BR122016030041A2 - syringe pump to deliver an agent to a patient - Google Patents

Abstract

The present invention relates to a method for discharging fluid from a syringe and for attenuating occlusion conditions including actuating the plunger of a syringe within a barrel. The method monitors fluid pressure within the syringe barrel and determines that there is an occlusion when fluid pressure exceeds a predetermined limit. The method actuates the plunger out of the barrel in a predetermined amount in response to the detected occlusion and actuates the syringe plunger within the barrel until a measured fluid pressure within the syringe barrel exceeds another predetermined limit.

Description

1/294

Invention Patent Report for SYRINGE PUMPS TO ADMINISTER AN AGENT TO A PATIENT.

[001] Divided from BR112015015081-0, deposited on 12/20/2013.

CROSS REFERENCES TO RELATED APPLICATIONS [002] This application is a Non-Interim Application claiming the benefit of US Serial Patent Application No. ² 61 / 904,123, filed on November 14, 2013 and entitled Syringe Pump and Related Method (Number of the Lawyer Dossier L33); and Provisional Patent Application No. ² , US 61 / 894.801, filed on October 23, 2013 and entitled Syringe Pump and Related Method (Lawyer Dossier Number K88), each of which is incorporated into this document by way of reference in its entirety.

[003] This application is also a Continuation in Part of US Patent Application No. ² Serial 13 / 833,432, filed on March 15, 2013 and entitled Syringe Pump and Related Method, now Publication No. ² US-2013-0281965- A1, published on October 24, 2013 (Lawyer Dossier Number K21), which claims the priority and benefit of the following:

[004] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30); and [005] Provisional Patent Application No. ² , US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), both of which are incorporated. this document as a reference in its entirety.

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2/294 [006] US Patent Application Serial No. ² 13 / 833,432 (Lawyer Dossier Number K21) claims priority for and is also a Continuation Request in Part of the following:

[007] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [008] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO); and [009] US Patent Application No. ² Serial 13 / 723,238, filed December 21, 2012 and entitled System, Method, and Apparatus for Clamping, now Publication No. ² US-2013-0182381-A1, published on December 18 July 2013 (Lawyer Dossier Number J47), which claims priority and benefit from the following:

[0010] Provisional Patent Application No. ² , serial US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0011] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0012] Provisional Patent Application No. ² , serial US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

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3/294 [0013] Provisional Patent Application No. ² Serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30 ); and [0014] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), each of which is incorporated into this document as a reference in its entirety.

[0015] The Patent Application No. ² of US 13 / 723,238 number (Attorney Dossier J47) claims priority to and is a Continuation in Part Application of the following:

[0016] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0017] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0018] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 723,235, filed on December 21, 2012 and entitled System, Method, and Apparatus for Dispensing Oral Medications, now Publication No. ² US-2013-0197693-A1, published on August 1, 2013 (Lawyer Dossier Number J74), which claims prioriPetição 870160077500 , of 12/20/2016, p. 20/484

4/294 quality and benefit of the following:

[0019] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0020] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0021] Provisional Patent Application No. ² , serial US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0022] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30); and [0023] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), each of which is incorporated into this document as a reference in its entirety.

[0024] The Patent Application No. ² of US 13 / 723,235 number (Attorney Dossier Number J74) claims priority to and is a Continuation in Part Application of the following:

[0025] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Number of

Lawyer Dossier I97), and

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5/294 [0026] PCT application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication No. ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0027] The Patent Application No ² of US 13 / 833,432 number (Dossier Number Attorney K21) is also a Continuation Application of Part PCT Application No ² Serial No. PCT / US12 / 71131, filed on December 21, 2012 and entitled System, Method, and Apparatus for Dispensing Oral Medications, now International Publication No. ² WO 2013/096718, published on June 27, 2013 (Lawyer Dossier Number J74WO), which claims priority and benefit from the following:

[0028] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0029] Provisional Patent Application No. ² , US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0030] Provisional Patent Application No. ² , US 61 / 578,674, filed December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0031] Provisional Patent Application No. ² , US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and

Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and

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6/294 [0032] Provisional Patent Application No. ² serial No. 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Dossier Attorney Number J30 ), each of which is incorporated into this document as a reference in its entirety.

[0033] PCT Order No. ² PCT / US12 / 71131 (Lawyer Dossier Number J74WO) claims priority for and is a Continuation Request in Part of the following:

[0034] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0035] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0036] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 724,568, filed on December 21, 2012 and entitled System, Method, and Apparatus for Estimating Liquid Delivery, now Publication No. ² US-2013-0184676-A1, published on July 18, 2013 (Lawyer Dossier Number J75), which claims priority and benefit of the following:

[0037] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method,

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7/294 and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0038] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0039] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0040] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30); and [0041] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), each of which is incorporated into this document as a reference in its entirety.

[0042] The Patent Application No. ² of US 13 / 724,568 number (Attorney Dossier Number J75) claims priority to and is a Continuation in Part Application of the following:

[0043] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0044] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ²

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8/294

WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0045] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 725,790, filed on December 21, 2012 and entitled System, Method, and Apparatus for Infusing Fluid, now Publication No. ² US-2013-0177455-A1, published on July 11, 2013 (Lawyer Dossier Number J76), which claims priority and benefit of the following:

[0046] Provisional Patent Application No. ² , serial US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0047] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0048] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0049] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30); and [0050] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Advo Dossier Number

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9/294 cattle J46), each of which is incorporated in this document as a reference in its entirety.

[0051] The Patent Application No. ² of US 13 / 725,790 number (Attorney Dossier Number J76) claims priority to and is a Continuation in Part Application of the following:

[0052] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0053] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0054] The Patent Application No ² of US 13 / 833,432 number (Dossier Number Attorney K21) is also a Continuation Application of Part PCT Application No ² Serial No. PCT / US12 / 71490, filed on December 21, 2012 and entitled System, Method, and Apparatus for Infusing Fluid, now International Publication No. ² WO 2013/096909, published on June 27, 2013 (Lawyer Dossier Number J76WO), which claims priority and benefit from the following:

[0055] Provisional Patent Application No. ² of series US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0056] Provisional Patent Application No. ² , US 61 / 578,658, filed on December 21, 2011 and entitled System, Method,

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10/294 and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0057] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0058] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30); and [0059] Provisional Patent Application No. ² , US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), each of which is incorporated into this document as a reference in its entirety.

[0060] PCT Order No. ² PCT / US12 / 71490 (Lawyer Dossier Number J76WO) claims priority for and is a Continuation Request in Part of the following:

[0061] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US-2012-0185267-A1, published on 19 July 2012 (Lawyer Dossier Number I97), and [0062] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication No. ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0063] US Patent Application No. ² Serial 13 / 833,432 (Number

Petition 870160077500, of 12/20/2016, p. 27/484

11/294 of Lawyer Dossier K21) claims priority for and is also a Continuation Request in Part of US Patent Application Serial No. ² 13 / 723,239, filed on December 21, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US-2013-0297330-A1, published on November 7, 2013 (Lawyer Dossier Number J77), which claims priority and benefit from the following:

[0064] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0065] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0066] Provisional Patent Application No. ² , serial US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0067] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [0068] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30), each of which is incorporated into this document as a reference in its entirety.

[0069] The patent application US Serial ² 13 / 723,239 (Number

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12/294 of Lawyer Dossier J77) claims priority for and is a Continuation Request in Part of the following:

[0070] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0071] PCT Application Serial No. ² PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0072] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 723,242, filed on December 21, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US-2013-0317753-A1, published on November 28, 2013 (Lawyer Dossier Number J78), which claims priority and benefit of the following:

[0073] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46), which is incorporated into this document as a reference in its entirety.

[0074] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 723,244, filed on December 21, 2012 and entitled

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13/294

System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow, now Publication No. ² US-2013-0188040A1, published July 25, 2013 (Lawyer Dossier Number J79), which claims priority and benefit from the following :

[0075] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0076] Provisional Patent Application No. ² , US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0077] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0078] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [0079] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30), each of which is incorporated into this document as a reference in its entirety.

[0080] The Patent Application No. ² of US 13 / 723,244 number (Attorney Dossier Number J79) claims priority to and is a Continuation in Part Application of the following:

[0081] U.S. Patent Application Serial Number 13 / 333,574, of

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14/294 issued on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0082] PCT application No. ² PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication No. ² WO 2013/095459, published on September 12 2013 (Lawyer Dossier Number I97WO), both of which are incorporated into this document as a reference in their entirety.

[0083] US Patent Application No. ² Serial 13 / 833,432 (Lawyer Dossier Number K21) claims priority for and is also a Part Continuing Application for PCT Application No. ² PCT / US12 / 71142, filed on December 21, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow, now International Publication No. ² WO 2013/096722, published on June 27, 2013 (Lawyer Dossier Number J79WO), which claims priority and benefit from the following:

[0084] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0085] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0086] Provisional Patent Application No. ² , serial US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Dossier Number

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15/294 of Lawyer J05);

[0087] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [0088] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30), each of which is incorporated into this document as a reference in its entirety.

[0089] PCT Order No. ² PCT / US12 / 71142 (Lawyer Dossier Number J79WO) claims priority for and is a Continuation Request in Part of the following:

[0090] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [0091] PCT Application Serial No. ² PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[0092] US Patent Application No. ² Serial 13 / 833,432 (Lawyer Dossier Number K21) claims priority for and is also a Part Continuing Application for US Patent Application No. ² Serial 13 / 723,251, filed on December 21, 2012 and entitled System, Method, and Apparatus for Estimating Liquid Delivery,

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16/294 now Publication No. ² US-2013-0204188-A1, published on August 8, 2013 (Lawyer Dossier Number J81), which claims priority and benefit from the following:

[0093] Provisional Patent Application No. ² of series US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[0094] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[0095] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[0096] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [0097] Provisional Patent Application No. ² , serial US 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number J30), each of which is incorporated into this document as a reference in its entirety.

[0098] The Patent Application No. ² of US 13 / 723,251 number (Attorney Dossier Number J81) claims priority to and is a Continuation in Part Application of the following:

[0099] U.S. Patent Application Serial Number 13 / 333,574, filed December 21, 2011 and entitled System, Method,

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17/294 and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [00100] PCT Application No. ² PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication No. ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), and both are incorporated by reference in their entirety for reference in their entirety.

[00101] The Patent Application No ² of US 13 / 833,432 number (Dossier Number Attorney K21) is also a Continuation Application of Part PCT Application No ² Serial No. PCT / US12 / 71112, filed on December 21, 2012 and entitled System, Method, and Apparatus for Estimating Liquid Delivery, now International Publication No. ² WO 2013/096713, published on June 27, 2013 (Lawyer Dossier Number J81W0), which claims priority and benefit from the following:

[00102] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[00103] Provisional Patent Application No. ² , US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[00104] Provisional Patent Application No. ² , US 61 / 578,674, filed December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[00105] Provisional Patent Application No. ² , serial US 61 / 651,322,

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18/294 filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [00106] Provisional Patent Application No. ² Serial No. 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Dossier Number Attorney J30) each of which is incorporated into this document as a reference in its entirety.

[00107] PCT Order No. ² PCT / US12 / 71112 (Lawyer Dossier Number J81W0) claims priority for and is a Continuation Request in Part of the following:

[00108] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US2012-0185267-A1, published on July 19, 2012 (Lawyer Dossier Number I97), and [00109] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication n ² WO 2013/095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[00110] The Patent Application No. ² of US 13 / 833,432 number (Dossier Number Attorney K21) claims priority to , and is also a Continuation Application of U.S. Patent Application Part No ² standard US 13 / 723,253, filed on December 21, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US-2013-0191513-A1, published on July 25, 2013 (Lawyer Dossier Number J85), which claims priority

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19/294 and benefit from the following:

[00111] Provisional Patent Application No. ² , US 61 / 578,649, filed on December 21, 2011 and entitled System, Method, and Apparatus for Infusing Fluid (Lawyer Dossier Number J02);

[00112] Provisional Patent Application No. ² , serial US 61 / 578,658, filed on December 21, 2011 and entitled System, Method, and Apparatus for Estimating Liquid Delivery (Lawyer Dossier Number J04);

[00113] Provisional Patent Application No. ² , US 61 / 578,674, filed on December 21, 2011 and entitled System, Method, and Apparatus for Dispensing Oral Medications (Lawyer Dossier Number J05);

[00114] Provisional Patent Application No. ² , serial US 61 / 651,322, filed on May 24, 2012 and entitled System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number J46); and [00115] Provisional Patent Application No. ² Serial No. 61 / 679,117, filed on August 3, 2012 and entitled System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Dossier Number Attorney J30) each of which is incorporated into this document as a reference in its entirety.

[00116] The Patent Application No. ² of US 13 / 723,253 number (Attorney Dossier Number J85) claims priority to and is a Continuation in Part Application of the following:

[00117] Patent Application Serial Number US 13 / 333,574, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now Publication No. ² US US-2012-0185267-A1, published on 19 July 2012 (Number of

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20/294

Lawyer Dossier 197), and [00118] PCT Application No. ² serial PCT / US11 / 66588, filed on December 21, 2011 and entitled System, Method, and Apparatus for Electronic Patient Care, now International Publication No. ² WO 2013 / 095459, published on September 12, 2013 (Lawyer Dossier Number I97WO), both of which are incorporated by reference in their entirety for reference.

[00119] This application may also be related to one or more of the following U.S. patent applications filed on March 15, 2013, all of which are incorporated by reference in their entirety for reference in their entirety:

[00120] Non Provisional Order for Apparatus for Infusing Fluid (Lawyer Dossier Number K14) which has Serial Number 13 / 840.339;

[00121] PCT application for Apparatus for Infusing Fluid (Lawyer Dossier Number K14W0);

[00122] Non Provisional Application for System and Apparatus for Electronic Patient Care (Lawyer Dossier Number K22) which has Serial Number 13 / 836,497;

[00123] Non Provisional Application for System, Method and Apparatus for Clamping (Lawyer Dossier Number K23) that has Serial Number 13 / 833,712; and [00124] Non-Interim Order for System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number K28) that has Serial Number 13 / 834.030.

[00125] This request can also be related to the following requests that are incorporated into this document as a reference in their entirety:

[00126] Provisional Order for Electronic Order Intermediation System for a Medicai Facility (Lawyer Dossier Number H53)

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21/294 that has the Serial Number 61 / 297,544, deposited on January 22, 2010;

[00127] Non Provisional Order for Electronic Patient Monitoring System (Lawyer Dossier Number I52) which has Serial Number 13 / 011.543, filed on January 21, 2011;

[00128] Provisional Application for System, Method, and Apparatus for Bubble Detection in a Fluid Line Using a Split-Ring Resonator (Lawyer Dossier Number J31) that has Serial Number 61 / 860,398, filed on July 31, 2013 ;

[00129] Provisional Application for System, Method, and Apparatus for Detecting Air in a Fluid Line Using Active Rectification (Lawyer Dossier Number J32) that has Serial Number 61 / 738.447, filed on December 18, 2012;

[00130] Provisional Application for System, Method, and Apparatus for Communicating Data (Lawyer Dossier Number J80) that has Serial Number 61 / 740,474, filed on December 21, 2012;

[00131] Provisional Application for System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow (Lawyer Dossier Number K52) that has Serial Number 61 / 900,431, filed on November 6, 2013;

[00132] Non Provisional Application for System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number K66) that has Serial Number 13 / 900,655, filed on May 23, 2013;

[00133] International Application for System, Method, and Apparatus for Electronic Patient Care (Lawyer Dossier Number K66WO) which has the Serial Number PCT / US13 / 42350, filed on May 23, 2013;

[00134] Provisional Application for System, Method, and Apparatus

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22/294 for Clamping (Lawyer Dossier Number K75) which has Serial Number 61 / 843,574, filed on July 8, 2013;

[00135] Non-Interim Application for Electronic Patient Monitoring System (Lawyer Dossier Number K84) which has Serial Number 13 / 971.258, filed on August 20, 2013;

[00136] Non Provisional Application for System, Method, and Apparatus for Detecting Air in a Fluid Line Using Active Rectification (Lawyer Dossier Number L05) that has Serial Number 14 / 101,848, filed on December 10, 2013;

[00137] Non Provisional Application for Syringe Pump, and Related Method and System, filed on December 20, 2013 (Lawyer Dossier Number L50);

[00138] Non-Interim Application for Computer-Implemented Method, System, and Apparatus for Electronic Patient Care, filed on December 20, 2013 (Lawyer Dossier Number K50); and [00139] International Application for Computer-Implemented Method, System, and Apparatus for Electronic Patient Care, filed on December 20, 2013 (Lawyer Dossier Number K50WO).

BACKGROUND

RELEVANT FIELD [00140] The present disclosure refers to pumps. More particularly, the present disclosure relates to a system, method and apparatus for estimating liquid delivery from a syringe pump. DESCRIPTION OF THE RELATED TECHNIQUE [00141] Syringe pumps are used in a variety of medical applications, such as for the intravenous delivery of liquid medications, for example, to a patient in an intensive care unit (ICU), over a space of extended time. The pumps

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23/294 can be designed so that needles, tubing or other attachments are attached to the syringe pump. Syringe pumps typically include a plunger mounted on an axis that pushes liquid out of a reservoir. The reservoir can be a tube-shaped structure that has a port at one end so that the plunger can push (ie, discharge) the liquid out of the syringe pump. Syringe pumps can be coupled to an actuator that mechanically drives the plunger to control delivery of the liquid to the patient.

[00142] Syringe pumps can also be used to deliver various drugs including pain relievers, antiemetics or other fluids. The medication can be administered through an intravenous liquid line very quickly (for example, in a cake) or over a period of time. Syringe pumps can also be used in non-medical applications, such as in micro-reactors, in laboratory testing and / or in chemical processing applications.

SUMMARY [00143] According to one embodiment of the present disclosure, a pump for delivering an agent to a patient can comprise a housing. Within said housing may be a motor, a gearbox operatively connected to said motor, a means for capturing the rotation of said motor, a controller that acts to control the operation of said motor and monitor the quantity of said agent delivered to said patient and a pump set. The pump can be configured so that the pump is interchangeable from a syringe pump or peristaltic pump, respectively, to a peristaltic pump or syringe pump by replacing a pump set with a different pump set. [00144] In some modalities, the pump can be interchanged

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24/294 field pump from a syringe pump or peristaltic pump, respectively, to a peristaltic pump or syringe pump by replacing a pump set with a different pump set.

[00145] According to another embodiment of the present disclosure, a syringe pump for administering an agent to a patient can comprise a housing, a lead screw and a sliding block assembly. The sliding block assembly may comprise a cam, a cam projection fixedly coupled to the cam and a threaded portion which has the ability to engage and disengage the lead thread. The threaded portion can be configured to act between engagement and disengagement on the lead thread by means of cam rotation and cam projection.

[00146] In some embodiments, the sliding block assembly may comprise a slot with a straight extension and an arcuate extension.

[00147] In some embodiments, rotation of the cam can cause the cam projection to move inside the slot. As the cam projection moves within the straight extension of the slot, the threaded portion can be configured to be actuated between engagement and disengagement with the lead thread.

[00148] In some embodiments, the syringe pump may additionally comprise a gripping means configured to hold any of a range of piston flange sizes.

[00149] In some embodiments, the cam projection may not enter the straight length of the slot until the largest of the sizes of the plunger flange size range has been released by the medium configured to secure any of a range of flange sizes of plunger.

[00150] In some embodiments, the syringe pump can with

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25/294 additionally attach a plunger head assembly coupled to the sliding and operative block to drive a syringe plunger into a syringe barrel. A plunger tube can couple the plunger head assembly to the sliding block.

[00151] In some embodiments, the plunger tube can perform at least one or more additional functions from a list consisting of: a bushing holder for at least one rotating shaft, a channel for electrical conduits to and from the set of plunger head and a channel for data transmission ducts to and from the plunger head assembly.

[00152] In some embodiments, the syringe pump may additionally comprise a barrel flange clamp configured to retain a syringe barrel flange.

[00153] In some embodiments, the drum flange clamp may comprise a means of detecting the presence of a drum flange. The means of detecting the presence of a drum flange can comprise an optical sensor and a light source. The light source can be obscured in the presence of the drum flange.

[00154] In some embodiments, the location of the cam of the sliding block assembly can be adjustable so that a user can perfect the engagement of the threaded portion on the lead thread.

[00155] In some embodiments, the sliding block assembly may additionally include at least one bias member. The biasing member can be configured to orient the threaded portion in one of a position engaged in the lead thread and a disengaged position in the lead thread.

[00156] According to another aspect of the present disclosure, a syringe pump for delivering an agent to a patient can comprise a housing, a lead screw and a sliding block assembly. The sliding block assembly can comprise

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26/294 a threaded section configured to engage and disengage the lead thread. The syringe pump may additionally comprise a plunger head assembly coupled to said sliding and operative block for driving a syringe plunger within a syringe barrel. The syringe pump may additionally comprise a gripping means configured to hold any of a range of piston flange sizes. The means configured to secure any of a range of piston flange sizes may comprise at least a first piston flange gripper and a second piston flange gripper. The first and second piston flange grips can be configured to be actuated from a first position to a position in which at least one point of each of the first and second piston flange grips is in contact with an edge of the plunger flange that forces the plunger flange against the plunger head assembly and acts as an anti-siphon mechanism.

[00157] In some embodiments, the means configured to fix any of a range of piston flange sizes may comprise a cam, at least one cam follower and at least one bias member. The biasing member can guide said configured means to fix any one of a range of piston flange sizes towards a first position. In some embodiments, the movement of at least one cam follower along the cam can overcome the bias member and allow the configured medium to secure any one of a range of plunger flange sizes to move towards a second position.

[00158] In some embodiments, the cam, at least one cam follower and at least one bias member can be acted upon

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27/294 jokes to a rotating axis. The cam may not be rotatable with said axis, but it may be displaceable along an axial dimension of said axis. The at least one cam follower can be fixedly coupled to the axis and rotatable with the axis. Rotation of the shaft can cause the movement of at least one cam follower along the cam, thereby displacing the cam along the axial dimension of the shaft.

[00159] In some embodiments, the bias member can automatically return the configured medium to fix any range of piston flange sizes to the first position in the absence of sufficient force to overcome the bias member.

[00160] In some embodiments, the cam may comprise at least one holder, each of said holders being reached by one of the at least one cam follower when the means configured to fix any range of piston flange sizes has been enabled to move to the second position.

[00161] In some embodiments, the plunger head assembly may additionally comprise a pressure sensor to monitor the pressure of the agent that is dispensed from the syringe.

[00162] In some embodiments, the plunger flange of the syringe can be held against the pressure sensor by the means configured to fix any range of plunger flange sizes.

[00163] In some embodiments, the syringe pump may additionally comprise a barrel flange clamp. The barrel flange clamp can be configured to retain a barrel flange from the syringe.

[00164] In some embodiments, the drum flange clamp may comprise a means of detecting the presence of a drum flange. The means of detecting the presence of a drum flange can comprise an optical sensor and a light source. The light source can be obscured in the presence of said drum flange.

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According to another aspect of the present disclosure, a syringe pump for administering an agent to a patient may comprise a housing, a lead screw and a sliding block assembly. The sliding block assembly may comprise a threaded section configured for engaging and disengaging with said lead thread and movable along said lead thread. The syringe pump may additionally comprise a plunger head assembly coupled to said sliding and operative block for driving a syringe plunger within a barrel of said syringe. The syringe pump may additionally comprise a gripping means configured to hold any of a range of piston flange sizes. The syringe pump may further comprise a means of monitoring the gripping means. The means of monitoring the gripping means may have the ability to generate data to determine at least one characteristic of the attached syringe.

[00166] In some modalities, the means of monitoring the gripping means can be a potentiometer.

[00167] In some modalities, the data generated by means of monitoring the means of grasping can be evaluated through the reference of said data against a database.

[00168] In some modalities, the data generated by the means of monitoring the grasping medium can be evaluated by reference of said data against a database and data generated by at least one other sensor.

[00169] In some embodiments, the gripping means may comprise a cam, at least one cam follower and at least one bias member. The propensity member can orient the said means of gripping towards a first position. The movement of at least one cam follower along the cam can

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29/294 overcome the propensity member and allow the gripping means to move towards a second position.

[00170] In some embodiments, the cam, at least one cam follower and at least one bias member can be coupled to a rotary axis. In some specific embodiments, the cam may not be rotatable with the axis, but it can be displaced along an axial dimension of said axis. The at least one cam follower can be fixedly coupled to the axis and rotatable with the axis. Rotation of the axis can cause movement of at least one cam follower along the cam, displacing the cam along the axial dimension of the axis.

[00171] In some modalities, the propensity member can automatically return the pre-configured grip medium to the first position in the absence of sufficient force to overcome the propensity member.

[00172] In some embodiments, the cam may comprise at least one keeper. Each of the holders can be reached by one of at least one cam follower when the means for securing any range of piston flange sizes has been made possible to move to the second position.

[00173] In some embodiments, the plunger head assembly may additionally comprise a pressure sensor to monitor the pressure of the agent that is dispensed from the syringe.

[00174] In some embodiments, a syringe plunger flange can be held against the pressure sensor by the gripping means.

[00175] In some embodiments, the drum flange clamp may comprise a means of detecting the presence of a drum flange. The means of detecting the presence of said drum flange can comprise an optical sensor and a light source. The light source can be obscured in the presence of said drum flange.

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According to another aspect of the present disclosure, a syringe pump for administering an agent to a patient may comprise a housing, a lead screw and a plunger head assembly operatively coupled to drive a plunger of a syringe inside the barrel of a syringe with the rotation of said advance thread. The syringe pump may additionally comprise at least one set of redundant sensors. Redundant sensors can be configured so that, if part of a set of redundant sensors is compromised, the syringe pump can operate in a failure operating mode for at least the duration of a therapy. One or more of the set of redundant sensors are configured to monitor the volume that is infused.

[00177] According to another aspect of the present disclosure, a syringe pump for administering an agent to a patient may comprise a syringe barrel housing and retainer which can be movable between a first position and a second position. The syringe barrel retainer can be guided by a biasing member either to the first position or to the second position. The syringe pump may additionally comprise a syringe barrel contact member. The drum contact member can be coupled to said syringe drum retainer and configured to hold the syringe in place in the housing. The syringe pump may additionally comprise a detector that has the ability to capture the position of the syringe barrel retainer and generate the position data based on the position of the syringe barrel retainer. When a syringe is in place in said housing, the syringe barrel retainer can be oriented so that the syringe is held in place in said housing. The position data generated by said detector can be indicative of at least one characteristic of the

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31/294 syringe and evaluated to determine said characteristic.

[00178] In some modalities, the detector can be a linear potentiometer.

[00179] In some modalities, the detector can be a linear magnetic position sensor.

[00180] In some embodiments, the syringe barrel retainer can be configured to be locked in at least one of the first and second positions.

[00181] In some embodiments, the biasing member can cause the syringe barrel retainer to automatically adjust to the syringe size.

[00182] In some embodiments, the position data generated by the detector can be referenced against a database to determine at least one characteristic of the syringe.

[00183] In some embodiments, the position data generated by the detector can be referenced against a database and the data from at least one other sensor to determine at least one characteristic of the syringe.

[00184] According to another aspect of the present disclosure, a method for administering an agent to a patient by means of a syringe pump may comprise defining one or more parameters for an infusion through a syringe pump interface. The method may further comprise referencing said parameters against a medical database and placing restrictions on additional parameters to be defined via the syringe pump interface. One of the additional parameters can be an end of the infusion behavior to be performed by the syringe pump after a volume to be infused has been infused. The method can additionally comprise infusing said agent to said patient according to the parameters defined for the infusion and executing the final

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32/294 specified infusion behavior.

[00185] In some modalities, the end of the infusion behavior can be selected from a list consisting of: interrupting an infusion, infusing an open rate of maintenance vein and continuing to infuse at the rate of the finished infusion.

[00186] In some modalities, referencing parameters against a database and placing restrictions on additional parameters may include referencing the agent against the database.

[00187] According to one embodiment of the present disclosure, a syringe pump includes a housing, a syringe holder and a stop. The syringe holder is attached to the housing. The stop is attached to the housing adjacent to the syringe holder. The stop may at least partially surround a corner of the syringe holder.

[00188] In another embodiment of the present disclosure, a syringe pump includes a housing, a syringe holder and a power supply. The syringe holder is attached to the housing. The power supply is coupled to the housing so that the housing is configured as a heat sink for the power supply. The syringe pump can include a motor, and the motor can be coupled to the housing so that the housing is a heat sink for the motor. The housing can be cast in a mold. The housing can comprise at least one metal and / or it can be a unitary body.

[00189] In another embodiment of the present disclosure, a syringe pump includes a user interface, an antenna and a split ring resonator. The user interface has a front and a back side. The antenna is arranged on the back side of the user interface. The split ring resonator is arranged in a spaced relation with the user interface and is configured to operate with the anticipation 870160077500, from 12/20/2016, p. 49/484

33/294 na.

[00190] The user interface may include a touchscreen sensor. The split ring resonator can be arranged on a rear side of the touchscreen sensor. A frame can surround the touchscreen sensor that has a gap, so that the frame defines the split ring resonator. A dielectric can be disposed within the gap.

[00191] In another embodiment of the present disclosure, a syringe pump includes a housing, a lead screw, a motor, a rotary position sensor, a sliding block assembly, a linear position sensor and one or more processors. The lead thread is rotatable inside the housing. The motor is operatively coupled to the lead thread and is configured to turn the lead thread. The engine has an integral engine speed sensor configured to provide an engine speed signal. The rotary position sensor is operatively coupled to the motor or the lead thread to provide a rotation signal. The rotary position sensor can be a magnetic encoder sensor. The sliding block assembly is configured to engage the lead thread to actuate the sliding block assembly along the lead thread according to the lead thread rotation. The linear position sensor is operatively coupled to the sliding block assembly and is configured to provide a linear position signal. The one or more processors are configured to control the engine speed. The one or more processors operatively receive the motor speed signal from the motor integral motor speed sensor, the rotation signal from the rotary position sensor and the linear position signal from the linear position sensor. The one or more processors are configured to determine if a discrepancy exists between the engine speed signal, the speed signal and the linear position signal. One or more processors can be added

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34/294 internationally configured to continue an infusion treatment by ignoring an inoperative one among the integral motor speed sensor, the rotary position sensor and a linear position sensor. [00192] In another embodiment of the present disclosure, a syringe pump includes a housing, a lead screw, a sliding block assembly, a plunger and the first and second articulated claw members. The lead thread is rotatable inside the housing. The sliding block assembly is configured to engage the lead thread to move along the lead thread according to the lead thread rotation. The plunger head assembly is coupled to the sliding block assembly and is configured to drive a syringe plunger inside a syringe barrel. The first and second articulated claw members are each articulated to the plunger head assembly. The first and second hinged claw members are configured to pivot towards each other to retain a syringe plunger flange. The first hinged claw member and / or the second hinged claw member includes a fold.

[00193] The syringe pump can additionally include a dial coupled to the slide block assembly. The dial can be operatively coupled to the first and second articulated claw members to actuate the first and second articulated claw members in an articulated manner. The pump may include a bias member configured to orient the dial in a direction of rotation. The bias member can be configured to automatically return the first and second articulated claw members to a position away from each other. The bias member can be configured to automatically return the first and second articulated claw members to a position towards each other.

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35/294 [00194] In another embodiment, a syringe pump includes a housing, a syringe holder attached to the housing and a holding finger. The retaining finger is pivotally coupled to the housing and is configured to rotate towards a syringe arranged inside the syringe holder to retain the syringe.

[00195] In another embodiment of the present disclosure, a method is provided to remove the slack effects on a syringe pump that has a syringe loaded on the syringe pump. The syringe has a barrel and a plunger arranged inside the barrel. The method includes the actions of: receiving a target flow rate from the syringe loaded into the syringe pump; determine a therapy performance speed that corresponds to the target flow rate; actuating the syringe plunger out of the barrel at a first predetermined speed until a force sensor coupled to the plunger measures a force that is less than a first predetermined force limit; actuating the syringe plunger inside the barrel at a second predetermined speed greater than the therapy actuation speed until the force sensor coupled to the plunger measures a force that exceeds a second predetermined limit; and actuate the syringe plunger inside the drum at the therapy actuation speed. The therapy actuation speed can correspond to the target flow rate when there is no gap in the syringe pump or syringe. The method can additionally include the actions of: estimating an unloaded volume that starts from the position of the plunger when the second predetermined limit has been exceeded; and / or stop the syringe pump when the estimated discharged volume is equal to or exceeds a target volume.

[00196] In another embodiment of the present disclosure, a method is provided to remove the slack effects on a syringe pump that has a syringe loaded on the syringe pump. The syringe has

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36/294 a drum and a plunger disposed within the drum. The method includes the actions of: receiving a target flow rate from the syringe loaded into the syringe pump; determine a therapy performance speed that corresponds to the target flow rate; actuating the syringe plunger outside the barrel at a first predetermined speed until a force sensor coupled to the plunger measures a force that is less than a first predetermined force limit or the plunger travels out of the barrel at a first predetermined distance; actuate the syringe plunger inside the barrel at a second predetermined speed greater than the therapy actuation speed until the force sensor coupled to the plunger measures a force that exceeds a second predetermined limit or the plunger moves inside the barrel in a second predetermined distance; and actuate the syringe plunger inside the drum at the therapy actuation speed. [00197] The speed of actuation of therapy can correspond to the target flow rate when there is no gap in the syringe pump or syringe. The method can additionally include the actions of: estimating an unloaded volume that starts from the position of the plunger when the second predetermined limit has been exceeded; stop the syringe pump when the estimated discharged volume is equal to or exceeds a target delivery volume; and / or use an alarm if the plunger moved inside the drum by the second predetermined distance without the force sensor measuring a force that exceeds the second predetermined limit.

[00198] In another embodiment of the present disclosure, a syringe pump includes a housing, a syringe holder, a lead screw, an engine, a slide block assembly, a plunger head assembly and one or more processors. The syringe holder is attached to the housing and is configured to retain a syringe that has a barrel and a plunger disposed within the barrel. THE

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37/294 lead thread is rotatable inside the housing. The motor is coupled to the lead thread and is configured to turn the lead thread. The sliding block assembly can be configured to engage the lead thread to move along the lead thread according to the lead thread rotation. The plunger head assembly is coupled to the sliding block assembly and is configured to drive a syringe plunger inside a syringe barrel. The plunger head assembly has a force sensor operatively coupled to the syringe plunger to measure a force from the plunger head assembly to the syringe plunger. The one or more processors are operatively coupled to the motor and are configured to control the rotation of the motor to control, thus, the performance of the piston head assembly. The one or more processors are also operatively coupled to the force sensor to receive a measured force from it and are configured to: receive a target flow rate from the syringe loaded on the syringe pump; determine a therapy performance speed that corresponds to the target flow rate; command the motor to actuate the syringe plunger out of the barrel at a first predetermined speed until the force sensor coupled to the plunger measures a force that is less than a first predetermined force limit; command the motor to actuate the syringe plunger inside the barrel at a second predetermined speed greater than the therapy actuation speed until the force sensor coupled to the plunger measures a force that exceeds a second predetermined limit; and control the motor to actuate the syringe plunger inside the drum at the therapy actuation speed. The therapy actuation speed can correspond to the target flow rate when there is no gap in the syringe pump or syringe.

[00199] The one or more processors can be configured to

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38/294 to estimate an unloaded volume that starts from the position of the plunger when the second predetermined limit has been exceeded.

[00200] The one or more processors can be additionally configured to stop the syringe pump when the estimated discharged volume is equal to or exceeds a target delivery volume.

[00201] In yet another embodiment of the present disclosure, a syringe pump includes a housing, a syringe holder, a lead screw, an engine, a slide block assembly, a plunger head assembly and one or more processors. The syringe holder is attached to the housing and is configured to retain a syringe that has a barrel and a plunger disposed within the barrel. The lead thread is rotatable inside the housing. The motor is coupled to the lead thread and is configured to turn the lead thread. The sliding block assembly can be configured to engage the lead thread to move along the lead thread according to the lead thread rotation. The plunger head assembly is coupled to the sliding block assembly and is configured to drive a syringe plunger inside a syringe barrel. The plunger head assembly has a force sensor operatively coupled to the syringe plunger to measure a force from the plunger head assembly to the syringe plunger. The one or more processors are operatively coupled to the motor and are configured to control the rotation of the motor to control, thus, the performance of the piston head assembly. The one or more processors are also operatively coupled to the force sensor to receive a measured force from it and are configured to: receive a target flow rate from the syringe loaded on the syringe pump; determine a therapy performance speed that corresponds to the target flow rate; command the engine to actuate the piston of the

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39/294 syringe out of the barrel at a first predetermined speed until a force sensor coupled to the plunger measures a force that is less than a first predetermined force limit or the plunger travels out of the barrel by a first predetermined distance; command the engine to actuate the syringe plunger inside the barrel at a second predetermined speed greater than the therapy actuation speed until the force sensor coupled to the plunger measures a force that exceeds a second predetermined limit or the plunger moves in the inside the drum for a second predetermined distance; and control the motor to actuate the syringe plunger inside the drum at the therapy actuation speed. The therapy actuation speed can correspond to the target flow rate when there is no gap in the syringe pump or syringe.

[00202] The one or more processors can be additionally configured to estimate a discharged volume that starts from the plunger position when the second predetermined limit has been exceeded and / or interrupt the syringe pump when the estimated discharged volume is equal to or exceeds one target volume.

[00203] The one or more processors can be additionally configured to emit an alarm if the piston has moved inside the drum by the second predetermined distance without the force sensor having measured a force that exceeds the second predetermined limit.

[00204] The syringe pump described in this document can additionally comprise a transceiver, and the one or more processors are configured to communicate through the transceiver with a monitoring client.

[00205] In some embodiments, the syringe pump includes a patient-controlled analgesia button (PCA) to deliver at

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40/294 minus one pain medication.

[00206] Some embodiments of the present disclosure include a system for attaching the syringe of a syringe pump to the side of the pump. The side loading mechanism includes a pump housing, a platform, a fixing arm and a force mechanism. The platform extends horizontally from the side of the pump housing when the pump is oriented for use. The clamping arm is pivotally connected to the pump housing and the power mechanism. The force mechanism creates a rotational force on the fixation arm that is activated within the platform or by a syringe placed on the platform. The force mechanism can allow the fixation arm to lock in an upward position, where it is removed from the syringe on the platform. A wire structure can be attached to the end of the clamping arm opposite the axis of rotation in order to engage the syringe. The fixation arm can apply between 0.45 and 1.36 kilograms (one and three pounds) of force on the syringe.

[00207] In some embodiments, the force mechanism includes a second arm, a roller and a coupling plate. A first end of the second arm is connected to the first arm. The roller is attached to the second arm at the end opposite the first. The coupling plate is positioned to be engaged by the second arms and create a force on the arm that translates to the rotational force on the connected fixation arm.

[00208] In certain embodiments of the present disclosure, the coupling plate is connected to a pivot point at its first end and to a spring at its second end. When the second arm engages the plate, the spring force and the shape of the plate induce the arm to rotate, ultimately resulting in the rotational force of the clamping arm. A section of the hitch plate surface engages

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41/294 by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact as it is rotated thirty-five degrees.

[00209] In another embodiment of the present disclosure, the coupling plate is on a rail, allowing free movement in a plane substantially perpendicular to the surface engaged by the second arm. A spring pushes the plate towards the engaged secondary arm. The shape of the plate combined with the spring force induces the arm to rotate, ultimately resulting in the rotational force of the clamping arm. A section of the hitch plate surface engaged by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact as it is rotated thirty degrees.

[00210] In yet another embodiment of the present disclosure, the force mechanism includes a second arm and a hitch plate. The second arm comprises a first component connected to the clamping arm, sharing its geometric axis of rotation and extending outward substantially perpendicular to the geometric pivot axis. A second component is attached to the first component at the end opposite the pivot and had the ability to slide towards and away from the pivot while its other movements remain uniform with the first component. A spring is connected to the first and second components that propel the two apart. A roller is attached to the second component at the end opposite the pivot. The engagement plate is positioned to be engaged by the roller and compresses the spring, resulting in forces that induce the second arm and the attached fixation arm to rotate. A section of the hitch plate surface engaged by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact while rotating five degrees.

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42/294 [00211] In yet another embodiment of the present disclosure, the force mechanism includes an axle, a first cam component, a second cam component, a spring and an anchor. The axis is connected in an articulated way to the fixation arm, which has its longitudinal geometric axis aligned with the geometric axis of rotation of the fixation arms. The first cam component is arranged axially around, but not connected to, the axis. The first cam component is connected to and rotates with the fixing arm. A first end of the first cam component has a flat portion, a portion indented from the flat portion and a portion that joins the two portions with a cone. The second cam component is axially disposed around the axis immediately after the first cam, but is not connected to the axis. The second component has a fixed rotational orientation and the ability to slide back and forth on the axis. The end of the second component contiguous with the first end of the first cam component mirrors the shape of the first component. The spring is arranged around the axis immediately after the second cam component on the side opposite the first component. The strut is positioned to compress the spring which results in the spring forcing the second component towards the first.

[00212] In some modalities a sensor can be used to capture the angle of the fixation arm. This sensor can be a Halifax sensor. The sensor data can be used to determine which type of syringe is being used. The system can also use the sensor data in conjunction with the sensor data from a plunger trigger sensor to determine which type of syringe is being used.

[00213] Certain embodiments of the present disclosure involve a method for attaching the syringe of a syringe pump to the side

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43/294 of the pump. The method involves 1.) lifting a loaded clamping arm with a downward force in a locked up position, 2.) placing a syringe on a syringe holding protrusion below the clamping arm, and 3.) releasing the arm for fixing the locked position to engage the syringe with the force loaded on the fixing arm. In some embodiments, the downward force on the clamping arm is created by a spring. In other modalities, a sensor tracks the positions of the arm. The sensor can be a Halifax sensor. The position of the arm can be used to indicate that the syringe is properly positioned or to determine the type of syringe that is used. The data from a plunger sensor can be used in conjunction with the position of the clamping arm to determine the type of syringe that is used.

[00214] Certain embodiments of the present disclosure use an apparatus to attach the syringe of a syringe pump to the side of the pump. The device includes a pump housing, a platform, a fixing arm and a force mechanism. The platform projects horizontally outwards from the side of the pump housing when the housing is positioned for use. The rotating clamping arm has a first end operatively connected to the pump housing above the protrusion. The force mechanism is attached to the clamping arm and produces a rotational force on the clamping arm that drives the end of the clamping arm opposite the pivot at the top of the projection. The fixation arm may have the ability to lock in an up position, removed from the protrusion. The fixation arm can also have a wire structure, configured to engage a syringe, connected at its second end. The fixation arm can apply between 0.45 and 1.36 kilograms (one and three pounds) of force on the syringe when in an attachment position.

[00215] In some modalities, the force mechanism may include

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44/294 include a secondary arm, a roller and a coupling plate. The second arm has a first end operatively attached to the secondary arm sharing its point of rotation. The roller is attached to the secondary arm at its opposite end. The coupling plate is positioned to engage the secondary arm with a force that induces the clamping arm to rotate on top of the ledge.

[00216] In specific embodiments, one end of the coupling plate is operatively attached to the pump housing by a hinge connector and the opposite end is attached to a spring. The spring is configured to force the hitch plate towards the second engaged arm, creating the rotational force on the connected arms. A section of the hitch plate surface engaged by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact as it is rotated thirty degrees.

[00217] In other modalities, the coupling plate has a free range of movement in a single direction with a spring providing a force on the plate parallel to the range of movement. The spring pushes the plate towards the second engaged arm, creating the rotational force on the arm. A section of the hitch plate surface engaged by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact as it is rotated thirty degrees.

