuge
US5437624A (en) * 1993-08-23 1995-08-01 Cobe Laboratories, Inc. Single needle recirculation system for harvesting blood components
WO1994025086A1 (en) * 1993-04-27 1994-11-10 Haemonetics Corporation Apheresis apparatus and method
SE9302369D0 (sv) * 1993-07-08 1993-07-08 Omega Medicinteknik Ab Paassystem avsett foer centrifugalseparationsamt an vaendning av detta paassystem
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
US5704888A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
DE19637892A1 (de) * 1996-09-17 1998-03-19 Basf Ag Verfahren zur Herstellung von Alkoxybutenen

Also Published As

Publication number Publication date
US5980760A (en) 1999-11-09
DE69836586D1 (de) 2007-01-18
WO1999001225A1 (en) 1999-01-14
CN1268075A (zh) 2000-09-27
EP1003609B1 (en) 2006-12-06
CN1113702C (zh) 2003-07-09
EP1003609A1 (en) 2000-05-31
CA2293298A1 (en) 1999-01-14
DE69836586T2 (de) 2007-09-13
ES2278414T3 (es) 2007-08-01
JP4076588B2 (ja) 2008-04-16
EP1003609A4 (en) 2004-12-15
JP2002511785A (ja) 2002-04-16

Similar Documents

Publication Publication Date Title
BR9810649A (pt) "sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue"
BR9806231A (pt) Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada
BR0204453A (pt) Sistema automatizado e método para a retirada de compostos do sangue
BR0204451A (pt) Sistemas automatizados de processamento de sangue e fluidos de múltiplas finalidades, e métodos
WO2003065007A3 (en) Sample level detection system
ATE240409T1 (de) Nicht-invasive pränatale diagnose
BR0014802A (pt) Sistemas e métodos automatizados para a coleta para obter células sanguìneas vermelhas, plaquetas e plasma do sangue total
ES2194101T3 (es) Sistemas de procesamiento de sangre y metodos para recoger celulas mononucleares.
Kekomäki et al. Successful treatment of platelet transfusion refractoriness: the use of platelet transfusions matched for both human leucocyte antigens (HLA) and human platelet alloantigens (HPA) in alloimmunized patients with leukaemia
Remacha et al. Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 status
BRPI0519952A2 (pt) sistema de detecção de mau acondicionamento de láminas
Dede et al. Serum biochemical profile and protein fractions in cattle with Theileriosis
Giovazzino et al. Reduced regulatory T cells (Treg) in bone marrow preferentially associate with the expansion of cytotoxic T lymphocytes in low risk MDS patients.
Igbokwe et al. Effect of acute Trypanosoma vivax infection on cattle erythrocyte glutathione and susceptibility to in vitro peroxidation
Sultan et al. Fiber type-specific expression of major proteolytic systems in fast-to slow-transforming rabbit muscle
DE3169374D1 (en) Compositions able to separate the erythrocytes from the serum or plasma in blood analysis samples, and the method which uses them
Mirkin et al. Different Trypanosoma cruzi strains promote neuromyopathic damage mediated by distinct T lymphocyte subsets
Neppelenbroek et al. Cytomegalovirus-associated thrombosis
EP1242099A4 (en) METHOD FOR THE TREATMENT OF INFECTION DISEASES
Esievo et al. Electrophoresis of bovine erythrocyte sialic acids: existence of additional band in trypanotolerant Ndama cattle
Bumm et al. T-lymphocyte subpopulations and HLA-DR antigens in patients with Bell’s palsy, hearing loss, neuronitis vestibularis, and Meniere’s disease
Malapati et al. Analysis of blood parameters in HIV positive patients
Caruso et al. HLA‐DR phenotypes and blood levels of T cell subsets
Bernard et al. Spontaneous phenotypic and molecular blood remission in a case of chronic lymphocytic leukaemia.
EP1816478A3 (de) Nachweisverfahrenö für Fibrinogen und/oder Fibrinogen-Derivate

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/04/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)