BR9709778A - Sistemas liquissólidos e métodos de preparação dos mesmos. - Google Patents

Sistemas liquissólidos e métodos de preparação dos mesmos.

Info

Publication number
BR9709778A
BR9709778A BR9709778-0A BR9709778A BR9709778A BR 9709778 A BR9709778 A BR 9709778A BR 9709778 A BR9709778 A BR 9709778A BR 9709778 A BR9709778 A BR 9709778A
Authority
BR
Brazil
Prior art keywords
coating materials
liquid
carrier
compressible
flowing
Prior art date
Application number
BR9709778-0A
Other languages
English (en)
Inventor
Spiridon Spireas
Sanford M Bolton
Original Assignee
Spiridon Spireas
Sanford M Bolton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24641555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9709778(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Spiridon Spireas, Sanford M Bolton filed Critical Spiridon Spireas
Publication of BR9709778A publication Critical patent/BR9709778A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

<B>SISTEMAS LIQUISSóLIDOS E MéTODOS DE PREPARAçãO DOS MESMOS<D>. Sistemas liquissólidos são formas em pó aceitavelmente fluentes e compressíveis de medicações líquidas. De acordo com o conceito de sistemas liquissólidos, drogas lipofílicas líquidas ou drogas insolúveis em água dissolvidas em solventes não voláteis adequados podem ser convertidas em pós facilmente compressíveis e de fluxo livre mediante mistura simples com excipientes em pó selecionados referidos como materiais portador e de revestimento; um esboço esquemático das etapas pode ser traçado para o processo. Vários tipos de celulose microcristalina ou amorfa podem ser usados como portadores, ao passo que pós de sílica com tamanho de partícula muito fino podem ser usados como materiais de revestimento. Baseado na teoria de que os materiais portador e de revestimento podem reter apenas certas quantidades de líquido e ao mesmo tempo manter propriedades de fluxo e de compressão aceitáveis, um novo modelo matemático de formulação é provido para calcular as quantidades ótimas de materiais portador e de revestimento exigidos para produzir misturas de líquido/pó aceitavelmente fluentes e compressíveis.
BR9709778-0A 1996-06-10 1997-06-09 Sistemas liquissólidos e métodos de preparação dos mesmos. BR9709778A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/658,514 US5800834A (en) 1996-06-10 1996-06-10 Liquisolid systems and methods of preparing same
PCT/US1997/010093 WO1997047290A1 (en) 1996-06-10 1997-06-09 Liquisolid systems and methods of preparing same

Publications (1)

Publication Number Publication Date
BR9709778A true BR9709778A (pt) 2000-01-11

Family

ID=24641555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709778-0A BR9709778A (pt) 1996-06-10 1997-06-09 Sistemas liquissólidos e métodos de preparação dos mesmos.

Country Status (13)