[00218] In another embodiment of the present disclosure, the force mechanism includes a secondary arm and a coupling plate. The secondary arm comprises a first component connected to the fixation arm, sharing its geometric axis of rotation and extending outward substantially perpendicular to the geometric axis. A second component, connected to the first component at the end opposite the geometric axis of rotation, which has the release

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45/294 of moving in relation to the longitudinal geometric axis of the first component. A spring pushes the two components apart. A roll is connected to the end of the second component opposite the first component. The engagement plate is positioned to be engaged by the roller and compress the spring between the two components creating a force that impels the secondary arm to rotate. A section of the hitch plate surface engaged by the second arm can define a peak. The plate can also be sized to allow the second arm to maintain contact as it is rotated thirty-five degrees. [00219] In another embodiment of the present disclosure, the force mechanism includes an axle, a first cam component, a second cam component, a spring and an anchor. The axis is connected to the fixation arm at its point of rotation by aligning its longitudinal axis with the axis of rotation of the fixation arm. The first cam component is arranged axially around, but not connected to, the axis. The first cam component is connected to and rotates with the fixing arm. The first end of the component has a flat portion, a portion indented from the flat portion and a portion that joins the two portions with a cone. The second cam component is also axially disposed around the axis and positioned immediately after the first end of the first cam. The second component is not connected to the axis, it is held in a fixed rotation position and has the ability to slide up and down the axis. The end of the second cam component contiguous with the first cam component mirrors the shape of the first component. The spring pushes the second cam component against the first, having the ability to propel the first component and the shaft to rotate depending on the orientation of the meat.

[00220] In some modalities a sensor can be used to

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46/294 capture the angle of the fixing arm. This sensor can be a Halifax sensor. The sensor data can be used to determine which type of syringe is being used. The system can also use the sensor data in conjunction with the sensor data from a plunger trigger sensor to determine which type of syringe is being used.

[00221] In another embodiment of the present disclosure, a method is provided to attenuate the lead thread eccentricity. This method can be applied to a syringe pump that uses a lead screw to control the delivery of fluid from the syringe. The method includes: tracking the lead screw speeds using a rotating position sensor; track the linear output of the lead screw with the use of a linear position sensor; convert the rotary position data into distance output data, create the error data by comparing the distance sensor data and the converted rotational data, estimate a phase and amplitude of the error data using a processor; and control the lead thread output incorporating the estimated deviations in the assumed direct relation of rotation to the lead thread distance output. The estimation of the eccentricity phase and amplitude can be performed by cross-correlating a sine and cosine wave with the deviation data. Before cross-correlating the sensor data, the data can be stored as a single value for each degree of advance thread rotation and filtered through a low-pass filter. The eccentricity estimation can include taking into account changes in the deviation amplitude when a lead thread displacement component approaches an end of the threaded drive shaft.

[00222] The distance tracking sensor can be an optical mouse sensor. The data from the optical mouse sensor can be

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47/294 normalized before being used to estimate a phase and amplitude to prevent sensor drift. The CIP data of the optical sensor can be normalized after every ten degrees of advance thread rotation. The optical sensor can produce data in the range of 3,000 CPI to 8,200 CPI.

[00223] In another embodiment of the present disclosure, a system is provided to attenuate the advance thread eccentricity. The system includes a distance sensor, a rotation sensor, a processor and a controller. The distance sensor has the ability to track linear changes in distance and is configured to track changes in a lead screw mechanism output distance and create distance data. The rotational sensor has the ability to track the rotational changes of an axis and is configured to track the rotations of the lead screw drive shaft and create the rotational data. The rotational sensor can be a Halifax sensor. The processor converts the rotational data into estimated distance output data and compares this to the distance sensor's distance data. The processor then estimates the amplitude and phase of the difference between the distance sensor data and the estimated distance data from the rotational sensor. The amplitude and phase can be estimated by cross-correlating a sine and cosine wave with the distance sensor data. The processor can estimate the deviation of eccentricity using data from just the previous four rotations. The processor can also filter the distance data to a single value for each rotational degree. In some instances, the processor may not estimate the phase and amplitude of the eccentricity deviation until it has received one hundred and eighty degrees of data. The controller controls the lead screw output using the rotational sensor to create a linear distance output and incorporating the estimated amplitude and phase of the

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48/294 deviations to consider the lead thread eccentricity. The controller can assume a decrease in the amplitude of the eccentricity deviation when the half nut approaches an end of the lead thread.

[00224] The distance tracking sensor can be an optical mouse sensor. The data from the optical mouse sensor can be normalized before being used to estimate a phase and amplitude to prevent sensor drift. The CIP data of the optical sensor can be normalized after every ten degrees of advance thread rotation. The optical sensor can produce data in the range of 3,000 CPI to 8,200 CPI.

[00225] In another embodiment of the present disclosure, an apparatus is provided to supply DC power to an infusion pump. The device includes a power supply, a power input module and an output adapter. The power input module is connected to an infusion pump and is configured to receive a current from the power supply and supply power to the pump. The power supply comprises an AC to DC conversion module, an AC in the outlet configured to receive the AC current and supply the AC side of the conversion module and a DC outside the outlet configured to receive the DC current from the conversion module and emit the DC current. The power supply is configured to be removable from the power input module. The output adapter is in electrical communication with AC at the power supply outlet and is configured to connect to a wall outlet and supply power to the power source. A processor can be used to monitor the pump's power requirements and adjust the power source output based on the pump's needs.

[00226] When attached, the power supply can be located on the top, bottom, back or side of the infusion pump. O

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49/294 pump display can be oriented towards the side of the pump on which the power supply is located when attached.

[00227] An AC on the cable can be used to connect the output adapter and the AC to the power supply outlet. The power supply may have a winding structure attached to it on the outside which is configured to have AC on the cable wrapped around it when the cable is not connected to the wall. The power supply can also have a port configured to receive the output adapter once the cable has been wrapped around the winding structure. The power supply can also incorporate a mechanism that automatically coils the cable when commanded by a user.

[00228] DC out of cable can be used to connect DC out of the power supply socket to the power input module. The DC outside the cable can be removed from the power input module.

[00229] The power input module can be configured to attach to a support, making the support or power supply interchangeable.

[00230] In some instances, the power supply can be attached to a pole on which pumps to which it is supplying energy are mounted.

[00231] The power supply may also include a battery that has a negative terminal in electrical communication with the DC outside the power supply socket and the positive terminal in electrical communication with the power input module. A processor and electrical circuit can also be included. The processor and electrical circuit will be configured to charge the battery when the power supply is receiving AC power and to discharge the battery when no AC power is being received.

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50/294 [00232] In some embodiments, the power supply will need to be removed from the pump in order to attach the pump to a pole.

[00233] In another embodiment of the present disclosure, a system is provided to supply energy to an infusion pump. The system comprising a power supply and a pump. The pump includes a DC in the outlet (hereinafter also referred to as the DC in the port). The power supply comprises an AC to DC converter, an AC at the port (hereinafter also referred to as an AC at the outlet) and a DC outside the port and is configured to supply power to the pump through the DC at the outlet. The power supply may be able to be removed from the pump.

[00234] The DC outside the power supply port can connect directly to the DC in the pump outlet, securing the power supply to the pump. The power supply can be located on the top, bottom, side or back of the pump when attached.

[00235] A power out of the cable can be used to connect the DC outside the power module port to the DC in the outlet on the pump, putting the two in electrical communication. For instances where the power supply is connected to the pump with a cable, a case configured to hold the power supply can be mounted on the pump.

[00236] An energy in the cable can be connected to the AC at the power supply port to a wall outlet adapter, putting the two in electrical communication. The power in the cable can be removed from the power supply. The power supply may include a winding structure configured to have the energy in the wire wrapped around it. The power supply may also include a port configured to receive the wall outlet adapter once the cable is wound.

[00237] A power supply can be configured there

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51/294 menting multiple pumps. The power supply can be attached to a pole on which a pump is mounted. The DC outlet of the pump can be configured to attach the pump to a stand when the power source is not attached.

[00238] The power supply may include a battery configured to be charged by the power supply when current is flowing to the AC port and supply power to the DC outside the port when no power is flowing to the AC at the port. The AC at the power supply port must receive a current and convert it to the DC current before charging the battery.

[00239] In another embodiment, a syringe pump includes a body, a motor, a lead screw, a syringe holder and a plunger head assembly. The syringe holder can be configured to tilt towards a downward angle. The motor is operatively coupled to the body. The lead thread is operatively coupled to the motor and the motor is configured to actuate the lead thread. The plunger head assembly includes a dial, a plunger tube, a plunger head and a half-nut assembly. The dial has a fully open position and a fully closed position. The display is configured to act between the fully open position and the fully closed position. The plunger tube is configured to slide into the body. The plunger head is operatively coupled to the plunger tube. The half-nut assembly is configured to engage the advance thread when the dial is actuated by a predetermined amount from the fully open position to the fully closed position. The predetermined quantity can be less than an actuation position midway between the fully open position and the fully closed position.

[00240] The plunger head assembly can include two members

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52/294 articulating jaws configured to grip a syringe positioned inside the syringe holder. The dial can be configured to actuate the claw members in an open position.

[00241] The syringe pump can additionally include an axis operatively coupled to the display so that the axis and the display are configured so that the display actuation acts on the axis. A cam can be attached to the shaft. A swing arm can be pivotally coupled to the plunger head assembly. The swing arm may have a cam follower configured to engage the cam. One or more articulating claw members can be operatively coupled to the swing arm.

[00242] The syringe pump can additionally include the first and second gears. The first gear is coupled to the swing arm and the articulated claw member. The second gear is coupled to another articulating claw member. The first and second gears are configured to engage with each other and grasp a syringe arranged inside the syringe holder. The cam and swing arm can be configured so that the addition actuation of the dial towards the closed position when the pivotable claw members cling to the syringe causes the cam follower to disengage the cam. A spring can propel the cam follower from the swing arm towards the cam. The cam may include a detent configured to retain the cam in the detainer until a predetermined amount of torque is applied to the dial to urge the dial towards the closed position. The plunger head can include an axle that has a rod actuator attached to it. The plunger tube may include a rod, and the rod is coupled to a link within the plunger head. The half-nut assembly additionally comprises a linear cam and the rod can be operative

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53/294 coupled to the linear cam.

[00243] The half-nut assembly may additionally include the first and second half-nut arms each having a first end and a second end. The first ends of the first and second half-nut arms are configured to engage the lead thread. The first and second half-nut arms can be pivotally coupled together. The second ends of the first and second half-nut arms can be configured to engage the linear cam so that the actuation of the linear cam towards the half-nut assembly causes the second ends of the first and second half-nut arms to approach articulated to each other. The first ends of the first and second half-nut arms each include threads configured to engage the feed thread when the second ends of the first and second half-nut arms approach each other.

[00244] In another embodiment, a syringe pump includes a body, a motor, a lead screw, a syringe holder and a plunger head assembly. The motor is operatively coupled to the body. The lead thread is operatively coupled to the engine and is configured to actuate the lead thread. The plunger head assembly includes a dial, a plunger tube, a plunger head assembly and a half-nut assembly. The dial has a fully open position and a fully closed position. The display is configured to act between the fully open position and the fully closed position. The plunger tube is configured to slide into the body. The plunger head is operatively coupled to the plunger tube. The half-nut assembly is configured to engage the advance thread when the dial is actuated by at least a predetermined amount from the full position.

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54/294 te open to the fully closed position. The half-nut assembly includes the first and second half-nut arms hinged together and configured to engage the lead thread.

[00245] In another embodiment, a system for attaching a syringe to a syringe pump includes a pump housing, a platform, an articulated fixation arm, a force mechanism and a display. The platform (a syringe holder) extends horizontally from one side of the housing. The articulated fixation arm is configured to engage a syringe that rests on the platform. The force mechanism is connected to the arm and is configured to apply a rotational force to the arm which results in a downward force applied to the syringe. The display can be attached to one side of the housing. The display can additionally include a power button, an alarm silence button and / or a menu button. A monitoring client can be provided that is configured for at least one among receiving the syringe pump data or controlling the syringe pump as described in this document. The monitoring client can be a tablet computer.

[00246] A method for discharging fluid from a syringe and to alleviate clogging conditions includes actuating the plunger of a syringe inside a barrel. The method monitors the fluid pressure inside the syringe barrel and determines that an obstruction exists when the fluid pressure exceeds a predetermined limit. The method acts the plunger out of the barrel in a predetermined amount in response to the detected obstruction and acts the plunger of the syringe inside the barrel until a fluid pressure measured inside the syringe barrel exceeds another predetermined limit.

[00247] According to one embodiment of the present disclosure, a system for attaching a syringe to a syringe pump may include

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55/294 have a pump housing, a platform that extends horizontally from one side of the housing, an articulated clamping arm configured to engage a syringe resting on the platform and a force mechanism connected to the clamping arm. The force mechanism can be configured to apply a rotational force to the fixation arm which results in a downward force applied to the syringe.

[00248] In some embodiments of the system, the force mechanism may include a second arm that has a first end connected to the fixation arm and a second opposite end. In some embodiments, a roller can be attached to the second arm at the second end. An engagement plate configured to engage the roller and propel the second arm in a direction that creates the rotational force on the connected fixation arm can be included.

[00249] In some embodiments, such a system may include a first end of the coupling plate connected to a pivot point and a second opposite end affixed to a bias member. The bending member can be configured to create a force that drives the second arm. The bending member may be a spring.

[00250] In some embodiments, a surface of the hitch plate engaged by the second arm can define a peak. The plate can be sized to allow the second arm to maintain contact while rotating at least thirty degrees. The engagement plate can be configured to move freely in a plane substantially perpendicular to a surface engaged by the second arm. A bias member that pushes the engagement plate towards the second arm can be included. The engagement plate can be oriented to create a force that impels the second arm. A surface of the engagement plate engaged by the second arm can define a peak.

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56/294

The hitch plate can be sized to allow the second arm to maintain contact with the hitch plate while it is rotated substantially at least thirty degrees.

[00251] In some embodiments, the force mechanism may include a second arm connected to a fixation arm. A first component having a first end connected to the fixing arm and a second opposite end can be included. A second component affixed to the first component at its second end can be included. The second component can be configured to move back and forth in relation to a longitudinal geometric axis of the first component while movements in other directions are in tandem with the movement of the first component. A bias member connected to the first and second components that drives the two apart can be included. A roll affixed to one end of the second component opposite the first component can be included. An engagement plate positioned to be engaged by the roller thereby impelling a force on the second arm that creates the rotational force on the attachment arm can be included. A surface of the engagement plate engaged by the second arm can define a peak. The hitch plate can be sized to allow the second arm to maintain contact with the hitch plate while it is rotated substantially at least thirty degrees.

[00252] In some embodiments, the force mechanism may include an axis attached to the fixation arm where a longitudinal axis of the axis is coaxial with a geometric axis of rotation of the fixation arm. A first cam component disposed around the axis configured to rotate with the clamping arm can be included. A first end of the component can have a flat portion, a portion indented from the flat portion and a portion

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57/294 tapered that joins the two portions with a cone. A second cam component disposed around the axis adjacent the first end of the first cam component can be included. The component may have a fixed rotational orientation and an ability to move back and forth on the axis. An end of the second cam component contiguous to the first cam component can mirror the shape of the first cam component. A bias member can be arranged around the axis adjacent to the second cam component on a side opposite the first cam component. A strut positioned to guide the bias member and transfer a force from the bias member to propel the second cam component towards the first can be included. The tapered portions of the meat can be tapered at an angle of about forty-five degrees to the flat portion. Each cam component can have two tapered sections.

[00253] In some embodiments, the force mechanism can be configured to allow the fixation arm to lock in an upward position, where it is removed from the syringe on the platform.

[00254] Some embodiments may additionally comprise a wire structure connected to one end of the fixation arm opposite a geometric axis of rotation. The wire frame can be configured to engage a syringe when the arm is turned down.

[00255] In some modalities, the fixation arm can apply between 0.45 and 1.36 kilograms (one and three pounds) of force in the syringe when in a fixing position. Some embodiments may additionally comprise a sensor configured to track an angle of the fixation arm. The sensor can be a Hall effect sensor. The sensor data can be used to determine one or more characteristics of the syringe. In some modalities,

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58/294 sensor data, together with data from a plunger trigger sensor, can be used to determine one or more characteristics of the syringe.

[00256] According to one embodiment of the present disclosure, a method for attaching a syringe to a syringe pump includes: Overcoming a propensity force by moving an attachment arm to a first locked position; placing a syringe on a syringe holding platform below the clamping arm and releasing the clamping arm from the first position to thereby secure the syringe to the clamping arm by means of the propensity force.

[00257] In some modalities, the propensity force can be created by a spring. Some modalities may additionally include capturing the position of the fixation arm. Some modalities of the method may include alerting a user if the fixation arm is not properly fixing the syringe based on the position of the fixation arm. Some modalities of the method may additionally include determining at least one characteristic of the syringe using the data collected from capturing the position of the fixation arm. Some embodiments may additionally include using a processor to determine fluid flow based on the change in the position of a syringe plunger in conjunction with at least one particular syringe characteristic. Some embodiments may include using the data from a plunger drive arm in conjunction with a position of the clamping arm to determine at least one characteristic of the syringe. Some embodiments of the method may additionally include using a processor to determine fluid flow based on the change in the position of a syringe plunger in conjunction with at least one particular syringe characteristic. In some embodiments, a Hall effect sensor is used to capture the position of the fixation arm.

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[00258] According to another embodiment of the present disclosure, an apparatus for attaching a syringe to a syringe pump may include a pump housing having a top, bottom and two sides; a platform that projects outwards horizontally from one side of the pump housing; a rotating clamping arm that has a first end attached to the pump housing above the platform and a second opposite end configured to engage a top of the platform in a rotational position of the clamping arm; and a force mechanism attached to the fixation arm. The force mechanism can be configured to produce a rotational force on the clamping arm to thereby propel the second end towards the top of the platform, in some embodiments, the force mechanism can include a secondary arm that has a first end operatively attached to the fixation arm that shares its axis of rotation and a second opposite end. A roll affixed to the secondary arm at the second end where the roll extends beyond the second end of the secondary arm can be included. A latch plate configured to engage the roller with a force that causes the second arm to rotate in a direction that translates to the force below the clamping arm can be included. A first end of the coupling plate can be operatively attached to the pump housing by a hinge connector. A second end of the engagement plate can be operably attached to a bias member. The biasing member can propel the engagement plate towards the second engaged arm, thereby creating a force that induces the second arm to rotate. A surface of the engagement plate that can be engaged by the second arm can define a peak. The hitch plate can be sized to allow the second arm to maintain contact with the hitch plate while it is rotated substantially at least thirty degrees. THE

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60/294 hitch plate can have a linear free range of motion in a single plane at a degree of freedom. A bias member can impart a force to the engagement plate, at least one component of the force may be in the direction of the range of motion. The biasing member can propel the engagement plate towards the second engaged arm to thereby induce the second arm to rotate. A section of a surface of the engagement plate engaged by the second arm can define a peak. The engagement plate can be dimensioned to allow the second arm to maintain contact with a portion of the engagement plate while the second arm is rotated substantially at least thirty degrees. In some embodiments, the force mechanism may include a secondary arm operatively attached to the fixation arm so that it shares its geometric axis of rotation. The second arm may include a first component that has a first end connected to the fixing arm and a second end extending from the first end and oriented substantially perpendicular to the geometric axis of rotation. A second component that has a first end connected to the second end of the first component and an opposite second end can be included. The second component may have a single degree of freedom to move, but may otherwise be restricted to tandem movement with the first component. A bias member that has a first portion attached to the first component and a second portion attached to the second component can be included. The bias member can be configured to provide a bias force that guides the first component and the second component apart from each other. A roll affixed to the second end of the second component can be included. The roll can extend beyond the second end of the second component. A hitch plate configured to be fitted

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61/294 triggered by the roller to thus compress the bending member and thus generate the rotational force transferred to the fixation arm can be included.

[00259] In some embodiments, a surface of the hitch plate engaged by the second arm can define a peak. The engagement plate can be dimensioned to allow the second arm to maintain contact with a portion of the engagement plate while the second arm is rotated substantially at least thirty degrees.

[00260] In some embodiments, the force mechanism may include an axis attached to the fixation arm so that it shares its geometric axis of rotation and that its longitudinal geometric axis is aligned with the geometric axis of rotation. A first cam component disposed around the axis configured to rotate with the clamping arm can be included. A first end of the component may have a flat portion, a portion indented from the flat portion and a cone portion that joins the two portions with a cone. A second cam component disposed around the axis adjacent the first end of the first cam component can be included. The component may have a fixed rotational orientation and the ability to move back and forth on the axis. One end of the component contiguous to the first cam component can mirror the shape of the first cam component. A bias member configured to urge the second cam component towards the first cam component can be included.

[00261] In some embodiments, the force mechanism can be configured to allow the fixing arm to lock in an upward position, where the fixing arm does not make contact with the platform. A wire structure connected to the second end of the fixation arm configured to engage a syringe when the arm

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62/294 is rotated to a display position can be included. The fixation arm can apply between about 0.45 and about 1.36 kilograms (about 1 and about 3 pounds) of force in a syringe when in a fixing position. A sensor configured to capture the angle of the fixation arm can be included. The sensor can be a Hall effect sensor. The sensor data can be used to determine at least one characteristic of the syringe. In some embodiments, sensor data in conjunction with data from a plunger trigger sensor can be used to determine one or more characteristics of the syringe.

[00262] In accordance with one embodiment of the present disclosure, an apparatus for supplying an infusion pump with DC power may include at least one energy input module connected to an infusion pump housing, configured to receive the DC current from a power source and supply power to an infusion pump. The module can have a port configured to receive a current. The power supply can be configured to be removably attached to the power input module creating electrical communication between the power supply and the power input module when attached. The power supply may include an AC to DC conversion module configured to convert AC current to DC current and supply a current of a constant voltage to the pump. An AC in the outlet configured to receive AC current and supply an AC side of the conversion module can be included. A DC outside the outlet configured to receive the DC current from the conversion module and output the DC current can be included. An output adapter in electrical communication with AC at the power supply outlet, configured to connect to an AC wall outlet to supply, thus, AC current to AC at the outlet can be included. The power supply, when attached, can be located

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63/294 on any of the top, bottom, back or side of the infusion pump. A display can be arranged near the location of the power supply when the power supply is attached. An AC on the cable (hereinafter also referred to as a power cord) can connect the output adapter to the AC outlet on the power supply. The AC on the cable can be removable from the power supply. A winding structure affixed to an exterior of the power supply configured to have the power cable wrapped around it when the cable is not connected can be included. The power supply may include a port configured to receive the output adapter once the cable has been wrapped around the winding structure. A closed coil configured to automatically wind the power cable when commanded by a user can be included. A DC out of the cable to connect the DC out of the power supply socket to the power input module creating electrical communication between the two can be included. The DC outside the cable can be removed from the power input module. The power input module can be configured to attach to a bracket, making the bracket or power supply interchangeable. Connecting the power supply to the power input module can secure the power supply to the pump. The power supply can be configured to supply multiple pumps with power. Multiple out-of-cable DCs configured to connect the DC out of the power supply socket to the power input modules of the multiple pumps creating electrical communication between the power supply and the pumps can be included. The power supply can be mounted on a pole on which pumps to which it is supplying energy are also mounted. A battery that has a negative terminal operatively connected to the DC outside the power supply socket and the positive terminal operative

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64/294 directly connected to the power input module can be included. A processor and electrical circuit configured to charge the battery when the power supply is receiving AC power and to discharge the battery when no AC power is being received can be included. In some embodiments, the power supply must be removed from the pump in order to attach the pump to a pole. A processor to monitor the pump's power needs and adjust the power source output based on those needs can be included. The conversion module can regulate a voltage and current from the electricity entering the pump. In some embodiments, the pole may include a power supply and one or more display devices to attach an infusion pump to the pole.

[00263] According to one embodiment of the present disclosure, a system for supplying DC power to an infusion pump may include a pump, including a DC in the outlet and a power source configured to supply power to the pump through the DC in the outlet. The power supply can be removed from the pump. The pump can include an AC to DC converter, an AC on the adapter, a DC off the adapter, and an AC output adapter configured to connect to an AC outlet that is communicating with the AC on the power supply adapter. The DC outside the power supply adapter can connect directly to the DC in the pump outlet, attaching the power supply to the pump and creating electrical communication between the power supply and the DC outside the adapter. The attached power supply can be located on any of the rear, side, top and bottom of the pump. The power supply can additionally comprise an out-of-cable DC configured to connect the DC out of the power module adapter to the DC in the pump outlet, thus creating a

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65/294 electrical communication between the two. The pump may include a case configured to secure the AC to DC converter from the power supply to the pump. An AC on the cable that has a first end configured to connect to the AC on the power supply port and a second end that has a wall outlet adapter can be included. The AC on the cable can be removable from the power supply. The power supply may additionally comprise a winding mechanism for winding the AC on the cable. The winding structure can be configured to have an AC on the cable wrapped around it by a user. The power supply may include a port configured to receive the wall outlet adapter once the cable is wound. A single power supply can be configured to power multiple pumps. The power supply may have the ability to be attached to the pole, with the pole including at least one attachment feature for an infusion pump. The DC at the pump outlet can be configured to attach the pump to a support and receive current from the support when the power source is not attached. The power supply can include a battery configured to be charged by the power supply when current is flowing to AC at the door and supplying power to DC outside the door when no power is flowing to AC at the door.

[00264] According to one embodiment of the present disclosure, a method of mitigating the lead screw eccentricity error may include tracking the speeds of a lead screw using a rotary position sensor. The method may include tracking the distance output of a lead screw mechanism using a linear position sensor. The method may include converting the rotary position sensor output to a linear displacement output of the lead screw mechanism. The method may include creating error data by determining the difference between the position sensor data

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66/294 linear and the converted data from the rotary position sensor. The method may include estimating, based on the error data, a phase and an amplitude of deviations from a presumed direct ratio of rotations to the distance output of the lead screw mechanism, using a processor. The method may include controlling, with a controller, the output of the lead screw mechanism. The controller can compensate for estimated deviations.

[00265] In some modalities, the linear position sensor can be an optical mouse sensor. The optical mouse sensor can output data at a frequency of 3,000 CPI to about 8,200 CPI. The method may further comprise normalizing the optical mouse sensor data before estimating a phase and amplitude to thereby attenuate the sensor drift. Normalizing the optical mouse sensor data may involve recalibrating the optical mouse sensor CPI after every ten degrees of rotation of the lead thread. The estimation of the phase and amplitude may involve the cross correlation of a sine and cosine wave with the deviation data. The method may further comprise storing the error data for a single degree of feed thread rotation at a value before cross-correlation. The estimation step can take into account a change in the deviation amplitude when a lead thread displacement component approaches an end of the threaded drive shaft. The rotating position sensor can be a Hall effect sensor. The phase and amplitude of the eccentricity deviation can be estimated using data from only the previous four feedrate rotations. The method may additionally comprise filtering the error data before estimating its phase and amplitude. The error data can be filtered using a low pass filter.

[00266] In accordance with one embodiment of the present disclosure, a

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67/294 system for attenuating the lead thread eccentricity may include a linear position sensor configured to track the distance output of a lead thread mechanism and generate the distance data. A rotary position sensor configured to track feedrate speed and generate rotational data can be included. A processor can be included. The processor can be configured to convert the rotational data to the converted distance output of the lead screw mechanism. The processor can be configured to create the error data by determining the difference between the converted rotational data and the distance data. The processor can be configured to estimate the amplitude and phase of the error data. A controller configured to control the distance output of the lead screw mechanism can be included. The controller can compensate for the phase and amplitude of the error data.

[00267] In some modalities, the linear position sensor can be an optical mouse sensor. The optical mouse sensor can output data at a frequency of 3,000 CPI to 8,200 CPI. The distance data, before the error data is created, can be normalized to account for the deviation. The distance data can be normalized by the processor every ten degrees of advance thread rotation. The phase and amplitude of the error data can be estimated by cross-correlating a sine and cosine wave with the error data. The rotation sensor can be a Hall effect sensor. The controller can assume a decrease in the amplitude error data when a half-nut of the lead thread mechanism approaches an end of the lead thread. The phase and amplitude of the error data can be estimated using the error data only from the previous four rotations. The distance data can be filtered to a single value for each rotational degree of the advance thread offset. The processor may not estimate the phase and

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68/294 error data amplitude until it has received one hundred and eighty degrees of sensor data. The error data can be filtered before estimating its phase and amplitude. The error data can be filtered using a low-pass filter.

[00268] According to one embodiment of the present disclosure, a syringe pump may include a body, a motor and a lead screw operatively coupled to the motor. The motor can be configured to actuate the advance thread. A syringe holder and plunger assembly can be included. The plunger head assembly may include a dial having a first position and a second position. The display can be configured to act between the first position and the second position. A plunger tube configured to slide into the body can be included. The plunger head can be operatively coupled to the plunger tube. A half-nut set configured to engage the advance thread when the dial is actuated by a predetermined amount from the fully position to the second position can be included. The predetermined amount can be less than a position midway between the first position and the second position.

[00269] In some embodiments, the plunger head assembly may include two articulating claw members configured to grip a plunger positioned within the syringe holder. The dial can be configured to actuate the articulated claw members. An axis can be operatively coupled to the display. The axis and the display can be configured so that the actuation of the display acts on the axis. A cam can be attached to the shaft. A swing arm articulated to the plunger head assembly can be included. The swing arm may have a cam follower configured to engage the cam. A claw member arti

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69/294 can be operatively coupled to the swing arm.

[00270] In some embodiments, a first gear coupled to the swing arm and articulating claw member can be included. A second gear coupled to another articulating claw member can be included. The first and second gears can be configured to engage each other. Articulating claw members can be configured to grip a plunger. The cam and swing arm can be configured so that the additional actuation of the dial towards the second position when the pivotable claw members cling to the plunger causes the cam follower to disengage the cam. A bias member configured to urge the cam follower from the swing arm towards the cam can be included. The cam may include a detent configured to retain the cam in the detainer until a predetermined amount of torque is applied to the dial to urge the dial towards the second position. The plunger head may include a shaft that has a rod actuator attached to it. The plunger tube may include a rod. The rod can be coupled by means of a link inside the plunger head. The half-nut assembly may comprise a linear cam. The rod can be operatively coupled to the linear cam. The half-nut assembly may additionally include the first and second half-nut arms each having a first end and a second end. The first ends of the first and second half-nut arms can be configured to engage the lead thread. The first and second half-nut arms can be pivotally coupled together. The second ends of the first and second half-nut arms can be configured to engage the linear cam so that the actuation of the linear cam towards the half-nut assembly causes the second ends

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70/294 activities of the first and second half-nut arms are articulated to each other. The first ends of the first and second half-nut arms may each include threads configured to engage the advance thread when the second ends of the first and second half-nut arms approach each other. The syringe holder can include at least one slanted face.

[00271] According to one embodiment of the present disclosure, a syringe pump may include a body, a motor and a lead screw operatively coupled to the motor. The motor can be configured to actuate the advance thread. A syringe holder and plunger assembly can be included. The plunger head assembly may include a dial that has a fully open position and a fully closed position. The display can be configured to act between the fully open position and the fully closed position. A plunger tube configured to slide into the body can be included. The plunger head can be operatively coupled to the plunger tube. A half-nut assembly configured to engage the advance thread when the dial is actuated by at least a predetermined amount from the fully open to the fully closed position can be included. The half-nut assembly may include the first and second half-nut arms hinged together and configured to engage the lead thread.

[00272] According to one embodiment of the present disclosure, a system for attaching a syringe to a syringe pump may include a pump housing. A platform that extends horizontally from one side of the housing can be included. The articulated fixation arm configured to fix a syringe resting on the platform can be included. A force mechanism, connected to the

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71/294 arm, configured to apply a rotational force to the arm that results in a clamping force applied to the syringe can be included. A user interface attached to the housing can be included.

[00273] In some embodiments, the user interface may additionally include a power button, an alarm silence button and a menu button.

[00274] A monitoring client can be configured for at least one among receiving the data from the syringe pump or controlling the syringe pump. The monitoring client can be a tablet computer. A monitoring client can be configured to receive data from the syringe pump.

[00275] According to one embodiment of the present disclosure, a syringe pump includes a housing, a syringe holder, a plunger head, a pressure sensor and an engine and one or more processors. The syringe holder is operatively attached to the housing and is configured to retain a syringe. The plunger head is configured to engage a syringe plunger to actuate the syringe plunger. The pressure sensor is configured to be coupled to the syringe to operatively estimate a fluid pressure inside the syringe. The motor is operatively coupled to the plunger head to actuate the plunger head to actuate the head plunger.

[00276] The one or more processors can be configured to cause the actuator to act in a first direction, thus causing the syringe to discharge the fluid. The processor (s) can monitor the pressure sensor to estimate the fluid pressure inside the syringe and determine that an obstruction exists when the fluid pressure exceeds a predetermined limit. The processor (s) can cause the actuator to actuate the plunger out of the drum in a predetermined amount and cause the actuator

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72/294 actuate the syringe plunger inside the barrel until a measurement of the fluid pressure inside the syringe exceeds another predetermined limit.

[00277] In some embodiments, the predetermined amount in which the plunger can be actuated out of the drum can be a function of an internal diameter of the drum. The other predetermined limit can be a function of an inner diameter of the drum.

[00278] In some embodiments, the predetermined limit can be in a plurality of predetermined limits located within a lookup table. The predetermined limit corresponds to a syringe model number as found in the lookup table.

[00279] In some embodiments, the other predetermined limit is in a plurality of predetermined limits located within a lookup table. The other predetermined limit can correspond to a syringe model number as found in the lookup table.

[00280] The predetermined quantity in which the plunger is actuated out of the barrel is in a plurality of predetermined quantities located within a lookup table. The predetermined amount in which the plunger is actuated out of the barrel can correspond to a syringe model number.

[00281] In some embodiments, a force sensor coupled to the plunger can be used to monitor the fluid pressure inside the syringe barrel. The predetermined amount can be a predetermined actuation distance from the plunger outside the syringe and / or it can be a predetermined change in the expansion volume inside the barrel.

BRIEF DESCRIPTION OF THE DRAWINGS [00282] These and other aspects will become more apparent alongside

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73/294 from the following detailed description of the various modalities of the present disclosure with reference to the drawings in which:

[00283] Figure 1 is an illustration of an electronic patient care system that has a syringe pump according to one embodiment of the present disclosure;

[00284] figures 2 to 5 show different views of a bedside system according to one embodiment of the present disclosure;

[00285] figure 6 shows an approximate view of a portion of a clamp interface that is fixable to a pump shown in figures 2 to 5 according to an embodiment of the present disclosure;

[00286] figure 7 shows another approximate view of another portion of the interface shown in figure 6 according to an embodiment of the present disclosure;

[00287] figure 8 shows a perspective view of a pump attachable to the bedside system of figures 2 to 5 according to an embodiment of the present disclosure;

[00288] figure 9 shows a perspective view of a pump shown in figures 2 to 5 according to an embodiment of the present disclosure;

[00289] figures 10 to 13 show different views of a syringe pump according to one embodiment of the present disclosure.

[00290] figure 14 shows several syringe pumps of figures 10 to 13 mounted on a pole 322 according to one embodiment of the present disclosure;

[00291] figures 15 and 16 illustrate portions of the operation of the syringe pump of figures 10 to 13 according to an embodiment of the present disclosure;

[00292] figures 17 and 18 illustrate various medical devices

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74/294 mounted on a pole according to one embodiment of the present disclosure;

[00293] figures 19 to 22 show different views of a medical device of figures 17 and 18 according to an embodiment of the present disclosure;

[00294] figure 23 shows several assemblies mounted on a pole according to one embodiment of the present disclosure;

[00295] figures 24 to 26 show several views of an assembly of figure 23 according to one embodiment of the present disclosure;

[00296] figure 27 shows a circuit diagram that has a speaker and a battery according to a modality of the present disclosure;

[00297] figure 28 shows a view of an exemplary embodiment of a syringe pump according to an embodiment of the present disclosure;

[00298] figure 29 shows a front view of an exemplary embodiment of a syringe pump according to an embodiment of the present disclosure;

[00299] figure 30 is a view of an exemplary embodiment of the syringe pump assembly according to one embodiment of the present disclosure;

[00300] figure 31 is another view of an exemplary embodiment of the syringe pump assembly according to one embodiment of the present disclosure;

[00301] figure 32 is another view of an exemplary embodiment of the syringe pump assembly according to an embodiment of the present disclosure;

[00302] figure 33 is another view of an exemplary embodiment of the syringe pump set according to an embodiment of

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75/294 present disclosure;

[00303] figure 34 is another view of an exemplary embodiment of the syringe pump assembly according to one embodiment of the present disclosure;

[00304] figure 35 is a view of an exemplary embodiment of the plunger head assembly, plunger tube and sliding block assembly of the syringe pump assembly according to an embodiment of the present disclosure;

[00305] figure 36 is another view of an exemplary embodiment of the plunger head assembly, plunger tube and sliding block assembly of the syringe pump assembly according to one embodiment of the present disclosure;

[00306] figure 37 is an exploded view of an exemplary embodiment of the top of the piston head assembly with half of the piston head assembly removed in accordance with an embodiment of the present disclosure;

[00307] figure 38 is an assembled view of an exemplary embodiment of the top of the piston head assembly with half of the piston head assembly removed in accordance with an embodiment of the present disclosure;

[00308] figure 39 is a bottom view of an exemplary embodiment of the top of the plunger head assembly according to an embodiment of the present disclosure;

[00309] figure 40 is an assembled top view of an exemplary embodiment of the bottom of the plunger head assembly and all of plunger according to one embodiment of the present disclosure;

[00310] figure 41 is an exploded view of an exemplary embodiment of the display axis and related parts of the syringe pump according to an embodiment of the present disclosure;

[00311] figure 42 is an assembled view of the exemplified modality

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76/294 captive of figure 41 according to one embodiment of the present disclosure;

[00312] figure 43 is a partially assembled view of an exemplary embodiment of the plunger head and all plunger assembly according to one embodiment of the present disclosure;

[00313] figure 44 is a view of an exemplary embodiment of the plunger head assembly with the top of the plunger head assembly removed in accordance with an embodiment of the present disclosure;

[00314] figure 45 is a top view of the exemplary embodiment of figure 44 according to one embodiment of the present disclosure;

[00315] figure 46 is a partial view of an exemplary embodiment of the plunger head assembly in which the D-shaped connector is shown in cross section according to one embodiment of the present disclosure;

[00316] figure 47 is a view of an exemplary embodiment of the plunger head assembly, plunger tube and sliding block assembly in which the sliding block assembly is exploded in accordance with one embodiment of the present disclosure;

[00317] figure 48A is an exploded view of an exemplary embodiment of the sliding block assembly according to an embodiment of the present disclosure;

[00318] figure 48B is a view of an exemplary embodiment of the advance thread, half-nut, drum cam and drive shaft according to one embodiment of the present disclosure;

[00319] figure 49 is a partial front view of an exemplary embodiment of the half-nut and drum cam in which the half-nut is shown as transparent according to one embodiment of the present disclosure;

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77/294 [00320] figure 50 is a front view of an exemplary embodiment of the sliding block assembly in which the half-nut is in an engaged position according to one embodiment of the present disclosure;

[00321] figure 51 is a front view of an exemplary embodiment of the sliding block assembly in which the half-nut is in the engaged position according to one embodiment of the present disclosure;

[00322] figure 52 is a front view of an exemplary embodiment of the sliding block assembly in which the half-nut is in the disengaged position according to one embodiment of the present disclosure;

[00323] figure 53 is a cross-sectional view of an exemplary embodiment of the sliding block assembly on the lead thread and guide rod according to one embodiment of the present disclosure;

[00324] figure 54 is a view of an exemplary embodiment of the rear face of the syringe pump assembly according to an embodiment of the present disclosure;

[00325] figure 55 is another view of an exemplary embodiment of the rear face of the syringe pump assembly with the gearbox in place according to one embodiment of the present disclosure;

[00326] figure 56 is an interior view of an exemplary embodiment of the syringe pump assembly according to an embodiment of the present disclosure;

[00327] figure 57A is another interior view of an exemplary embodiment of the syringe pump assembly with the slide block assembly and linear position sensors in place according to an embodiment of the present disclosure;

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78/294 [00328] figure 57B is a top view of an embodiment of a magnetic linear position sensor according to an embodiment of the present disclosure;

[00329] figure 58 is a partially assembled front view of an exemplary embodiment of the sliding block assembly, plunger tube and plunger head assembly in accordance with an embodiment of the present disclosure;

[00330] figure 59A is a view of an exemplary embodiment of the syringe pump assembly according to an embodiment of the present disclosure;

[00331] figures 59B to 59J are electrical schematics of the syringe pump according to one embodiment of the present disclosure;

[00332] figure 60 is a partial bottom view of an exemplary embodiment of the syringe pump assembly according to an embodiment of the present disclosure;

[00333] figure 61 is a partial view of an exemplary embodiment of the syringe pump assembly in which a barrel flange of a small syringe has been clamped by the barrel flange clamp according to an embodiment of the present disclosure;

[00334] figure 62 is a partial view of an exemplary embodiment of the syringe pump assembly in which a barrel flange of a large syringe has been clamped by the barrel flange clamp according to an embodiment of the present disclosure;

[00335] figure 63 is a view of an exemplary embodiment of the syringe barrel retainer according to an embodiment of the present disclosure;

[00336] figure 64 is a partial view of an exemplary embodiment of the syringe barrel retainer according to an embodiment of the present disclosure;

[00337] figure 65 is a view of an exemplary modality

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79/294 of the syringe barrel retainer wherein the syringe barrel retainer is locked in the fully open position in accordance with an embodiment of the present disclosure;

[00338] figure 66 is a view of an exemplary embodiment of the syringe barrel retainer linear position sensor in which the linear position sensor printed circuit board is shown as transparent according to one embodiment of the present disclosure;

[00339] figure 67 is a view of an exemplary embodiment of a phase change detection linear position sensor according to a embodiment of the present disclosure;

[00340] figure 68 shows a schematic of the exemplary view of a linear position sensor for detecting phase change according to an embodiment of the present disclosure;

[00341] figure 69 shows a schematic of the exemplary view of a linear position sensor for detecting phase change according to an embodiment of the present disclosure;

[00342] figure 70 shows a schematic of the exemplary view of a phase change detection linear position sensor according to an embodiment of the present disclosure;

[00343] figure 71 shows a perspective view of a pump with the graphical user interface shown on the screen according to one embodiment of the present disclosure;

[00344] figure 72 shows an example infusion programming screen of the graphical user interface according to a modality of the present disclosure;

[00345] figure 73 shows an example infusion programming screen of the graphical user interface according to a modality of the present disclosure;

[00346] figure 74 shows an infusion programming screen

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80/294 exemplary of the graphical user interface according to one embodiment of the present disclosure;

[00347] figure 75 shows an example infusion programming screen of the graphical user interface according to one embodiment of the present disclosure;

[00348] figure 76 shows an example infusion programming screen of the graphical user interface according to a modality of the present disclosure;

[00349] figure 77 shows a graphical representation of the infusion rate over time of an exemplary infusion according to one embodiment of the present disclosure;

[00350] figure 78 shows a graphical representation of the rate of infusion over time of an exemplary infusion according to one embodiment of the present disclosure;

[00351] figure 79 shows a graphical representation of the rate of infusion over time of an exemplary infusion according to one embodiment of the present disclosure;

[00352] figure 80 shows a graphical representation of the rate of infusion over time of an exemplary infusion according to one embodiment of the present disclosure;

[00353] figure 81 shows a graphical representation of the rate of infusion over time of an exemplary infusion according to one embodiment of the present disclosure;

[00354] figure 82 shows an exemplary drug administration library screen of the graphical user interface according to one embodiment of the present disclosure;

[00355] figure 83 shows a block software diagram according to an embodiment of the present disclosure;

[00356] figure 84 shows a state diagram illustrating a method for providing surveillance functionality according to

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81/294 an embodiment of the present disclosure;

[00357] figures 85A to 85F show a circuit diagram of a surveillance system that is a modality that implements the surveillance functionality of the state diagram of figure 84 according to another embodiment of the present disclosure;

[00358] figure 86 shows another embodiment of the syringe pump having a stop according to one embodiment of the present disclosure;

[00359] figure 87 shows an exploded view of the syringe pump of figure 86 according to an embodiment of the present disclosure;

[00360] figure 88 shows an approximate view of the upper housing, the lower housing and the power supply of the syringe pump of figure 86 according to an embodiment of the present disclosure;

[00361] figure 89A shows a front view of the pump display of figure 86 according to an embodiment of the present disclosure;

[00362] figure 89B shows a rear view of the pump display of figure 86 according to an embodiment of the present disclosure;

[00363] figure 90 shows the rear part of the sensor portion of the touchscreen and a split ring resonator based on frame for use with a near field antenna according to one embodiment of the present disclosure;

[00364] figure 91 shows a diagram illustrating the use of the pump sensors of figure 86 when one or more of the sensors are unavailable according to one embodiment of the present disclosure;

[00365] figure 92 shows a side view of a syringe pump having a holding finger for retaining a syringe according to an embodiment of the present disclosure;

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82/294 [00366] figure 93 shows an approximate view of the syringe pump of figure 92 according to an embodiment of the present disclosure;

[00367] figure 94 shows a circuit for storing data within an RFID tag associated with a syringe pump according to an embodiment of the present disclosure;

[00368] figure 95 shows an equivalent circuit for impedance as seen from the RFID tag of figure 94 according to an embodiment of the present disclosure;

[00369] figure 96 shows another circuit for storing the data within an RFID tag associated with a syringe pump according to an embodiment of the present disclosure;

[00370] figure 97 shows a split ring resonator used with the circuit of figure 96 according to an embodiment of the present disclosure;

[00371] figure 98 shows a flow chart illustrating a method for removing the effects of clearance in a syringe pump that has a syringe loaded in the syringe pump according to an embodiment of the present disclosure;

[00372] figure 99A shows a perspective view of an apparatus for side loading of a syringe into an infusion pump showing a syringe holding arm shown of the apparatus in a loading position according to one embodiment of the present revelation;

[00373] figure 99B shows another perspective view of the apparatus of figure 99A showing the syringe holding arm shown in a display position in accordance with an embodiment of the present disclosure;

[00374] figure 100A shows a modality of a force mechanism that activates a shown syringe fixation arm, the

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83/294 syringe fixation arm shown in a fixation position, according to one embodiment of the present disclosure;

[00375] figure 100B shows the force mechanism that drives a syringe holding arm shown in figure 100A with the syringe holding arm shown in a display position in accordance with an embodiment of the present disclosure;

[00376] figure 101A shows another embodiment of a force mechanism that drives a shown syringe clamping arm, the syringe clamping arm shown in an affixing position, in accordance with an embodiment of the present disclosure;

[00377] figure 101B shows the force mechanism that drives a syringe holding arm shown in figure 101A with the syringe holding arm shown in a display position in accordance with an embodiment of the present disclosure;

[00378] figure 102A shows another embodiment of a force mechanism that drives a shown syringe clamping arm, the syringe clamping arm shown in a loading position, in accordance with an embodiment of the present disclosure;

[00379] figure 102B shows the force mechanism that drives a syringe holding arm of figure 102A with the syringe holding arm shown in a display position in accordance with an embodiment of the present disclosure;

[00380] figure 103A shows another embodiment of a force mechanism that drives a syringe clamping arm, the syringe clamping arm shown in a loading position, in accordance with an embodiment of the present disclosure;

[00381] figure 103B shows the force mechanism that drives a syringe clamping arm of figure 103A with the syringe clamping arm shown in an affixing position according to one embodiment of the present disclosure;

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84/294 [00382] figure 104A shows the cam of the force mechanisms of figures 103A and 103B when the syringe holding arm is in the display position according to one embodiment of the present disclosure;

[00383] figure 104B shows the cam of the force mechanisms of figures 103A and 103B when the fixation arm is in an intermediate position according to one embodiment of the present disclosure;

[00384] figure 104C shows the cam of the force mechanisms of figures 103A and 103B when the fixation arm is in a loading position according to an embodiment of the present disclosure;

[00385] figure 105 shows a flow chart of a method for side loading a syringe into an infusion pump according to one embodiment of the present disclosure;

[00386] figure 106 shows a modality of a system for attenuating the advance thread eccentricity error according to one embodiment of the present disclosure;

[00387] figure 107 shows a flowchart of a method for attenuating the advance thread eccentricity error according to one embodiment of the present disclosure;

[00388] figure 108 shows a side view of a pump with a modular power supply attached to the rear of the pump according to an embodiment of the present disclosure;

[00389] figure 109 shows a side view of a pump with an external power supply according to an embodiment of the present disclosure;

[00390] figure 110 shows a side view of a pump with a power supply affixed to the bottom of the pump according to an embodiment of the present disclosure;

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85/294 [00391] figure 111 shows a side view of a pump with a power supply affixed to the top of the pump according to an embodiment of the present disclosure;

[00392] figure 112 shows a structure for attaching a power cable to the power supply according to an embodiment of the present disclosure;

[00393] figure 113 shows a system that has a support with a power supply to feed several pumps attached to the support according to one embodiment of the present disclosure;

[00394] Figures 114A to 114J show different views of a syringe pump assembly according to one embodiment of the present disclosure;

[00395] figures 115A to 115B show two views of a retaining clip of the syringe pump assembly shown in figures 114A to 114J according to an embodiment of the present disclosure;

[00396] figures 116A to 116C show several views of the syringe pump assembly shown in figures 114A to 114J with the syringe holder removed in accordance with an embodiment of the present disclosure;

[00397] figures 117A to 117C show various views of the syringe holder of the syringe pump assembly shown in figures 114A to 114J according to an embodiment of the present disclosure;

[00398] figures 118A to 118C show several views of the syringe pump assembly shown in figures 114A to 114J with the syringe holder removed in accordance with an embodiment of the present disclosure;

[00399] figures 119A to 119B show several views of the syringe pump assembly shown in figures 114A to 114J to illustrate the action of the claw member of gripping a flange of a syringe plunger according to one embodiment of the present reveals

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86/294 tion;

[00400] figure 120 shows the plunger head with the cover removed from the syringe pump assembly shown in figures 114A to 114J to illustrate the mechanical effects of the rotation of the dial according to one embodiment of the present disclosure;

[00401] figures 121A to 121C show various views of the plunger head with the cover removed and a circuit board removed from the syringe pump assembly shown in figures 114A to 114J to illustrate the mechanical effects of rotating the dial according to a modality of the present disclosure;

[00402] figures 122A to 122B show two views of a cam used within the plunger head assembly of the syringe pump assembly shown in figures 114A to 114J according to an embodiment of the present disclosure;

[00403] figures 123A to 123B show two approximate views of the internal cavity of the plunger head assembly of the syringe pump assembly shown in figures 114A to 114J according to an embodiment of the present disclosure;

[00404] figure 124 shows the plunger head assembly of the syringe pump assembly shown in figures 114A to 114J according to an embodiment of the present disclosure;

[00405] figures 125A to 125B show two views of the plunger head assembly of the syringe pump assembly shown in figures 114A to 114J with the plunger tube removed in accordance with an embodiment of the present disclosure;

Figures 126A to 1261 show several additional views of the syringe pump assembly of figures 114A to 114J according to an embodiment of the present disclosure;

[00407] figure 127 shows a side perspective view of the syringe pump assembly shown in figures 114A to 114J according to

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87/294 with an embodiment of the present disclosure in which the assembly is coupled to a display; and [00408] figure 128 shows a flow chart of a method for discharging fluid from a syringe and for providing mitigation for an obstruction condition according to one embodiment of the present disclosure.

DETAILED DESCRIPTION [00409] Figure 1 shows an exemplary arrangement of a system 1 for electronic patient care according to one embodiment of the present disclosure. System 1 includes a monitoring client 2 which is connected to various patient care devices via anchors 3 and 11, including an infusion pump 4 connected to and delivering from a smaller bag of liquid 5, a pump infusion 6 connected to and delivering from a larger bag of liquid 7, a drip detection device 8 connected to tubing in the smaller bag 5 and a microinfusion pump 9. System 1 also includes a syringe pump 10 connected in a non-slip manner monitoring client 2. In some embodiments, monitoring client 2 can communicate with these patient care devices in a wired manner, as shown in figure 1 for infusion pumps 4 and 6 and the infusion pump. microinfusion 9 (using anchors 3 and 11). In addition or alternatively, the monitoring client 2 can communicate wirelessly with the patient care devices, as suggested by the absence of a wired connection between the syringe pump 10 and the monitoring client 2.

[00410] In some embodiments, a wired connection between the monitoring client 2 and a patient care device also provides an opportunity for electrical power to be supplied to the patient care device from the client

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Monitoring 2. In this example, the monitoring client 2 may include the electronic circuitry necessary to convert the voltage to supply the patient care device or from a battery attached to the monitoring client 2 or from an alternating current (AC) line voltage fed to monitoring client 2 from an energy outlet (not shown) in a patient's room. Additionally or alternatively, the anchorage 3 supplies energy to the infusion pumps 4 and 6 and to the micro infusion pump 9, for example, from a signal generated from the AC line voltage.

[00411] In one modality, the monitoring client 2 has the ability to receive information about each patient care device with which it is connected, either directly from the device itself or through an docking station, such as such as, for example, the socket 3 in which the patient care device can be mounted. Anchorage 3 can be configured to receive one or more patient care devices via a standardized connection assembly or, in some cases, via an individualized connection assembly for the particular device. For example, infusion pumps 4 and 6 can be mounted on anchor 3 using a similar connection assembly, while the microinfusion pump 9, for example, can be mounted on anchor 3 using a configured connection assembly. for the particular dimensions of the microinfusion pump housing 9.

[00412] Anchorage 3 can be configured to electronically identify the private patient care device that is mounted on the docking station and to transmit this identification information to the monitoring client 2, either wirelessly or via a wired connection. Additional or alternative

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89/294 wirelessly, patient care devices can wirelessly transmit identifying information wirelessly to monitoring client 2, for example, during a disclosure protocol. In addition, the private patient care device can be pre-programmed with treatment information (for example, patient treatment parameters such as an infusion rate for a predetermined infusion liquid) which is transmitted to the monitoring client 2 For example, syringe pump 10 may include identity information and treatment information, such as which medication was prescribed to the patient, which liquid is in the syringe pump reservoir 10, how much and for how long the liquid is prescribed for be delivered to the patient, who are the authorized health professionals, etc. In some modalities of the present disclosure, the monitoring client 2 communicates with EMR records to verify that the preprogrammed treatment information is safe for an identified patient and / or that the preprogrammed treatment information corresponds to the prescribed treatment stored in the EMR records .

[00413] In some embodiments, the drip detection device 8 can communicate with the monitoring client 2 either wirelessly or over a wired connection. If an aberrant liquid flow condition is detected (for example, because the tubing to the patient has become obstructed), a signal can be transmitted to the monitoring client 2, which (1) can display the liquid flow rate from the container of liquid 5 on a user interface or locally on the monitoring client 2 or more remotely to a user interface on a nursing station or a portable communications device, (2) can trigger an auditory or visual alarm and / or (3 ) can cause the monitoring client 2 to change the infusion rate of a pump 4 connected to a bag 5, or

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90/294 ending the infusion or otherwise changing the pumping rate. The aberrant liquid flow condition can also cause an audible alarm (and / or vibration alarm) on the infusion pump 4 or drip detection device 8 or cause the infusion pump 4 to modify or stop the pumping, for example example, when the aberrant liquid flow condition exceeds the predefined ranges of the operation.

[00414] Alarms can occur simultaneously on several devices or can follow a predetermined schedule. For example, when an obstruction occurs on a line connected to the infusion pump 4, (1) the drip detection device 8 sounds the alarm using its internal speaker and an internal vibration motor, (2) later , the infusion pump 4 sounds the alarm using its internal speaker and an internal vibration motor, (3) then, the monitoring client 2 sounds the alarm using its internal speaker and an motor internal vibration, and (4) finally, a remote communicator (for example, a smart phone, blackberry-based phone, Android-based phone, iphone, etc.) sounds the alarm using its internal speaker and a internal vibration motor. In some embodiments, the syringe pump 10 can be connected to the drip detection device 8 and can detect aberrant liquid flow conditions as described above.

[00415] In some embodiments, the syringe pump 10 can be programmable to allow continuous operation at a predetermined pumping rate if communications fail between the monitoring client 2 and the syringe pump 10, or because of a malfunction. operation on the monitoring client 2, on the communications channel between the monitoring client 2 and the syringe pump 10 or on the syringe pump itself 10. In some embodiments, this

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91/294 independent option is allowed when the measurement to be infused is pre-designated to not be suspended or retained in the event of malfunction in other parts of the system. In some embodiments, the syringe pump 10 is programmed to operate independently in a fail safe mode and can also be configured to receive information from a drip detection device 8 directly, rather than through a monitoring client 2 (for example, in the mode in which the drip detection device 8 is used in conjunction with the syringe pump 10); with this option, the syringe pump 10 can be programmed, in some embodiments, to stop an infusion if the drip detection device 8 detects an aberrant flow condition (such as, for example, a free flow condition or a bubble of air present in the infusion line). In some embodiments, one or more of pumps 4, 6 and 10 can be internal liquid flow meters and / or can operate independently as a stand-alone device. Additionally or alternatively, an internal liquid flow meter of the syringe pump 10 can be independently determined by a drip detection device flow meter 8 by the monitoring client 2, in the manner in which devices 8 and 10 are used in set.

[00416] Monitoring client 2 can also remotely send a prescription to a pharmacy. The prescription can be a prescription to infuse a fluid using the syringe pump

10. The pharmacy may include one or more computers connected to a network, for example, the internet, to receive the prescription and queue the prescription inside one or more computers. The pharmacy can use the prescription to compose the drug (for example, with the use of an automated composition device coupled to one or more computers, or manually by a pharmacist who has seen the drug 870160077500, from 12/20/2016, page 108/484

92/294 sualizes the queue of one or more computers), pre-fill a reservoir or fluid cartridge from a syringe pump 10 and / or program the syringe pump 10 (for example, a treatment regime is programmed in the syringe pump 10) at the pharmacy according to the prescription. The reservoir or cartridge can be automatically filled by the automatic computing device and / or the syringe pump 10 can be automatically programmed by the automatic computing device. The automatic computing device can generate a barcode, RFID tag and / or data. Information within the bar code, RFID tag and / or data may include the treatment regimen, prescription and / or patient information. The automatic computing device can: affix the barcode to the syringe pump 10 or to the reservoir, cartridge or disposable portion of the syringe pump 10; affix the RFID tag to the syringe pump 10 or to the reservoir, cartridge or disposable portion of the syringe pump 10; and / or program the RFID tag or memory inside the syringe pump 10 or the reservoir, cartridge or disposable portion of the syringe pump 10 with the information or data. The data or information can be sent to a database that associates the prescription with the syringe pump 10 or the reservoir, cartridge or disposable portion of the syringe pump 10, for example, using a serial number or other information from identification within the barcode, RFID tag or memory.

[00417] The syringe pump 10 may have a scanning device, for example, an RFID interrogator that interrogates a reservoir, disposable portion or cartridge of the syringe pump 10 to determine that it is the correct fluid within the fluid reservoir or is the reservoir, disposable portion or correct fluid cartridge, the treatment programmed in the syringe pump 10 corresponds to the fluid inside the

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93/294 reservoir, disposable portion or fluid cartridge and / or syringe pump 10 and the reservoir, disposable portion or cartridge of syringe pump 10 are correct for the particular patient (for example, as determined from a patient bars, RFID or other patient identification). For example, a reservoir serial number, disposable portion as swept by the syringe pump 10 is compared to a serial number in electronic medical records to determine whether it correctly matches a patient's serial number within electronic medical records. ; the syringe pump 10 can scan a patient's RFID tag or barcode to obtain a patient's serial number which is also compared to the patient's serial number within electronic medical records (for example, the serial number of a reservoir, disposable portion or cartridge of the syringe pump 10 or a serial number stored within the memory of the syringe pump 10 must be associated with the patient's serial number as scanned into the electronic medical records). The syringe pump 10 can issue an error or alarm if the serial numbers do not match, in some specific ways. In addition or alternatively, the monitoring client 2 can scan the reservoir, disposable portion, cartridge or syringe pump 10 to determine that it is the correct fluid within the fluid reservoir, it is the correct fluid reservoir, the treatment programmed in the syringe pump 10 corresponds to the fluid inside the fluid reservoir or cartridge and / or the fluid reservoir and syringe pump 10 are correct for the particular patient (for example, as determined from a patient barcode, RFID or other identification patient). In addition or alternatively, the monitoring client 2 or the syringe pump 10 can interrogate a database of electronic medical records and / or the farm

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94/294 cia to check the prescription or download the prescription, for example, using a barcode serial number on the syringe pump 10 or a reservoir, cartridge or disposable portion of the syringe pump 10.

[00418] The liquid that is delivered to a patient can be monitored by monitoring client 2 to determine whether all medications that are delivered are safe for the patient. For example, the monitoring client 2 can register the medication delivered from the syringe pump 10 as communicated by the syringe pump 10 to the monitoring client 2 and the monitoring client 2 can also register the medication that is delivered by the syringe pumps. infusion 4 and 6 and / or by the micro infusion pump 9. Monitoring client 1 can make a determination from the recorded data to determine whether the aggregated quantities and types of medication that are delivered are safe. For example, the monitoring client 2 can determine whether the IV bag 5 is contraindicated with the medication in the syringe pump 10. Additionally or alternatively, in some modalities, the monitoring client 2 can monitor the delivery of the liquid in the IV bag 8 and one or more boluses delivered by the syringe pump 10 to determine if the total dose exceeds a predetermined limit, for example, the medication in the IV bag 5 and the syringe pump 10 can be of the same type or class of drug and the monitoring client 2 can determine whether drugs are safe when combined as they are delivered to the patient. The syringe pump 10 can also communicate with infusion pumps 4 and 6 and / or the micro infusion pump 9 to make the same determination; in this exemplary embodiment, the syringe pump 10 can communicate with the devices directly (via wired or wireless communications) or via the monitoring client 2 (via wired or wireless communications)

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95/294 wireless way). In some embodiments of the present disclosures, one or more communication modules (for example, each having the ability to communicate through one or more protocols) can be connected to the syringe pump 10 and / or can be connected in and then connected to the syringe pump 10 to allow the syringe pump 10 to communicate through the communication modules.

[00419] Syringe pump 10 includes a touch screen interface 11 (which can be separable), a start button 12 and a stop button 13. However, in some alternative embodiments, button 12 is a PCA button to deliver pain medications to a patient. User interface 11 can be used to program treatment regimens, such as flow rates, bolus quantities or other treatment parameters. After a treatment regimen is programmed into the syringe pump 10, the syringe pump 10 can query a database (for example, Electronic Medical Records (EMR), Drug Error Reduction System (DERS) or another database ) to determine whether the treatment regimen is safe for the private patient or for any patient. For example, syringe pump 10 can query the EMR database (for example, via a wireless link, wired link, WiFi, mobile phone network or other communications technology) to determine whether the treatment regimen of the syringe pump 10 is safe based on the patient information stored (for example, age, weight, allergies, condition, etc.) in the EMR records. In addition or alternatively, the syringe pump 10 can consult the DERS database (for example, via a wireless link, wired link, WiFi, mobile phone network or other communications technology) to determine whether the Treatment of the syringe pump 10 is safe based on the safety criteria

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96/294 ended in DERS records.

[00420] In some modalities, if the treatment regime is determined to be safe, a notice may request confirmation of the user of the treatment regime. After confirming the user, the user (for example, healthcare professional, nurse or other authorized person) can press the start button 12. In some modalities, the stop button 13 can be pressed at any time to interrupt the treatment.

[00421] In some modalities, if the EMR and / or DERS determines that the treatment regime exceeds a first set of criteria, the treatment can continue if the user confirms the treatment (for example, with an additional warning, user password and / or additional authentication or authorization, etc.); in this modality, the EMR or DERS can prevent the treatment from being delivered if the EMR and / or DERS determines that the treatment regimen exceeds a second set of criteria, for example, the treatment is not safe under any circumstances for any patient, for example example. EXEMPLIFICATIVE BEDSIDE ARRANGEMENT [00422] Figures 2 to 9 show several views related to a system 200. Figure 2 shows a system 200 that includes several pumps 201, 202 and 203. The pumps 201, 202, 203 can be coupled together to form a group of pumps that are connectable to a pole 208. System 200 includes two syringe pumps 201, 202 and a peristaltic pump 203; however, other combinations of various medical devices can be employed.

[00423] Each of the pumps 201, 202, 203 includes a touchscreen 204 that can be used to control pumps 201, 202, 203. The touchscreen 204 of one of the pumps (for example, 201, 202 , 203) can also be used to coordinate the operation of all pumps 201, 202, 203 and / or to control the other pumps

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97/294 among the pumps 201,202, 203.

[00424] Pumps 201, 202 and 203 are chained together in series so that they are in electrical communication with each other. Additionally or alternatively, pumps 201, 202 and / or 203 can share energy with one another or with each other; For example, one of pumps 201, 202 and / or 203 may include an AC / DC converter that converts AC electricity to DC power suitable for powering the other pumps.

[00425] Within system 200, pumps 201, 202 and 203 are stacked together using the respective Z 207 frames. Each of the Z 207 frames includes a lower portion 206 and an upper portion 205. A lower portion 206 of a Z 207 frame (for example, the bottom portion 206 of the pump 201) can engage an upper portion 205 of another Z frame 207 (for example, the top portion 205 of the Z frame 207 of the pump 202).

[00426] A clamp 209 can be coupled to one of pumps 201, 202, 203 (for example, pump 202 as shown in figure 3). That is, the clamp 209 can be attached to any of the pumps 201, 202, 203. The clamp 209 can be attached to the back of any of the pumps 201, 202, 203. As is easily seen in figure 5, each of the pumps 201, 202, 203 include an upper display member 210 and a lower display member 211. A clamp adapter 212 facilitates the attachment of clamp 209 to pump 202 by means of an upper display member 210 and lower display member 211 respective pumps (for example, 201, 202, or 203). In some embodiments, the clamp adapter 212 may be integral with the clamp 209.

[00427] Figure 6 shows an approximate view of a portion of a clamp interface (i.e., clamp adapter 212) that is attachable to pump 202 (or pumps 201 or 203) shown

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98/294 in figures 2 to 5 according to an embodiment of the present disclosure. The clamp adapter 212 includes a hole 213 to which a lower display member 211 (see figure 5) can be attached. That is, the lower display member 211 is a hook-type protrusion that can be inserted into orifice 213 and subsequently rotated to secure the lower display member 211 therein.

[00428] As is easily seen in figure 7, the clamp adapter 212 also includes a lock 214. The lock 214 is pivotally mounted to the clamp adapter 212 by means of pivots 216. The lock 214 can be spring-oriented by spring means 218 which are coupled to hooks 220. Stop members 219 prevent lock 214 from pivoting beyond a predetermined amount. After orifice 213 is inserted into the lower fixing member 211 (see figures 5 and 6), the clamp adapter 212 can be rotated to bring lock 214 towards the upper fixing member 210 so that lock 214 is compressed down by the upper fixing member 210 until the protrusion 215 fits into a complementary space of the upper fixing member 210. The hooks 220 help to secure the clamp adapter 212 to the pump 202.

[00429] Each Z 207 frame of pumps 201, 202, 203 includes a recessed portion 223 (see figure 5) and a protrusion 224 (see figure 8). A protrusion 224 of the Z frame 207 of a pump (for example, pumps 201, 202 or 203) can engage a recessed portion 223 of another pump to allow the pumps to be stacked on top of each other. Each of pumps 201, 202, 203 includes a locking latch member 221 that allows another one of pumps 201, 202, 203 to be attached to it via a lock 222 (see figure 8). Lock 222 can include a small spring loaded flange that can fit into the space formed under locking latch member 221. Lock 222 can be

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99/294 hingedly coupled to the bottom portion 206 of the Z 207 frame.

[00430] As seen in figure 3, latch 222 of pump 201 can be pulled to remove a portion of latch 222 out of the space under latch member 221 of pump 202. Thereafter, pump 201 can be rotated to extract the protrusion 224 from the pump 201 out of the recessed portion 223 of the Z frame 207 of the pump 202 so that the pump 201 can be removed from the pump stack 202, 203 (see figure 4).

[00431] Each pump 201, 202, 203 includes an upper connector 225 (see figure 9) and a lower connector 226 (see figure 8). Connectors 225 and 226 allow stacked pumps 201, 202 and 203 to communicate with each other and / or supply power to each other. For example, if the intermediate pump 202 battery (see figure 2) fails, then the upper pump 201 and / or the lower pump 203 can power the intermediate pump 202 as a backup while audibly ringing the alarm.

EXEMPLIFICATIVE SYRINGE PUMP MODE AND RELATED HEADSIDE ARRANGEMENT [00432] Figures 10 to 13 show different views of a syringe pump 300 according to one embodiment of the present disclosure. Syringe pump 300 can have a syringe 302 loaded or turned to the left (as shown in figures 10 to 13) or to the right (see figure 16, described below). That is, the syringe pump 300 is a bidirectional syringe pump.

[00433] Syringe 302 can be loaded into syringe retainer 306 of syringe pump 300. A flange end piece 310 of syringe 302 can be placed on the left flange receiver 311 or the right flange receiver 312. When the part flange terminal 310 is inserted into the left flange receiver 311, syringe 302 is

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100/294 facing left outlet 308, which can hold a tube that is fluidly coupled to syringe 302. An engaging member 314 can be coupled to an end fitting 315 of syringe 302 when or after syringe 302 is loaded in the syringe retainer 306. A threaded shaft 315 that is coupled to a motor can be rotated to move the engagement member 314 in any direction to discharge the fluid from the syringe 302.

[00434] Syringe 302 can also be loaded on the right (not shown in figures 10 to 13). Syringe retainer 306 can be moved and / or adjusted so that it is moved to the right so that syringe 302 can be loaded. The syringe retainer 306 can be manually moved and / or an electric motor can move the syringe retainer 306 to the right. In some embodiments of the present disclosure, syringe retainer 306 extends sufficiently left and right so that no adjustment is used.

[00435] In the case where the syringe 302 is loaded facing right, the flange end piece 310 is loaded into the right flange receiver 312. The engaging member 314 subsequently moves to the right so that the fluid can be discharged through a tube that passes through a straight exit 309.

[00436] The pump 300 can be controlled by means of a touch screen 304 to define the flow rate, flow profile and / or to monitor or otherwise control the syringe pump 300. A clamp 316 can be used to attach the syringe pump 300 to a pole (for example, using a screw clamp).

[00437] Figure 14 shows several syringe pumps 300 of figures 10 to 13 mounted on a pole 322 according to one embodiment of the present disclosure. That is, figure 14 shows a system 320

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101/294 using several 300 syringe pumps mounted on pole 312. The pole 322 can be used in a hospital and / or in a home environment.

[00438] Figures 15 and 16 illustrate portions 327 of the syringe pump operation 300 of figures 21 to 24 according to an embodiment of the present disclosure. Figure 15 shows the loaded syringe 302 turned to the left and Figure 16 shows the loaded syringe 302 to the right. As shown in figures 15 and 16, a motor 326 is coupled to threaded shaft 315 so that motor 326 can rotate threaded shaft 315.

[00439] A left syringe diameter sensor 324 measures the diameter of the syringe 305 to estimate the cross-section size of the inner space of the syringe barrel 302. The left syringe diameter sensor 325 can be a bar that is attached to a column so that the bar is raised to cover the syringe 302; the movement of the column outside the syringe pump body 300 can be measured by a linear sensor to estimate the diameter of the syringe barrel 302. Any linear sensor can be used including linear potentiometer technology, optical linear sensor technology, a hall effect sensor technology, etc. The movement of the motor 326 can therefore be correlated to the fluid discharged from the syringe 302 using the estimate of the diameter of the inner space of the syringe barrel 302. Similarly, the right syringe diameter sensor 325 can be used to estimate the diameter syringe barrel 302, which can be used to estimate the fluid discharged from syringe 302 to the right.

[00440] In some embodiments of the present disclosure, the touch screen 304 prompts the user for information when the syringe 302 is loaded into the syringe pump 300 (in the left or right configuration) and the syringe diameter sensor 324 or 325 is

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102/294 used to estimate the diameter of the internal space of the 305 syringe barrel; the user is prompted by a request from the touch screen 304 for the user to insert the syringe manufacturer 305 on the touch screen 304. An internal database inside the syringe pump 300 can be used to narrow the range of possible models associated with an estimate of the 305 syringe diameter. When the user enters the 305 syringe manufacturer, the database can be used to identify a particular model number of the 305 syringe and / or a subset of possible model numbers that corresponds to the estimate of the diameter of the 305 syringe and the information entered by the user, which, in turn, can provide a more accurate internal diameter value (as stored within the database). The user can be prompted by the 304 touchscreen display to select the syringe model from a list or enter the model of the syringe that will deliver the medication. The user can be guided through a selection process on the 304 touch screen to identify the syringe loaded on the machine using one or more of the following aspects: syringe barrel size, plunger head size, syringe images and model numbers. The selection process can access a database of syringes including manufacturer, model, internal diameter and image. Syringe pump 300 can use the identified syringe to define the internal diameter value for volume calculations.

EXEMPLIFICATIVE BEDSIDE ARRANGEMENTS [00441] Figures 17 and 18 illustrate several medical devices 402 mounted on a pole 403 according to one embodiment of the present disclosure. Figures 19 to 22 show different views of the medical device 402 of figures 17 and 18. The medical device 402 is mounted on the pole by means of the clamp 401. The clamp 401 allows

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103/294 ensure that the medical device 402 is removed and adjusted. The medical device 402 can be any medical device, such as an infusion pump, a syringe pump, a monitoring client, etc.

[00442] Medical device 402 is coupled to pole 403 by means of arms 403 so that medical device 402 can be pulled away from the pole (see figure 20) and / or articulated on arms 403.

[00443] Figure 23 shows several assemblies 406 mounted on a pole 405 and figures 24 to 26 show several views of an assembly of figure 23 according to one embodiment of the present disclosure. Each of the assemblies 406 includes a clamp 407 (for example, a threaded clamp), a first arm 408 hingedly mounted on the clamp 407 and a second arm 411 hingedly mounted on the first arm 408 by means of a hinge 409 The end of the second arm 411 includes a coupling member 410 that can be coupled to a medical device.

EXAMPLIFIER SPEAKER AND BATTERY TEST [00444] Figure 27 shows a circuit diagram 420 that has a speaker 423 and a battery 421 according to one embodiment of the present disclosure. Battery 421 can be a backup battery and / or speaker 423 can be a backup alarm speaker. That is, circuit 420 may be a backup alarm circuit, for example, a backup alarm circuit in a medical device, such as a syringe pump.

[00445] In some embodiments of the present disclosure, battery 421 can be tested simultaneously with speaker 423. When a switch 422 is in an open position, a voltmeter 425 can be used to measure the open circuit voltage of battery 421 .

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104/294

Thereafter, switch 422 can be closed and the closed circuit voltage of battery 421 can be measured. The internal resistance of battery 421 can be estimated using the known impedance, Z, of speaker 423. A processor can be used to estimate the internal resistance of battery 421 (for example, a syringe pump processor). The processor can correlate the internal resistance of the battery 421 to the operation of the battery 421. In some embodiments of the present disclosure, if the closed circuit voltage of the battery 421 is not in a predetermined range (the range may be a function of the closed circuit voltage battery 421), speaker 423 can be determined to have failed.

[00446] In some additional embodiments of the present disclosure, switch 422 can be modulated so that speaker 423 is tested simultaneously with battery 421. A microphone can be used to determine whether speaker 423 is transmitting a signal within the predetermined operational parameters (eg volume, frequency, spectral compositions, etc.) and / or the internal impedance of the battery 421 can be estimated to determine whether it is within the predetermined operational parameters (for example, the complex impedance, for example). The microphone can be attached to the processor. In addition or alternatively, a test signal can be applied to speaker 423 (for example, by modulating switch 422) and the current waveform of speaker 423 can be monitored by a current sensor 426 to determine the total harmonic distortion of loudspeaker 423 and / or the magnitude of the current; a processor can monitor these values using the current sensor 426 to determine if a fault condition exists within speaker 423 (for example, the total harmonic distortion or the magnitude of the current is not within the predetermined ranges).

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105/294 [00447] Various sine waves, periodic waveforms and / or signals can be applied to speaker 423 to measure its impedance and / or to measure battery impedance 421. For example, a pump processor syringe disclosed in this document can modulate switch 422 and measure voltage across battery 421 to determine whether battery 421 and speaker 423 have an impedance within predetermined ranges; if the estimated impedance of battery 421 is outside a first range, the processor will determine that the battery is in a fault condition and / or if the estimated impedance of the speaker is outside a second range, the processor will determine that the loud speaker 423 is in a fault condition. Additionally or alternatively, if the processor cannot determine whether battery 421 or speaker 423 has a fault condition, but has determined that at least one exists in a fault condition, the processor can issue an alert or alarm that circuit 420 is in a fault condition. The processor can alarm or alert a user or remote server of the fault condition. In some embodiments of the present disclosure, the syringe pump will not operate until the failure is addressed, mitigated and / or corrected.

EXEMPLIFICATIVE SYRINGE PUMP MODALITY [00448] In an exemplary mode, as shown in figure 28, a syringe pump 500 is pictured. The syringe pump 500 can be used to deliver an agent, such as, without limitation, an analgesic, medication, nutrient, chemotherapeutic agent, etc. to a patient. The syringe pump can be used to deliver precisely an amount of an agent to a patient or to deliver an accurate amount of an agent over a period of time. The syringe pump 500 can be used in any suitable application, such as, but without limitation, intra-delivery

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106/294 nosa, intrathecal delivery, intra-arterial delivery, enteral delivery or food, etc.

[00449] The syringe pump 500 comprises a housing 502 and a syringe pump assembly 501. In the exemplary embodiment in figure 28, housing 502 is substantially a rectangular box. In alternative embodiments, housing 502 can take any one of a variety of other suitable formats. Housing 502 may be made of any of several materials or a combination of materials, including, without limitation, metal or plastic. Housing 502 can be extruded, injection molded, die cast, etc. In some embodiments, housing 502 may comprise several separate parts that can be coupled together by any suitable means. In some embodiments, housing 502 can be disassembled or comprised of a removable panel to allow syringe pump 500 to be easily repaired.

[00450] As shown in figure 28, a syringe 504 can be seated on the syringe pump assembly 501. Syringe 504 can be a glass, plastic or any other type of syringe 504. Syringe 504 can be a syringe 504 of any capacity. In some embodiments, including the embodiment in figure 28, syringe 504 can be seated on a syringe holder 506 that comprises part of the syringe pump assembly 501. Syringe holder 506 may comprise an outline that allows syringe 506 to be supported by syringe holder 506. Syringe holder 506 can be made of the same material as the rest of housing 502, a different material or can be made of different materials. The syringe holder 506 can be attached to housing 502 by an assembly 508 that can also serve as a protection against leakage, splashing, dripping, fluid or debris.

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107/294 [00451] In some embodiments, the syringe holder 506 may comprise part of housing 502. In the embodiment shown in figure 28, syringe holder 506 is part of a syringe pump assembly 503 of the injection pump assembly syringe 501. In some embodiments, the housing syringe pump assembly 503 can be at least partially formed as an extrusion. In such embodiments, the contours of the syringe holder 506 can be formed during extrusion.

[00452] The syringe pump assembly 501 can be inserted into housing 502 or can be coupled to it. In the exemplary embodiment in figure 28, the syringe pump assembly 501 is mainly disposed within the housing 502. The syringe holder 506, the syringe barrel retainer 518, the drum flange clamp 520, the plunger head assembly 522 and the plunger tube 524, each part of the syringe pump assembly 501, are not arranged inside the housing 502 in the exemplary embodiment shown in figure 28. In the arrangements where the syringe holder 506 is not part of the housing 502 , assembly 508 may comprise a gasket that acts as a seal to prevent unwanted foreign material from entering housing 502 and reaching the portions of syringe pump assembly 501, which are arranged within housing 502. In some embodiments, the mount 508 can project the syringe holder 506 and can function as a drip edge, splash protection, etc. that will pour the liquid out and away from the syringe pump

500.

[00453] In some embodiments, the syringe pump 500 can be converted into a different device such as, however, without limitation, a large volume peristaltic pump. This can be accomplished by removing the 501 syringe pump assembly from the housing

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108/294 to 502 and replacing the syringe pump assembly 501 with another desired assembly. Replacement sets may include, for example, other sets of infusion pumps such as a peristaltic infusion pump set.

[00454] In some embodiments, a clamp 510 can be attached to housing 502. Clamp 510 can be any type of clamp, for example, a standard pole clamp 510 or a quick release pole clamp 510 (shown). The clamp 510 can be used to hold the syringe pump 500 in a desired location on an object such as an IV pole. The clamp 510 can be removably attached to housing 502 via a clamp assembly 512. In some embodiments, the clamp assembly 512 can comprise any of a variety of fasteners such as threads, dowels, adhesive, velcro tape, quick fit, friction fit, magnets, etc. In some embodiments, the clamp 510 or a part of the clamp 510 may be formed as an integral part of the housing 502 during manufacture.

[00455] As shown in figure 28, housing 502 can also include a display 514. Display 514 can function as a graphical user interface and allow a user to program and monitor the operation of the pump. The display 514 can be an electronic visual display such as a liquid crystal display, touch screen, L.E.D. display, plasma display, etc. In some embodiments, the display can be complemented by any number of data entry means 516. In the example, the data entry means 516 are several buttons that can be pressed by the user. The buttons can have fixed functions such as start, stop, silence, emergency stop, initiate therapy or lock. The lock function can lock all user inputs to prevent inadvertent commands

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109/294 to be issued to the syringe pump 500, due to a touchscreen display 514 being touched, buttons being pressed or touched or any other inadvertent gesture. The data entry means 516 of other modalities may differ. In embodiments where the display 514 is a touchscreen display, the data entry means 516 may include several physically pressing buttons. The physically pressing button data entry means 516 can be a support for the touchscreen display 514 and can be used in the event that the touchscreen display 514 is compromised or becomes otherwise non-functional .

[00456] In an example of a non-limiting modality, the data entry means 516 can be constructed as a touchscreen monitor 514. The touchscreen monitor can detect the position of a finger or fingers user on the screen. The touchscreen can be a capacitive touchscreen or any other type of touchscreen. The software can display virtual buttons, slides and other controls. The software can also detect the user's touch or the touch of a pen to control the machine and interact with remote computers that can communicate with the syringe pump 500. The software can also recognize multi-touch gestures that they can control: the monitor , operation of the syringe pump 500, interaction of the syringe pump 500 with one or more remote computers, etc. In some embodiments, the syringe pump 500 may include sensors that detect user gestures when the user is not in contact with the monitor. These motion detection sensors may comprise a device that transmits invisible proximal infrared light, which measures your flight time after it reflects objects. Such a measure may allow the syringe pump 500 to detect the location of

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110/294 objects and the distance from the syringe pump 500 to said objects. The syringe pump 500 may therefore have the ability to monitor and receive commands through the user's limbs, hands and fingers or movements of the user's limbs, hands and fingers. An example of a motion detector is the PrimeSense 3D sensor made by the Israeli company PrimeSense. In some embodiments, monitor 514 and data entry means can be mounted on housing 502 during manufacture of syringe pump 500. Monitor 514 can be removed and replaced during maintenance if necessary.

[00457] Syringe pump 500 may include a syringe barrel retainer 518. Syringe barrel retainer 518 can securely hold syringe barrel 540 against syringe holder 506. Syringe barrel retainer 518 may be easily adjusted by a user to accommodate 504 syringes of various sizes. In some embodiments, syringe barrel retainer 518 can be oriented to automatically adjust to syringe diameter 504 of any size after syringe barrel retainer 518 is pulled out by a user. The 518 syringe barrel retainer will be further elaborated later in the specification.

[00458] The syringe pump 500 can also include a drum flange clamp 520. The drum flange clamp 520 in the embodiment example depicted in figure 28 is arranged at one end of the syringe pump assembly housing 503 and has the ability to hold syringe drum flange 542 in place against the end of syringe pump assembly housing 503. Drum flange clamp 520 also has the ability to retain any of a variety of flange types and sizes syringe barrel 542 that may be available to a user.

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111/294

The drum flange clamp 520 will be further elaborated later in the specification. For a more detailed description of the drum flange clamp 520, see Figure 61 and Figure 62. [00459] The syringe pump 500 can additionally include a plunger head assembly 522. Plunger head assembly 522 can be attached to the syringe pump assembly 501 by a plunger tube 524. In the embodiment example shown in figure 28, the plunger head assembly 522 and plunger tube 524 extend out of housing 502 towards the right of the page.

[00460] The syringe pump 500 may also comprise a downstream pressure sensor 513 as shown in figure 28. The downstream pressure sensor 513 may comprise part of the syringe pump assembly 501 or the housing 502. The pressure sensor downstream 513 can take pressure measurements from a fluid line, i.e., tubing extending from syringe 504 to a patient. In some embodiments, the fluid line may include a pipe span that is different from the rest of the pipe. For example, an amplitude of the fluid line can be made of a deformable PVC material. Such modalities can make fluid line pressures easier to determine.

[00461] The downstream pressure sensor 513 may comprise a support with a pressure sensor, such as a force sensor. In such embodiments, the fluid line can be held against the support and pressure sensor of the downstream pressure sensor 513 by a non-deformable or deflectable structure. The downstream pressure sensor 513 can cause the syringe pump 500 to trigger the alarm if the detected pressure is outside an acceptable range. The measurement of the downstream pressure sensor 513 can be used as a reference in comparison to a survey table to determine the pressure in the fluid line. If an abnormal pressure reading (for example

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112/294 pio, a high pressure generated during an occlusion event beyond a predetermined limit) is obtained, a syringe pump control system 500 can interrupt fluid delivery. In some embodiments, the syringe pump 500 may be induced to pause and relieve part of the pressure in response to the detection of pressures that suggest an occlusion.

[00462] Figure 29 shows the syringe pump 500 from another perspective. In this view, monitor 514 and data entry means 516 coupled to housing 502 are facing the front of the page. The clamp 510 is coupled to the housing 502 by a clamp assembly 512. The syringe pump assembly 501 is arranged mostly within the housing 502. The syringe holder 506, which comprises part of the syringe pump assembly

501, forms a substantial part of one side of housing 502. Assembly 508 holds syringe pump assembly 501 and helps seal the interior of housing 502 against exposure to debris. In embodiments where assembly 508 acts as a gutter edge, assembly 508 can cover the syringe pump assembly 501 and assist in the flow of liquid away from the interior of the housing

502. The syringe barrel holder 518 extends through the syringe holder 506. In the position shown in figure 29, the syringe barrel holder 518 has been pulled away from its resting position and is oriented so that it can automatically retract back towards housing 502. In some embodiments, the syringe barrel clamp 518 can be locked in a position other than at rest, such as the position depicted in figure 31. The drum flange clamp 520 is visible and arranged at the end of the syringe pump assembly housing 503 closest to the plunger head assembly 522. Plunger tube 524 connects plunger head assembly 522 to the rest of the plunger assembly

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113/294 syringe pump 501 as described above. The downstream pressure sensor 513 is arranged on the syringe holder 506.

[00463] In some specific embodiments, an 8127 camera is positioned to view the syringe. The 8127 camera can be coupled to the RTP 3500 and / or the 3600 processor of figure 59J to provide image data to it. The 8127 camera can include a CCD image sensor, a CMOS image sensor or any other type of imaging sensor. In some embodiment of the present disclosure, camera 8127 includes an array of image sensors.