Country Link
US (2) US5800834A (pt)
EP (1) EP0946154B1 (pt)
JP (1) JP2000512295A (pt)
CN (1) CN1224379C (pt)
AT (1) ATE486584T1 (pt)
BR (1) BR9709778A (pt)
CA (1) CA2257890C (pt)
DE (1) DE69740040D1 (pt)
ES (1) ES2355871T3 (pt)
HK (1) HK1022844A1 (pt)
IL (1) IL127295A (pt)
RU (1) RU2209623C2 (pt)
WO (1) WO1997047290A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
ATE462417T1 (de) 1998-08-13 2010-04-15 Cima Labs Inc Microemulsionen als feste dosisformen zur oralen verabreichung
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
DK1140027T3 (da) * 1998-12-23 2006-02-27 Alza Corp Doseringsformer indeholdende poröse partikler
US6635281B2 (en) 1998-12-23 2003-10-21 Alza Corporation Gastric retaining oral liquid dosage form
US6793934B1 (en) 1999-12-08 2004-09-21 Shire Laboratories, Inc. Solid oral dosage form
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
WO2001052818A1 (en) * 2000-01-19 2001-07-26 Pharmaceutical Discovery Corporation Dry powder formulations of antihistamine for nasal administration
US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US7056951B2 (en) 2000-09-26 2006-06-06 Mutual Pharmaceutical Co., Inc. Stable solid dosage forms of amino acids and processes for producing same
US6855333B1 (en) 2000-10-03 2005-02-15 Mutual Pharmaceutical Co., Inc. Stabilization of solid thyroid drug formulations
US6979462B1 (en) * 2000-10-03 2005-12-27 Mutual Pharmaceutical Co., Inc. Stabilization of solid drug formulations
AU2001241730B2 (en) * 2001-02-23 2007-03-15 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
ITMI20012366A1 (it) * 2001-11-09 2003-05-09 Farmatron Ltd Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali
US20030099699A1 (en) * 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
RU2342953C2 (ru) * 2003-02-24 2009-01-10 Фармасьютикал Продакшенз, Инк. Трансмукозная система доставки лекарственных средств
JP2007507527A (ja) * 2003-09-30 2007-03-29 スフェリックス， インコーポレイテッド 生物学的に活性なナノ粒子治療用因子
EP2110124B1 (en) * 2004-03-08 2013-07-17 Spiridon Spireas Bioavailable Solid Dosage Forms of Metaxalone
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
CA2577583A1 (en) * 2004-08-19 2006-03-02 Alza Corporation Controlled release nanoparticle active agent formulation dosage forms and methods
FR2894822B1 (fr) * 2005-12-20 2011-11-18 Pf Medicament Composition pharmaceutique contenant des acides gras omega-3
US7569612B1 (en) 2006-08-21 2009-08-04 Mutual Pharmaceutical Company, Inc. Methods of use of fenofibric acid
US10004682B2 (en) 2010-08-24 2018-06-26 Rutgers, The State University Of New Jersey Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
CN102949363A (zh) * 2012-11-28 2013-03-06 山东省中医药研究院 熊果酸液固压缩片
EP2950923B1 (en) 2013-02-01 2022-03-09 W.R. Grace & CO. - CONN. Porous silica gel as a carrier for liquid technologies
GB201812022D0 (en) * 2018-07-24 2018-09-05 Univ Of Sussex Pharmaceutical methods and compositions
US10744137B1 (en) * 2020-01-06 2020-08-18 King Abdulaziz University Liquisolid tablet containing combined dose of tadalafil and dapoxetine
CN111067875B (zh) * 2020-01-16 2021-11-30 兰州大学 一种阿苯达唑液固压缩片及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1368112A (en) * 1971-09-08 1974-09-25 Geistlich Soehne Ag Chemical compositions for the treatment of hyperlipemia
DE2400819C2 (de) * 1974-01-09 1982-04-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung

Also Published As

Publication number Publication date
JP2000512295A (ja) 2000-09-19
IL127295A (en) 2002-05-23
ATE486584T1 (de) 2010-11-15
WO1997047290A1 (en) 1997-12-18
EP0946154B1 (en) 2010-11-03
ES2355871T3 (es) 2011-03-31
IL127295A0 (en) 1999-09-22
HK1022844A1 (en) 2000-08-25
EP0946154A4 (en) 2007-02-07
US5968550A (en) 1999-10-19
DE69740040D1 (de) 2010-12-16
US5800834A (en) 1998-09-01
CA2257890C (en) 2003-10-28
CA2257890A1 (en) 1997-12-18
AU3387097A (en) 1998-01-07
CN1224379C (zh) 2005-10-26
CN1221337A (zh) 1999-06-30
RU2209623C2 (ru) 2003-08-10
EP0946154A1 (en) 1999-10-06
AU709566B2 (en) 1999-09-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]

Free format text: REFERENTE A RPI 1812 DE 27/09/2005.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO COM BASE NO DISPOSTO NO ARTIGO 10 (I) DA LEI 9279/96

B12B Appeal against refusal [chapter 12.2 patent gazette]