[00464] An image of the syringe loaded inside the syringe holder 506 can be displayed on monitor 514 as seen from camera 8127. Processors 3500 and / or 3600 can use images from camera 8127 to: read QR codes on the syringe to identify the syringe, detect particulates or bubbles in the syringe, measure the location of the plunger to measure the volume delivered and, thus, the remaining volume, determine when the status of the syringe has changed, determine whether the syringe is present, estimate discharges bolus, check the color of the fluid to determine if it is the correct fluid and / or to determine if the syringe is missing or improperly loaded.

[00465] Through the use of frame differentiation to detect movement and a Gaussian filter to help reduce the shooting noise of the 8127 camera (which refers to an impurity, however less), the impurities that move can be detected. To locate the syringe plunger, the fiducials on the syringe can be used, a gauge equality test (where the plunger is the template) can use pattern recognition to locate the fiducials and thus the plunger.

[00466] Figures 30 to 34 illustrate how a user can allocate

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114/294 a syringe 504 inside the syringe pump assembly 501. The syringe pump assembly 501 is shown isolated in figure 30. Syringe 504 is not seated against syringe holder 506. As shown, the head assembly piston 522 comprises two jaws, an upper piston gripper 526 and a lower piston gripper 528. the upper piston gripper 526 and the lower piston gripper 528 are in the open position. The upper plunger gripper 526 and the lower plunger gripper 528 have the ability to clamp and retain plunger flange 548 on plunger 544 of syringe 504. The upper plunger gripper 526 and the gripper claw 526 lower piston 528 can be actuated to open or closed positions by rotating a dial 530 comprising part of the piston head assembly 522. The piston head assembly 522 may also comprise a piston pressure sensor 532.

[00467] In figure 31, the syringe pump assembly 501 is shown again isolated. Syringe 504 that was not seated on syringe holder 506 in figure 30 is seated in place on syringe holder 506 in figure 31. Syringe barrel flange 542 is clamped in place by drum flange clamp 520. The syringe barrel 518, was pulled out so that syringe 504 could be placed inside syringe pump assembly 501, but it has not yet been allowed to automatically adjust to the diameter of syringe barrel 540. In the example example shown in In figure 31, the syringe barrel retainer 518 has been rotated 90 ° clockwise from its orientation in figure 30 to lock it in position. Alternative modalities may require counterclockwise rotation, a different degree of rotation or may not require rotation to lock the 518 syringe barrel retainer in

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115/294 position. The plunger tube 524 and the plunger head assembly 522 attached are fully extended away from the rest of the syringe pump assembly 501. Since the dial 530 has not been rotated from the orientation shown in figure 30, the gripping claw upper plunger 526 and lower plunger gripper 528 are still in the open position.

[00468] In figure 32, the syringe pump assembly 501 is shown again isolated. Syringe 504 is seated against syringe holder 506. Syringe barrel retainer 518 has been turned out of the locked position and has been allowed to automatically adjust to the diameter of syringe barrel 540. Syringe barrel retainer 518 holds the syringe 504 in place in syringe pump assembly 501. Syringe 504 is additionally held in place in syringe pump assembly 501 by barrel flange clamp 520 that holds syringe barrel flange 542. plunger tube 524 and the plunger head assembly 522 attached is fully extended away from the rest of the syringe pump assembly 501. Since the dial 530 has not been rotated from the orientation shown in figure 30, the upper plunger gripper 526 and the lower plunger gripper 528 are still in the open position.

[00469] In figure 33, the syringe pump assembly 501 is shown again isolated. Syringe 504 is seated against syringe holder 506. Syringe barrel retainer 518 is pressed against syringe barrel 540 and holds syringe 504 in place in syringe pump assembly 501. Drum flange clamp 520 holds the syringe barrel flange 542 and helps hold syringe 504 in place in syringe pump assembly 501. The amount that plunger tube 524 extends away from the rest of syringe pump assembly 501 has been adjusted so that plunger head assembly 522 is in contact with plunger flange 548 on

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116/294 syringe plunger 544. Since the dial 530 has not been rotated from the orientation shown in figure 30, the upper plunger gripper 526 and the lower plunger gripper 528 are still in the open position. Plunger flange 548 is in contact with plunger pressure sensor 532.

[00470] In figure 34 the syringe pump set 501 is shown again isolated. Syringe 504 is seated against syringe holder 506. Syringe barrel retainer 518 is pressed against syringe barrel 540 and holds syringe 504 in place in syringe pump assembly 501. Drum flange clamp 520 clips the syringe barrel flange 542 and helps hold syringe 504 in place in syringe pump assembly 501. The amount that plunger tube 524 extends away from the rest of syringe pump assembly 501 has been adjusted so that the plunger head assembly 522 is in contact with the plunger flange 548 on the syringe plunger 544. The dial 530 has been rotated from the orientation shown in figures 30 to 33. Consequently, the upper plunger gripper 526 and the lower plunger gripper 528 have moved to a closed position where the plunger flange 548 of syringe plunger 544 is retained by plunger head assembly 522. Since the upper plunger gripper r 526 and the lower plunger gripper 528 close on the horizontal center line of the plunger head assembly 522, the plunger flange 548 has been centered on the plunger head assembly 522.

[00471] In the preferred mode, each of the upper plunger gripper 526 and the lower plunger gripper 528 comprises a fin 529 as shown in figure 34. The fins 529 curve away from the plunger head assembly 522 and towards the left of the page (in relation to figure 34). The fins 529 are arranged over the plunger gripper su

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Perior 117/294 526 and the lower plunger gripper 528 so that the fins 529 are the only part of the upper plunger gripper 526 and the lower plunger gripper 528 to make contact with a plunger flange 548 when a syringe 504 is allocated in the syringe pump assembly 501. As the upper plunger gripper 526 and the lower plunger gripper 528 are closed on a plunger flange 548 the thickness and diameter of the flange of plunger 548 determine when the upper plunger gripper 526 and the lower plunger gripper 528 stop moving. At least some part of the fins 529 will project the plunger flange 548 and ensure that the plunger flange 548 is retained. Since the upper plunger gripper 526 and the lower plunger gripper 528 do not deviate, this forces the plunger flange 548 against the rest of the plunger head assembly 522. That is, the contact angle of the gripper upper plunger gripper 526 and lower plunger gripper 528 on plunger flange 548 results in a force with a component that pushes plunger flange 548 against plunger head assembly 522. This resulting force additionally has a component that centralizes the plunger flange 548 in the plunger head assembly 522. This is especially desirable due to the fact that such an arrangement does not allow any shaking of the plunger flange 548 between the upper plunger gripper 526 and the lower plunger gripper 528 and the rest of the plunger head assembly 522. In addition, such an arrangement is desirable due to the fact that it not only maintains the flange of piston 548 in place against the piston head assembly 522 securely, but also functions as a mechanism antissifão. Such an arrangement furthermore ensures that the plunger flange 548 consistently contacts the plunger pressure sensor 532. Any

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118/294 force component generated by the upper plunger gripper 526 and the lower plunger gripper 528 that may affect readings from the plunger pressure sensor 532 can be predicted and subtracted or otherwise rewarded.

[00472] In other embodiments, the upper plunger gripper 526 and the lower plunger gripper 528 may not comprise fins 529. Instead, the upper plunger gripper 526 and the lower plunger gripper 528 protrude from a portion of the plunger flange 548 when in the gripping position. The upper plunger gripper 526 and the lower plunger gripper 528 can interrupt movement when they are in contact with the cruciform that comprises the plunger rod 546. In other embodiments, the upper plunger gripper 526 and the lower plunger gripper 528 can hold a plunger rod 546 that does not need to be a cruciform. In another embodiment, the upper plunger gripper 526 and the lower plunger gripper 528 may include a wedge, ramp or tapered rib feature on the surfaces of the grips that faces the pump head assembly 522. A wedge, ramp or tapered rib serves to push the plunger flange 548 towards the pump head assembly 522 until the plunger flange 548 is held securely against the pump head assembly 522.

[00473] To dispense the contents of the syringe 504, the syringe pump 500 can actuate the plunger head assembly 522 to thereby push the plunger 544 into the syringe barrel 540. Since the contents of syringe 504 can does not flow through or beyond the plunger propellant 550, the contents of syringe 504 are forced out of syringe outlet 552 as plunger 544 is advanced into syringe barrel 540. Any

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119/294 the pressure generated as the plunger 544 advances inside the syringe barrel 540 is transmitted to the plunger pressure sensor 532. The plunger pressure sensor 532 may, in some embodiments, comprise a force sensor such as a effort beam. When an occlusion occurs, fluid within the syringe barrel 540 and / or the fluid lines prevent movement of the plunger 544. When the plunger head assembly 522 continues to advance, high forces are produced between the plunger 544 and the head assembly plunger 522. The pressure transmitted to the plunger pressure sensor 532 can have an acceptable programmed range so that possible occlusions can be identified. If the pressure applied to the plunger pressure sensor 532 exceeds a predetermined limit, the syringe pump 500 can trigger the alarm or issue an alert.

[00474] Figure 35 shows the piston head assembly 522 with the upper piston grip jaw 526 and the lower piston grip jaw 528 in the fully closed position. The dial 530 is oriented so that the raised part of the dial 530 is in a plane substantially parallel to the top and bottom faces of the plunger head assembly 522. The plunger tube 524 is shown to extend from the head assembly plunger 522 for sliding block assembly 800. One end of a flexible connector 562 is attached to sliding block assembly 800. A position indicator mark has been placed on dial 530 for illustrative purposes only in figure 35 and figure 36.

[00475] The view shown in figure 36 is similar to the view shown in figure 35. In figure 36, the dial 530 on the piston head assembly 522 was rotated approximately 135 ° in the clockwise direction. This rotation, in turn, caused the upper plunger gripper 526 and the lower plunger gripper 528 to separate and move to the fully open position. In modalities

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120/294 alternatives, the display 530 may require more or less rotation than the approximately 135 ° shown in the modality example to carry out the transition of the upper piston grip jaw 526 and the lower piston grip jaw 528 from one position fully open to a fully closed position. The plunger head assembly may be able to remain in that position (described later in the specification).

[00476] An exploded view of the top half of the plunger head assembly 522 is shown in figure 37. As shown, the upper plunger gripper 526 comprises two supports 570. In other embodiments, there can only be one support 570. In some embodiments, there may be more than two supports 570. When the plunger head assembly 522 is fully engaged, the supports 570 can interdigitate with a corresponding number of upper clutch pinion gears 572. The upper claw pinion gears 572 rotate on the geometric axis of an upper jaw drive shaft 574. The upper jaw drive shaft 574 may also comprise an upper jaw drive gear 604 which will be constructed later.

[00477] The piston head assembly 522 may comprise a number of bearing surfaces for the upper jaw drive shaft 574. In the embodiment example in figure 37, the piston head assembly 522 comprises two upper bearing surfaces 576 and a lower bearing surface 578 for the upper jaw drive shaft 574. The upper bearing surfaces 576 can be coupled inside the top of the piston head assembly housing 600. The upper bearing surfaces 576 can be coupled to the top of the plunger head assembly housing 600 by any of a variety of means including, but not limited to, threads, screws,

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121/294 adhesive, grip, friction fit, welds, a grooved tongue, pins, or can be formed as a continuous part of the top of the 600 piston head assembly housing (shown). The upper bearing surfaces 576 provide a bearing surface for at least one span of the top half of the upper jaw drive shaft 574.

[00478] The lower bearing surface 578 is coupled inside the top of the piston head assembly housing 600. The lower bearing surface 578 may be coupled to the top of the piston head assembly housing 600 by any suitable means such as as, however, not limited to, 580 threads (shown), screws, adhesive, grip, friction fit, magnets, welds, a grooved tongue, etc. In some embodiments, the lower bearing surface 578 can be formed as a continuous portion of the top of the plunger head assembly housing 600. The lower bearing surface 578 provides a bearing surface for at least a range of the bottom half of the upper claw drive shaft 574.

[00479] In some embodiments, there may also be an upper dial shaft bearing surface 651 that engages inside the top of the piston head assembly housing 600. The upper dial shaft bearing surface 651 can be coupled to the interior of the top of the plunger head assembly 600 housing by any of a variety of means that include, but are not limited to, threads, screws, adhesive, grip, friction fit, welds, a tongue in groove arrangement (shown), pins, or can be formed as a continuous part of the top of the piston head assembly housing 600. The upper display shaft bearing surface 651 will be further elaborated later.

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122/294 [00480] The upper jaw drive shaft 574 can also comprise a D-shape amplitude 582. The D-shape amplitude 582 can be located at one end of the upper jaw drive shaft 574 as shown in the example of modality in figure 37. The D 582-shaped amplitude of the upper jaw drive shaft 574 can engage inside a complementary shaped hole on one side of a D-584 shaped connector. The D-582 shaped amplitude of the upper jaw drive shaft 574 may not extend all the way through the D-584-shaped connector. In some embodiments, the hole can travel through the entire D-584-shaped connector. The other side of the D-shaped connector D 584 can be coupled to a D 586-shaped shaft that projects out of a 588 piston grip jaw position sensor. Any rotation of the upper jaw drive shaft 574 can cause the D-shaped connector 584 also rotate. This in turn can generate rotation of the D 586-shaped shaft that projects from the 588 piston grip claw position sensor. In some embodiments, the D 582-shaped amplitude of the upper claw drive shaft 574 it can extend directly inside the 588 piston grip grips position sensor. In such embodiments, the D 584-shaped connector and D 586-shaped shaft may not be necessary. In some modalities, the amplitude in D 582 format, the connector in D 584 format and the axis in D 586 format do not need to be in D format. In some modalities they may have a triangular shape, square shape , star shape, etc.

[00481] In some embodiments, the 588 piston grip claw position sensor may comprise a potentiometer. According to the D 586-shaped axis that projects from the sensor

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123/294 position of the 588 piston grip jaws rotates, the pot cleaner is slid through the resistive element of the pot, which in this way varies the resistance measured by the pot. The resistance value can then be interpreted to indicate the position of the upper piston grip jaw 526 and the lower piston grip jaw 528. Alternatively, the 588 piston grip jaw position sensor may comprise a magnet at the end of the upper claw drive shaft 574 and a rotary encoder such as the AS5030ATSU with Austrianmicrosytems in Austria. Alternatively, the position of the upper jaw 526 and or lower jaw 528 can be measured with a linear encoder or a linear potentiometer.

[00482] By obtaining a position from the 588 plunger gripper position sensor, the syringe pump 500 may be able to determine a number of factors. The position can be used to indicate whether a plunger flange 548 has been secured by plunger head assembly 522. The position can indicate whether a plunger flange has been properly secured by plunger head assembly 522. This can be achieved through doing reference to the determined position in relation to a position or a range of positions that may be acceptable for a specific 504 syringe. Information about the specific 504 syringe that is used can be entered by a user or can be gathered by one or more other sensors which comprise other parts of the syringe pump 500. [00483] Since the position measured by the 588 plunger gripper position sensor depends on the diameter and thickness of a stuck plunger flange 548, positional information can also be used to determine information about the specific 504 syringe that is used (for example, type, brand, volume, etc.). This can be achieved by referring to the position

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124/294 tion measured against a database of positions that would be expected for different syringes 504. In modalities where there are a number of sensors that gather information about the 504 syringe, the positional information generated by the gripper position sensor plunger 588 can be checked against data from other sensors to make a more informed decision on which specific syringe 504 is used. If the position measured by the 588 plunger gripper position sensor does not correlate with data gathered by other sensors, the syringe pump 500 can trigger the alarm.

[00484] As shown in figure 37, the top of the piston head assembly housing 600 can also accommodate the aforementioned piston pressure sensor 532. The plunger pressure sensor 532 can comprise a 590 plunger pressure sensor thrust plate. The 590 plunger pressure sensor thrust plate can be a protuberance, a disc or any other suitable shape. The 590 piston pressure sensor thrust plate can be flat or round. The plunger pressure sensor thrust plate 590 can extend out of the plunger head assembly 522 so that it can physically make contact with a plunger flange 548 secured against the plunger head assembly 522. The plunger plate piston pressure sensor 590 thrust can directly transmit any force applied to it to a 596 piston pressure sensor input surface. In some embodiments, the 590 piston pressure sensor thrust plate can be attached to a lever piston pressure sensor 592. The piston pressure sensor lever 592 can be pivotally coupled to a 594 piston pressure sensor pivot. The 594 piston pressure sensor pivot can be arranged anywhere at along the length of the wing

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125/294 piston pressure sensor lever 594. In the embodiment example in figure 37, any force applied to the plunger pressure sensor thrust plate 590 is transmitted through the piston pressure sensor lever 592 to the surface plunger pressure sensor input 596. In some specific embodiments, the plunger pressure sensor lever 592 and plunger pressure sensor pivot 594 can serve to constrict the movement of the plunger pressure plate 590 to a perpendicular plane to the plunger flange 548 and minimize resistance to prevent movement of the plunger pressure plate 590. Although the location of the plunger pressure sensor 594 relative to the plunger pressure sensor 590 does not multiply the force exerted against the 596 piston pressure sensor inlet surface in figure 37, other modalities may use different arrangements to create an advantage mechanics.

[00485] The measured force that is read through the piston pressure sensor 532 can be interpreted to determine the hydraulic pressure of the fluid that is dispensed. This can contribute to the safety of operation due to the fact that the fluid pressure captured can be useful for the identification of possible occlusions so that they can be corrected. The pressure can be monitored so that if the pressure exceeds a predefined value, the syringe pump 500 can trigger the alarm. The pressure measured from the plunger pressure sensor 532 can be checked against the pressure measured from the downstream pressure sensor 513 (see figure 28) in modalities that include both a plunger pressure sensor 532 and a sensor downstream pressure gauge 513. This can help ensure greater accuracy. If the pressure measurements do not correlate, an alarm can be generated. Additionally, since the sensors are redundant, if one of the piston pressure sensor 532 or

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126/294 downstream pressure sensor 513 fails during therapy, syringe pump 500 can operate on only one of the sensors in a failed operating mode.

[00486] As shown in figure 37, a number of conduits 598 travel to and from both the plunger pressure sensor 532 and the plunger gripper position sensor 588. Conduits 598 supply power to the plunger sensor plunger pressure 532 and plunger gripper position sensor 588. Electrical conduits 598 also comprise data communication routes to and from plunger pressure sensor 532 and plunger gripper position sensor 588 .

[00487] Figure 38 shows a coupled view of the top half of the plunger head assembly 522. In figure 38, the upper plunger gripper 526 is in a closed position. The two supports 570 on the upper piston grip jaw 526 are engaged with the two pinion gears 572 on the upper jaw drive shaft 574 so that any rotation of the upper jaw drive shaft 574 translates to linear displacement of the grip jaw upper piston 526. The upper jaw drive shaft 574 is surrounded by the upper bearing surfaces 576 and the lower bearing surface 578.

[00488] The D 582-shaped amplitude of the upper jaw drive shaft 574 and the D-586 axis of the 588 plunger gripper position sensor are coupled together by the D-584 connector. Any rotation of the upper jaw drive shaft 574 will generate amplitude rotation in D 582 shape, connector in D shape 584 and axis in D shape 586. As mentioned above, this rotation can cause the wiper to slide through the resistive element of the 588 piston grip claw position sensor in modes where the

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127/294 plunger gripping position 588 comprises a potentiometer.

[00489] The plunger pressure sensor 532 is also shown in figure 38. The plunger pressure sensor thrust plate 590 can extend out of the plunger head assembly 522 so that it can physically make contact with a plunger flange 548 (see figure 30) secured against plunger head assembly 522. plunger pressure sensor thrust plate 590 can directly transmit any force applied to it to a plunger pressure sensor inlet surface 596. In some embodiments, including the one shown in figure 38, the plunger pressure sensor 590 plate can be attached to a 592 plunger pressure sensor lever. The 592 plunger pressure sensor lever can be attached articulated to a 594 piston pressure sensor pivot. The 594 piston pressure sensor pivot can be arranged at any point along the length of the ê pressure sensor lever. plunger 592. In the embodiment example in figure 38, any force applied to the plunger pressure sensor thrust plate 590 is transmitted through the plunger pressure sensor lever 592 to the plunger pressure sensor input surface 596 Although the location of the 594 plunger pressure sensor pivot relative to the 590 plunger pressure sensor thrust plate does not multiply the force exerted against the 596 plunger pressure sensor input surface in figure 38, other modalities may use different provisions to create a mechanical advantage.

[00490] The top of the piston head assembly housing 600 also includes the top half of a display axis passage 648 to a display axis 650 (not shown) which will be explained later in the specification. In the example of mo

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128/294 quality shown in figure 38, the display shaft passage 648 passes through the right face of the top of the piston head assembly housing 600.

[00491] Figure 39 shows another coupled view of the top half of the plunger head assembly 522. As shown in figure 39, the top of the plunger head assembly 600 may comprise upper jaw guides 569. The upper jaw 569 are sized and arranged so that they form a tracking path along which the upper plunger gripper 526 can move. In the embodiment example, the upper jaw guides 569 are formed as a continuous part of the top of the plunger head assembly 600 and span the entire height of the side wall of the top of the plunger head assembly 600. In others embodiments, the upper jaw guides 569 can only span a portion of the height of the top sidewall of the plunger head assembly 600.

[00492] As shown in figure 39, the piston pressure sensor 532 can comprise a 595 piston pressure sensor force concentrator. In embodiments where the 590 piston pressure sensor thrust plate transmits force directly to the surface 596 piston pressure sensor input concentrator, the 595 piston pressure sensor force concentrator can help concentrate the applied force to the 590 piston pressure sensor thrust plate while exerting it against the inlet pressure surface. plunger pressure sensor 596. In embodiments where the plunger pressure sensor 532 comprises a plunger pressure sensor lever 592 in a plunger pressure sensor 594, the plunger pressure sensor force 595 can be at the end and face of the sensor sensor lever

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129/294 piston pressure 592 pressing against the 596 piston pressure sensor inlet surface. This can help to concentrate the force exerted against the 596 piston pressure sensor inlet surface which can increase accuracy. It can also help to concentrate the force in the center of the 596 piston pressure sensor inlet surface, which makes measurements more consistent and accurate.

[00493] The bottom half of the plunger head assembly 522 and the plunger tube 524 are shown in figure 40. As shown, the lower plunger grip jaw 528 comprises two lower plunger grip jaw holders 610. In other embodiments, there can only be one 610 lower piston grip claw holder. In some embodiments, there can be more than two 610 lower piston grip claw holders. Each 610 lower piston hold grab holder supports with a gear lower piston grip jaw pinion 612. Lower piston grip jaw pinion gears 612 have the ability to rotate about the geometric axis of a lower grip jaw drive shaft 614. A jaw drive gear lower claw 620 is also arranged on the lower claw drive shaft 614. The lower claw drive gear 620 will be made later.

[00494] Similar to the upper half of the plunger head assembly 522 the lower half of the plunger head assembly 522 may comprise a number of bearing surfaces for the lower jaw drive shaft 614. In the embodiment example in figure 40, the plunger head assembly 522 comprises an upper bearing surface 616 and two lower bearing surfaces 618 for the lower jaw drive shaft 614. The upper bearing surface 616 is coupled to the bottom of the housing

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130/294 piston head assembly 602. The upper bearing surface 616 may be coupled to the bottom of the piston head assembly housing 602 by any of a variety of means that include, but are not limited to, threads 617 ( shown), screws, adhesive, grip, friction fit, welds, a grooved tongue, pins or can be formed as a continuous part of the bottom of the 602 piston head assembly housing. The upper bearing surface 616 provides a bearing surface for at least one span of the top half of the lower jaw drive shaft 614.

[00495] The lower bearing surfaces 618 are coupled to the bottom of the plunger head assembly 602. The lower bearing surfaces 618 can be coupled to the bottom of the plunger head assembly 602 by any suitable means such as, but not limited to, threads, screws, adhesive, grip, friction fit, magnets, welds, a groove tongue, pin (shown), etc. In some embodiments, the lower bearing surfaces 618 may be formed as a continuous portion of the bottom of the piston head assembly housing 602. The lower bearing surfaces 618 provide a bearing surface for at least a range of the bottom half of the lower claw drive shaft 614.

[00496] In some embodiments, there may also be a lower dial shaft bearing surface 649 that is coupled to the bottom of the plunger head assembly housing 602. The lower dial shaft bearing surface 649 may be coupled to the bottom of the plunger head assembly housing 602 by any of a variety of means that include, but are not limited to, threads, screws, adhesive, snap fit, snap fit

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131/294 friction, welds, a grooved tongue, pins or can be formed as a continuous part of the bottom of the plunger head assembly 602 as shown. The lower half of the display shaft passage 648 mentioned above is cut through the right face of the bottom of the piston head assembly housing 602 the lower display shaft bearing surface 649 and the display shaft passage 648 will be additionally elaborated later.

[00497] As shown in figure 40, the plunger tube 524 can be coupled inside the bottom half of the plunger head assembly 522. In the embodiment example shown in figure 40, the plunger tube 524 is coupled by two threads 630 on a plunger tube support 631. In other embodiments, the quantity or type of coupling / closing method may be different. For example, the plunger tube 524 can be attached to the plunger tube support 631 by any other suitable means such as, but not limited to, screws, adhesive, grip, friction fit, magnets, welds, a tongue in slot, pin, etc. The plunger tube support 631 may comprise arched ribs 633 which are domed so that they are aligned with the outer surface of the plunger tube 524 and support the plunger tube 524. In some embodiments, a portion of the arc of the plunger tube plunger 524 can be eliminated in the breadth of plunger tube 524 which is coupled within plunger head assembly 522 when syringe pump 500 is fully coupled. In the embodiment shown in figure 40, about 180 ° of the segment, or the upper half of the plunger tube 524 has been eliminated. The end of the plunger tube 524 opposite the end of the plunger tube 524 coupled to the plunger tube support 631 may comprise a number of plunger tube cutouts 802 which will be explained later. also

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132/294 there may be a conduit opening 632 next to the plunger tube cutouts 802.

[00498] In figure 41, the display 530 of the plunger head assembly 522 is shown blown away from a display axis 650 to which it joins when coupled. As shown, the display axis 650 comprises a square-shaped end 653. The square-shaped end 653 of the display axis 650 fits within a square-shaped hole 655 in the display 530 so that as per the display 530 is rotated, the display axis 650 is also induced to rotate. In other embodiments, the square-shaped end 653 of the display axis 650 and the square-shaped hole 655 in the display 530 do not necessarily have to be square in shape, but instead, in the shape of D, hexagonal or any other suitable shape .

[00499] A display axis gear 652 can be arranged on the display axis 650. As the display axis 650 is rotated, the display axis gear 652 can be induced to rotate on the geometric axis of the display axis 650 A display axis cam 654 can be slidably coupled to display axis 650 so that display axis cam 654 has the ability to slide along the axial direction of display axis 650 and display axis 650 rotates freely within the display shaft cam 654. The display shaft cam 654 may comprise one or more display shaft cam ears 656. The display shaft cam ears 656 may also be referred to as display cam guides. display axis as they perform a guide function. In the embodiment example, the display shaft cam 654 comprises two ears of the display shaft cam 656. In the embodiment example, the

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The display shaft cam 654 cam substantially is a section of a double helix. At the cam surface end of the display shaft cam 654 there may be one or more display shaft cam holders 660. The display shaft cam end 654 opposite the cam surface may be substantially flat.

[00500] A display axis cam follower 658 can be coupled inside the display axis 650 so that it rotates with the display axis 650. In the example example shown in figure 41, the axis cam follower display 658 follows through the display axis 650 so that at least a portion of the display axis cam follower 658 protrudes from the display axis 650 on each side of the display axis 650. This effectively creates two followers of display axis cam 658 which are offset 180 ° to each other. Each end of the display axis cam follower 658 follows a helix of the double helix shaped cam surface of the display axis cam 654.

[00501] A bias member can also be allocated on the display axis 650. In the example of an example, a display axis compression spring 662 is allocated on the display axis 650. The display axis compression spring 662 may have a coil diameter dimensioned to fit concentric around the display axis 650. In the embodiment example shown in figure 41, the display axis compression spring 662 is retained at each end by display axis washers 664. One Display shaft retainer ring 665 can fit into an annular groove 666 retained within display shaft 650.

[00502] In figure 41, the end of the dial shaft 650 opposite the end with a square shape 653 has the projection of the pin type 770. The projection of the pin type

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134/294

770 can engage inside a joint of a double universal joint 772. The projection of the type of pin 770 can engage within the double universal joint 772 by any suitable means such as, but not limited to, threads, screws, adhesive, grip, friction fit, magnets, welds, one grooved tongue, pin (shown), etc. The other joint of the double universal joint 772 can also be coupled to a driven shaft 774. The other joint of the double universal joint 772 can be coupled to the driven shaft 774 by any suitable means such as, but not limited to, threads, screws, adhesive , push-in fitting, friction fitting, magnets, welds, one grooved tongue, pin (shown), etc. The display axis 650 and the driven axis 774 can be oriented approximately perpendicular to each other.

[00503] In some embodiments, a driven shaft cushion 776 can be included in driven shaft 774. In the example example shown in figure 41 the driven shaft cushion 776 is a sleeve cushion. The inner surface of the driven shaft cushion 776 comprises the bearing surface for the driven shaft 774. The outer surface of the driven shaft cushion 776 can comprise a number of projections of the driven shaft cushion 778 that extend outwardly from the outer surface of the driven shaft cushion 776. In the example of embodiment in figure 41, the projections of driven shaft cushion 778 are separated approximately 120 ° from each other along the arc of the outer surface of the driven shaft cushion 776. In the example of the embodiment shown in Fig. 41, the driven shaft cushion projection 778 projecting towards the top of the page comprises a protrusion 780 extending from the top edge of the driven shaft cushion projection 778 towards the top of the page. The driven shaft cushion 776 is held in place on the driven shaft 774 by driven shaft retaining rings 782. One of

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135/294 driven shaft retaining rings 782 can be stapled in place to driven shaft 774 on either side of driven shaft cushion 776. The end of driven shaft 774 not coupled within the double universal joint 772 may comprise a shaft segment triggered in D 784 format.

[00504] When coupled, as shown in figure 42, the display shaft compression spring 662 tilts the display shaft cam 654 against the display shaft cam follower 658 so that the ends of the shaft cam follower dial shafts 658 are at the bottom of the cam surface of dial shafts 654. One dial shafts 664 is in contact with dial shafts retaining ring 665 and the other dial shafts 664 is in contact with the flat side of the display shaft cam 654. Preferably, the distance between the display shaft washers 664 is at no point greater than or equal to the resting length of the display shaft compression spring 662. This ensures that there is no spine and that the display shaft cam 654 is always tilted against the ends of the display shaft cam follower 658.

[00505] As shown, the double universal joint 772 connects the display shaft 650 to the driven shaft 774 when coupled. Driven shaft cushion 776 is clamped in place on driven shaft 774 by driven shaft retaining rings 782 (see figure 41). In the mode shown in figure 42, the display axis 650 functions as the drive axis for the driven axis 774. Any rotation of the display axis 650 generated through the rotation of the display 530 will be transmitted through the double universal joint 772 to the driven axis 774 .

[00506] Figure 43 shows the entire plunger head assembly 522 with the plunger tube 524 attached in place. The top half

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136/294 of the plunger head assembly 522 is blown away from the bottom half of the plunger head assembly 522. The bottom half of the display shaft 650 rests on the lower display shaft bearing 649 at the bottom of the assembly housing plunger head 602. Another amplitude of the bottom half of the display shaft 650 is seated on the portion of the display shaft pass 648 located at the bottom of the plunger head assembly 602. As shown, the dial 648 acts as a second bearing surface for dial shaft 650. The square-shaped end 653 of dial axis 650 extends beyond the passage of dial shaft 648 and engages inside the hole with a square shape 655 in the dial 530.

[00507] As shown in figure 43, the display shaft gear 652 on the display shaft 650 is interdigitated with the lower jaw drive gear 620. As the display 530 is rotated, the display shaft 650 and the display shaft gear 652 also rotate. Rotation is transmitted through the display shaft gear 652 to the lower jaw drive gear 620. The rotation of the lower jaw drive gear 620 rotates the lower grip jaw drive shaft 614 and the jaw pinion gears of lower grip 612 on the lower grip claw drive shaft 614. Since the lower grip claw pinion gears 612 prohibit any rotation of the lower grip claw pinion gears with the lower plunger claw holders 610 612 is translated into the linear displacement of the lower piston grip jaw 528. Thus, in the mode shown, rotating the dial 530 is the means by which a user can actuate the lower piston grip jaw 528 to an open position or in

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137/294 hold.

[00508] In the mode shown in figure 43, rotation of the display 530 also generates a linear displacement of the display axis cam 654 away from the display 530 and in the axial direction of the display axis 650. As shown in the example of the mode, the surface upper bearing shaft 616 for the lower grip jaw drive shaft 614 comprises a display shaft cam ear groove 690 that functions as a track for a display shaft cam ear 656. One of the shaft cam ears dial 656 protrudes into the dial shaft cam groove 690. This ensures that dial shaft cam 654 may not rotate with dial 530 and dial axis 650 due to the fact that rotation of the dial ear Display shaft cam 656 is blocked by the rest of the upper bearing surface 616 for the lower grip jaw drive shaft 614.

[00509] The display axis cam ear groove 690, however, allows the display axis cam 654 to move linearly along the axial direction of the display axis 650. According to display 530 and display axis 650 are rotated, the display axis cam follower 658 also rotates. The location of the display axis cam follower 658 on the display axis 650 is fixed so that the display axis cam follower 658 is unable to perform linear displacement. As the ends of the display axle cam follower 658 rise to the cam surface of the display axle cam 654, the display axle cam 654 is forced to shift toward the right face of the bottom of the head assembly housing piston 602 (in relation to figure 43). The display shaft cam ears 656 also slide in that direction within the

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138/294 display shaft 690. This causes the display shaft compression spring 662 to compress between the display shaft washer 664 which is in contact with the display shaft cam 654 and the display shaft washer 664 which is in contact with the display shaft retainer ring 665. The restoration force of the display shaft compression spring 662 serves to orient the display 530, and all parts actuated by the display 530 to their original positions prior to any dial rotation 530. If dial 530 is released, dial 530 and all parts actuated by dial 530 will be forced to automatically return to their original orientations prior to any dial rotation 530 due to expansion of the compression spring of compressed dial axis 662. In the modality example, the original position prior to any dial rotation 530, is the position depicted in figure 35 where the claw the upper plunger gripper 526 and the lower plunger gripper 528 are fully closed.

[00510] In some embodiments, including the embodiment shown in figure 43, the display axis cam 654 may comprise a holding display axis cam 660 along the cam surface of the display axis cam 654. The axis cam display shaft cam 660 may allow a user to park the display shaft cam follower 658 at a desired point along the cam surface of the display shaft cam 654. In the embodiment example, the display shaft cam 660 can be reached by the display axis cam follower 658 when the display 530 has been fully rotated. When the display shaft cam follower 658 is on the holding display shaft cam 660, the display shaft compression spring 662 may not automatically return display 530 and all parts actuated by

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139/294 display 530 for orientation prior to any rotation of display 530. A user may need to rotate display 530 so that display shaft cam follower 658 moves out of the holder display shaft cam 660 before the restoring force of the compressed display shaft compression spring 662 can be allowed to expand the display shaft compression spring 662 to a less compressed state.

[00511] Figure 44 shows a view similar to the view illustrated in figure 43. In figure 44, the top of the plunger head assembly 600 and some parts comprising the top half of the plunger head assembly 522 are not visible. Among the parts that are visible are the upper display shaft bearing 651, the upper grip jaw drive shaft 574, the upper grip jaw pinion gears 572 and the upper jaw drive gear 604. As shown in Fig. 44, when coupled, the display shaft 650 is sandwiched between the upper display shaft bearing 651 and the lower display shaft bearing 649, where the display shaft gear 652 on the display shaft 650 is interdigitated with the upper jaw drive gear 604. As dial 530 is rotated, dial shaft 650 and dial shaft gear 652 also rotate. The rotation is transmitted through the display shaft gear 652 to the upper jaw drive gear 604. The rotation of the upper jaw drive gear 604 rotates the upper grip jaw drive shaft 574 and the claw pinion gears gripper 572 on the upper gripper drive shaft 574.

[00512] Referring again to figure 38, the upper grip jaw pinion gears 572 interdict with the upper piston grip jaw holders 570. Any rotation

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140/294 of the upper grip jaw pinion gears 572 is translated into the linear displacement of the upper piston grip jaw 526. Thus, the rotation of the dial 530 is the means by which a user can actuate the grip jaw upper piston 526 (not shown in figure 44) to an open or gripping position.

[00513] The lower bearing surface 578 for the upper jaw drive shaft 574 is also visible in figure 44. The lower bearing surface 578 for the upper jaw drive shaft 574 may comprise a second cam ear groove of display shaft 690 in embodiments where the display shaft cam 654 comprises more than one display shaft cam ear 656. The second display shaft cam ear grooves 690 may function as a track for a display shaft ear. display shaft 656. One of the display shaft cam ears 656 projects into the second display shaft cam ear groove 690. This ensures that the display shaft cam 654 may not rotate with the display 530 and the display shaft 650 due to the fact that rotation of the display shaft cam ear 656 is blocked by the rest of the lower bearing surface 578 for the upper gripping drive shaft 57 4.

[00514] The second display axis cam ear groove 690, however, allows the display axis cam 654 to move linearly along the axial direction of the display axis 650. According to display 530 and display axis 650 are rotated, the display axis cam follower 658 also rotates. The location of the display axis cam follower 658 on the display axis 650 is fixed so that the display axis cam follower 658 is unable to perform linear displacement. Confor

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141/294 m and the ends of the display axis cam follower 658 rise to the display surface of the display axis cam 654, the display axis cam 654 is forced to move towards the right face of the bottom of the display housing. plunger head assembly 602 (with reference to figure 44). A display shaft cam ear 656 also slides in that direction within the second display shaft cam ear groove 690. This causes the display shaft compression spring 662 to compress between the display shaft washer 664 that is in contact with the display shaft cam 654 and the display shaft washer 664 which is in contact with the display shaft retainer ring 665. The display shaft compression spring 662, the display 530 and all parts actuated by display 530 can then behave as described above.

[00515] In some embodiments, the upper jaw drive gear 604 (best shown in figure 37) and the lower jaw drive gear 620 (best shown in figure 43) can be substantially identical gears. In addition, the upper claw pinion gears 572 (best shown in figure 37) and the lower claw pinion gears 612 (best shown in figure 40) can be substantially identical gears. In such embodiments, the upper plunger gripper 526 and the lower plunger gripper 528 (see figures 30 to 34) will experience an amount of linear displacement equal to the degree of rotation of the display 530. Since the interdigitation point of the upper jaw drive gear 604 on the display shaft gear 652 is opposite to the interdigitation point of the lower jaw drive gear 620 on the display shaft gear 652, the upper piston grip jaw 526 and the gripping jaw lower piston 528 will shift

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142/294 move linearly in opposite directions.

[00516] Figure 45 shows a view similar to the view shown in figure 44. Figure 45 describes an coupled view of the plunger head assembly 522 from a slightly different perspective. As shown in Figure 45, display 530 is coupled to display shaft 650. Display shaft gear 652 is in an interdigitation relationship with both the upper jaw drive gear 604 and the lower jaw drive gear 620. The upper jaw drive gear 604 is arranged on the upper jaw drive shaft 574 together with two upper jaw pinion gears 572. The upper jaw pinion gears 572 can be separated by the lower bearing surface 578 for the upper jaw drive 574 as shown in figure 45.

[00517] The plunger pressure sensor 532 in the embodiment shown in figure 45 comprises a plunger pressure sensor 590 thrust plate that extends out of the plunger head assembly 522 so that it can physically make contact with a plunger flange 548 (as shown in figure 34) secured against plunger head assembly 522. Plunger pressure sensor thrust plate 590 is attached to a plunger pressure sensor lever 592. The sensor lever piston pressure sensor 592 is pivotally coupled to a 594 piston pressure sensor pivot. The 594 piston pressure sensor pivot is arranged on the left end of the 594 piston pressure sensor lever (with reference to the figure 45). In the embodiment example in figure 45, any force applied to the plunger pressure sensor 590 thrust plate is transmitted through the plunger pressure sensor lever 594 to the 596 plunger pressure sensor input surface. pivot location

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143/294 piston pressure sensor 594 in relation to the 590 piston pressure sensor thrust plate do not multiply the force exerted against the 596 piston pressure sensor inlet surface in figure 45, other modalities may use different arrangements for create a mechanical advantage. The plunger pressure sensor 532 in figure 45 also comprises a plunger pressure sensor force concentrator 595 which is a small projection that extends from the plunger pressure sensor lever 592 to the inlet sensor surface. piston pressure 596. The 595 piston pressure sensor force concentrator concentrates force exerted against the 596 piston pressure sensor input surface to help promote a more accurate pressure reading.

[00518] Figure 46 shows an approximation of how the upper jaw drive shaft 574 is connected to the D-shaped shaft 586 that projects from the 588 piston grip jaw position sensor. In the mode depicted in figure 46 , the upper jaw drive shaft 574 comprises a D 582-shaped amplitude. The D 582-shaped amplitude of the upper jaw drive 574 projects into a complementary shaped hole in the D-shaped connector 584. The D-shaped connector 584 in figure 46 is shown in cross section. A 586 D-shaped shaft that projects out of the 588 plunger gripper position sensor also projects into the 584 D-shaped connector. Any rotation of the upper claw drive shaft 574 can cause the connector D-shaped 584 also rotate. This in turn can generate rotation of the D 586-shaped shaft that projects from the 588 piston grip claw position sensor. As mentioned above, this rotation can cause the wiper to slide through the resis element

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144/294 active piston grip claw position sensor 588 in embodiments where the 588 piston grip claw position sensor comprises a potentiometer.

[00519] Figure 46 also shows the display axis 650 connected to the double universal joint 772. As shown in the modality example in figure 46, the driven shaft 774 is also coupled to the double universal joint which is projected downwards inside the tube of hollow piston 524. The protrusion 780 in the projection of the driven shaft cushion 778 of the driven shaft cushion 776 is seated in a plunger tube notch 786 retained within the rim of the plunger tube 524 to lock the protrusion 780 into the notch plunger tube 786. Placing protrusion 780 in plunger tube notch 786 prevents the driven axle pad 776 from rotating due to the fact that protrusion 780 may not rotate through the sides of plunger tube notch 786. Each projection of the driven shaft cushion 778 is in contact with the inner surface of the plunger tube 524 that keeps the driven shaft cushion 776 centralized in the plunger tube 524.

[00520] Plunger tube 524 can also serve as a conduit for electrical conduits 598 to and from plunger gripper position sensor 588 and plunger pressure sensor 532. Since plunger tube 524 is sealed to liquid when the syringe pump is fully attached, plunger tube 524 protects electrical conduits 598 from exposure to liquid. The electrical conduits 598 leave the plunger tube 524 through the conduit opening 632 of the plunger tube 524 shown in figure 47.

[00521] Figure 47 depicts an exploded view of a sliding block assembly 800. As shown, the plunger tube 524 extending from the plunger head assembly 522 comprises two plunger tube cutouts 802. The cutouts of tube of

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145/294 plunger 802 are cut inside the front and rear sides of plunger tube 524. In figure 47, only the cutout of front plunger tube 802 is visible. The plunger tube cutouts 802 allow the plunger tube to be coupled non-rotationally to the sliding block assembly 800. In the embodiment example, two plunger tube coupling threads 804 follow through a plunger tube fork 806 , below the plunger tube cutouts 802 and inside a plunger tube holder 808. Plunger tube 524 is thus pressed tightly between the plunger tube fork 806 and the tube holder plunger 808. Any rotation of plunger tube 524 is obstructed by plunger tube coupling threads 804 which are in contact with the top and bottom edges of the plunger tube cutouts 802. Similarly, any axial displacement of the tube plunger tube 524 is blocked by the plunger tube coupling threads 804 which are in contact with the sides of the plunger tube cutouts 802. In other embodiments, the plunger tube 524 can be coupled to the slide block assembly 800 by any other suitable means such as, but not limited to, screws, adhesive, grip, friction fit, magnets, welds, a grooved tongue, pin, etc.

[00522] An exploded view closer to the sliding block assembly 800 is shown in figure 48A. The sliding block assembly 800 comprises a number of parts. The sliding block assembly 800 comprises a half-nut housing 810, a drum cam 820, a half-nut 830 and a half-nut cover plate 840. The half-nut housing 810 can be produced from any suitable resistant material that will not deform significantly under the applied loads such as metal, nylon, glass-filled plastics, molded plastic, plastic

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146/294 polyethylene methylene such as Delrin, etc. The half-nut 830 is preferably manufactured from bearing metals such as brass, bronze, etc., which interact well with stainless steel surfaces typical of lead threads. The drum cam 820 is preferably manufactured from a carbide such as stainless to form a good bearing pair with the half nut 830. The half nut housing 810 comprises an empty space of lead thread 810A. The lead thread empty space 81OA allows the lead thread 850 (not shown, see figure 48B) to pass through the half-nut housing 810. The lead thread empty space 810A has a larger diameter than the lead thread feed 850 which ensures that feed thread 850 passes unimpeded through the gap of feed thread 810A regardless of the point on feed thread 850 where the sliding block assembly 800 is located. Sliding block assembly 800 includes ribbon cable 562 for receiving power from and for communications with circuit board 1150 (referring to figure 58A).

[00523] The half-nut housing 810 may also comprise a guide rod pad 810B. The guide rod cushion 810B in the example of example shown in figure 48A is formed as a continuous part of the half-nut housing. The guide rod 852 (not shown, see figure 48B) extends through the guide rod pad 810B in the half-nut housing 810 with the inner surface of the guide rod pad 810B which serves as a bearing surface for the guide rod 852. In some embodiments, the guide rod pad 810B may not be formed as a continuous part of the half-nut housing 810, but instead is coupled to the half-nut housing 810 in any number of suitable ways. The 810B guide rod cushion can be made from a slippery material such as bronze, brass, PTFE, delrin etc., which provides a su

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147/294 low friction surface to pair with a hard surface of an 852 guide rod (figure 48B).

[00524] The half-nut housing 810 may also comprise an 810C drum cam void. The empty space of the drum cam 810C can be dimensioned so that it has a diameter slightly larger than the diameter of the drum cam 820. When the slide block assembly 800 is fully coupled, the drum cam 820 can fit inside of the drum cam void 810C in the half-nut housing 810. In some embodiments, the drum cam void 810C may extend all the way through the half-nut housing 810. In the example example shown in the figure 48A, the drum cam void 810C does not extend all the way through the half-nut housing 810. The drum cam void 810C can act as a cushion for the drum cam 820 when the slide block assembly 800 is fully coupled. The empty space of drum cam 810C and drum cam 820 can be manufactured with a loose fit. In one example, the diameter gap between the drum cam 810C void and the drum cam 820 is 0.03 to 0.13 millimeters (0.001 to 0.005 inches).

[00525] In some embodiments, including the embodiment shown in figure 48A, the half-nut housing 810 may include an empty half-nut space 810D. The half-nut void 810D can be retained within the half-nut housing 810 so that the half-nut 830 can fit in the half-nut void 810D when the sliding block assembly 800 is fully coupled. In some embodiments, the lead thread void 810A, drum cam void 810C and half nut void 810D can all be part of a single void retained within the half nut housing 810.

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148/294 [00526] The half-nut housing 810 may comprise a driven shaft crack 810E. The driven shaft crack 810E extends through the half-nut housing 810 and into the empty drum cam space 810C. In figure 48A the D-shaped shaft segment or shaft collar 784 is shown as projecting into the empty space of the 810C drum cam through the driven shaft crack 810E.

[00527] The half-nut housing 810 may additionally comprise a half-nut housing groove 810F. In the embodiment example in figure 48A, the half nut housing groove 810F is retained within the half nut housing 810. The half nut housing groove 810F is retained along the entire side of the half nut housing 810. The half-nut housing groove 810F extends in a direction parallel to the elongation direction of the plunger tube 524, lead thread 850 and guide rod 852 (shown, for example, in figure 48B).

[00528] In some embodiments, the half-nut housing 810 may comprise at least one limit switch 810G (not shown). In the embodiment example shown in Figure 48A, the half nut housing 810 can comprise two limit switches 810G (not shown). One 810G limit switch is located at the front of the 810G half-nut housing and the other 810G limit switch is located at the rear of the 810G half-nut housing. The 810G limit switch (s) can ( m) be used to limit the range of motion of the sliding block assembly along the lead thread 850 (figure 48B). The 810G limit switches will be further elaborated later.

[00529] As previously mentioned, the drum cam 820 fits inside the empty space of the drum cam 810C in the half-nut housing 810 when the sliding block assembly 800

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149/294 is fully coupled. As shown, the drum cam 820 comprises a D-shaped hole 820A that extends through the entire drum cam 820 along the axial direction of the drum cam 820. The D-shaped hole 820A is sized and shaped to allow the drum cam 820 to be coupled to the driven shaft segment in D 784 shape. When the D shaped hole 820A of the drum cam 820 is coupled to the driven shaft segment in D shape 784 any rotation of the driven shaft 774 and D 784 driven shaft segment causes the drum cam 820 to rotate as well. The drum cam 820 can be joined to the driven shaft 774 in any of the standard methods that include, but are not limited to, set of threads, pins, adhesive, friction fitting, welds, etc.

[00530] As shown in figure 48A, the drum cam 820 is generally a truncated cylinder and comprises a plane of the drum cam 820B which is cut inside the drum cam 820 along a line from the base towards the front of the drum. drum cam cylinder 820. The drum cam plane 820B can be cut so that some distance from the center line of the drum cam so that the full diameter of the drum cam 820 is maintained. The drum cam material 820 remaining on the far side of the center line from the bearing surface of the half nut 830B provides a bearing surface for transferring forces from the half nut 820 to the empty space of the drum cam 820C along the entire length of the drum cam 820. [00531] The plane of the drum cam 820B may not extend across the entire drum cam 820 which leaves part of the cylinder of the drum cam 820 to have a cylindrical shape unadulterated classic. This is desirable due to the fact that the classic cylindrical shaped drum cam portion 820 can act as

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150/294 a trunnion within the empty 810C drum cam space that can act as a cushion. In the embodiment example depicted in figure 48A, the plane of the drum cam 820B extends along the drum cam 820 until a shoulder of the drum cam 820C starts. The drum cam shoulder 820C can extend perpendicularly from the surface of the drum cam plane 820B. In the example of embodiment in figure 48A, the expansion of the drum cam 820 with the classic unadulterated cylindrical shape is the drum cam shoulder 820C.

[00532] As shown, the drum cam 820 may also comprise a drum cam pin 820D. The drum cam pin 820D in the embodiment example in figure 48A projects perpendicularly from the forward facing base of the drum cam cylinder 820. The drum cam pin 820D projects from the forward facing base. of the drum cam 820 close to the line from which the drum cam plane 820B has been extended inside the cylinder of the drum cam 820.

[00533] The sliding block assembly 800 may also comprise a half nut 830 as mentioned above. In the embodiment example in figure 48A, the half-nut 830 comprises a half-nut slot 835. The half-nut slot 835 is dimensioned so that it can act as a tracking path for the drum cam pin. 820D. The half-nut slot 835 comprises an arcuate section 835A and an end section 835B that is not curved or domed. The half-nut slit 835 can be cut inside a half-nut slit plate 835C that extends perpendicularly from a half-nut cam follower surface 830B. The half-nut cam follower surface 830B and the half-nut slot 835 will be further elaborated in the following paragraphs.

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151/294 [00534] The half-nut 830 may comprise an empty space of guide rod cushion 830A. The 830A guide rod pad empty space of the 830 half-nut allows the 81OB guide rod pad to pass through the 830 half-nut. In the embodiment example shown in figure 48A, the 830A guide rod pad empty space is substantially greater than the diameter of the 81 OB guide rod cushion. In addition, the empty space of the guide rod cushion 830A in the half nut 830 can be elliptical or stadium shaped. Such a shape allows the guide rod cushion 810B to fit comfortably into the empty space of the guide rod cushion 830A when the half nut 830 is engaged, disengaged or in transition between both positions.

[00535] The half-nut 830 can also comprise a range of threading of half-nut 830C. The 830C half-nut threads are capable of engaging the threads of the 850 lead thread (not shown, see figure 48B). In the modality example shown in figure 48A, 830C half-nut threads are V-shaped threads. V-shaped threads may be desirable due to the fact that such a shape can help to self-align the half-nut threads. 830C on the 850 lead thread.

[00536] As mentioned above, the sliding block assembly 800 can also comprise a sliding block cover plate 840. In the sliding block, the cover plate 840 can be coupled to the half-nut housing 810 so that the drum 820 and half-nut 830 are held in place within the sliding block assembly 800 when the sliding block assembly 800 is fully engaged. In the example of embodiment shown in figure 48A, the sliding block cover plate 840 can be coupled to the half nut housing 810 by cover plate threads.

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152/294 sliding block texture 840A as shown, or by any suitable means such as, but not limited to, screws, adhesive, grip, friction fitting, magnets, welds, a tongue in groove arrangement, pin, etc. . The sliding block cover plate 840 can comprise a cover plate slot 840B to assist in guiding the half-nut housing 810. The cover plate slot 840B can be retained within the sliding block cover plate 840. In the example of embodiment shown in figure 48A the cover plate slot 840B is retained along an entire side edge of the sliding block cover plate 840. The cover plate slot 840B can be sized and arranged so that it align with the 81 OF half-nut housing slot in the 810 half-nut housing.

[00537] The sliding block cover plate 840 may comprise a crack in the guide rod cushion 840C. The 840C guide rod cleft crack is sized and arranged so that the 810B guide rod cushion can project through the 840C guide rod cleft. The 840C guide rod cleft crack may have a diameter substantially equal to, or slightly larger than, the outer diameter of the 810B guide rod cushion.

[00538] The edge of the sliding block cover plate 840 opposite the slot of the cover plate 840B, may comprise an 840D lead thread undercut. The 840D lead thread lowering may be a domed section retained within the edge of the sliding block cover plate 840. The 840D lead thread lowering, together with the 810A lead thread empty space of the nut 810 allows the sliding block assembly 800 to be allocated to the lead thread 850. [00539] In operation, the sliding block assembly 800 can be induced to move along the axial direction of the lead thread 850 and

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153/294 guide rod 852 as a result of rotation of the lead thread 850. The sliding block assembly 800 can also be moved along the axial direction of the lead thread 850 and guide stem 852 by a user. For a user to move the sliding block assembly 800 along the axial direction of the feed thread 850 the user may need to adjust the location of the plunger head assembly 522 in relation to the rest of the syringe pump assembly 501 as shown and described in in relation to figures 32 to 33. This can only be done by a user when the half nut 830 is not engaged with the lead thread 850 [00540] Figure 48B shows the half nut 830 in a position engaged on the lead thread 850. The half-nut housing 810 and the half-nut cover plate 840 visible in figure 48A have been removed in figure 48B. When the half-nut 830 is engaged with the lead thread 850, the half-nut threads 830C can be operatively engaged with the threads of the lead thread 850. Any rotation of the lead thread 850 can cause the half-nut nut 830 moves in the axial direction of the advance thread 850.

[00541] To move the half-nut 830 between a engaged and disengaged position on the lead thread 850, the drum cam 820 must be rotated. As the drum cam 820 is rotated, the drum cam pin 820D can move along the half nut slot 835 in the half nut slot plate 835C. In the example of embodiment shown in figure 48B, when the drum cam pin 820D is located in the arcuate section 835A of the half-nut slot 835, the half-nut 830 is engaged with the lead thread 850. The arcuate section 835A of the half-nut 835 can be shaped so that any movement of the drum cam pin 820D within the arcuate section 835A of half-nut slot 835 does not result in which

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154/294 wants movement of the half-nut 830.

[00542] When the drum cam 820 is rotated so that the drum cam pin 820D enters the straight end section 835B of the half nut slot 835, further rotation of the drum cam 820 can cause the half nut 830 disengages from lead thread 850. The straight nature of end section 835B ensures that the additional rotation of the drum cam 820 causes the drum cam pin 820D to pull the half nut 830 away from the thread advance 850 until the drum cam pin 820D reaches the end of the end section 835B. Rotating the drum cam 820 in the opposite direction will cause the drum cam pin 820D to push the half nut 830 back into engagement with the lead thread 850.

[00543] In the example of embodiment in figure 48B, when the drum cam 820 disengages the half nut 830 from the lead thread 850, the follower surface of the half nut cam 830B rests in the empty space created by the plane drum cam 820B. When the half-nut 830 is disengaged, the distance between the half-nut threadings 830C and the full engagement point of the same in the lead thread 850 is less than or equal to the length of the sagittal of the cylindrical segment removed from the cam. drum 820 to create the drum cam plane 820B. As the drum cam 820 is rotated to engage half nut 830 with lead thread 850, pin 820D in straight end section 835B moves the half nut toward lead thread 850 until half nut 830 is at least partially engaged with the lead thread 850. As pin 820D leaves end section 835B, the uncut truncated cam cam 820 rotates on the cam nut surface 830B of the cam nut 830. The cam the truncated barrel can drive the 830 half-nut inside the coupling with

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155/294 complete with feed thread 850 and supplement the action of the drum cam pin 820D in the half-nut slot 835.

[00544] With reference again to the example of modality shown in figure 48A, the driven shaft 774 to which the drum cam 820 is coupled, may not deflect when the drum cam 820 is engaged, disengaged or making the transition between the half-nut 830 from an engaged or disengaged position on the lead thread 850. As shown, the drum cam gap 810C in the half-nut housing 810 supports the drum cam 820 when the slide block assembly 800 is fully coupled. Consequently, any force that promotes the deflection of the driven shaft 774 is verified by the drum cam 820 which is in contact with the sides of the empty space of the drum cam 810C. This ensures that the 830C half-nut threading cannot jump on the threading of the 850 lead thread under high axial loads. It also creates minimal drag as the sliding block assembly 800 travels along the feed thread 850 with feed thread rotation 850.

[00545] In some embodiments, the fitting of the half nut 830 and the drum cam 820 can be adjustable. In such embodiments, a portion of the drum cam housing 810 defining the empty space of the drum cam 810C can have an adjustable position with respect to the guide rod which can be adjusted for example by rotating a set thread or other means adjustment. This can also allow a user to adjust the 820 drum cam to an ideal or close to ideal position. Alternatively, inserts can be added to the drum cam 810C void or the drum cam 820 can be replaced with differently sized drum cam 820 to position the half-nut interface 830D / drum cam 820 on the ideal location. In

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156/294 such a position, the drum cam 820 can engage the half-nut threads 830C in the lead thread 850 so that there is zero or a minimum withdrawal without loading the half-nut threads 830C against the lead thread 850 and create excessive drag.

[00546] In alternative embodiments, the 820D drum cam pin can be optional. In some alternative embodiments, the 820D drum cam pin can be replaced by one or more bias members. The bending members can orient the half nut 830 to the disengaged position. In such embodiments, rotation of the drum cam 820 can cause the half nut 830 to engage or disengage with the lead thread 850. When the drum cam plane 820B is not connected to the half cam follower surface nut 830B the one or more propensity members can be overcome and the half-nut threads 830C can be engaged with the threads of the lead thread 850. As the drum cam plane 820B rotates on the half-cam follower surface nut 830B, the bias member (s) can act as a spring return that automatically tilts the half nut 830 out of engagement with the lead thread 850 and against the drum cam plane 820B. The drum cam 820 may include a transition cam surface between the drum cam plane 820 B and the non-truncated drum cam arc 820 to facilitate displacement of the half nut 830 towards the lead thread 850. The use of the 820D drum cam pin may be desirable due to the fact that such an arrangement requires less torque to engage or disengage the 830 half-nut than arrangements that can employ one or more bias members as a substitute. Some embodiments may use both the 820D drum cam pin and one or more bias members to engage or disengage the sock

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157/294 nut 830.

[00547] In some embodiments, the biasing member can orient the half-nut 830 towards the engaged position, in which case, the drum cam pin 820 can be configured to lift the half-nut threads 830C a from the 850 lead thread.

[00548] In another alternative embodiment, the drum cam 820 may not comprise a drum cam pin 820D and the half-nut 830 may not comprise a half-nut slot 835. In such embodiments, the plane of the cam cam drum 820B may comprise a magnet and the half-nut cam follower surface 830B may also comprise a magnet. Instead of using the drum cam pin 820D to extract the half nut 830 away from the lead thread 850, the magnet on the cam follower surface of the half nut 830B can be attracted to the magnet on the cam plane drum 820B and be extracted from the lead thread 850 towards the drum cam plane 820B when the drum cam 820 has been rotated the appropriate amount. In some embodiments, the drum cam 820 may be a simple two-pole magnet. In such embodiments, the drum cam 820 can be arranged so that it can repel or attract a magnet on the half nut cam follower surface 830B. When similar poles of the magnets are directed towards each other, the half-nut is forced into engagement with the lead thread 850. Through the rotation of the driven shaft 774 and, therefore, of the magnetic drum cam 820, opposite poles can be induced to be directed towards each other. This in turn can cause the half-nut 830 to disengage from the lead thread 850 as it is attracted to the magnetic drum cam 820.

[00549] In some embodiments, a magnet can be configured to guide the half nut 830 towards the engaged position, in

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158/294 that, in this case, the drum cam pin 820 can be configured to lift the half-nut threads 830C from the lead thread 850.

[00550] The guide rod 852 is also visible in figure 48B. In figure 48B the guide rod 852 extends in an axial direction parallel to that of the advance thread 850. The guide rod passes through the empty space of the guide rod pad 830A in the half-nut 830. In the example of example, the guide rod 852 is made of a rigid and durable material. For example, in some embodiments, the guide rod 852 can be made of a material such as stainless steel. In other embodiments, the guide rod 852 can be plated with chrome.

[00551] Figure 49 shows an approach view of the 835C half-nut slit plate. The half-nut slot plate 835C is transparent in figure 49. The half-nut slot 835 is shown on the half-nut slot plate 835C. As described above, the half-nut slot 835 comprises an arcuate section 835A and a straight end section 835B. The drum cam 820 is shown behind the 835C transparent half-nut slit plate. As shown, drum cam pin 820D is located in arcuate section 835A of half-nut slot 835. As mentioned above, when drum cam pin 820D is in arcuate section 835A of half-nut slot 835 at half - nut 830 is engaged with the advance thread 850 as shown in figure 48B. The drum cam 820 is arranged in the drum cam void 810C in the half-nut housing 810. The drum cam void 810C acts as a cushion for the drum cam 820 and supports the drum cam 820.

[00552] Figures 50 to 52 show the sliding block assembly 800 with the cover plate of half-nut 840 and half-nut 830 shown as transparent. In figures 50 to 52, the half nut 830

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159/294 transitions from an engaged position (figure 50) to an uncoupled position (figure 52). As shown in figure 50 the half nut 830 is in the engaged position. The drum cam pin 820D is located in the arcuate section 835A of the half-nut slot 835. The half-nut threadings 830C are in the extreme left extension (in relation to figures 50 to 52) of their movement range. The guide rod pad 810B of the half-nut housing 810 projects through the gap of the guide rod pad 830A of the half-nut 830. As shown, the guide rod pad 810B is located at the far right end of the void space. guide rod cushion 830A. In the embodiment example shown in figures 50 to 52 the empty space of the guide rod cushion 830A in the half nut 830 has approximately a stadium shape.

[00553] The drum cam 820 has been rotated so that the drum cam pin 820D is about to traverse from the arched section 835A of the half-nut slot 835 and into the end section 835B of the half-slot - nut 835 in figure 51. As shown, the half-nut threads 830C did not move from the engaged position and are still in the extreme left extension (in relation to figures 50 to 52) of their movement range. Similarly, the half-nut 830 may not have moved in relation to the guide rod pad 810B from the position shown and described in relation to figure 50.

[00554] In figure 52 the drum cam 820 has been rotated so that the drum cam pin 820D has moved inside the straight end section 835B of the half-nut slot 835. As described above, the additional rotation of the drum cam 820 as the drum cam pin 820D enters end section 835B of half-nut slot 835 causes half-nut 830 to disengage. As shown, the half-nut 830, and consequently

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160/294 the half-nut threading 830C, moved from the extreme left extension (in relation to figures 50 to 52) of their movement range and towards the right of the page. The half nut 830 has moved in relation to the guide rod cushion 810B, so that the guide rod cushion 81OB is now close to the far left end of the empty space of the guide rod cushion 830A.

[00555] Figure 53 shows a cross-section of most of the components comprising a modality of the sliding block assembly 800. The sliding block assembly 800 is pictured fully coupled in figure 53. The lead thread 850 and guide rod 852 are not depicted in cross-section in figure 53. As shown, the lead thread 850 extends through the lead thread empty space 810A in the half nut housing 810 and over the lead thread lowering 840D in the half nut cover plate 840 The guide rod extends through the 810B guide rod pad. The guide rod cushion 810B extends through both the empty space of the guide rod cushion 830A in the half nut 830 and the crack in the guide rod cushion 840C in the cover plate of the half nut 840.

[00556] In the example of modality shown in figure 53, the half nut 830 is in the disengaged position. Half-nut threading 830C is not operationally interdigited with threading of lead thread 850. Guide rod pad 810B is close to the top of the 830A guide rod pad empty space in half nut 830. The cam follower surface of half-nut 830B is close to or makes contact with (depending on the modality) the drum cam plane 820B on the drum cam 820. Additionally, the drum cam pin 820D is at the end of the straight end section 835B of the 835 half-nut that is cut

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161/294 inside the 835C half-nut slit plate.

[00557] Figure 53 also shows the D-shaped hole 820A of the drum cam 820 coupled to the D-shaped driven shaft segment 784 of the driven shaft 774. The plunger tube 524 through which the driven shaft 774 is arranged it can be seen coupled to the sliding block assembly 800 by means of threads that run through the plunger tube cutouts 802 and inside the plunger tube holder 808.

[00558] Figure 54 shows a view of a portion of one embodiment of the syringe pump assembly 501. On the left side of figure 54, a section of the plunger head assembly 522 is visible. As shown in figure 54, the rear face 900 of the syringe pump assembly 501 can comprise a rear face guide rod hole 901. The rear face guide rod hole 901 can run through the entire rear face 900 of the syringe pump 501 at an angle perpendicular to the rear face 900 of syringe pump assembly 501. As shown, the guide rod bore 901 can be substantially cylindrical.

[00559] The rear face 900 of the syringe pump assembly 501 can comprise a gearbox depression 902. As shown, the gearbox depression 902 is retained within the rear face 900 of the syringe pump assembly 501. In the embodiment example, the gearbox depression 902 is an approximately rectangular shaped depression. In other embodiments, the gearbox depression 902 may have alternative shapes.

[00560] As shown in figure 54, an anti-rotation pin 904 projects out of the gearbox depression 902. Anti-rotation pin 904 in the embodiment example shown in figure 54 is cylindrical. In alternative modalities, the anti-rotation pin 904 can

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162/294 have any other suitable format. As shown in figure 54, the gearbox depression 902 on the rear face 900 of the syringe pump assembly 501 can also comprise a lead screw gap 906. The lead thread gap 906 can be cut across path through the rear face 900 of the syringe pump assembly 501 and allow at least a portion of the advance thread 850 to project beyond the rear face 900 of the syringe pump assembly 501. As shown in the example example, the thread section lead 850 projecting beyond the rear face 900 of the syringe pump assembly 501 is not threaded.

[00561] In the example of modality shown in figure 54, the section of the advance thread 850 that is visible is smaller in diameter than the empty space of the advance thread 906. This is desirable due to the fact that it can allow a rear face advance thread bearing 908 is allocated in the lead thread empty space 906 to provide a bearing surface for the lead thread 850. In the embodiment example in figure 54 a lead thread bearing is disposed in the void space feed thread 906 to provide a bearing surface for the feed thread 850.

[00562] As shown, the end of the lead thread 850 projecting out from the rear face 900 may comprise a threaded cavity 910. In the embodiment example shown in figure 54, a gearbox attachment closure 912 is coupled inside the threaded cavity 910 at the end of the lead thread 850. In the embodiment example, the gearbox attachment closure 912 is a thread with a hex head. In other embodiments, any other suitable closure, or closure head, may be used.

[00563] In figure 55, another view of a portion of a fashion

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163/294 the syringe pump assembly 501 is shown. On the left side of figure 55, part of the plunger head assembly 522 is also visible. Gearbox 940 is shown in place on gearbox depression 902 on the back face 900 of syringe pump assembly 501. As shown, anti-rotation pin 904 can project through an anti-rotation pin hole 942 in gearbox 940 The anti-rotation pin 904 ensures that the gearbox 940 generates rotation of the lead thread 850 and that the gearbox 940 cannot rotate around the geometric axis of the lead thread 850. As shown, the anti-rotation pin 942 does not help hold gearbox 940 against the back face 900 of syringe pump assembly 501. In alternative embodiments, the anti-rotation pin 904 may have a threaded anti-rotation pin cavity 944 (not shown) similar to that of the end of the lead thread 850 described above in relation to figure 54. A 946 anti-rotation pin gearbox lock can be threaded inside the anti-rotation pin cavity thread 944 to help hold gear box 940 against the back face 900 of syringe pump assembly 501. Gear box 940 can be frictionally locked on lead thread 850 to ensure that rotation of the gears in the gear box gears 940 is transmitted to the lead thread 850 with zero or a minimum recoil.

[00564] In embodiments where the syringe pump set 501 can be removed from housing 502 (see figure 28) and replaced with another set such as a large volume peristaltic pump set, in which the gearbox 940 can be compatible with a replacement set.

[00565] Figure 56 shows a modality inside the syringe pump assembly 501. As shown, the front face 888 of the

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164/294 syringe pump assembly 501 is shown as transparent. As shown, the guide rod 852 projects perpendicularly from the inside of the rear face 900 of the syringe pump assembly 501 and towards the front of the page. The advance thread 850 can project similarly into the syringe pump assembly 501 through the rear face advance thread bearing 908 at an angle perpendicular to the interior of the rear face 900 of the syringe pump assembly 501. A guide rod 852 and lead thread 850 can follow parallel to each other. In the example of modality in figure 56, the lead thread 850 is deflected towards the left of the page from the guide rod 852.

[00566] As shown, one end of the guide rod 852 is seated in the rear face guide rod hole 901. The other end of the guide rod 852 is seated in the front face 888 of the syringe pump assembly 501. In the example of the pictured embodiment in figure 56, the end of the guide rod 852 that is directed to the front of the page is smaller in diameter than the rest of the guide rod 852. This section of the guide rod 852 can be allocated in a hole of the guide rod 1002 on the front face 888 syringe pump assembly 501 when syringe pump assembly 501 is fully engaged. The guide rod hole 1002 can extend across the entire front face 888 of the syringe pump assembly 501 at an angle substantially perpendicular to the front face 888. The smaller diameter section of the guide rod 852 may be slightly in diameter, although not substantially , less than the diameter of the guide rod hole 1002 so that the guide rod 852 can fit securely in the guide rod hole 1002 when the syringe pump assembly 501 is coupled. The end of the guide rod 852 can be aligned with the plane of the front face 888 of the syringe pump assembly 501. Although both the guide rod hole 1002 and the guide rod section 852

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165/294 seated in the guide rod hole 1002 are cylindrical in the example of the modality shown in figure 56, their shape may differ in alternative modalities.

[00567] The lead screw 850 is seated in a lead screw depression 1000 on the front face 888 of the syringe pump assembly 501. In the embodiment example shown in figure 56, the depth of the lead screw depression 1000 is substantially the thickness of the front face 888 of the syringe pump assembly 501. In embodiments where the depth of the advance thread depression 1000 is substantially the depth of the front face 888, a circular plateau 1004 can be raised from the front face 888 of the assembly syringe pump 501 to accommodate the depth of the 1000 lead screw depression. The center of the circular plateau 1004 can be concentric with the center of a 1000 lead screw depression as shown in figure 56. In some embodiments, the edges circular plateau 1004 can extend perpendicularly from the front face 888 of the syringe pump assembly 501 to the circular plateau it vado. In the example of embodiment illustrated in figure 56, the edges of the circular plateau 1004 curve upwards from the front face 888 of the syringe pump assembly 501 to the circular plateau 1004.

[00568] As shown, the advance thread depression 1000 can accommodate a front face advance thread bearing 1006 that surrounds the end of the advance thread 850 and provides a bearing surface for the advance thread 850. In some embodiments , like the mode depicted in figure 56, a Belleville washer 1008 can be seated against the bottom of the 1000 lead screw depression. The Belleville washer 1008 can guarantee that there is no chatter of the 850 lead thread when the feed 850 is seated in the feed thread depression 1000.

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166/294 [00569] In some embodiments, the Belleville washer 1008 can be replaced by a non-compliant plug that carries the front face advance thread bearing 1006 against the 850 lead thread. In such embodiments, the plug can be threaded in the external diameter of the same. The advance thread depression 1000 can be used as a complementary thread for which the plug can be threaded. Again, the plug can also ensure that there is no chattering of the feed thread 850 when feed thread 850 is seated in feed thread depression 1000.

[00570] Figure 57 shows a view of the inside of the syringe pump assembly 501. The front face 888 which is shown as transparent in figure 56, is not present in figure 57A. As shown, the slide block assembly 800 described above is in place within the syringe pump assembly 501. The guide rod 852 extends through the guide rod pad 810B in the half-nut housing 810. When the half-nut 830 is disengaged from the lead thread 850, the sliding block assembly 800 can become free to slide over the axial direction of the guide rod 852.

[00571] Movement of the sliding block assembly 800 is also guided by a syringe pump assembly guide rail 1010. In the embodiment example shown in figure 57, the syringe pump assembly guide rail 1010 extends from of the inner face of the syringe holder 506. The syringe pump assembly guide rail 1010 is shaped so that the half-nut housing groove 810F and the cover plate groove 840B in the sliding block assembly 800 can fit on the 1010 syringe pump assembly guide rail and slide along the 1010 syringe pump assembly guide rail. The 1010 syringe pump assembly guide rail also ensures that the block assembly de

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167/294 level 800 cannot rotate inside the syringe pump assembly 501. The syringe pump assembly guide rail 1010 can be formed as part of the extrusion in embodiments where the syringe pump assembly housing 503 is formed by extrusion.

[00572] As shown in figure 57, when the half-nut 830 of the sliding block assembly 800 is engaged with the lead thread 850, the lead thread 850 can generate linear movement of the sliding block assembly 800 along the axial direction the lead thread 850. To generate linear movement of the sliding block assembly 800, the lead thread 850 must be rotated. In the modality example in figure 57, the rotational movement of the lead thread 850 causes the half-nut 830 and, consequently, the sliding block assembly 800 to move along the lead thread 850 due to the gap between the threads of the lead thread 850. The amount of linear motion per 360 ° rotation of the advance thread 850 can vary depending on the thread range of the advance thread 850 which can differ in several modalities.

[00573] As mentioned above, the half-nut housing 810 of the sliding block assembly 800 may comprise one or more limit switches 810G. In the embodiment example in figure 57, an 810G limit switch is not shown, although it is indicated that an 810G limit switch can be located on the front of the 810 half-nut housing. In other embodiments, there may be multiple limit switches 810G which can be arranged on other portions of the sliding block set 800. In embodiments where a limit switch can be arranged on the front of the half-nut housing 810, the limit switch 810G can prevent the sliding block set 800 is conducted inside the front face 888 (shown in figure 56) of the syringe pump assembly 501.

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168/294 [00574] In embodiments comprising an 810G limit switch, the 810G limit switch can be a micro switch, although magnets and hall effect sensors, optical sensors, etc. could also be used. In embodiments where the 810G limit switch comprises a micro switch, the micro switch can be actuated when the sliding block assembly 800 approaches a predefined location along the advance thread 850. In some embodiments, when the 810G limit switch is in the actuated position, the lead thread 850 may not be additionally rotated to advance the sliding block assembly 800 in the direction of the preset location.

[00575] As shown in figure 57, the syringe pump assembly 501 may additionally comprise a sliding block linear position sensor 1050 to determine the location of the sliding block assembly 800 on the lead thread 850. In some embodiments, the sensor linear block position sensor 1050 can be used to determine the amount of contents remaining in a syringe 504 that may be in place in the syringe pump assembly 501. In such embodiments, the linear position block sensor 1050 can be used to determine a quantified syringe volume content 504 or can be used as a gasoline indicator that generates a more general syringe content volume reading 504.

[00576] In some embodiments, the 1050 sliding block linear position sensor may comprise a linear potentiometer. In such embodiments, the sliding block linear position sensor cleaner 1050 can be arranged so that it slides through the resistive element of the pot with movement of the sliding block assembly 800 along the lead thread 850. The resistance measured by 1050 po sliding block linear position sensor

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169/294 to be used to determine the location of the sliding block assembly 800 along the lead thread 850.

[00577] In some embodiments, including the example of modality shown in figure 57, the sliding block linear position sensor 1050 can comprise an array of sliding block magnetic linear position sensors 1054. Sliding block magnetic linear position sensors 1054 can be any suitable magnetic linear position sensor. An example of a suitable magnetic linear position sensor is the AS5410 Absolute Linear 3D Hall Encoder available from Austriamicrosystems in Austria. As shown, the sliding block assembly 800 may include a sliding block assembly magnet 1056 that is mounted at a suitable distance away from the 1054 sliding block magnetic linear position sensors and can be used in conjunction with the sensor array. Sliding block magnetic linear position 1054 in order to determine the location of sliding block assembly 800 on the lead thread 850. In some embodiments, the location of the sliding block magnetic linear position sensors 1054 may differ. As shown, the sliding block 800 includes a second magnet 1057 arranged so that it can interact with the sliding block magnetic linear position sensors 1054 when they are located in an alternating location.

[00578] Figure 57B shows an example of a possible 1100 linear position sensor arrangement to estimate the position of a sliding block assembly 800. In the 1100 linear position sensor arrangement example, the 1100 linear position sensor comprises a array of 1102 magnetic linear position sensors such as the AS5410 Absolute Linear 3D Hall Encoder available from Austriamicrosystems in Austria mentioned above. A shift block 1104 (for example, the sliding block assembly 800) is re

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170/294 treated in a position along a position change block advance thread 1106. A position change block arm 1108 projects out of the page as indicated by the dashed line that defines the rightmost edge of the page. . An object attached to the position block arm 1108 can be induced to move with the position change block 1104 as the position change block 1104 moves along the lead thread 1106. The position change block 1104 on Fig. 57B can be considered the sliding block assembly 800 in Fig. 57A.

[00579] In the 1100 linear position sensor arrangement example shown in Figure 57B, the position change block 1104 comprises a position change block magnet 1110. As shown, the position change block magnet is located on the face of the shift block closest to the array of magnetic linear position sensors 1102. The shift block magnet 1110 is a dipole magnet. The north pole of the 1110 position block magnet is oriented to be positioned towards the right of the page while the south pole is directed to the left of the page. As the shifting block 1104 moves along the shifting block advance thread 1106, the shifting block magnet 1110 also moves. This movement can be measured by the array of magnetic linear position sensors 1102 and analyzed to determine an absolute location of the position change block 1104 along the position change block advance thread 1106. In some embodiments, the sensor matrix linear position sensors 1102 can be used to determine differential movements of the position change block 1104.

[00580] As shown in figure 58, a modality of the sliding block assembly 800 is shown attached to the cover plate.

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171/294 840 half nut (see figure 48) removed. Half nut 830 is pictured in the engaged position and is shown as transparent so that half nut housing 810 and drum cam 820 can be seen behind it. The D-shaped shaft segment 784 of the driven shaft 774 is shown in the D-shaped hole 820A of the drum cam 820. The driven shaft 774 extends through the plunger tube 524 that couples the sliding block assembly 800 and the plunger head assembly 522 with each other.

[00581] With reference again to figure 42, the driven shaft 774 engages inside a double universal joint 772. The double universal joint 772 translates any rotational movement from the dial 530 that rotates the dial shaft 650 to rotational movement of the axis driven 774. The rotational movement of the driven shaft 774, in turn, generates rotation of the drum cam 820. Rotation of the drum cam 820 engages or disengages the half-nut 830 as described above.

[00582] As also detailed above, the rotation of the dial 530 generates linear displacement of the upper piston grip jaw 526 and lower piston grip jaw 528. The dial 530 is, therefore, multifunctional. When rotated, the dial 530 either engages or disengages the half-nut 830 or opens or closes the upper piston grip jaw 526 and the lower piston grip jaw 528. It should be noted that the arcuate section 835A of the half groove -nut 835 is shaped so that half-nut 830 does not start to disengage until the largest plunger flange 548 (not shown) that can be accepted by the upper plunger gripper 526 and the lower plunger gripper 528 has been released by the upper plunger gripper 526 and by the lower plunger gripper 528. When the plunger flange 548 (not shown) has been released and the half nut 830 has been released

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172/294 triggered, the display axis cam follower 658 on the display axis 650 can rest on the display axis cam holders 660 of the display axis cam 654 as described in relation to figure 43. As detailed in the detailed description of Figure 43, this would allow a user to park the dial 530 in the fully rotated position where the half nut 830 is disengaged and the upper plunger gripper 526 and the lower plunger gripper 528 are in the open position. In the example example depicted in figure 58, when the display 530 is in the parked position, a user can remove his hand from the display 530 and easily adjust the plunger head assembly 522 so that a syringe 504 (not shown) can be inserted on syringe pump set 501 (see figures 30 to 34 for examples of illustrations and discussion of syringe allocation 504 on syringe pump set 501).

[00583] Figure 59A shows an embodiment of the syringe pump assembly 501. As shown, the syringe pump assembly 501 is fully coupled. A syringe 504 is seated on the syringe holder 506 of the syringe pump assembly housing

503. Gearbox 940 is shown in place on syringe pump assembly 501. The motor 1200 that drives gearbox 940 is also shown coupled to gearbox 940. A main printed circuit board (PCB) 1150 is shown transparently on syringe pump assembly 501. Main PCB 1150 is coupled to the top of syringe pump assembly housing 503. In the embodiment example, flexible connector 562 extending from sliding block assembly 800 it is connected to the main PCB 1150. The electrical system comprising the main PCB will be described in figures 59A to 59J.

[00584] The electrical system 4000 of the syringe pump 500 (see

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173/294 to figure 28) is described in a block diagram in figures 59B to 59J. The 4000 electrical system controls the operation of the syringe pump 500 based on inputs from the 3700 user interface and 3501 sensors. The 4000 electrical system includes an energy system with a 3420 rechargeable main battery and the 3422 battery charger that plugs in inside the AC media. The 4000 electrical system is designed to provide safe operation with redundant safety checks and allow the syringe pump 500 to operate in failed operating modes for some errors and fail-safe for the rest.

[00585] The high-level architecture of multiple processors is shown in the last block diagram that details the electrical system 4000, figure 59J. In one example, the 4000 electrical system has two main processors, a 3500 real-time processor and a 3600 safety / user interface processor. The 4000 electrical system can also comprise a 3460 surveillance circuit, 3431 motor control elements , 3501 sensors and input / output elements. A main processor called the real-time processor (from now on in the document called RTP) 3500 can control the speed and position of the engine 1200 that turns the lead thread 850 (see figure 48B). The RTP 3500 can control engine 1200 based on input from sensors 3501 and commands from the Security Processor & User Interface (from now on in the document called UIP) 3600. UIP 3600 can manage telecommunications, manage the 3701 user interface and provide security checks on the RTP 3500. The UIP 3600 can estimate the pumped volume based on the output of a 1202 encoder motor and can signal an alarm or alert when the estimated volume differs by more than a specified amount to desired volume or the reported volume eg

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Io RTP 3500. vigilância surveillance circuit 3460 monitors the operation of the RTP 3500. If the RTP 3500 fails to clear the surveillance circuit 3460 on schedule, surveillance 3460 can disable the 3431 motor controller, sound an alarm and turn on one or one number of fault lights on user interface 3701. The RTP 3500 uses the sensor inputs to control the position and speed of the 1200 motor on a closed-loop controller (additionally described below). Telecommunications can include a WIFI driver and antenna to communicate with a central computer or accessories, a Bluetooth driver and antenna to communicate with accessories, tablet computers, cell phones, etc. and a Near Field Communication (NFC) driver and antenna for RFID tasks and a Bluetooth. In figure 59J these components are collectively referred to by reference number 3721. User interface 3701 may include a monitor 514 (see figure 28). In some embodiments, the 514 monitor may be a touchscreen. In some embodiments the user interface 3701 may comprise one or more buttons or data entry means 516 (see figure 28) through which a user can communicate with the syringe pump 500.

[00586] The electrical connections and detailed components of the electrical system 4000 are shown in figures 59B to 59I. Figures 59B to 59I also describe a number of line strokes 5000 to 5169 which proceed to and from various components. A number of syringe pump 500 sensors are shown in figure 59B. As shown, the 3950 plunger position sensors, a 3951 drum diameter sensor, a 3952 plunger capture pot sensor, a 3953 plunger force sensor and other 3954 sensors are shown. The 3950 plunger position sensors can be any of the plunger position sensors described

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175/294 in this document. The 3951 drum diameter sensor can be the 1540 syringe barrel retainer linear position sensors to be described in this document. The 3952 plunger capture pot sensor may not necessarily be a pot sensor in all modes. In some embodiments, the 3952 plunger capture pot sensor may be the 588 plunger gripper position sensor described in this document. The 3953 piston force sensor can be the 532 piston pressure sensor described in this document. The plunger capture pot 3952 can be a switch to detect a syringe 504 loaded inside the syringe holder 506. The sensors above can communicate respective signals and indicative of what they capture for the RTP 3500 or another component.

[00587] As shown in figure 59C, a 3540 thermistor can provide a signal to RTP 3500 indicative of the temperature of the infusate in an infusion line. Alternatively, the 3540 thermistor can measure a temperature at the syringe pump 500 or the temperature of the circuit 4000. In different embodiments, suitable replacement components can be used in place of the specific parts listed in figures 59B to 59I. In some embodiments, the electrical system 4000 may comprise additional components. In some embodiments the electrical system 4000 may comprise fewer components than the number of components shown in figures 59B to 59J.

[00588] Two sensors that can be located downstream of the syringe pump 500 are shown in figure 59C. One sensor is a 3545 inline air sensor. The other is a 3535 occlusion sensor. Both are connected to the RTP 3500. These sensors are optional. The 3545 inline air sensor can detect the presence of air in the

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176/294 infusion line in a 3545 in-line air proximity sensor. In one example, the 3545 in-line air sensor may comprise a 3545B ultrasonic sensor, a 3545A logic unit and a signal conditioning unit 3545C. In some embodiments, the syringe pump 500 may not comprise a 3545 inline air sensor.

[00589] The 3535 occlusion sensor can measure the internal pressure of an infusate in an infusion line. In some embodiments, the 3535 occlusion sensor may be the downstream pressure sensor 513 described in this document. In an example of an embodiment, the 3535 occlusion sensor may comprise a 3535B force sensor, a 3535A amplifier, a 3535C signal amplifier and a 3535D buffer. The 3535D temporary storage can protect the RTP 3500 from voltage overload due to high forces generated from pressures applied to the 3535B force sensor. In alternative modalities, the 3535 occlusion sensor may differ.

[00590] The 3460 surveillance circuit is shown in figure 59D. The surveillance circuit 3460 can be enabled by an I2C command from RTP 3500. The surveillance circuit 3460 can signal an error and disable the motor controller 3430 (for example, via chip 3434) if it does not receive a signal from RTP 3500 at a specified frequency. The 3460 surveillance circuit can signal the user via an audible alarm. The audible alarm can be emitted through a 3464 amplifier and / or a 3468 standby speaker. The 3460 surveillance circuit can signal the user with 3750 visual alarm LEDs (shown in figure 59F) if an abnormal condition is detected. In one embodiment, the RTP 3500 must clear the 3460 surveillance between 10 m and 200 m after the last cleaning of the 3460 surveillance circuit. In some modes, the 3460 surveillance circuit is equipped with a 3460A window surveillance, a logic circuit

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3460Β (which may include one or more flip-flop switches) and an IO 3460C expander that communicates with the RTP 3500 over an I2C bus. A 3450 standby battery (see figure 59C) can supply power to the 3460 surveillance circuit and standby speaker system (which may comprise a 3464 audio amplifier, and a standby 3468 speaker) in the event of the main battery 3420 (see figure 59E) fails. The 3450 backup battery can supply power to the RTP 3500 and UIP 3600 to maintain the internal time stamp, which can be especially desirable when the 3420 main battery is changed. The RTP 3500 can also monitor the backup battery voltage 3450 with a switch such as the FAIRCHILD FPF1005 LOAD SWITCH 3452 shown in figure 59C.

[00591] The RTP 3500 directly controls the speed and position of the 1200 motor. The 1200 motor can be any of a number of types of 1200 motors that include a brushed DC motor, a stepper motor or a brushless DC motor. In the modality illustrated in figures 59B to 59J, the syringe pump 500 is driven by a brushless direct current servo motor (BLDC) 1200. In one example, the RTP 3500 receives signals from the hall effect sensors 3436 of a 1200 brushless DC motor and performs the calculations to switch power to the 1200 motor winding to achieve a desired speed or position. Switching signals can be sent to the 3430 motor controller which selectively connects the windings to the 3434 motor power supply. The 1200 motor can be monitored for dangerous or damaging operation via 3432 current sensors and a temperature sensor 1200A.

[00592] The signals from the 3436 hall effect sensors can be provided for both the RTP 3500 and an encoder 1202. In one embodiment, three hall effect signals are generated. Any

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178/294 two of the three hall effect signals can be sent to encoder 1202. Encoder 1202 can use these signals to provide a position signal for UIP 3600. UIP 3600 estimates the total volume of fluid delivered by the syringe pump 500 from encoder position signal 1202. In some specific embodiments, each syringe pump 500 can be calibrated during assembly to establish the nominal stroke / volume that can be stored in memory. The estimated volume of the UIP 3600 can then be compared at regular intervals with the volume that would be expected for a controlled therapy. In some embodiments, the interval between comparisons may be shorter for different infusates, for example short half-life infusates. The therapy can specify, among other parameters, a flow rate, duration and a total volume to be infused (VTBI). In any case, the volume predicted based on the therapy programmed in a given period of time during which the therapy can be calculated and compared to the volume estimated by UIP 3600. UIP 3600 can signal an alert or alarm if the difference between estimated volume UIP 3600 and the volume foreseen for therapy is outside a predefined limit. The UIP 3600 can signal an alarm if the difference between the estimated volume of the UIP 3600 and the volume predicted for the therapy is outside another predefined limit.

[00593] UIP 3600 can also compare the estimated volume to the volume reported by RTP 3500. UIP 3600 can signal an alert if the difference between the estimated volume of UIP 3600 and the reported volume of RTP 3500 is outside a predefined limit. The UIP 3600 can signal an alarm if the difference between the estimated volume of the UIP 3600 and the reported volume of RTP 3500 is outside a second limit.

[00594] In some modalities, UIP 3600 can compare the reported volume of RTP 3500 with the volume predicted for therapy and

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179/294 signal an alert if the two values differ by more than a predefined limit. The UIP 3600 can signal an alarm if the difference between the reported volume of RTP 3500 and the volume predicted for therapy differs by more than another predefined limit. Alert values and alarm limits may differ from comparisons between different sets of volumes. The limits can be stored memory. The limits may vary depending on a number of different parameters, such as, but not limited to, medication, medication concentration, clinical use, patient, type of therapy or location. The limits can be predefined in a DERS (Drug Error Reduction System) database and downloaded from the device's communication port server.

[00595] Optionally, in some embodiments, a 5430 rotary encoder can be used to estimate the rotation of the 1200 threaded motor thread. The 5430 motor sensor can be formed by a magnet on the motor shaft 1200 with a Hall Effect sensor nearby to estimate the position of the threaded shaft.

[00596] An RFID 3670 tag (see figure 59E) can be connected via an I2C bus to the UIP 3600 and to a near field antenna 3955. The RFID 3670 tag can be used by medical technologists or other users or employees to acquire or store information when the syringe pump 500 is in a de-energized state. The UIP 3600 can store service records, error codes, etc. RFID tag 3670. Service records, error codes, etc. may be accessible by an RFID reader. A medical technologist, for example, could inspect de-energized syringe pumps 500 or evaluate out-of-use syringe pumps 500 by using an RFID reader to interrogate RFID tag 3670. In another example, a medical technologist or other employees can

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180/294 service the syringe pump 500 and store any related service information on the RFID 3670 tag. The UIP 3600 can then select the latest service information from the RFID 3670 tag and store it in 3605 memory ( see figure 59E).

[00597] The main battery 3420 can supply all the energy to the syringe pump 500. The main battery 3420 can be connected via a system power port element 3424 to the motor power supply 3434. All sensors and processors described in this document can be powered by one of several 3428 voltage regulators (see figure 59E). The main battery 3420 can be charged from AC power through a battery charger 3422 and an AC / DC converter 3426. UIP 3600 can be connected to one or more 3605 memory chips.

[00598] UIP 3600 controls the main audio system comprising a 3615 main speaker and the 3610 audio chips (audio codec), 3612 (audio amplifier) (see figure 59E). The main audio system may have the ability to produce a range of sounds that indicate, for example, alerts and alarms. The audio system can also provide confirmation sounds to facilitate and improve user interaction with the 514 monitor and / or 516 data entry means (see figure 28). The main audio system can include a 3617 microphone that can be used to confirm the operation of the 3615 main speaker as well as the 3468 standby speaker. The main audio system can produce one or more tones, sequences and / or patterns modulation module and the 3610 audio codec chip can compare the signal received from the 3617 microphone with the signal sent to the 3615 main speaker. The use of one or more tones and signal comparison may allow the system to

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181/294 theme confirm the 3615 main speaker function regardless of any ambient noise. Alternatively, UIP 3600 or audio codec 3610 can confirm that microphone 3617 produces a signal in the same amount of time as a signal is sent to speaker amplifier 3612.

[00599] UIP 3600 can provide a range of different wireless signals for different uses. The UIP 3600 can communicate with the hospital's wireless network via bandwidth WiFi using chips 3621, 3620 and 3622 and antennas 3720 and 3722. The spatially diverse dual antenna may be desirable due to the fact that it may have the ability to overcome dead spots within a room due to multiple trajectories and cancellations. A hospital device communication port can communicate DERS, CQI (Continuous Quality Improvement), prescriptions, patient data, etc. to the syringe pump 500 via the WiFi system.

[00600] The Bluetooth system you use, the same chips 3621, 3620 and 3622 (see figure 59E) and antennas 3720 and 3722 (see figure 59F), can provide a convenient method for connecting auxiliaries to the syringe pump 500 that can include pulse oximeters, blood pressure scanners, barcode scanners, tablet computers, phones, etc. Bluetooth may include version 4.0 to allow low-energy assistants that can communicate with the syringe pump 500 periodically such as, for example, a continuous glucose meter that sends an update once a minute.

[00601] The NFC system can be equipped with an NFC controller 3624 (see figure 59E) and an antenna 3724 (see figure 59F). The NFC 3624 controller can also be called an RFID reader. The NFC system can be used to read RFID chips that identify drugs or other stock information. RFID chips can also be used to identify patients and

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182/294 health professionals. The NFC 3624 controller can also interact with a similar RFID reader on, for example, a phone or tablet computer to enter information that includes prescriptions, barcode information, patient, healthcare professional identities, etc. The NFC 3624 controller can also provide information to phone or tablet computers such as syringe pump history 500 or service conditions. The RFID antennas 3720 and 3722 and / or NFC antenna 3724 can preferably be located around or near the screen of monitor 514, so that all interaction with the syringe pump 500 takes place on or near monitor 514 either through from reading an RFID chip as through interaction with a touchscreen monitor 514 or other data entry means 516 close to the monitor.

[00602] UIP 3600 can include a medical grade connector 3665 (see figure 59I) so that other medical devices can plug into the syringe pump 500 and provide additional capabilities. The 3665 connector can implement a USB interface.

[00603] Monitor 514 may include RFID antennas 3720, 3722, NFC antenna 3724, monitor 514, touchscreen 3735, an LCD backlight driver 3727, a 3740 light sensor, a driver for 16-channel 3745 LED, LED indicator lights 3747 and 3749 and three buttons 3760, 3765, 3767. The buttons can collectively be referred to in this document as data entry means 516. Monitor 514 may include a 3727 backlight and a sensor 3740 ambient light to allow the brightness of the 514 monitor to automatically respond and / or adjust to the ambient light. The first 3760 button can be the power button, while another 3765 button can be an infusion stop button. These 3760 buttons,

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3765 may not provide direct control of the syringe pump 500, but instead provide a signal to the UIP 3600 to both start and end the infusion. The third button 3767 can silence an alarm or alert on main speaker 3615 and backup speaker 3468. Silencing the alarm or alert will not clear the fault, but it can end the audible alarm or alert. The electrical system 4000 described above, or an alternative embodiment of the electrical system 4000 described above, can be used with the syringe pump 500 described herein.

[00604] Figure 60 shows an exemplary embodiment of the syringe pump assembly 501. In figure 60 the syringe pump assembly housing 503 that is shown in figure 59A has been removed. As shown, a syringe 504 is in place in syringe pump assembly 501 and is held by syringe barrel retainer 518. Sliding block assembly 800 is located approximately in the middle of the axial length of the lead thread 850. Since the plunger tube 524 connects sliding block assembly 800 to plunger head assembly 522, plunger head assembly 522 is in a location where it has caused syringe plunger 544 to dispense about half of the syringe content 504.

[00605] As shown, a motor 1200 is operatively coupled to gearbox 940 in figure 60. Rotation of motor 1200 is transmitted through gearbox 940 to guide the rotation of the lead thread 850. As described above, since the upper plunger gripper 526 and lower plunger gripper 528 are closed on plunger flange 548, half nut 830 is engaged with feed thread 850. Consequently, in the mode depicted in figure 60, as the engine 1200 does cause the lead thread 850 to rotate, the slide block assembly

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800 will move along the axial length of the lead thread 850. As the engine 1200 rotates the lead thread 850 so that the slide block assembly 800 moves towards the left of the page (in relation to figure 60), the Movement of the sliding block assembly 800 will additionally cause the plunger tube 524 and plunger head assembly 522 to move towards the left of the page. As the plunger head assembly 522 moves towards the left of the page, syringe plunger 544 is advanced into syringe barrel 540 of syringe 504 and the contents of the syringe are dispensed.

[00606] Motor 1200 can be any suitable motor 1200. As shown in figure 59A, a small profile 1200 pancake motor can be used to guide the rotation of the 850 lead thread. The mode shown in figure 60 does not use a motor of pancake type 1200. The motor 1200 shown in figure 60 is an alternative motor that also has hall effect sensors 3436 to inform switching of motor 1200. As shown in figure 60, motor 1200 can comprise a magnet on the rotor that is detected by a rotary encoder 1202. The rotary encoder 1202 can be any of a variety of suitable rotary encoders 1202 such as AS5055 from Austrianmicrosystems in Austria. In some embodiments, rotary encoder 1202 may be a magnet. The rotary encoder 1202 can be used to monitor rotation of the advance thread 850. Information from the rotary encoder 1202 can be used to determine when a given amount of syringe contents 504 has been dispensed. In addition, rotary encoder 1202 can be used to determine the location of the sliding block assembly 800 on the lead thread 850.

[00607] To ensure that the rotary encoder 1202 works properly, a self test can be performed. The engine 1200 po

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185/294 must be energized to move the sliding block assembly 800 back and forth over a distance from the lead thread 850. Measurements from rotary encoder 1202 can be confirmed in comparison to the measurements from the sensor assembly linear position of sliding block 1050. The same self test can also be used to confirm that the 3436 hall effect sensors on the 1200 brushless motor function properly.

[00608] As previously indicated, the syringe pump 500 includes a number of sensor redundancies. This allows the syringe pump 500 to operate in a failed operating mode if deemed appropriate. In the event that the rotary encoder 1202 fails, the hall effect sensors 3436 of the brushless motor 1200 can be used in a faulty operating mode to measure syringe content dispensing 504 by rotating the motor 1200 and providing a feedback signal. for the motor controller. Alternatively, the location of the sliding block assembly 800 along the lead thread 850 can be used in a flawed operating mode to measure syringe content dispensing 504 by positioning the sliding block assembly 800 and providing a feedback signal to the controller. Alternatively, the linear sliding block position sensor assembly 1050, can be used to monitor syringe content dispensing 504 by positioning the sliding block assembly 800 on the lead thread and to provide a feedback signal to the controller. In some embodiments, the 3436 engine hall effect sensors or the linear slide block linear position sensor assembly 1050 can be used to monitor the position of the slide block assembly 800 on the lead thread 850 to avoid guiding the block assembly sliding 800 against the pump frame.

[00609] In the event of a failure of the rotary encoder 1202, the

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186/294 syringe pump 500 can terminate a therapy if a therapy is in progress and disable a user from starting another therapy until the syringe pump 500 has been served. In the event of a failure of the rotary encoder 1202 the syringe pump 500 can trigger the alarm. In some embodiments, if rotary encoder 1202 fails and motor 1200 is used to apply at a low flow rate, syringe pump 500 may not terminate therapy. If such a failure occurs, the syringe pump 500 can trigger the alarm and the syringe pump 500 can end a therapy if a therapy is in progress and disable a user from starting another therapy until the syringe pump 500 has been served. The syringe pump controller 500 can use as a basis for deciding whether to continue therapy based on the level of risk of the infusate that is applied to a patient. If the risk of non-application to a user is greater than the risk of application with reduced accuracy, the syringe pump 500 will apply in a faulty operating mode.

[00610] Figure 61 shows a small volume syringe 504 in place in syringe pump assembly 501. Only a small portion of syringe pump assembly 501 is visible in figure 61. As shown, syringe 504 is held in place against syringe holder 506 by syringe barrel clamp 518. Syringe barrel flange 542 is stapled in place against syringe pump assembly 501 by barrel flange clamp 520. Drum flange clamp 520 is slightly deflected from the rest of the syringe pump assembly 501 so that there is a small gap between the syringe pump assembly 501 and the drum flange clamp 520. When a user places syringe 504 on syringe holder 506, the The user can also allocate the syringe barrel flange 542 inside the small gap between the syringe pump assembly 501 and the barrel flange clamp 520.

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187/294 [00611] As shown in figure 61, the outward edge of the drum flange clamp 520 curves out toward the left of the page. This assists in guiding the syringe drum flange 542 into the gap between the drum flange clamp 520 and the syringe pump assembly 501. The drum flange clamp 520 can also include one or a number of cutouts 521. In the embodiment example in Fig. 61, the cutouts 521 of the drum flange clamp comprise two grooves. The first groove is retained within the central amplitude of the edge out of the drum flange clamp 520. The second groove, which is retained within the lowest amplitude of the first groove, is considerably smaller and shallower. In other modalities, the 521 cutouts can be different in shape, size, etc. Plunger 544 of small syringe 504 in Fig. 61 is located entirely within indentations 521 in drum flange clamp 520. Without indentations 521 in drum flange clamp 520, plunger 544 of syringe 504 would make contact with the outward edge of the drum flange clamp 520 and would obstruct the allocation of the syringe drum flange 542 by the user within the gap between the drum flange clamp 520 and the syringe pump assembly 501.

[00612] Figure 62 shows a large volume syringe 504 in place in syringe pump assembly 501. Only a small portion of syringe pump assembly 501 is visible in figure 62. As shown, syringe 504 is held in place against syringe holder 506 by syringe barrel clamp 518. Syringe barrel flange 542 is stapled in place against syringe pump assembly 501 by barrel flange clamp 520. Drum flange clamp 520 is slightly deflected from the rest of the syringe pump assembly 501 so that there is a small gap between the syringe pump assembly 501 and the clamp

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188/294 drum flange 520. When a user allocates syringe 504 to syringe holder 506, the user can also allocate syringe drum flange 542 inside the small gap between syringe pump assembly 501 and the clamp. drum flange 520.

[00613] As shown in figure 62, the drum flange clamp 520 can also include an approximately semicircular depression 519 that tunes the drum flange clamp 520. The approximately semicircular depression 519 can be included to accommodate the plunger flange 548 ( not shown) of a syringe

504. In embodiments where the drum flange clamp 520 includes the approximately semicircular depression 519, the plunger 544 can be advanced a distance equal to the depth of the semicircular depression 519 additionally within the syringe barrel 540. This is desirable due to the fact that it allows more of the contents of syringe 504 to be administered to a patient.

[00614] As shown in figure 62, the drum flange clamp 520 can include a drum flange sensor 700. The drum flange sensor 700 can be provided with any number of suitable sensors. In some embodiments, the drum flange sensor 700 can operate in a binary (yes / no) mode to indicate whether a syringe barrel flange 542 is clamped by the drum flange clamp 520. In some embodiments, the flange sensor drum 700 can comprise a micro switch that is actuated as the syringe drum flange 524 is allocated in the gap between the syringe pump assembly 501 and the drum flange clamp 520. In other embodiments, the drum flange sensor 700 can comprise a photosensor. The insertion of the syringe drum flange 542 into the gap between the syringe pump assembly and the drum flange clamp 520 can block a light source for the drum flange sensor 700 in embodiments where the

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189/294 drum flange 700 comprises a photosensor. In such embodiments, the drum flange sensor 700 can indicate whether a syringe drum flange 542 is stapled in place when the light source is blocked. In other embodiments, the drum flange sensor 700 may be provided with a sensor other than those described above. The drum flange sensor 700 can be induced to generate an alarm in the event that other sensors, such as the 588 piston grip claw position sensor (mentioned above) or the syringe drum retainer linear position sensor 1540 (see figure 66), detect a syringe 504 in place of syringe pump assembly 501 when the drum flange sensor 700 does not detect a syringe 504 in place and initiation of a therapy is attempted.

[00615] Figure 63 shows an embodiment of part of syringe barrel retainer 518. As shown in figure 63, syringe barrel retainer 518 comprises a syringe barrel retainer housing 1500. In the example of an embodiment, the housing syringe drum retainer plate 1500 has a flattened base plate 1502. The flattened base plate 1502 comprises a syringe drum retainer housing member 1504 at the left end thereof (with reference to figure 63). The syringe drum retainer housing member 1504 projects out from the bottom of the syringe drum retainer housing 1500 at an angle substantially perpendicular to the plane of the flattened base plate 1502. The syringe drum retainer housing member 1504 it can extend substantially perpendicularly over the entire length of the left end of the flattened base plate 1502. In some embodiments, the syringe barrel retainer housing member 1504 may take the form of a rectangular prism. In the example of embodiment shown in figure 63, the syringe drum retainer housing member 1504 is pro-shaped

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190/294 close to a rectangular prism, but the bottom edges of the syringe barrel retainer housing member 1504 have been rounded.

[00616] As shown in figure 63, the flattened base plate 1502 may have a base plate slot 1506 cut into it. The base plate slot 1506 can be cut inside the flattened base plate 1502 from the left edge (in relation to figure 63) of the flattened base plate 1502. The base plate slot 1506 can extend inside the plate flattened base 1502 at an angle substantially perpendicular to the left edge of the flattened baseplate 1502. The baseplate slot does not extend all the way through the flattened baseplate 1502 and to close to the right edge.

[00617] On the flanks of the base plate slot 1506, one or more syringe barrel retainer housing columns 1508 can be arranged. In the embodiment example shown in figure 63, four syringe barrel retainer housing columns 1508 flank base plate slot 1506. The four syringe barrel retainer columns 1508 are divided so that there are two columns of syringe drum retainer housing 1508 on each side of the base plate slot 1506. The syringe drum retainer columns 1508 extend substantially perpendicularly from the top face of the flattened base plate 1502 towards to the top of the page. The syringe drum retainer housing columns 1508 in the embodiment example shown in figure 63 are in the form of rectangular prisms. In an alternative embodiment, the syringe drum housing columns 1508 can be cylindrical or have any other suitable shape.

[00618] The flattened base plate 1502 can also comprise

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191/294 one or more syringe barrel retainer housing bodies 1510. In the embodiment example shown in figure 63, there are two syringe barrel retainer housing bodies 1510. The syringe barrel retainer housing bodies 1510 they project perpendicularly from the top of the flattened base plate 1502 towards the top of the page. The syringe barrel retainer housing bodies 1510 are in the form of rectangular prisms. As shown, the syringe drum retainer housing bodies 1510 can protrude from the right edge of the flattened base plate 1502. The syringe drum retainer housing bodies 1510 can comprise a side that is aligned with the leading edge or rear edge (in relation to figure 63) of the flattened base plate 1502.

[00619] In some embodiments, the syringe barrel retainer housing 1500 may comprise a T-shaped member 1512. In the embodiment example shown in figure 63, the rod portion of the T-shaped member extends toward the right of the page from the right edge of the flattened base plate 1502. The T-shaped member 1512 can extend in a plane substantially parallel to the plane of the flattened base plate 1502. In the embodiment example, the T-shaped member 1512 projects from approximately the center of the right edge of the flattened base plate 1502. The cross section of the T-shaped member 1512 is approximately parallel to the right edge of the flattened base plate 1502. The cross section of the flattened member T-shape 1512 sticks out the stick equally on both sides of the stick.

[00620] As shown in figure 63, 1514 syringe barrel retainer guide rails can extend substantially perpendicularly from the right face of the housing member

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192/294 syringe drum retainer 1504 and within the left faces of the transverse portions protruding the T-shaped member 1512. The syringe drum retainer guide rails 1514 can extend substantially parallel to each other. In the example of the embodiment shown in figure 63, a spiral spring 1516 surrounds each syringe barrel retainer guide rail 1514. One end of each spiral spring 1516 can be in contact with the left face of the transverse portion of the member with 1512 T-shape. In the example of an embodiment, coil springs 1516 are compression springs. In alternative modalities, other bias members or bias member provisions may be used.

[00621] As shown in the embodiment in figure 63, a syringe drum retainer printed circuit board (PCB) 1518 can be held in place on syringe drum retainer housing columns 1508. The syringe drum retainer PCB syringe can be coupled in place to syringe drum retainer housing columns 1508 by any suitable means. In the embodiment example shown in Figure 63, the syringe drum retainer PCB is coupled to the syringe drum retainer housing columns 1508 by threads.

[00622] Figure 64 shows an embodiment of part of syringe barrel retainer 518. In the embodiment shown in figure 64, the syringe barrel retainer PCB 1518 shown in figure 63 has been removed. As shown in figure 64, the base plate slot 1506 can extend downwardly inside the syringe barrel retainer housing member 1504. The base plate slot 1508 can comprise a base plate notch grip 1520. In embodiments where the base plate slot 1508 comprises a base plate slot holder 1520 the

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193/294 base plate 1520 can be an empty space in the flattened base plate 1502 of the syringe drum retainer housing 1500. In the embodiment example, the empty space of the base plate notch holder 1520 extends outward from the right end section of the base plate slot 1508 at an angle substantially perpendicular to the side of the base plate slot 1508.

[00623] The syringe barrel retainer 518 may also comprise a syringe barrel retainer arm stem 1522. In the embodiment example shown in figure 64, the syringe barrel retainer arm stem 1522 extends through a properly sized cavity in the approximate center of the 1512 T-shaped member (only the rod of the 1512 T-shaped member is visible in figure 64). The syringe barrel retainer arm rod 1522 can be movably coupled to the syringe barrel retainer 518. In embodiments where the syringe barrel retainer arm stem 1522 is movably coupled to the syringe barrel retainer 518, the syringe drum retainer arm rod 1522 can move along a direction parallel to the rod edges of the T-shaped member 1512. In the embodiment example in figure 64, the barrel retainer arm rod of syringe 1522 has the ability to slide along the cavity in the T-shaped member 1512 and uses the cavity in the T-shaped member 1512 as a linear motion bearing. In the embodiment example, the 1522 syringe barrel retainer arm rod is longer than the rod length of the T-shaped member 1512.

[00624] As shown in figure 64, one end of the syringe barrel retainer arm rod 1522 may comprise a collar which can be a U-shaped member 1524. The U-shaped member 1524 can be fixedly coupled The

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194/294 syringe barrel retainer arm stem 1522. In the example of embodiment, the bottom amplitude of the U-shaped member 1524 is thicker than the pilasters of the U-shaped member 1524. The thick bottom amplitude of the U-shaped member 1524 comprises a hole that allows the U-shaped member 1524 to be coupled to the syringe barrel retainer arm rod 1522 when syringe barrel retainer 518 is coupled. In the modality example, the U-shaped member 1524 pilasters extend upwardly through the base plate slot 1506 and are substantially aligned with the plane of the top face of the flattened base plate 1502. The U-shaped member pilasters in U 1524 they can constrict the syringe barrel retainer arm stem 1522 from rotation since any rotation is blocked by the pilasters of the U-shaped member 1524 which are in contact with the edges of the base plate slot 1506.

[00625] In the modality example shown in figure 64, the syringe barrel retainer 518 comprises a bias bar 1526. The bias bar 1526 in the example of the modality is approximately rectangular in shape. The bias bar 1526 can comprise two holes that allow the bias bar 1526 to be allocated on the syringe barrel retainer guide rails 1514. The bias bar 1526 may have the ability to perform guided movement along the axial direction of the syringe drum retainer guide rails 1514. In the example of an embodiment, the end of the coil springs 1516 on the syringe drum retainer guide rails 1514 that do not come into contact with the transverse portion of the T-shaped member 1512 are in contact with the front face of the bias bar 1526. In the example of embodiment shown in figure 64 the maximum distance between the face of the bias bar 1526 that one end of the coil springs

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195/294

1516 that is in contact and the face of the T-shaped member 1512 that the other end of the coil springs 1516 is in contact is shorter than the uncompressed length of the coil springs 1516. This ensures that the bias bar 1526 will be always oriented towards the position shown in figure 64.

[00626] As shown in figure 64, the bias bar 1526 may comprise a cutout that allows the bias bar 1526 to fit around at least part of the syringe barrel retainer arm rod 1522. The shaped member U 1524 can be in contact with the face of the bias bar 1526 opposite the side that the coil springs 1516 are in contact with. In such embodiments, the action of the coil springs 1516 that guide the bias bar 1526 towards the position depicted in figure 64, additionally tilts the syringe barrel retainer arm rod 1522 to the position depicted in figure 64.

[00627] In the example of embodiment in figure 65, the syringe barrel retainer 518 is shown in the fully open position. To move the syringe barrel retainer 518 to the fully open open position, a user can hold the syringe barrel retainer handle 1528. In the embodiment example shown in figure 65, the syringe barrel retainer handle 1528 is a projection extending from the barrel in contact with the syringe barrel retainer frame 1530 518 which is fixedly coupled to the syringe barrel retainer arm rod 1522. After holding the 1528 syringe barrel retainer handle , a user can extract the syringe drum retainer arm rod 1522 away from the syringe drum retainer housing 1500. This action causes the U-shaped member 1524 that is fixedly attached to the arm stem syringe drum retainer 1522 also moves. Since the U-shaped member 1524 may not pass

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196/294 through the bias bar 1526, the bias bar 1526 moves with the U-shaped member 1524 and the syringe barrel retainer arm rod 1522. As the bias bar 1526 moves along the syringe drum retainer guide 1514, the coil springs become compressed so that if a user releases the syringe drum retainer handle 1528, the restoring force of the coil springs will automatically return the bias bar 1526, the U-shaped member 1524 and the syringe barrel retainer arm stem 1522 to the positions shown in figure 64.

[00628] To keep the syringe barrel retainer 518 in the fully open position against the bias of the 1516 coil springs, the syringe barrel retainer 518 can be locked in the open position. As shown, the syringe barrel retainer 518 can be locked in the open position by turning the syringe barrel retainer arm stem 1522 and all parts fixedly coupled to the syringe barrel retainer arm stem 1522. In figure 65, the syringe barrel retainer arm rod 1522 has been rotated substantially 90 ° so that the bottom span of the U-shaped member 1524 is arranged within the base plate notch grip 1520. When the member U-shaped is rotated inside the base plate notch handle 1520, the restoring force of the coil springs 1516 do not have the ability to return the syringe barrel retainer 518 to the position shown in figure 64 due to the fact that the displacement of the U-shaped member 1524 is blocked by the base plate notch grip 1520.

[00629] After rotating the syringe barrel retainer arm rod 1522 so that the syringe barrel retainer 518 is locked in the open position, a user can release the

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197/294 syringe barrel 1528 to hold a 504 syringe (not shown) and put it in place. As mentioned above, the 518 syringe barrel retainer will remain in the fully open position. A user can then rotate the 1522 syringe barrel retainer arm stem 90 ° back to the original unlocked position and allow syringe barrel retainer 518 to hold syringe 504 in place.

[00630] Referring again to figure 31, the syringe barrel retainer 518 is shown fully open and rotated within the locked position. In the fully open position, the syringe barrel in contact with the frame 1530 and the syringe barrel retainer handle 1528 are as far away as possible from the syringe holder 506 of the syringe pump assembly 501. In some modalities, this distance can be substantially greater than the diameter of the largest syringe 504 that can be accepted by syringe pump 500. In figure 31, a syringe 504 has been placed in place against syringe holder 506 while syringe barrel retainer 518 was locked in the open position. In figure 32, the syringe barrel retainer was rotated out of the locked position and was allowed to automatically adjust to the size of syringe barrel 540. As mentioned in the discussion in figure 65, this automatic adjustment is a result of the restoring force the coil springs 1516 that automatically propel the bias bar 1526, the U-shaped member 1524 and the syringe barrel retainer arm stem 1522 towards the position depicted in figure 64.

[00631] In figure 66, an example of a syringe barrel retainer 518 is shown. In the embodiment depicted in figure 66 the syringe barrel retainer PCB 1518 is shown as transparent. The 1518 syringe barrel retainer PCB can

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198/294 comprise one or a number of 1540 syringe barrel retainer linear position sensors. In the embodiment example, there are three 1540 syringe barrel retainer linear position sensors. syringe 1518 can be used to determine the size of syringe 504 (not shown) that syringe barrel retainer 518 holds in place.

[00632] In some embodiments, there can only be a single 1540 syringe barrel retainer linear position sensor. In such embodiments, the 1540 syringe barrel retainer linear position sensor can be a linear potentiometer. In embodiments where the 1540 syringe barrel retainer linear position sensor is a linear potentiometer, the 1540 syringe barrel retainer linear position sensor may comprise a 1542 drum sizing cleaner that can slide through the resistive element of the pot with movement of the syringe barrel retainer arm rod 1522. When a syringe 504 (not shown) is maintained by syringe barrel retainer 518, syringe size 504 (not shown) will determine the position of the 1542 drum sizing cleaner when long linear position sensor of syringe barrel retainer of linear pot type 1540. Since the location of cleaner 1542 will vary the resistance measured by the linear position sensor 1540, the measured resistance can be used to establish information (size, volume, mark, etc.) over the 504 syringe (not shown) that is used. In some embodiments, the measured resistance can be used as a reference with a database or resistance measures that would be expected from different syringes 504 to determine information about the 504 syringe. The measured resistance can be additionally used to determine whether a syringe 504 is properly maintained by the drum retainer

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199/294 syringe 518. For example, if the measured resistance indicates that syringe barrel retainer 518 is in the fully open position (as shown in figure 66), an alarm may be generated and therapy may not be initiated.

[00633] In some embodiments, including the example example shown in figure 66, the linear position sensors of syringe barrel retainer 1540 can be magnetic linear position sensors. Any suitable magnetic linear position sensor can be used for the 1540 syringe drum retainer linear position sensor. The 1540 syringe drum retainer linear position sensors can be the same type of sensors as the linear position sensors of sliding block assembly 1050. An example of a suitable magnetic linear position sensor is the AS5410 Absolute Linear 3D Hall Encoder available from Austriamicrosystems in Austria. 1540 syringe drum retainer linear position sensors accumulate positional data from a 1544 syringe drum retainer magnet allocated at a suitable distance from the 1540 syringe drum retainer linear position sensors. example example shown in figure 66, the syringe drum retaining magnet 1544 rests on the bottom amplitude of the U-shaped member 1524 between the two pilasters of the U-shaped member 1524. The absolute location of the syringe drum retaining magnet can be measured by syringe barrel retainer linear position sensors 1540. Since the absolute location measurement of syringe barrel retainer magnet 1544 may vary depending on syringe 504 (not shown) that is maintained by syringe barrel retainer 518 , the absolute location of the 1544 syringe drum retaining magnet can be used to determine specific information (e.g., size, volume, mark, etc.) over the 504 syringe (not shown) that is maintained. In some moPetition 870160077500, from 12/20/2016, p. 216/484

200/294 dalities, the absolute location of the 1544 syringe drum retaining magnet can be used as a reference with a database to determine information about the 504 syringe that is used. In such embodiments, the database can be a database of absolute locations that would be expected with different syringes 504. The measured absolute position can also be used to determine whether a 504 syringe is correctly held in place by the syringe barrel retainer. 518. For example, if the measured absolute position indicates that the syringe barrel holder 518 is in the fully open position (as shown in figure 66), an alarm may be generated and therapy may not be initiated.

[00634] In some embodiments, the data gathered by the 1540 syringe barrel retainer linear position sensor can be compared to data gathered by other sensors to make a more informed decision on the specific syringe 504 that is used. For example, in modalities where a 588 plunger gripper position sensor can make a determination on the type of syringe 504 that is used (see discussion of figure 37) the data from the plunger gripper position sensor of piston 588 and linear position sensor 1540 can be compared. If the data collected by the 1540 syringe barrel retainer linear position sensor does not correlate with data collected by other sensors, an alarm can be generated.

[00635] In some embodiments, data from the 588 plunger gripper position sensor can first be compared with a syringe database 504 to reduce acceptable syringe barrel measurements 540. In some embodiments, data from the syringe barrel retainer linear position sensor can be used as a reference compared to a 504 syringe database to adjust a range of flange measurements from

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201/294 plunger 548 acceptable.

[00636] Figure 67 shows a basic example of part of an alternative linear position sensor. The part of the alternative linear position sensor in Figure 67 is a line extender 1600. In the example of an embodiment, the line extender 1600 comprises a stationary portion and a movable portion. The stationary portion comprises a PCB substrate FR-4 1602. On substrate 1602 there are two microlines 1604. As shown, microlines 1604 extend parallel to each other. The 1604 microlines act as transmission lines for a signal at a known frequency. The 1604 microlines do not allow the signal to propagate within the surrounding environment. The width of the micro lines 1604 is chosen so that it is suitable for the desired impedance. In an example of a modality, the desired impedance is 50 Ω.

[00637] The mobile portion in the embodiment example comprises a FR-4 1606 PCB substrate of mobile portion. As shown, the mobile portion FR-4 PCB substrate comprises a mobile portion micro line 1608. The mobile portion micro line 1608 can be substantially U-shaped. The pilasters of the mobile portion U-shaped micro line 1608 extend parallel to each other and are separated so that when the line extender 1600 is coupled, they can make contact with the two micro lines 1604 in the stationary portion. The movable portion microlines 1608 have a width chosen so that it is suitable for the desired amount of impedance (50 Ω in the modality example). The bottom amplitude of the U-shaped 1608 movable portion micro-line connects the two pilasters of the U-shaped 1608 movable portion micro-line and is substantially perpendicular to the two pilasters. When fully coupled, the bottom amplitude of the U-shaped 1604 movable portion micro-line forms

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202/294 a bridge between the two microlines 1604 in the stationary portion of the line extender 1600. Any signal sent through one of the microlines 1604 in the stationary portion can cross through the microline of the mobile portion 1608 to the other microline 1604 in the stationary portion. By sliding the mobile portion along the direction of extension of the stationary portion microlines 1604 the signal must travel a greater or lesser distance before crossing from one stationary portion microline 1604 to the other. By manipulating the amount of signal shift, a user can predictably create a phase change in the signal. To reduce wear on the 1604 and 1608 metal microlines, a thin sheet of insulation 1609 can be placed between the microlines 1604 and 1608, which creates a capacitive coupling.

[00638] Figure 68 shows an example of the line extender 1600 which is incorporated inside a phase change detector 1610. As shown, the phase change detector 1610 comprises a signal source shown as an RF source in the example shown in figure 68. The signal source in the example shown in figure 68 runs from the RF source to a power splitter. The power divider divides the signal, which keeps the two output signals in a constant phase relationship with each other. One of the signals travels directly to a frequency mixer. The other signal is delayed before it is allowed to reach the frequency mixer. In figure 68, the signal is delayed by the line extender 1600 (see figure 67). Signal delay causes the delayed signal to be predictably out of phase with the non-delayed signal that travels directly to the frequency mixer. The delayed signal travels from line extender 1600 to the frequency mixer. In the example of modality shown in figure 68 the frequency mixer is a frequency mixer

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203/294 double balanced. As is well known in the art, two signals of constant amplitude of identical frequencies sent to a mixer will result in a DC output that is proportional to the phase difference between the two signals.

[00639] Figure 69 describes a slightly different modality of the phase change detector 1610. In figure 69 the delay means are not a line extender 1600 as described in figure 67. The delay means are an open variable or short. As the object from which the linear position is to be measured moves linearly, the location of the short or open in a transmission line can be induced to move proportionally. As shown, the signal travels through a directional coupler which can be any suitable directional coupler. As one of the two signals, the signal enters the directional coupler from the power divider and is sent from another directional coupler port to an open or short one. The open or short causes the signal to reflect back to the door from which it moved to reach the open or short. The signal reflected back inside the door is then directed by the directional coupler to move inside the frequency mixer. The signal delay generated by the distance shifted to and from the reflection point generates a phase shift in the signal. The amount of phase shift of the signal depends on the distance from the port from which the signal leaves the directional coupler to open or short. This distance can be induced to change as a result of the movement of the object from which the linear position is to be measured. The second signal from the power divider travels directly to the frequency mixer. As is well known in the art, two signals of constant amplitude of identical frequencies sent to a mixer will result in a DC output that is proportional to the phase difference between the two signals.

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204/294 [00640] As shown in figure 70, the directional coupler can be replaced with another piece of equipment such as a circulator. The phase change detector 1610 in figure 70 works very similarly to the phase change detector 1610 in figure 69. A signal from the energy divider travels directly to the frequency mixer. The other signal is delayed. The delay is generated in the same way as described above. Instead of using a directional coupler, however, a circulator can be used to direct the signal. As the signal enters the circulator at port 1 the signal is circulated to port 2. The signal travels from port 2 to short or open and is reflected back inside port 2. The reflected shifted phase signal that enters port 2 of the circulator is circulated to port 3. The signal leaves port 3 and travels to the frequency mixer. As is well known in the art, two signals of constant amplitude of identical frequencies sent to a mixer will result in a DC output that is proportional to the phase difference between the two signals. Since the phase difference depends on the short or open distance from port 2 of the circulator and the distances vary in proportion to the location of the object from which the linear location is to be found, the mixer's DC output can be used to determine the location of objects.

[00641] In some embodiments, the 1610 phase shift detector can be used to replace for 1540 syringe barrel retainer linear position sensors (see figure 66) or 1054 sliding block magnetic linear position sensors ( see figure 57A). In some embodiments, only one of the 1540 syringe barrel retainer linear position sensors or the 1054 sliding block magnetic linear position sensors can be replaced with the 1610 phase shift detector. In some embodiments, a phase shift detector phase 1610 can be

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205/294 used in conjunction with one or both of the 1540 syringe barrel retainer linear position sensors or the 1054 sliding block magnetic linear position sensors and function as a cross-check or backup.

[00642] In modes where the 1054 sliding block linear position sensor assembly (see figure 57A) is replaced with a 1610 phase shift detector, the 1610 phase shift detector can be used to detect the position of the assembly sliding block 800 along the lead thread 850 (see figure 57A). If the phase shift detector 1610 uses a line stretcher 1600 (see figure 67) the movable portion of the line stretcher 1600 can be induced to move along the stationary portion of the line stretcher 1600 with movement of the sliding block assembly 800 along the 850 lead thread. This in turn would cause the degree of phase shift to reflect the position of the sliding block assembly 800 on the 850 lead thread. Consequently, the mixer's DC output voltage (see Figure 68) can be used to determine the position of the sliding block assembly 800. The positional data generated by the phase change detector 1610 can be used in the same way as described above in relation to the previous discussion of capturing the linear set position of sliding block 800.

[00643] In modes where the phase change detector 1610 uses a short or open variable (see figure 69 and figure 70), the movement of the sliding block assembly 800 along the advance thread 850 can cause the short or open, change its location along the transmission line. This in turn would cause the degree of phase change to specify the position of the sliding block assembly 800 along the lead thread 850. Consequently, the mixer's DC output voltage (see

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206/294 figure 69 and figure 70) can be used to determine the position of the sliding block assembly 800.

[00644] In modalities where the 1540 syringe barrel retainer linear position sensors (see figure 66) are replaced by the 1610 phase change detector, the 1610 phase change detector can be used to determine the size of the syringe 504 (see figure 28). If the phase change detector 1610 uses a line stretcher 1600 (see figure 67) the movable portion of the line stretcher 1600 can be induced to move along the stationary portion of the line stretcher 1600 with movement of the boom arm. syringe drum retainer 1522. In turn, this would cause the degree of phase change to reflect the position of the syringe drum retainer arm stem 1522. Since the syringe drum retainer arm stem position 1522 depends on various characteristics of syringe 504, the DC output voltage of the mixer (see figure 68) can be used to determine the position of the 1522 syringe barrel retainer arm stem and therefore a number of characteristics of the syringe 504.

[00645] In modalities where the 1610 phase change detector uses a variable open or short (see figure 69 and figure 70), the movement of the 1522 syringe barrel retainer arm rod can cause the short or change its location along a transmission line. This in turn would cause the degree of phase change to specify the position of the 1522 syringe drum retainer arm stem. Since the position of the 1522 syringe barrel retainer arm stem depends on various characteristics of the syringe 504, the DC output voltage of the mixer (see figure 69 and figure 70) can be used to determine the position of the 1522 syringe barrel retainer arm stem and therefore a number of syringe characteristics 504. The data

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207/294 positional signals generated by the 1610 phase shift detector can be used in the same manner as described above in relation to the previous discussion of capturing the linear position of the syringe barrel retainer.

[00646] An example of the modality of the graphical user interface (from this point on in the document called the GUI) 3300 is shown in figure 71. The GUI 3300 allows a user to modify the way an agent can be infused by the syringe pump 500 through the customization of various programming options. Although the following discussion details mostly the use of the GUI 3300 with the syringe pump 500, it should be understood that the GUI 3300 can be used with other pumps, including the other pumps mentioned in this specification. For example, GUI 3300 can be used with pump 201, 202, or 203 (as shown in figure 71) detailed in the discussion of figures 2 through 9. For example, the GUI 3300 detailed as follows, uses a screen 3204 which is a 514 touchscreen monitor (see figure 28) as a means of interacting with a user. In other modalities, the means of interaction with a user may be different. For example, alternative modalities may comprise user-depressable buttons or rotational displays, audible commands, etc. In other embodiments, screen 3204 can be any electronic visual display such as one, liquid crystal type monitor, L.E.D. type monitor, plasma type monitor, etc.

[00647] As detailed in the previous paragraph, GUI 3300 is displayed on monitor 514 of syringe pump 500. Each syringe pump 500 can have its own individual screen 3204. In arrangements where there are multiple syringe pumps 500 or a syringe pump

500 and one or more other pumps, the GUI 3300 can be used to control multiple pumps. Only the master pump can require a

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208/294 screen 3204. As shown in figure 71, pump 203 is seated on a Z frame 3207. As shown, GUI 3300 can monitor a number of 3250 interface fields. 3250 interface fields can monitor various information about pump 203, infusion status and / or medication, etc. In some embodiments, the 3250 interface fields on the 3300 GUI can be touched, touched, etc. to navigate to different menus, expand a 3250 interface field, enter data and the like. The 3250 interface fields displayed on the 3300 GUI can change from menu to menu.

[00648] The GUI 3300 can also have a number of virtual buttons. In the non-mode limiting example in figure 71 the monitor has a 3260 virtual power button, a 3262 virtual start button, and a 3264 virtual stop button. The 3260 virtual power button can turn syringe pump 500 on or off. The 3262 virtual start button can start an infusion. The 3264 virtual interrupt button can pause or interrupt an infusion. The virtual buttons can be activated by a user touch, tap, double tap or similar. Different GUI 3300 menus can comprise other virtual buttons. The virtual buttons can be scheumorfos to make their functions more immediately understandable or recognizable. For example, the virtual interrupt button 3264 can resemble a stop sign as shown in figure 71. In alternative modalities, the names, formats, functions, quantity, etc. the virtual buttons may differ.

[00649] As shown in the modality example in figure 72, GUI 3300 interface fields 3250 (see figure 71) can monitor a number of different programming parameter input fields. For GUI 3300 to monitor parameter input fields, a user may be required to navigate through

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209/294 of one or a number of menus. Additionally, it may be necessary for the user to enter a password before the user can manipulate any of the parameter input fields.

[00650] In figure 72, a medication parameter input field 3302, drug quantity parameter input field in container 3304, total volume parameter input field in container 3306, concentration parameter input field 3308 , dose parameter input field 3310, volume flow rate parameter input field (from this point on in the document abbreviated as rate) 3312, volume parameter input field to be infused (from this point on document called VTBI) 3314 and time parameter input field 3316 are displayed. The parameters, number of parameters, parameter names, etc. may differ in alternative modalities. In the modality example, the parameter input fields are graphically displayed boxes that are substantially rectangular with rounded corners. In other embodiments, the format and size of the parameter input fields may differ.

[00651] In the modality example, GUI 3300 is modeled to be intuitive and flexible. A user can choose to fill in a combination of parameter input fields that are simpler or more convenient for the user. In some embodiments, the parameter input fields left empty by the user can be automatically calculated and displayed by the GUI 3300 as long as the empty fields do not operate independently of completed parameter input fields and sufficient information can be obtained from the completed fields for calculate the empty field or fields. Through figures 72 to 76, fields that depend on one another are linked by arrows with two curved ends.

[00652] The 3302 po medication parameter input field

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210/294 to be the parameter input field in which a user adjusts the type of infusate agent to be infused. In the modality example, the medication parameter input field 3302 was filled in and the infusate agent was defined as 0.9% NORMAL SALINE SOLUTION. As shown, after the specific infusate has been adjusted, GUI 3300 can fill in the medication parameter input field 3302 by displaying the name of the specific infusate in the medication parameter input field 3302.

[00653] To adjust the specific infusate agent to be infused, a user can touch the medication parameter input field 3302 in GUI 3300. In some modalities, this can select a list of different possible infusates. The user can browse through the list until the desired infusate is located. In other modalities, touching the parameter input field on medication 3302 can select a virtual keyboard. The user can then type the correct infusato on the virtual keyboard. In some modes, the user may only need to type a few letters of the infusate on the virtual keyboard before the GUI 3300 displays a number of suggestions. For example, after typing NORE the GUI 3300 can suggest NOREPINEFRINA. After locating the correct infusate, the user may be required to perform an action such as, but not limited to, tapping, tapping twice, or touching and dragging the infusate. After the required action is completed by the user, the infusate can be displayed by GUI 3300 in the medication parameter input field 3302. For a further detailed description of another example infusate selection medium, see figure 82.

[00654] In the example mode, in figure 72, the parameter input fields were arranged by a user to perform an infusion based on volume (for example, ml, ml / h, etc.). As a result, the drug quantity parameter input field

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211/294 co in container 3304 and the parameter input field in total volume container 3306 were left unfilled. The concentration parameter input field 3308 and the dose parameter input field 3310 were also left unfilled. In some embodiments, the drug quantity parameter input field in container 3304, the parameter input field in total volume container 3306, the concentration parameter input field 3308 and the dose parameter input field 3310 can be locked, disabled or not displayed on GUI 3300 when such an infusion has been selected. The drug quantity parameter input field in container 3304, the parameter input field in total volume container 3306, the concentration parameter input field 3308 and the dose parameter input field 3310 will be further elaborated in subsequent paragraphs.

[00655] When the GUI 3300 is being used to program a volume based infusion, the rate parameter input field 3312, the VTBI parameter input field 3314 and the time parameter input field 3316 do not operate independent of each other. You can only require a user to define any two of the rate parameter input field 3312, the VTBI parameter input field 3314 and the time parameter input field 3316. The two user-defined parameters can be the most convenient parameters for a user to define. The parameter left empty by the user can be automatically calculated and displayed by GUI 3300. For example, if a user fills in the rate parameter input field 3312 with a value of 125 ml / h (as shown) and fills in the input field value of VTBI 3314 with a value of 1,000 ml (as shown), the value of the time parameter input field 3316 can be cal

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212/294 calculated by dividing the value in the VTBI 3314 parameter input field by the value in the 3312 rate parameter input field. In the exemplary mode shown in figure 72, the quotient of the above calculation, 8 h and 0 min, is correctly filled in by GUI 3300 in the time parameter input field 3316.

[00656] For a user to fill in the rate parameter input field 3312, the parameter input field of VTBI 3314 and the time parameter input field 3316, the user can tap or tap the input field of desired parameter in GUI 3300. In some modalities, it can select a numeric keypad with a range or number, such as 0 to 9, displayed as individual selectable virtual buttons. A user may be required to enter the parameter by tapping individually, tapping twice, tapping and dragging, etc. the desired numbers. Once the desired value has been entered by a user, a user may be required to tap, double tap, etc. on a virtual confirm button, enter, etc. To fill in the field. For another detailed description of another exemplary way of defining numerical values, see figure 82.

[00657] Figure 73 shows a scenario in which the infusion parameters that are programmed are not those of a volume-based infusion. In figure 73, the infusion profile is that of a continuous time / volume dose rate. In the exemplary modality shown in figure 73, all of the parameter entry fields have been completed. As shown, the medication parameter input field 3302 in GUI 3300 was filled with ΉΕPARINA, according to the defined infusate. As shown, the drug quantity parameter input field in container 3304, the total volume container input field 3306 and the concentration parameter input field 3308 are filled in.

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213/294 of those in figure 73. Additionally, since a time / volume infusion is being programmed, the dose parameter input field 3310 shown in figure 72 has been replaced with a dose rate parameter input field 3318.

[00658] The drug quantity parameter input field in container 3304 is a two-part field in the exemplary embodiment shown in figure 73. In the exemplary embodiment in figure 73 the left field of the drug quantity parameter input field in container 3304 is a field that can be filled with a numeric value. The numeric value can be defined by the user in the same way that a user can define values in the rate parameter input field 3312, in the parameter input field of VTBI 3314 and in the time parameter input field 3316. In the example mode shown in figure 73, the numerical value displayed by GUI 3300 in the field to the left of the drug quantity parameter input field in container 3304 is 25,000.

[00659] The parameter defined by the field to the right of the drug quantity parameter input field in container 3304 is the unit of measurement. To define the right of the drug quantity parameter input field in container 3304, a user can touch the drug quantity parameter input field in container 3304 in GUI 3300. In some modalities, the user can select a list of possible acceptable units of measure. In such modalities, the desired unit of measurement can be defined by a user, in the same way that a user can define the correct infusate. In other embodiments, touching the drug quantity parameter input field in container 3304 can select a virtual keyboard. The user can then enter the correct unit of measurement on the virtual keyboard. In some modalities, it may be required

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214/294 let the user tap, double tap, etc. a virtual confirm button, enter, etc. to fill the left field of the drug quantity parameter input field in container 3304.

[00660] The parameter entry field in the total volume container 3306 can be filled in by a numeric value that defines the total volume of a container. In some embodiments, the GUI 3300 can automatically fill in the parameter entry field in the full volume container 3306 based on data generated by one or more sensors. In other embodiments, the parameter entry field in the full volume container 3306 can be entered manually by a user. The numeric value can be defined by the user in the same way that a user can define values in the rate parameter input field 3312, in the parameter input field of VTBI 3314 and in the time parameter input field 3316. In the example mode shown in figure 73, the parameter entry field in the full volume container 3306 was filled with the value 250 ml. The parameter input field in the full volume container 3306 can be restricted to a unit of measurement, such as ml, as shown.

[00661] The concentration parameter input field 3308 is a two-part field similar to the drug quantity parameter input field in container 3304. In the exemplary embodiment in figure 73, the left field of the parameter input field of concentration 3308 is a field that can be filled with a numeric value. The numeric value can be defined by the user in the same way that a user can define values in the rate parameter input field 3312, in the parameter input field of VTBI 3314 and in the time parameter input field 3316. In the example mode shown in figure 73, the value

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215/294 numeric displayed by GUI 3300 in the field to the left of the 3308 concentration parameter input field is 100.

[00662] The parameter defined by the right field of the 3308 concentration parameter input field is a unit of measure / volume. To define the right field of the 3308 concentration parameter input field, a user can touch the 3308 concentration parameter input field on the GUI 3300. In some modalities, the user can select a list of possible acceptable units of measurement. In such modalities, the desired unit of measurement can be defined by a user, in the same way that a user can define the correct infusate. In other modalities, touching the 3308 concentration parameter input field can select a virtual keyboard. The user can then enter the correct unit of measurement on the virtual keyboard. In some modalities, the user may be required to tap, double tap, etc. a virtual confirm button, enter, etc. to store the selection and move to a list of acceptable volume measurements. The desired volume measurement can be defined by a user, in the same way that a user can define the correct infusate. In the exemplary modality shown in figure 73, the right field of the 3308 concentration parameter input field is filled with the unit of measure / volume UNITS / ml.

[00663] The drug quantity parameter input field in container 3304, the total volume container input field 3306 and the concentration parameter input field 3308 are not independent of each other. As such, a user can only be required to define any of the two within the drug quantity parameter input field in container 3304, the total volume container input field 3306 and the parameter input field of concentration 3308. For example, if a

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216/294 user to fill in the concentration parameter input field 3308 and the parameter input field in the total volume container 3306, the drug quantity parameter input field in the container can be automatically calculated and filled in GUI 3300 .

[00664] Since the GUI 3300, in figure 73, is being programmed for a continuous time / volume dose, the dose rate parameter input field 3318 has been filled. The user can define the rate at which the infusate is infused by filling in the dose rate parameter input field 3318. In the example embodiment in figure 73, the dose rate parameter input field 3318 is a field of two parts similar to the drug quantity parameter input field in container 3304 and the concentration parameter input field 3308 described above. A numeric value can be defined in the left field of the dose rate parameter input field 3318, by the user, in the same way that a user can define values in the rate parameter input field 3312. In the exemplary mode in figure 73, the left field of the dose rate parameter input field 3318 was filled with the value 1,000.

[00665] The right field of the dose rate parameter input field 3318 can define a unit of measurement / time. To define the right field of the dose rate parameter input field 3318, a user can tap the dose rate parameter input field 3318 in the GUI 3300. In some modalities, the user can select a list of possible dose units. acceptable measures. In such modalities, the desired unit of measurement can be defined by a user in the same way that a user can define the correct infusate. In other embodiments, touching the dose rate parameter input field 3304 can select a virtual keyboard. O

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The user can then enter the correct unit of measurement on the virtual keyboard. In some modalities, the user may be required to tap, double tap, etc. a virtual button to confirm, enter, etc. to store the selection and move to a list of acceptable time measurements. The acceptable time measurement can be defined by a user, just as a user can define the correct infusate. In the exemplary modality shown in figure 73, the right field of the dose rate parameter input field 3318 is filled with the unit of measurement / time UNITS / h.

[00666] In the exemplary embodiment, the dose rate parameter input field 3318 and the rate parameter input field 3312 are not independent of each other. After a user fills in the dose rate parameter input field 3318 or the rate parameter input field 3312, the parameter input field left empty by the user can be automatically calculated and displayed by GUI 3300, whereas the field concentration parameter input 3308 has been defined. In the exemplary embodiment shown in figure 73, the rate parameter input field 3312 was filled with an infusate flow rate of 10 ml / h. The dose rate parameter input field 3318 was populated with 1,000 UNITS / h.

[00667] In the exemplary modality shown in figure 73, the parameter input field of VTBI 3314 and the time parameter input field 3316 were also filled in. The VTBI 3314 parameter input field and the 3316 time parameter input field can be filled in by a user, in the same manner as described, in relation to figure 72. When GUI 3300 is being programmed for a rate infusion continuous time / volume dose, the parameter input field of VTBI 3314

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218/294 and time parameter input field 3316 are dependent on each other. A user may only need to fill in one of the VTBI 3314 parameter input field or the 3316 time parameter input field. The field left empty by the user can be automatically calculated and displayed in GUI 3300.

[00668] Figure 74 shows a scenario in which the infusion parameters that are programmed are those of an infusion based on the amount of drug referred to in this document as an intermittent infusion. In the exemplary modality shown in figure 74, all parameter input fields have been filled out. As shown, the medication parameter entry field 3302 in GUI 3300 was filled with the antibiotic VANCOMICINA, according to the defined infusate.

[00669] As shown, the drug quantity parameter input field in container 3304, the total volume container input field 3306 and the concentration parameter input field 3308 are arranged in the same way as in figure 73. In the exemplary embodiment in figure 74, the left field of the drug quantity parameter input field in container 3304 was filled with 1. The right field of the drug quantity parameter input field in container 3304 was filled with g. Then, the total amount of Vancomycin in the container was defined as one gram. The parameter entry field in the 3306 total volume container was filled with 250 ml. The left field of the concentration parameter input field 3308 was filled with 4.0. The right field of the concentration parameter input field was filled with mg / ml.

[00670] As mentioned, in relation to the other possible types of infusions that a user may be able to program through GUI 3300, the quantity parameter input field

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219/294 of drug in container 3304, the input field in total volume container 3306 and the concentration parameter input field 3308 are dependent on each other. As above, it is indicated by the double curved arrows that connect the parameter input field names. By filling in any of two of these parameters, the third parameter can be automatically calculated and displayed in the correct parameter entry field in GUI 3300.

[00671] In the exemplary embodiment in figure 74, the dose parameter entry field 3310 has been filled. As shown, the dose parameter input field 3310 comprises a left and a right field. A numeric value can be defined in the right field of the dose parameter input field 3310, by the user, in the same way that a user can define values for other parameter input fields that define numerical values. In the exemplary modality in figure 74, the left field of the dose parameter input field 3310 was filled with the value 1,000.

[00672] The right field of the dose parameter input field 3310 can define a mass measurement unit. To define the right field of the dose parameter input field 3310, a user can touch the dose parameter input field 3310 in the GUI 3300. In some modalities, the user can select a list of possible acceptable units of measurement. In such modalities, the desired unit of measurement can be defined by a user, in the same way that a user can define the correct infusate. In other embodiments, touching the 3310 dose parameter input field can select a virtual keyboard. The user can then enter the correct unit of measurement on the virtual keyboard. In some modalities, the user may be required to tap, double tap

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220/294 te, slide, etc. a virtual confirm button, enter, etc. to store the selection and move to a list of acceptable mass measurements. The desired mass measurement can be defined by a user, just as a user can define the correct infusate. In the exemplary embodiment shown in figure 74, the right field of the dose parameter input field 3310 is filled with the measurement unit mg.

[00673] As shown, the rate parameter input field 3312, the VTBI parameter input field 3314 and the time parameter input field 3316 have been populated. As shown, the rate parameter input field 3312 was filled with 125 ml / h. The parameter input field of VTBI 3314 was defined as 250 ml. The time parameter input field 3316 was set to 2 h 00 min.

[00674] The user may not need to individually define each of the dose parameter input field 3310, the rate parameter input field 3312, the parameter input field of VTBI 3314 and the input parameter field of time 3316. As indicated by the double curved arrows, the dose parameter input field 3310 and the parameter input field of VTBI 3314 are dependent on each other. Entering one value can allow the other value to be automatically calculated and displayed by GUI 3300. The rate parameter input field 3312 and the time parameter input field 3316 are also dependent on each other. The user may only need to define a value and then allow the undefined value to be automatically calculated and displayed in GUI 3300. In some embodiments, the rate parameter input field 3312, the parameter input field of VTBI 3314 and the time parameter input field 3316 can be locked on GUI 3300 until the input field of

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221/294 drug quantity parameter in container 3304, parameter input field in total volume container 3306 and concentration parameter input field 3308 have been defined. These fields can be locked due to the fact that the automatic calculation of the rate parameter input field 3312, the VTBI parameter input field 3314 and the time parameter input field 3316 is dependent on values in the input field of drug quantity parameter in container 3304, in the parameter input field in the total volume container 3306 and in the concentration parameter input field 3308.

[00675] In scenarios where an infusate may require a dosage based on body weight, a weight parameter input field 3320 can also be displayed on GUI 3300. The example GUI 3300 shown in figure 75 has been arranged so that a user can program a dosage based on body weight. The parameter input fields can be defined by a user, as detailed in the discussion above. In the exemplary modality, the infusate in the medication parameter 3302 input field was defined as DOPAMINE. The left field of the drug quantity parameter input field in container 3304 has been defined as 400. The right field of the drug quantity parameter input field in container 3304 has been defined as mg. The parameter entry field in the total volume container 3306 has been defined as 250 ml. The left field of the concentration parameter input field 3308 was set to 1.6. The right field of the concentration parameter input field 3308 was defined as mg / ml. The weight parameter 3320 input field was defined as 90 kg. The left field of the 3318 dose rate parameter parameter input field was set to 5.0. The right field of the dose rate parameter input field

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3318 was defined as mcg / kg / min. The rate parameter input field 3312 was defined as 16.9 ml / h. The parameter input field of VTBI 3314 was defined as 250ml. The time parameter input field 3316 was defined as 14 h 48 min.

[00676] To define the weight parameter input field 3320, a user can tap or tap the weight parameter input field 3320 on the 3300 GUI. In some modalities, the user can select a numeric keypad with a range numbers, such as 0 to 9, displayed as individual selectable virtual buttons. A user may be required to enter the parameter by tapping individually, tapping twice, tapping and dragging, etc. the desired numbers. Once the desired value has been entered by a user, a user may be required to tap, double tap, etc. a virtual confirm button, enter, etc. to fill the field.

[00677] As indicated by the double curved arrows, some parameter input fields displayed in GUI 3300 may be dependent on each other. As in previous examples, the drug quantity parameter input field in container 3304, the parameter input field in total volume container 3306 and the concentration parameter input field 3308 can be dependent on each other. In figure 75, the weight parameter input field 3320, the dose taxator parameter input field 3318, the rate parameter input field 3312, the VTBI parameter input field 3314 and the input field time parameter 3316 are all dependent on each other. When sufficient information has been defined by the user in these parameter input fields, the parameter input fields not filled in by the user can be automatically calculated and displayed in the GUI 3300.

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223/294 [00678] In some modalities, a user may be required to define a specific parameter input field, even if sufficient information is defined to automatically calculate the field. This can improve usage security by providing more opportunities for user insertion errors to be caught. If a value entered by a user is not compatible with values already defined, the GUI 3300 can display an alert or alarm message, asking the user to double check the values that the user has entered.

[00679] In some scenarios, infusate delivery can be reported by a patient's body surface area (BSA). In figure 76, the GUI 3300 was configured for an infusion based on body surface area. As shown, a BSA 3322 parameter input field can be displayed on GUI 3300. Parameter input fields can be defined by a user, as detailed in the discussion above. In the exemplary modality, the infusate in the medication parameter input field 3302 was defined as FLUOROURACILA. The left field of the drug amount parameter input field in container 3304 has been defined as 1700. The right field of the drug amount parameter input field in container 3304 has been defined as mg. The parameter input field in the total volume container 3306 has been defined as 500 ml. The left field of the 3308 concentration parameter input field was set to 3.4. The right field of the concentration parameter input field 3308 was defined as mg / ml. The parameter input field of BSA 3320 was defined as 1.7 m ² . The left field of the dose rate parameter input field 3318 was defined as 1000. The right field of the dose rate parameter input field 3318 was defined as mg / m2 / day. The parameter input field

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224/294 rate ratio 3312 was defined as 20.8 ml / h. The parameter input field of VTBI 3314 was set to 500ml. The time parameter input field 3316 was defined as 24 h 00 min. The dependent parameter input fields are the same as in figure 75, with the exception that the BSA 3322 parameter input field has replaced the weight parameter input field 3320.

[00680] To fill in the BSA 3322 parameter input field, the user can tap or tap the BSA 3322 parameter input field in GUI 3300. In some modalities, the user can select a numeric keypad with a strip numbers, such as 0 to 9, displayed as individual selectable virtual buttons. In some embodiments, the numeric keypad and any of the numeric keypads detailed above can also feature symbols, such as a decimal point. A user may be required to enter the parameter by tapping individually, tapping twice, tapping and dragging, etc. the desired numbers. Once the desired value has been entered by a user, a user may be required to tap, double tap, etc. a virtual confirm button, enter, etc. to fill the field.

[00681] In some modalities, a patient BSA can be calculated automatically and displayed in GUI 3300. In such modalities, GUI 3300 can consult the user for information about the patient when a user touches, taps, etc. in the parameter input field of BSA 3322. For example, the user may be asked to define a patient height and a body weight. After the user has defined these values, they can be executed using an appropriate formula to find the patient's BSA. The calculated BSA can then be used to fill in the

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225/294 BSA 3322 parameter entry in GUI 3300.

[00682] In operation, the values displayed in the parameter input fields can change throughout the course of a programmed infusion to reflect the current state of the infusion. For example, as the infusate is infused to a patient, the values displayed by GUI 3300 in the drug quantity parameter input field in container 3304 and in the parameter input field in total volume container 3306 may decline to reflect the volume of the remaining contents of the container. In addition, the values in the parameter input field of VTBI 3314 and in the time parameter input field 3316 can also decline, as the infusate is infused into the patient.

[00683] Figure 77 is an exemplary time-on-rate graph that details a behavioral configuration of a 500 syringe pump (see figure 28) over the course of an infusion. Although the discussion below details mainly behavioral configurations of a syringe pump 500, it should be noted that the graphs shown in figures 77 to 81 can also detail the behavioral configurations of other pumps, including the other pumps mentioned in this specification. The graph in figure 77 details an exemplary behavioral configuration of the syringe pump 500, where the infusion is a continuous infusion (an infusion with a dose rate). As shown, the graph in figure 77 starts at the beginning of the infusion. As shown, the infusion is administered at a constant rate over a period of time. As the infusion progresses, the amount of infusate remaining is emptied.

[00684] When the amount of infusate that remains reaches a predetermined threshold, an INFUSION ALERT NEAR THE END can be triggered. The point at which the INFUSION ALERT NEAR THE END is issued can be configured by the user. O

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INFUSION ALERT NEAR THE END can also be configured to trigger immediately for short half-life drugs. THE INFUSION ALERT NEAR THE END can be in the form of a message in GUI 3300 and can be accompanied by flashing lights and audible noises, such as several beeps. THE INFUSION ALERT NEAR THE END allows time for the health and pharmacy professional to prepare the materials to continue the infusion, if necessary. As shown, the infusion rate cannot change over the INFUSION ALERT TIME NEAR THE END.

[00685] When the syringe pump 500 (see figure 28) has infused the VTBI to a patient, a ZERO ALERT VTBI can be triggered. The ALERT OF ZERO VTBI can be in the form of a message in the GUI 3300 and can be accompanied by flashing lights and audible noises, such as beeps. As shown, ZERO ALERT VTBI causes the pump to switch to a rate to keep the vein open (hereinafter KVO), until a new infusate container can be put in place. The KVO rate is a low infusion rate (for example, 5 to 25 ml / h). The fee is set to hold the infusion site open until a new infusion can be started. The rate of KVO can be configurable by the group (elaborated later) or the medication and can be modified in the syringe pump 500. The rate of KVO is not allowed to exceed the rate of continuous infusion. When the KVO rate can no longer be prolonged and the syringe has reached the end of its stroke, a LIMIT ALARM can be triggered. When the STOPPER ALARM is triggered, the entire infusion may stop. THE END OF COURSE ALARM can be in the form of a message in GUI 3300 and can be accompanied by flashing lights and audible noises, such as beeps.

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227/294 [00686] Figure 78 shows another exemplary time-to-rate graph that details a behavioral configuration of a 500 syringe pump (see figure 28) over the course of an infusion. The graph in figure 78 details an exemplary behavioral configuration of a syringe pump 500 in which the infusion is a continuous infusion (an infusion with a dose rate). The alerts in the graph shown in figure 78 are the same as the alerts shown in the graph in figure 77. The conditions under which the alerts are propagated are also the same. The rate, however, remains constant, over the entire graph, until the LIMIT ALERT is triggered and the infusion is stopped. Continuing the infusion at a constant rate, it is guaranteed that the blood plasma concentration of the drug remains at therapeutically effective levels. Configuring the pump to continue the infusion at a constant rate may be especially desirable in situations where the infusate is a drug with a short half-life. In some embodiments, the end of the infusion behavior of the syringe pump 500 may be restricted, depending on the defined infusate. For example, when the defined infusate is a short half-life drug, the end of the syringe pump 500 infusion behavior can be limited only to the continuation to infuse at the rate of the completed infusion.

[00687] The syringe pump 500 (see figure 28) can also be used to deliver a primary or secondary intermittent infusion. During an intermittent infusion, an amount of a drug (dose) is administered to a patient as opposed to a continuous infusion in which the drug is given at a specified dose rate (amount / time). An intermittent infusion is also delivered over a defined period of time, however, the time period and dose are independent of each other. The figure previously described 73 shows a GUI 3300 configuration for an infusion

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228/294 continuous. The figure previously described 74 shows a GUI 3300 configuration for an intermittent infusion.

[00688] Figure 79 is an exemplary time-on-rate graph that details a behavioral configuration of a syringe pump 500 (see figure 28) over the course of an intermittent infusion. As shown, the intermittent infusion is given at a constant rate, until any infusate programmed for the intermittent infusion has been emptied. In the exemplary behavioral configuration, the syringe pump 500 has been programmed to issue a ZERO ALERT VTBI and for infusion when all infusate has been dispensed. In this configuration, the user may be required to manually clear the alert before another infusion can be started or renewed.

[00689] Depending on the group (further elaborated later) or the medication, it may be desirable to configure the syringe pump 500 to behave differently after an intermittent infusion. Other configurations can cause a syringe pump 500 (see figure 28) to behave differently. For example, in scenarios where the intermittent infusion is a secondary infusion, the pump 201,202, 203 (see figure 2) can be configured to automatically switch back to the primary infusion after issuing a notification that the intermittent secondary infusion has been completed. In alternating configurations, a syringe pump 500 can be configured to emit a VTBI ZERO ALERT and lower the infusion rate to a KVO rate after completing the intermittent infusion. In such settings, the user may be required to manually clear the alert before a primary infusion is renewed.

[00690] A bolus can also be delivered as an intermittent primary infusion, when it may be necessary or desirable to achieve a higher plasma drug concentration

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229/294 blood or manifest a more immediate therapeutic effect. In such cases, the bolus can be delivered by a pump 201, 202, 203 (see figure 2) that performs the primary infusion. The bolus can be delivered from the same container that the primary infusion is being delivered to. A bolus can be performed at any point during an infusion as long as there is enough infusate to deliver the bolus. Any volume delivered via a bolus to a patient is included in the value displayed by the VTBI 3314 parameter input field of the primary infusion.

[00691] Depending on the infusate, a user may be prohibited from making a bolus. The dosage of a bolus can be predefined, depending on the specific infusate or the concentration of infusate that is used. Additionally, the time period over which the bolus occurs can be predefined, depending on the infusate that is used. After making a bolus, the bolus function can be locked for a predefined period of time. In some embodiments, a user may be able to adjust these presets by adjusting various settings in GUI 3300. In some situations, such as those where the drug that is infused has a long half-life (vancomycin, teicoplanin, etc.) , a bolus can be given as a loading dose to more quickly achieve a therapeutically effective blood plasma drug concentration.

[00692] Figure 80 shows another time graph on the rate at which the infusate flow rate was titrated to increase the patient's infusate. Titration is often used with drugs that have a rapid therapeutic effect, but that have a short half-life (such as norepinephrine). To the holder, the user can adjust the infusate delivery rate, until the desired therapeutic effect is manifested. Each adjustment can be checked against several defined limits for the specific infusate that is administered to the patient. If an

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230/294 merger is changed by more than a predefined percentage, an alert can be issued. In the example graph shown in figure 80, the rate was titrated higher once. If necessary, the rate can be titrated higher more than once. Additionally, in cases where the titration is being used to gradually decrease one of a patient, the rate can be titrated lower, any suitable number of times.

[00693] Figure 81 is another time graph on the rate at which the infusion was configured as a multi-step infusion. A multistage infusion can be programmed in a number of different steps. Each stage can be defined by a VTBI, a time and a dose rate. Multi-step infusions can be useful for certain types of infusates, such as those used for parenteral nutrition applications. In the graphical example shown in figure 81, the infusion was configured as a five-step infusion. The first stage infuses a VTBI 1 for a period of time, Time 1, at a constant rate, Rate 1. When the time interval for the first stage has elapsed, the pump moves to the second stage of the multistage infusion. The second step infuses a VTBI 2 for a period of time, Time 2, at a constant rate, Rate 2. As shown, Rate 2 is higher than Rate 1. When the time interval for the second step has elapsed , the pump moves to the third stage of the multistage infusion. The third step infuses a VTBI 3 for a period of time, Time 3, at a constant rate, Rate 3. As shown, Rate 3 is the highest rate of any of the steps in the multistage infusion. Tempo 3 is also the longest duration of any stage of the multistage infusion. When the time interval for the third stage has elapsed, the pump moves to the fourth stage of the multistage infusion. The fourth stage infuses a VTBI 4 for a period of time,

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Time 4, at a constant rate, Rate 4. As shown, Rate 4 was titrated lower from Rate 3. Rate 4 is approximately the same as Rate 2. When the time interval for the fourth infusion step multistage has elapsed, the pump moves to the fifth stage. The fifth stage infuses a VTBI 5 for a period of time, Time 5, at a constant rate, Rate 5. As shown, Rate 5 was titrated lower from Rate 4 and is approximately the same as Rate 1.

[00694] THE INFUSION ALERT NEXT TO THE END is triggered during the fourth stage of the exemplary infusion, shown in figure 81. At the end of the fifth and last stage of the multi-step infusion, the ALERT ZERO VTBI is triggered. In the exemplary configuration shown in the graph in figure 81, the rate is lowered to a rate of KVO, after the multi-step infusion has been completed and the ALERT ZERO VTBI has been issued. Other settings may differ.

[00695] Each rate change in a multistage infusion can be handled in a variety of different ways. In some configurations, the syringe pump 500 (see figure 2) can display a notification and automatically adjust the rate to move to the next step. In other configurations, the syringe pump 500 can issue an alert before changing the rate and waiting for user confirmation, before adjusting the rate and moving to the next step. In such configurations, the pump 500 can stop the infusion or drop at a rate of KVO, until user confirmation has been received.

[00696] In some modalities, the user may be able to pre-program infusions. The user can pre-program an infusion so that it is automatically after a fixed time has elapsed (for example, 2 hours). The infusion can also be programmed to be automatically at a specific time in the

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232/294 day (e.g. 12:30 pm). In some modalities, the user may be able to program the syringe pump 500 (see figure 28) to alert the user with a return function, when it is time for the pre-infusion to be programmed. The user may need to confirm the start of the programmed pre-infusion. The return function can be several audible beeps, flashing lights, or the like. [00697] In arrangements where there is more than one pump 201, 202, 203 (see figure 2), the user may be able to program a relay infusion. The relay infusion can be programmed so that after a first pump 201, 202, 203 has completed its infusion, a second pump 201, 202, 203 can automatically be a second infusion and so on. The user can also program a relay infusion, so that the user is alerted via the return function, before the relay occurs. In such a programmed arrangement, the relay infusion cannot take place until a user's confirmation has been received. A pump 201, 202, 203 can continue a KVO fee, until user confirmation has been received.

[00698] Figure 82 shows an example block diagram of a data structure from the Drug Administration Library. The data structure can be stored in any file format or in any database (for example, an SQL database). In the upper right corner, there is a box that is substantially rectangular, although its edges are rounded. The box is associated with the name General Settings. General Settings can include settings that would be common to all devices in an installation, such as location name (for example, Hospital XZY), language, common passwords and the like.

[00699] In figure 82, the Drug Administration Library has two boxes that are associated with the names

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Group (ICU) and Group Settings. These boxes form the headers for your own columns. These boxes can be used to define a group within a facility (for example, pediatric intensive care unit, emergency room, sub-acute care, etc.) where the device is located. Groups can also be areas outside a parent facility, for example, a patient's home or inter-hospital transportation, such as an ambulance. Each group can be used to define specific settings for various groups within an installation (weight, titration limits, etc.). These groups can be defined alternatively in other ways. For example, groups can be defined by the level of user training. The group can be defined by a previously designated individual or any one of several previously designated individuals and changed if the patient or associated device is moved from a specific group within a facility to another.

[00700] In the exemplary mode, the left column is the Group Settings (ICU) which indicates that the syringe pump 500 (see figure 28) is located in the intensive care unit of the installation. The right column is for Group Settings and has not been defined further. In some embodiments, this column can be used to designate a subgroup, for example, operator training level. As indicated by the lines extending outside the box, to the left of the block diagram of the Group settings (ICU) and Group Settings columns, the settings for these groups can include a predefined number of pattern settings.

[00701] Group configurations can include limits on patient weight, limits on patient BSA, sensitivity to air alarm, sensitivity to obstruction, failure KVO rates, VTBI limits, etc.

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Group settings can also include parameters, such as whether or not a review of a scheduled infusion is required for high-risk infusates, whether the user needs to identify himself, before starting an infusion, whether the user needs to insert a text comment after a limit has been exceeded, etc. A user can also set defaults for various attributes, such as screen brightness or speaker volume. In some modalities, a user may be able to program the screen to automatically adjust the screen brightness, in relation to one or more conditions, such as, but not limited to, the time of day.

[00702] As shown also to the left of the block diagram in figure 82, each facility can have a Main Medication List that defines all of the infusates that can be used in the facility. The Main Medication List can comprise several medications that a qualified individual can update or maintain. In the exemplary modality, the Main Medication List has only three medications: Heparin, 0.9% Normal Saline and Alteplase. Each group within a facility can have its own list of medications used in the group. In the exemplary modality, the Group Medication List (ICU) includes only a single medication, Heparin.

[00703] As shown, each medication can be associated with one or several clinical uses. In Figure 82 the Clinical Use Records are defined for each medication in a Group Medication List and appear as an expanded subheader for each infusate. Clinical uses can be used to adapt the limits and predefined settings for each clinical use of the infusate. For Heparin, the weight-based dosage and the non-weight-based dosage are shown in figure 82 as possible clinical uses. In some modalities, there may be a configuration of

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Clinical Use that requires the user to review or reinsert a patient's weight (or BSA) before starting an infusion.

[00704] Clinical uses can also be defined for the different medical uses of each infusate (for example, stroke, heart attack, etc.) instead of or in addition to the infusate dose mode. Clinical use can also be used to define whether the infusate is given as a continuous primary infusion, intermittent primary infusion, secondary infusion, etc. They can also be used to provide appropriate limits on dose, rate, VTBI, time duration, etc. Clinical uses can also provide limits on titration changes, bolus availability, availability of loading doses and many other specific infusion parameters. In some modalities, it may be necessary to provide at least one clinical use for each infusate on the Group Medication List.

[00705] Each clinical use can additionally comprise another expanded subheader in which the concentration can also be defined. In some cases, there may be more than one possible concentration of an infusate. In the exemplary embodiment in figure 82, the clinical use of weight-based dosing has a concentration of 400 mg / 250 ml and a concentration of 800 mg / 250 ml. Clinical use of non-weight-based dosing has only one concentration, 400 mg / ml. The concentrations can also be used to define an acceptable range for cases where the user can customize the concentration of the infusate. The concentration setting can include information on drug concentration (as shown), diluent volume, or other related information.

[00706] In some modalities, the user can browse the Drug Administration Library to fill in some of the parameter input fields shown in figures 72 to 76. The user can also browse the Drug Administration Library

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Drug to choose, from the clinical uses for each infusate, what type of infusion the syringe pump 500 (see figure 28) will deliver. For example, if a user were to select the weight-based Heparin dosage in figure 82, GUI 3300 could display the infusion schedule screen shown in figure 75 with Heparin filled in the medication parameter input field 3302. The selection of a clinical use of a drug may also prompt a user to select a drug concentration. This concentration can then be used to fill in the 3308 concentration parameter input field (see figures 72 to 76). In some embodiments, the Drug Administration Library can be updated and kept external to the syringe pump 500 and communicated with the syringe pump 500, by any suitable means. In such modalities, the Drug Administration Library cannot be changed on the syringe pump 500, but it can only place limits and / or restrictions on the programming options for a user who fills in the parameter input fields shown in figures 72 to 76 .

[00707] As mentioned above, when choosing a medication and a clinical use from the Group Medication List, a user may also be setting limits in other parameter input fields for infusion programming screens. For example, when defining a medication in the Drug Administration Library, a user may also be setting limits for the dose parameter input field 3310, the dose rate parameter input field 3318, the parameter input field of rate 3312, the parameter input field of VTBI 3314, the time parameter input field 3316, etc. These limits can be predefined for each clinical use of an infusate, prior to the programming of an infusion by a user. In some modalities, the limits 870160077500, of 12/20/2016, p. 253/484

237/294 can have both a light and a heavy limit, the heavy limit being the maximum point for the light limit. In some modalities, the group settings may include limits for all of the medications available to the group. In such cases, the limits of clinical use can be defined for later adaptation of the group limits for each clinical use of a particular medication. [00708] The software architecture of the syringe pump 500 is shown schematically in figure 83. The software architecture divides the software into cooperative subsystems that interact to perform the required pumping action. The software is also applicable to all modalities described in this document. It is also possible to apply the software to other pumps not described in this document. Each subsystem can be composed of one or more streams of execution controlled by the underlying operating system. Useful terms used in the art include operating system, subsystem, process, process sub-element and task.

[00709] 4130 asynchronous messages are used to boost information for the destination task or process. The sender process or task does not get message delivery confirmation. The data delivered in this way is typically repetitive in nature. If messages are expected on a consistent schedule, the recipient process or task can detect a failure if a message does not arrive on time.

[00710] 4120 synchronous messages can be used to send a command to a task or process or to request (extract) information from a process or task. After sending the command (or request), the originating task or process suspends execution while waiting for a response. The reply may contain the requested information or may confirm receipt of the message sent. If a response is not received promptly, the process or

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238/294 submission task may have timed out. In such an event, the sending process or task may renew execution and / or may signal an error condition.

[00711] An operating system (OS) is a set of software that manages computer hardware resources and provides common services for computer programs. The operating system can act as an intermediary between programs and computer hardware. Although some application code can be executed directly by the hardware, the application code can often make a system call to an OS function or be interrupted by it.

[00712] The RTP 3500 can run a Real Time Operating System (RTOS) that has been certified to a security level for medical devices. An RTOS is a multitasking operating system that targets applications running in real time. Real-time operating systems often use specialized programming algorithms, so that they can achieve a deterministic nature of behavior. The UIP 3600 can run on a Linux operating system. The Linux operating system is a computer operating system similar to Unix.

[00713] A subsystem is a set of software (and perhaps hardware) determined by a specific set of (related) system functionality or functionality. A subsystem has clearly defined responsibilities and a clearly defined interface for other subsystems. A subsystem is an architectural division of software that uses one or more processes, discussion forums, or tasks.

[00714] A process is an executable execution independently of a Linux operating system that runs in its own virtual address space. Hardware management

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239/294 memory in the CPU is used to reinforce the integrity and isolation of that memory, protecting the code space by writing and disabling data access outside the process memory region. Processes can only pass data on to other processes using interprocess communication facilities.

[00715] In Linux, a process subelement is a concomitant trajectory, programmed separately from program execution. In Linux, a process subelement is always associated with a process (which must have at least one process subelement and can have multiple discussion forums). Discussion forums share the same memory space as your parent process. The data can be directly shared between all of the discussion forums that belong to a process, but care must be taken to properly synchronize access to shared items. Each process sub-element has a specific execution priority.

[00716] A Task in an RTOS (Real Time Operating System) is a concomitant path, programmed separately from program execution, analogous to a Linux process subelement. All tasks share the same memory address space, which consists of the entire CPU memory map. When using an RTOS that provides memory protection, each effective task memory map is constrained, by the Memory Protection Unit (MPU) hardware, to the common code space and the task stack and private data space.

[00717] The processes in UIP 3600 communicate via IPC calls, as shown by the unidirectional arrows in figure 83. Each solid line arrow represents a call and a 4120 synchronous message response, and the dotted line arrows are messages asynchronous 4130. The tasks on the RTP 3500

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240/294 nicely similar to each other. The RTP 3500 and UIP 3600 can be traversed by an asynchronous serial line 3601, with one of an InterCom 4110 Process or an InterCom 4210 Task on each side. The InterCom 4110 Process features the same communications API (Application Programming Interface) on both sides of the bridge, so all processes and tasks can use the same method calls to interact.

[00718] Executive Process 4320 can be invoked by the Linux system startup scripts after all of the operating system services have started. The 4320 Executive Process then starts the various executable files that comprise the software on the UIP 3600. If any of the software components should exit or fail unexpectedly, the 4320 Executive Process can be notified and can generate the appropriate alarm.

[00719] While the system is running, Executive Process 4320 can act as a software watch for various system components. After registering with Executive Process 4320, a process is required to periodically check or send a signal to Executive Process 4320. Failure to check within the required interval can be detected by Executive Process 4320. Upon detection of a failed subsystem, the Executive Process 4320 can take corrective action: do nothing, declare an alarm or restart the failed process. The corrective action taken is predetermined by a table entry compiled in Executive Process 4320. The check interval may vary from process to process. The amount of variation between check times for different processes can be based, in part, on the importance of the process. The check interval can also vary during syringe pump 500 operation to optimize the pump controller response while minimizing computer processes.

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In an exemplary embodiment, during syringe loading 504, the pump controller may check less frequently than during active pumping.

[00720] In response to the required check message, Executive Process 4320 can return to the various system status items for processes that have been checked. The system status items can be the status of one or more components in the syringe pump 500 and / or errors. System status items may include: battery status, WiFi connection status, device communication port connection status, device status (Idle, Infusion Execution, Diagnostic Mode, Error, etc.), indications technical error and engineering record levels.

[00721] A process sub-element running in Executive Process 4320 can be used to read the state of the 3420 battery from an internal monitor chip on the 3420 battery. This can be done at a relatively infrequent interval, such as every 10 seconds. .

[00722] The Vista de UI 4330 implements the graphical user interface (GUI 3300, see figure 71), which renders the display graphics on monitor 514 and which responds to insertions on the touchscreen in modalities that comprise a sensitive screen to the touch, or to the inserts communicated by another means of data entry 516. The Vista design of UI 4330 is stateless. The graph that is displayed can be controlled by the 4340 UI Model Process, along with any variable data to be displayed. The commanded graph can be restored periodically, without taking into account data changes.

[00723] The style and appearance of user input dialogs (Virtual keyboard, drop-down list, checkbox, etc.) can be specified by the screen design, and implemented entirely by the Vista 4330 UI. user can be collected

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242/294 via UI 4330 View, and sent to UI 4340 Model for interpretation. UI View 4330 can provide multilingual, multiregion support with facilities for the following list that includes, but is not limited to: virtual keyboards, single-code character sets, downloadable fonts, right-to-left input, installation of translation (downloadable translation files) and configurable numbers and date formats.

[00724] UI Model 4340 deploys screen streams, and then controls the user experience. The US 4340 Model interacts with UI View 4330, specifying the screen to display, and supplies any transient values to be displayed on the screen. Here, the screen refers to the image displayed on the physical monitor 514 and the defined interactive areas or user dialogs, that is, buttons, adjusters, numeric keypads, etc., on the 3735 touchscreen. The UI Model 4340 interprets any user inputs sent from the 4330 UI View and you can update the values on the current screen, command a new screen or pass the request on to the appropriate system service (ie the start of pumping is passed to the RTP 3500).

[00725] When selecting a medication to infuse from the Drug Administration Library, the UI Model 4340 interacts with the Drug Administration Library stored in the local database, which is part of the 4350 Database System. user selections configure the runtime settings to schedule and administer the desired medication.

[00726] While the operator is entering an infusion program, the UI Model 4340 can relay the user input values to the 4360 Infusion Manager for validation and interpretation. Therapeutic decisions cannot be made by the Model 4340 UI. Treatment values can be passed from the 4360 Infusion Manager to the Model 4340 UI so that the View

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UI 4330 is displayed to the user.

[00727] UI Model 4340 can continuously monitor the cumulative device status of Infusion Manager 4360 (current infusion progress, alerts, etc.) for possible display by UI View 4330. Alerts / Alarms and other changes in status system can cause a screen change by the Model 4340 UI.

[00728] The Infusion Manager (IM) Process 4360 can validate and control the infusion delivered by the syringe pump 500. To initiate an infusion, the user can interact with the Ul / Model 4330/4340 View to select a medication and specific clinical use. This descriptive report selects a specific Drug Administration Library (DAL) entry for use. The IM 4360 loads this DAL entry from the 4350 database, for use in validating and executing the infusion.

[00729] Once a Drug Administration Library entry is selected, the IM 4340 can pass the dose mode, the limits for all user parameters that can be entered and the default values (if defined) for the UI Model 4340. Using this data, UI Model 4340 can guide the user through the infusion program entry.

[00730] As each parameter is entered by the user, the value can be sent from the Ul / Model 4330/4340 View to the IM 4360 for checking. The IM 4360 echoes the parameters back to the Ul / Model 4330/4340 View, along with an indication of the parameter conformation to the DAL limits. This allows the Ul / Model 4330/4340 View to notify the user of any values that are outside the limits.

[00731] When a complete set of valid parameters has been entered, the IM 4360 can also return to a valid infusion indicator, which allows the Ul / Model 4330/4340 View to be displayed

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244/294 feels a start control for the user.

[00732] The IM 4360 can simultaneously make the infusion / pump situation available for the Ul / Model 4330/4340 View upon request. If the Ul / Modelo 4330/4340 View is showing a status screen, it can request this data to fill it out. The data can be a composite of the infusion state and the pump state.

[00733] When asked to perform the (valid) infusion, the IM 4360 can pass the Infusion Worksheet that contains the specified user data and the Infusion Template that contains the read-only limits of the DAL as a binary CRC block ' d for Infusion Control Task 4220 that runs on RTP 3500. Infusion Control Task 4220 on RTP 3500 obtains the same user inputs, conversions and DERS entries and recalculates the Infusion Worksheet. The calculated results of Infusion Control Task 4220 can be stored in a second binary block of CRC'd and compared to the first binary block of UIP 3600. Infusion calculations performed on UIP 3600 can be recalculated and double-checked on RTP 3500, before the infusion is performed.

[00734] The coefficients for converting the input values (ie, I, grams,%, etc.) to a standard unit, such as ml, can be stored in the UIP 3600 memory or in the 4350 database system. The coefficients can be stored in a lookup table or in specific memory locations. The lookup table can contain 10's of conversion values. In order to reduce the chance that reversing a single bit will result in the wrong conversion factor being used, the addresses for the conversion values can be distributed between the values from zero to 4294967296 or 2 ³² . The addresses can be selected so that the binary form of an address is never a bit different from a second address.

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245/294 [00735] While an infusion is running, the IM 4360 can monitor your progress, sequences, pauses, restarts, secondary infusions, boluses and KVO scenarios (keep vein open) as needed. Any user alerts requested during the infusion (Infusion near completion, KVO callback, secondary completion callback, etc.) can be tracked and triggered by the IM 4360.

[00736] The processes in UIP 3600 can communicate with each other, through a message transmission scheme to the owner, based on a message queue library that is available with Linux. The system provides both confirmation message (synchronous message 4120) and non-confirmation message (asynchronous message 4130).

[00737] Messages destined for the Real Time Processor (RTP) 3500 can be passed to the InterCom Process 4310 which forwards the messages to the RTP 3500 through a 3601 serial link. A similar InterCom Task 4210 on the RTP 3500 can relay the message to yours intended destination, through the RTP 3500 message transmission system.

[00738] The message transmission scheme used in this 3601 serial link can provide error detection and retransmission of messages not sent by failure. This may be necessary to allow the system to be less susceptible to electrical interference that can occasionally tamper with interprocessor communications.

[00739] To maintain a consistent interface across all tasks, the message payloads used with the message transmission system can be data classes derived from a common base class (Message-Base). This class adds both the data identity (message type) and the integrity

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246/294 of data (CRC) to messages.

[00740] The Audio Server Process 4370 can be used to render sounds in the system. All user feedback sounds (key press beeps) and alarm or alert tones can be produced by playing pre-recorded sound files. The sound system can also be used to play music or speech, if desired.

[00741] Sound requests can be symbolic (such as Play High Priority Alarm Sound), with the actual sound file selection built into the 4370 Audio Server Process. The ability to switch to an alternate sound environment can be provided. This ability can be used to customize sounds for linguistic or regional differences.

[00742] The Device Communication Port Communication Manager (DGCM) Process 4380 can manage communications with the Device Communication Port Server over a 3620, 3622,3720 Wi-Fi network. The DGCM 4380 can be started and monitored by the Executive Process 4320. If the DGCM 4380 exits unexpectedly, it can be restarted by the Executive Process 4320, but if the failures are persistent, the system can continue to function without the execution of a communication port .

[00743] It may be the function of the DGCM 4380 to establish and maintain the Wi-Fi connection and then establish a connection to a Device Communication port. All interactions between the DGCM 4380 and a Device Communication port use a system, such as the system described in the non-provisional cross-referenced application for System, Method, and Apparatus for Electronic Pacient Care (Lawyer Dossier No. J85).

[00744] If the connection to a communication port is unavailable or becomes unavailable, the DGCM 4380 may interrupt

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247/294 any transfers in progress, and try to reconnect the link. Transfers can be renewed when the link is re-established. The operational states of Network and Communication Port are periodically reported to Executive Process 4320. Executive Process 4320 distributes this information to display to the user.

[00745] The DGCM 4380 can function as a standalone subsystem, which interrogates the Device Communication Port Server for updates and which downloads newer items when available. In addition, the DGCM 4380 can monitor the registration tables in the database, which load new registration events, as soon as they are available. Events that are loaded successfully can be marked as such in the database. After reconnecting to the Device Communication Port Server, the DGCM 4380 can reach registration loads, which sends all items that were entered during communications interruption. Firmware and Drug Administration Library updates received from the Communication Port can be prepared in the UIP 3600 file system for subsequent installation. Infusion programs, clinical recommendations, patient identification and other data items intended for the device can be prepared in the database.

[00746] The DGCM 4380 can report the connection status and date / time updates to Executive Process 4320. There can be no other direct connections between the DGCM 4380 and any of the other operational software. Such a project decouples operational software from the potentially transient availability of the Device Communication Port and Wi-Fi network.

[00747] The Engine Check Software 4383 can read a hardware encoder or counter 1202 (figure 60) that reports the rotation

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248/294 of engine 1200. The software, in this module, can independently estimate the movements of engine 1200 and compare them to the expected movement, based on user inputs for the infusion rate. This can be an independent check for proper engine control. However, primary engine control software 1200 can run on RTP 3500.

[00748] Event information can be written to a record, via Registration Process 4386, during normal operation. These events may consist of the internal machine situation and measurements, as well as history of therapy events. Due to the volume and frequency of event log data, these log operations can be temporarily stored in a FIFO queue, while waiting to be written to the database.

[00749] An SQL database (PostgreSQL) can be used to store the Drug Administration Library, Local Machine Settings, Infusion History and Machine Registration data. The stored procedures performed by the database server can be used to isolate the application from the internal database structures.

[00750] The 4350 database system can be used as temporary storage for log data destined for the Device Communication Port Server, as well as a staging area for infusion settings and warnings sent to the Port Pump. Communication.

[00751] Upon request to start an infusion, the input of DAL and all selected user parameters can be sent to the Infusion Control Task 4220. All of the DAL validations and a recalculation of the infusion rate and volume based on the requested dose can be performed. The result can be che

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249/294 against the results calculated by IM 4360 at UIP 3600. These results may be required to combine to continue.

[00752] When executing an infusion, the Infusion Control Task 4220 can control the delivery of each infusion segment; that is, a part of an infusion consisting of a volume and a rate. Examples of segments are: a primary infusion, a KVO, a bolus, primary residue after bolus, primary after titration, etc. The infusion segments are sequenced by the IM 4360 Process at UIP 3600.

[00753] Pump Control Task 4250 can incorporate the controllers that drive the pumping mechanism. The desired rate and amount of pumping (VTBI) can be specified in commands sent from Infusion Control Task 4220.

[00754] The 4250 Pump Control can receive periodic sensor readings from the 4264 Sensor Task. The new sensor readings can be used to determine a motor position and speed and to calculate the desired command to send to the Motor Control Without Brush IRQ 4262. The receipt of the sensor message can trigger a recalculation of the controller output.

[00755] While pumping the fluid, Pump Control Task 4250 can perform at least one of the following tasks: controlling the pumping speed, measuring the volume delivered, measuring the detected air (through a spin time window), measure fluid pressure or other indications of obstructions and detect obstructions upstream.

[00756] Relevant measurements can be reported for RTP Status Task 4230 periodically. The 4250 Pump Control can execute an infusion segment at a time, stopping when the commanded delivered volume has been reached. The Sensor Task 4264 can read and aggregate the sensor data used for the diPetition control 870160077500, from 12/20/2016, pg. 266/484

250/294 pumping system dynamics.

[00757] The sensor task 4264 can be programmed to run at a consistent rate of 1 kHz (every 1.0 ms) through a dedicated timer / counter. After all of the relevant sensors have been read, the data can be passed to Pump Control Task 4250, via an asynchronous message 4120. The periodic receipt of this message can be used as the main time base to synchronize closed cycles syringe pump control valve 500.

[00758] The RTP Situation Task 4230 can be the central repository for both the state and the status of the various tasks that perform on the RTP 3500. The RTP Situation Task 4230 can distribute this information to both the IM 4360 that runs on the UIP 3600, regarding the tasks in the RTP 3500 itself.

[00759] The RTP Situation Task 4230 can also be loaded with fluid count for the ongoing infusion. Pump starts and stops, as well as pumping progress can be reported to the RTP 4230 Status by the Pump Control Task 4256. The RTP 4230 Status Task can count at least one of the following: total infused volume, volume primary delivered, primary VTBI (counted down), delivered volume and VTBI of a bolus, while the bolus is in progress, and the delivered volume and VTBI of a secondary infusion, while the secondary infusion is in progress.

[00760] All alerts or alarms that originate in RTP 3500 can be channeled through the Situation Task of RTP 4230, and subsequently passed to UIP 3600.

[00761] While the unit is in operation, the program light and RAM memory can be tested continuously by

Task of Czech Memory Pain 4240. This test may be non-DisPetition 870160077500, from 12/20/2016, p. 267/484

251/294 trutive. This test can be programmed so that the entire memory space on the RTP 3500 is tested every few hours. Additional periodic checks can be scheduled under this task, if necessary.

[00762] It can be required that the tasks that run on RTP 3500 communicate with each other, as well as with the tasks that are running on UIP 3600.

[00763] The RTP 3500 message transmission system can use a unified global addressing scheme to allow messages to be passed on to any task in the system. Local messages can be passed into memory using RTOS message passing facilities, with messages external to the chip routed through the 3601 asynchronous serial link by Task InterCom 4210.

[00764] Task InterCom 4210 can manage the RTP 3500 side of the 3601 serial link between the two processors. Task InterCom 4210 is the equivalent RTP 3500 of InterCom Process 4310 on UIP 3600. Messages received from UIP 3600 can be relayed to their destination on RTP 3500. Outgoing messages can be forwarded to InterCom Process 4310 on UIP 3600.

[00765] All messages between RTP 3500 and UIP 3600 can be checked for data corruption using an error detection code (32-bit CRC). Messages sent over the 3601 serial link can be resent if corruption is detected. This provides a communications system that is reasonably tolerant of ESD. Corrupted messages within the processor, between processes, can be handled as a severe system failure. All of the message payloads used with the message transmission system can be data classes derived from a common base class (Message-Base) for

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252/294 ensure consistency across all possible message destinations.

[00766] The Brushless Motor Control IRQ 4262 cannot perform as a task; it can be implemented as a strict advance process (interruption context). Interruptions are generated from the switch or hall effect sensors 3436, and the switching algorithm can be executed entirely in the interrupt service routine.

[00767] Figure 84 shows a state diagram illustrating a 50650 method of providing a surveillance functionality, according to one embodiment of the present disclosure. Method 50650 is shown as a state diagram and includes states 50670, 50690, 50990, 50720, 50750, 50770 and 50790, and transition conditions 50660, 50680, 50700, 50710, 50730, 50740, 50760, 50780, 50800 and 50810.

[00768] The 50650 method can be implemented by software, hardware, running software, or some combination of them (for example, as a hardware surveillance system). Method 5065 can be implemented by monitoring 3460 of figure 59J, so that it provides a motor capacity signal to motor controller 3431. Figures 85A to 85F show a specific modality of a system that implements method 50650 of figure 84.

[00769] Refer now to Figures 84 and 85A to 85F. When power is supplied to the surveillance system (eg 50030 system), transitions 50660 from method 50650 to the out-of-state surveillance system 50670 where the engine capacity signal is off (for example, line 50150), the alarm is off (for example, line 50160), and the timer is in an unknown state. The stopwatch can be part of the IC 50120 surveillance. The IC 50120 surveillance is a window surveillance. The 50030 system also

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253/294 includes I2C 50130 control lines that interface via a 50040 l / O expander (or other hardware locks). The I2C 50130 control lines can be part of the RTP 35000 connections for the 3460 surveillance in figure 59J. In addition, a clean surveillance signal (line 50140 of figure 85D) can also be received from RTP 35000 for surveillance 34600. That is, the clean surveillance line 50140 tames IC 50120 surveillance.

[00770] In transition 50680, the RTP 3500 (see figure 59J) clears the IC 50120 surveillance timer, via the 50140 surveillance clean line, and the RTP 35000 allows the IC 50120 surveillance output via the control lines I2C 50130 instructing the 50040 l / O expander to allow a 50180 surveillance capability line. This causes the 50650 method to enter state 50690. In state 50690, the timer is started (set to zero), the line motor capacity 50150 is set to off and alarm line 50160 is set to off.

[00771] The RTP 3500 allows motor power through the I2C 50130 control lines, defining the D flip-flop as true (using the predefined pin of a D 50050 flip-flop) and pauses for 1ms in transition 50700. Method 50650 changes to state 50990 where surveillance timer 5012 is running, engine capacity line 50150 is allowed and the timer is less than 200 milliseconds. If RTP 3500 defines the clean surveillance line 50140 when the surveillance is greater than 10 milliseconds and less than 200 milliseconds, transition 50710 changes method 50650 to the state 50720 in which the timer is reset. The 50650 method will change back to the 50990 state.

[00772] If the timer reaches 200 milliseconds or the timer is less than or equal to 10 milliseconds and the RTP 3500 defines the 50140 surveillance clean line, transition 50740 changes the method 870160077500, from 12/20/2016, p. 270/484

254/294 do to state 50750. In state 50750, surveillance IC 50120 sends a fault signal that is temporarily stored by a temporary storage 50090 that clears the flip-flop of D 50050, thus shutting down the 50150 motor line. In state 50750, surveillance IC 50120 also sends the fault signal that is received by a NAND 50080 port through an inverted input, which sends a signal to a 50090 logical buffer that clears a D 50070 flip-flip and turns on thus the alarm line 50160. The D 50070 flip-flop output is amplified by a 50060 load switch.

[00773] When the motor line capacity signal 50150 is set to stop the motor, the stop signal propagates through the non-reversing input of the NAND port 50080, after about 1 millisecond, which causes the transition 50760 change to state 50770, thus allowing the alarm to be disabled. An I2C Command can cause the 50800 transition to reset the 50030 system back to 50670 state.

[00774] Otherwise, the alarm line 50160 will continue to sound the alarm, until a silence button 50170 is pressed, which is associated with the D flip-flop preset of 50070 to set the alarm line 50160 to off. That is, the button will cause the 50780 transition to change the 50650 method to the 50790 state. An I2C signal, through the I2C control lines 50140, for the IO 50040 expander can cause the 50650 method to change to the state 50670.

[00775] Figure 86 shows another type of syringe pump

50200 having a stop 50210, according to an embodiment of the present disclosure. The 50200 pump can be attached to a pole via the 50280 clamp. The 50200 pump includes a 51000 syringe holder that accommodates a 50210 stop.

[00776] The 50200 pump also includes a touch screen

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255/294

50240 coupled to pump 50200, by means of an outer periphery 50250. The outer periphery 50250 includes a 50260 indicator light. The 50260 indicator light can fully wrap around the 50240 touchscreen. The 50260 indicator light may include a diffuser wrapped around the 50240 touchscreen with a plurality of LED lights embedded in it (or optically coupled to it). The 50260 indicator light may flash when the pump 50200 is running and / or it can be a specific color when the pump is running (for example, red, blue, green, yellow, etc.). The 50260 indicator light can be on continuously when the 50200 pump is not running or in a standby state. Additionally, alternatively or optionally the 50260 indicator light can be a specific color when the pump is not running or is in a standby state (for example, red, blue, green, yellow, etc.).

[00777] The 50200 pump can also include a 50940 gesture recognition device, which can be a camera. A pump processor 50200 can be coupled to the gesture recognition device 50940 to receive user input of a gesture by a user. That is, the processor can be configured to present a user with at least one option, through the 50240 user interface and receive an option selected from at least one, through the 50940 gesture recognition device. The processor coupled to the interface user 50240 can be configured to provide a plurality of pump parameter inputs, each of which among the plurality of pump parameter inputs is configured to receive a user input parameter. The processor can be configured to determine if all of the user input parameters of all of the plurality of pump parameters meet at least one

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256/294 predetermined security. Each of the plurality of pump parameter entries can be displayed without the other one of the plurality of pump parameter entries.

[00778] The processor can be configured to provide a plurality of pump parameter inputs, each of which among the plurality of pump parameter inputs is configured to receive a user input parameter. The processor can be configured to require that all of the plurality of pump parameter entries be inserted in a predetermined amount of time. The processor can be configured to receive a corresponding user input parameter for the plurality of pump parameter inputs in any order.

[00779] Figure 87 shows an exploded view of the syringe pump 50200 of figure 86, according to an embodiment of the present disclosure. The pump 50200 includes an upper housing portion 50290 and a lower housing portion 50300. Additionally or alternatively, the upper portion 50290 and the lower portion 50300 of the housing 50290, 50300 can be formed unitarily in some specific embodiments. A 51030 modular syringe pumping mechanism can be attached to housing 50290, 50300. A 51010 motor operates the 51030 modular syringe pumping mechanism. The 51010 motor can be controlled via a 51020 circuit board that is coupled to the 51010 motor. and various sensors, actuators, the 50240 touchscreen, etc. The 50200 pump also includes 50310 cabling and a 50270 battery disposed behind the 50240 touchscreen (when mounted). Fig. 88 shows a close view of the upper housing 50290, the lower housing 50300 and the power supply 50320. It can be seen how the power supply 50320 is thermally coupled to the lower portion of the lower housing 50600 through the conductive path 50330.

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257/294 [00780] The 50200 pump includes a 50320 power supply. The 50320 power supply is coupled to a 50330 conductive path to the 50300, 50290 housing (when mounted). Conductive path 50330 can be a piece of metal and can be formed individually with housing 50300 (or 50290). The 50320 power supply can use the 50290, 50300 housing as a heat sink. The power supply 50320 can use any surface of the housing 50290, 50300, so that it is thermally coupled to it and / or can be thermally coupled to the housing 50290, 50300, through the thermally conductive path 50330.

[00781] Figure 89A shows a front view of the pump monitor 50200, and figure 89B shows a rear view of the monitor pump 50200, according to one embodiment of the present disclosure. At the rear of the 50240 touchscreen (easily seen in figure 89B) a near field antenna 50340 is arranged. Figure 90 shows the sensor portion 51050 of the touchscreen, with the near field antenna 50340 disposed adjacent to the rear side of the sensor portion 51050 of the touchscreen 50240 (see figures 89A to 89B). A frame 50350 is shown, which forms a closed loop of metal with a gap 51040 that has a dielectric 50360 disposed within the gap 51040. Frame 50350 can be a frame for the 51050 sensor and / or the 50240 touch screen. antenna 50340 can operate at 13.56 mega-hertz and / or can be an NFC antenna. The metal frame 50350, together with span 51040 and dielectric 50260 disposed within the span can form a split ring resonator. The metal frame 50350 forms an inductive element of the split ring resonator, and the span 50140 with the dielectric 50360 arranged therein forms a capacitive element of the split ring resonator.

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258/294 [00782] Figure 91 shows a diagram that illustrates the use of the pump sensors of figure 86 when one or more of the sensors are unavailable, according to one embodiment of the present disclosure. Fig. 91 shows sensors 7001, 7002, and 7003. The rotary position sensor 7003 can be rotary sensor 1202 of figures 59J and 60 (for example, an encoder). The hall effect sensors for motor 7001 can be Hall Effect Sensors 3436 on motor 1200 of figure 59J and 60. The linear plunger position sensor 7002 can be, for example, the linear sensor 3950 of figure 59B or the linear position 1100, as shown in figure 57B.

[00783] Figure 91 can be implanted as a method of using feedback sensors from a 50206 syringe pump. The RTP 3500 of figure 59J can receive signals from sensors 7001, 7002, 7003.

[00784] The RTP 3500 can check by comparison a position of the sliding block assembly 800 using all three sensors 7001, 7002, and 7003, in relation to each other. The RTP 3500 can check the 7003 rotary position sensor for comparison with the 7001 engine hall effect sensors, and if they are out of agreement for a predetermined amount, the RTP 3500 will compare them to the 7002 linear plunger position sensor. to determine that one of the sensors 7001 and 7003 is operating properly. Thereafter, the RTP 3500 will use the sensor that operates properly between the 7001 and 7003 sensors. If the 7003 rotary position sensor is unavailable, the RTP 3500 will use the 700 hall motor effect sensors. The RTP 3500 can also check by comparison the 5042 rotary position sensor with the 5043 engine hall effect sensors.

[00785] If it is determined that both the 7001 motor hall effect sensors and the 7003 rotary position sensor are inoperative

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259/294 tes, the RTP 3500 can only use the linear plunger position sensor 7002.

[00786] Figure 92 shows a side view of a syringe pump 7004 that has a holding finger 7005 to retain a syringe, and figure 93 shows a close, partial view of the syringe pump 7004 of figure 92, according to with one embodiment of the present disclosure. The syringe end 7010 can be retained by hinged jaw members 7006, and 7007. Hinged jaw members 7006 and 7007 can include folds as shown. The dial 7008 can be operatively coupled to the articulated claw members 7006 and 7007 to make them pivot. The dial 7008 can be oriented to rotate the dial 7008 to cause the articulating claw members 7006 and 7007 to rotate towards each other or to rotate away from each other.

[00787] Figure 94 shows a circuit 8000 for storing data within an RFID tag 8008 associated with a syringe pump (for example, syringe pump 500 in figure 29, syringe pump 50200 in figure 86, or any other syringe pump), according to one embodiment of the present disclosure. The RFID tag 8009 of figure 94 can be the RFID tag 3670 of figure 95E. Antenna 8001 of Fig. 94 can be antenna 3955 of Fig. 59E.

[00788] The antenna 8001 is attached to an RFID tag 8008, so that an RFID reader (ie RFID interrogator) can communicate with the RFID tag 8008. The 8000 circuit can be placed on a 1x1 inch plate. PCB, with a solid metal ground plane on the rear side.

[00789] An internal closed loop 8002 with a capacitor 8003 can form a split ring resonator to increase the reading range capacity of the 8000 circuit. The RFID tag 8008 can be attached to the antenna 8001, by means of a network combining stop

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260/294 dance 8004, 8005, 8006, 8007. The 8000 circuit can be configured for use with a 900 Mega-hertz RFID reader.

[00790] A reader chip 8009 can interface via RFID tag 8008 to record data (for example, registration data) on it. The reader chip 8009 can communicate with the RFID tag 8008 using I2C, a CAN bus, or other communications link. Alternatively, 8009 can be an electrical connector, in some embodiments.

[00791] Figure 95 shows an equivalent circuit 8010 for impedance, as seen from RFID tag 8008 in figure 94, according to one embodiment of the present disclosure. A closed loop 8011 shows antenna 8001 of figure 94. Inductor 8012 shows inductor 8004 of figure 94. Resistors 8013 and 8014 are schematic representations of resistors 8006 and 8005, respectively. Capacitor 8015 shows capacitor 8007 of figure 94. Circuit elements 8012 to 8015 are used to match impedance, so that RFID tag 8008 is efficiently coupled to closed loop antenna 8001, as in circuit 8000 in figure 94 .

[00792] Figure 96 shows another circuit 8016 for storing data within an RFID tag 8022 associated with an infusion pump (for example, syringe pump 500 in figure 29, syringe pump 50200 in figure 86 or any other pump syringe), according to one embodiment of the present disclosure. The 8017 antenna is shown. The RFID tag 8022 of figure 96 can be the RFID tag 3670 of figure 95E. Antenna 8017 of Fig. 96 can be antenna 3955 of Fig. 59E.

[00793] The 8017 antenna may have capacitors attached to the gaps in the 8017 antenna, in some modalities. An 8018, 8020, 8021 impedance matching network can be used to efficiently couple the 8022 RFID tag to the 8017 antenna. An 8023 interface can

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261/294 be used to communicate with the RFID tag 8022 (for example, an I2C interface, a CAN interface, etc.).

[00794] Figure 97 shows a split ring resonator 8026 used with circuit 8016 of figure 96, according to one embodiment of the present disclosure. The 8026 split ring resonator can be printed on a PCB board with an internal closed loop

8025 and an external closed loop 8024. The split ring resonator

8026 can be placed adjacent to circuit 8016 of figure 96 to increase its reading range (for example, the two planes defined by the two circuit PCB boards can be parallel to each other).

[00795] Figure 98 shows a flow chart illustrating a 9000 method for removing the clearance effects on a syringe pump (for example, syringe pump 500 in figure 29, syringe pump 50200 in figure 86 or any other pump syringe) that has a syringe loaded in the syringe pump, according to one embodiment of the present disclosure. Method 9000 includes acts 9001 to 9010 which include two decision acts 9006 and 9009.

[00796] Act 9001 receives a target flow rate from a syringe loaded into a syringe pump. The syringe has a barrel and plunger arranged inside the barrel. Act 9002 determines a therapy actuation speed that corresponds to the target flow rate, when there is no clearance in the syringe pump or syringe. Act 9003 activates the syringe plunger outside the barrel at a first predetermined speed, until a force sensor coupled to the plunger measures a force that is less than a first predetermined force limit or the plunger moves out of the barrel for a first predetermined distance. Act 9004 acts the plunger of the syringe in the barrel at a second predetermined speed, greater than the therapy actuation speed, until the force sensor

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262/294 coupled to the plunger measure a force that exceeds a second predetermined limit or that the plunger travels outwardly in the barrel by a second predetermined distance. Act 9005 issues an alarm if the plunger travels in the drum by the second predetermined distance, without the force sensor measuring a force that exceeds the second predetermined limit. If an alarm is issued in Act 9005, Act 9006 branches method 9000 at the end of therapy 9010. Act 9007 acts on the syringe plunger in the barrel at the speed of therapy action. Act 9008 estimates the volume discharged that starts from the position of the plunger, when the second predetermined limit has been exceeded. Act 9009 will repeat Act 9008 until the target volume is discharged, after which Act 9009 will terminate therapy 9010.

[00797] Figures 99A to 99B show a 9900 device for side loading a syringe into an infusion pump, according to one embodiment of the present disclosure. Figure 99A shows device 9900 with a 9902 fixing arm in a loading position, while figure 99B shows device 9900 with fixing arm 9902 in a fixing position. Apparatus 9900, as shown in figures 99A to 99B, in addition to the clamping arm 9902, includes a platform (also referred to as a syringe holder) 9906 and a force mechanism 9904 for securely retaining a syringe. A 9901 plunger head assembly can be coupled to a syringe to discharge fluid into the syringe (the syringe is not shown in figures 99A to 99B) in a patient.

[00798] The 9904 force mechanism transmits a rotational force on the 9902 clamping arm, driving it towards the 9906 platform. When a syringe is placed on the 9906 platform, the 9902 clamping arm engages the syringe with sufficient force to retain fixed mode in place during pump operation. As good

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263/294 syringe bases using smaller syringes may need about 0.454 grams (one pound) of force applied to the syringe to secure it, while larger syringes may need about 1.36 grams (three pounds) of applied force the same. The 9904 force mechanism may be able to lock in an upward position, as shown in figure 99A, which allows a pump operator to easily position the syringe on the 9906 platform, before securing the syringe with the 9902 clamping arm. upward can be referred to as a loading position, due to the fact that moving the clamping arm 9902 off platform 9906 facilitates loading of the syringe onto platform 9906.

[00799] The fixing arm 9902 can be designed to allow sufficient viewing of the syringe. In some embodiments of the present disclosure, the 9902 holding arm can be configured to be substantially contiguous with the pump housing and only cover the syringe at the point of contact between the 9902 holding arm and the syringe. A wire structure can also be added to the engagement portion of the fixing arm 9902 which retains the volume of the fixing arm 9902 away from the syringe, leaving only a relatively thin wire that contacts the syringe. Other arrangements in which the 9902 holding arm is shaped to minimally obscure a syringe can also be used.

[00800] Figures 100A to 100B show an embodiment of a force mechanism used with the apparatus described in figures 99A to 99B or similar apparatus. The embodiment shown in figures 100A to 100B includes a secondary arm (hereinafter also referred to as a second arm) 9908, a roller 9910, a coupling plate 9914 and a bias member or spring 9912. The second arm 9908 is connected to the geometry axis of the rotation arm 9902 and is removed laterally from the arm 9902 in order to position the

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264/294 even through the coupling plate 9914. A roller 9910 is attached to the secondary arm 9908 at the end opposite the axis of rotation and extends beyond the end of the secondary arm 9908, so only the roller 9910 engages the plate hitch 9914. Hitch plate 9914 is positioned to be engaged by roller 9910. One end of plate 9914 is secured by a pivot 9920 and the other end is connected to a spring 9912 that pushes plate 9914 toward roller 9910, at secondary arm 9908. The engaging face of the coupling plate 9914 is angled with respect to the secondary arm 9908 which creates a rotational force on the secondary arm 9908 when the plate 9914 is propelled towards the secondary arm 9908. The rotational force of the second arm 9908 is transferred to the 9902 fixing arm, which results in the force that fixes the syringe. The engagement face of the engagement plate 9914 can also define a peak that has a first side 9918 oriented to cause a rotational force on the engaged secondary arm 9908 and a second side 9916 that locks the secondary arm 9908 in a position where the engagement arm Fixture 9902 is removed from platform 9906 and a syringe that can be on platform 9906 (see figures 99A to 99B), thus maintaining fixation arm 9902 in a loading position to load the syringe (shown in figure 100B).

[00801] Figures 101A to 101B show another embodiment of a force mechanism used with the apparatus described in figures 99A to 99B or similar devices. The 9932 hitch plate is not hinged at one end, it is on a 9926 track. The 9932 hitch plate can be spring oriented towards a 9922 secondary arm. The 9926 hitch guides the 9932 hitch plate towards the 9922 secondary arm. and allows linear motion instead of rotational motion. Having the 9932 hitch plate on the 9926 track does not result in a falling arm at the moment. The moment of decline arm

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265/294 mo means that a more rigid spring can be used to create the force output on the 9902 clamping arm.

[00802] A spring pushes the hitch plate 9932 towards the roller 9924, on the secondary arm 9922. The hitch face of the hitch plate 9932 is shaped to transmit a rotational force to the secondary arm 9922, which transfers the rotational force to the connected clamping arm 9902. A peak on the engaging surface of plate 9932 can define a parked section 9930 and a section that causes rotational force 9928. Clamping arm 9902 is shown in a clamping position in figure 101A and in the clamping position load in figure 101B.

[00803] Figures 102A to 102B show, yet, another modality of a force mechanism that can be used with the apparatus described in figures 99A to B or similar devices. In the mode 9904c shown in figures 102A to 102B, a coupling plate 9942 is attached and a secondary arm 9934 becomes shorter when rotated, because of the surface of the variable plate 9942. The secondary arm 9934 is made of two components, which include : a first component 9934a connected to the fixing arm 9902, in its geometric axis of rotation; and a second component 9934b which is made shorter in the first component 9934a. A spring positioned between components 9934a, 9934b forces the two out of each other. A roller 9944 is attached to the end of the second component 9934b to engage the engagement plate 9942. The engagement plate 9942 is positioned to be engaged by the secondary arm 9934 and compresses the spring located between the two secondary arm components 9934a, 9934b, at the as the secondary arm 9934 is rotated. A section 9940 of plate 9942 locks the mechanism in a position where the 9902 clamp arm is removed from the syringe (ie, a loading position) and the rotation of the clamp arm moves the secondary arm

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266/294 rio 9934 to section 9938 of the plate that transmits a rotational force on the arm (that is, to rotate the clamping arm 9902 to a clamping position). A loading position of the fixing arm 9902 is shown in figure 102A, and a fixing position of the fixing arm 9902 is shown in figure 102B.

[00804] In yet additional modalities, the secondary arm can be located laterally anywhere, while it is connected to the fixation arm. It can also be attached to the fixation arm at a point beyond the geometric axis of rotation. In the modalities described in this document, the location of the coupling plates and the angles of the fixation arm in the figures are only examples and can be oriented in any configuration, thus providing the same or substantially the same function, result, configuration or appearance .

[00805] Figures 103A to 103B show, yet, another embodiment of a force mechanism 9904d for use with the apparatus described in figures 99A to 99B or with similar apparatus. The 9904d mechanism includes a shaft 9950, a first cam component 9946, a second cam component 9948, a spring 9954 and a strut 9952. The shaft 9950 is pivotally connected to the clamping arm 9902 and shares its geometric axis of rotation. The first cam component 9946 is connected to the clamping arm 9902 and is arranged around the 9950 axis, while having the ability to pivot with the clamping arm 9902. The side of the first cam component 9946 facing the second cam component 9948 has a larger flat portion, a portion defined again from the flat portion and a portion that connects the two with a cone. The second cam component 9948 is positioned immediately next to the first cam component 9946, and reflects the shape of the first 9946 component that allows them to interlock uniformly

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267/294 to create a cylinder shape, as shown in figure 103B. The second cam component 9948 is retained in constant rotational alignment, but has the ability to move back and forth on the 9950 axis. The spring 9954 configured to urge the second cam component 9948 towards the first 9946 is arranged around of the axis 9950, between the second component 9948 and the strut 9952. a parked position is shown in figure 103A and an engaged position is shown in figure 103B.

[00806] Figures 104A to 104C show the different positions of the cam components 9946, 9948. Figure 104A is a retraction of the cam when the clamping arm 9902 (see figure 103B) is in a downward position. In this position, the second cam component 9948 is at its furthest point from the 9952 prop (see figure 103B). Figure 104B shows the meat 9946, 9948 when the clamping arm 9902 is rotated. The tapered portions of both meat 9946, 9948 slide along one another, forcing the second cam component 9948 out of the first portion of cam 9946 as the meat 9946, 9948 is rotated along axis 9950 (see figure 103B). The spring 9954 impels the second cam component 9948, towards the first 9946, causes them to slide back to the starting down position. This feature creates the rotational force that causes the 9902 fixation arm to push down on the syringe. Figure 104C shows the 9946, 9948 when the clamping arm 9902 is in the parked position. Once the 9902 clamping arm is rotated to the point where the tapered parts are no longer in contact, the flat surfaces will come into contact, resulting in the absence of rotational force caused by the 9954 spring, then the clamping arm 9902 will remain in place.

[00807] A sensor can be used to track a position or

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268/294 angle of clamping arm 9902. Sensor data can be used for multiple applications. A sensor position can be used to determine if the syringe is properly attached. This would be used in situations where the sensor already knew what type, or at least what size diameter the syringe is being used and at what angle the 9902 fixation arm or secondary arm should be when attached. The sensor can also be used to determine one or more characteristics of a syringe, for example, what size or even which specific syringe model is being used. By determining which syringe is being used, the pump can calculate the flow rate related to the displacement of the plunger. The data from a sensor in the mechanism that drives the syringe plunger can be used in conjunction with the clamping arm sensor data to determine the syringe model that is used. The sensor for determining a position of the 9902 fixing arm can be a Hall effect sensor.

[00808] Figure 105 shows a method 9960 for lateral loading of a syringe into an infusion pump, according to one embodiment of the present disclosure. The 9960 method includes an Act 9962, an Act 9964 of loading, an Act of 9966, an Act 9968 of capture and an Act of Processing 9970. Act 9962 of act involves acting a fixation arm in a loading position. Act 9962 can be performed by a pump operator. Once the securing arm has been lifted in the loading position, method 9960 moves to Act 9964.

[00809] Act 9964 loads a syringe onto a syringe holding platform (also referred to in this document as a syringe holding protrusion) located below a holding arm. For example, the flange on the syringe is inserted into a slot, or the barrel of the syringe is inserted into a drum groove. Once the syringe has been placed on the platform below the arm

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269/294 of fixation, method 9960 moves to Act 9966.

[00810] The Fixing Act 9966 fixes the fixing arm away from the loading position to engage the syringe with the force loaded on the fixing arm, causing the fixing arm to engage the syringe with the force loaded on it. Once the syringe has been attached, method 9960 can continue to Act 9968. Act 9968 pickup captures a position of the fixation arm. This can be done using a Hall effect sensor or a rotational pot. After Act 9968 of capture, method 9960 may implement the Act of Processing 9970.

[00811] Processing Act 9970 processes data from the position of the arm. A processor can use this data to determine what size of syringe is being used. Knowing the size of the syringe allows the pump to control fluid flow in relation to the plunger position. If the type of syringe is predefined, the sensor can alert the operator if the fixation arm is not in the correct position. If the fixation arm is not in the correct position, the syringe is not fixed properly.

[00812] Figure 106 shows a modality of a system to attenuate the lead screw eccentricity error, and figure 107 shows a flowchart of a method to attenuate the lead screw eccentricity error, according to a modality of present revelation. The lead thread eccentricity is a cyclic deviation from the assumed direction relationship between lead threads rotations and the change in distance of a device that is moved by the threading (for example, a half-nut assembly or a nut in the threading, etc.). This can be caused by the half-nut that changes the orientation, in relation to the threading, through a rotation, due to the forces acting on the mechanism. The lead screw error can be minimized by milling drive shafts and

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270/294 high precision half-nuts.

[00813] The 9120 system in figure 106 can implement the 9100 method in figure 107. The lead thread eccentricity can be mitigated by estimating the cyclical deviations caused by the eccentricity and compensating for the deviations by controlling the thread exit distance advance.

[00814] Figure 106 shows a modality of a 9120 system to attenuate the eccentricity error of the advance thread. This 9120 system includes a 9119 linear position sensor, a 9121 rotary position sensor, a 9123 processor and a 9125 controller. The 9121 rotary position sensor tracks the lead thread speed. An equation to determine the exit distance in centimeters (cm), based on the rotation data, is shown, as follows:

ΔΘ = rotational change of feed thread, in degrees β = Feed thread, per cm Outlet distance = * -.

Δθ B [00815] This equation for determining the actuated distance assumes that there is a direct relationship between the lead screw speeds and the exit distance. The eccentricity error is a cyclical deviation from the assumed linear output distance.

[00816] The 9119 linear position sensor is used to detect the eccentricity deviations by capturing the lead thread exit distance. In some embodiments of the present disclosure, an optical sensor, such as an optical mouse sensor, is attached to the half-nut described in this document, which is used to measure the displacement of the half-nut by examining the movement, as detected, against a surface of the syringe pump housing. In some embodiments, the optical sensor issues the change in position data in beads per inch (CPI). In some modalities

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271/294 des, the receiver is recalibrated by the 9123 processor to the current CPI, which is also referred to as normalization. Normalization is performed using the equation below:

Θ = Current Lead Thread Angle, in degrees

M = Optical Mouse Accounts

R = Rotating Distance, in millimeters (mm)

f = filter empirically revealed Mq ~ Mg_ ^ QO Inst CPIt = —---- 2.2 «. He ^- H „_io CPI, = f. (Inst CPI, - CPI,.,). [00817] This equation recalibrates the CPI every 10 degrees; meantime,

other recalibration fees can be used as well.

[00818] The magnitude and derivation of the signal can shift the phase

180 °, which results in normalization data that needs to be multiplied by -1. The magnitude can also be affected and the correction for this can be revealed empirically, by comparing the deviations with the use of a second more accurate distance measurement device.

[00819] The 9123 processor uses normalized distance data

to estimate a phase and an amplitude of the eccentricity deviations. The oscillations of the eccentricity deviation can occur in sync with each rotation of the feed thread. A low-pass filter can be applied to filter the sensor data and then store the data for a given lead thread angle at a value. An example of the algorithm used is:

Θ = Lead Thread Angle x = Sensor Data ω (θ) = Sinusoidal Sensor Data ω (θ) ι = 0.3 (%, - ¢ 0 (0) ^) + ωίθ) ^.

[00820] A data matrix is created using this algorithm that

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272/294 can be used for cross-correlation. Cross-correlation with a data matrix consisting of one or more rotations can be used to produce the phase and / or amplitude results. The matrix size can be the previous 4 rotations, in some modalities, which can consist of 1440 elements (360 degrees / rotation * 4 rotations).

[00821] Once the 9123 processor has created a matrix, it will correlate the data by comparison with a sine and cosine wave to determine the phase and amplitude of the data. The equation for correlating the two distinct functions by comparison is defined as follows:

(f * g) [n] = Em = -oo f * [n + m].

[00822] The equation used for this application is as follows:

l = length of the input matrix (f ★ β) = f \ ^l ~ m] 0 [m] m = 0 ★ sin = signal correlated by comparison with the sine wave ★ cos = signal correlated by comparison with the cosine wave a = Signal Amplitude φ = Phase Shift (X-inst ~ ★ sin ² + * cos ²

Win = atan2 (* cos, * sin).

[00823] In some embodiments, the phase shift may be constant along the path, while the amplitude may rise and fall as the half-nut assembly moves away from or near the end of the lead thread . The phase and amplitude estimates can be filtered by the 9123 processor to integrate this amplitude deviation using the following algorithm:

CCf CT ₍ i 0.0005 (cfy _- [^ inst)

Cinit T.

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273/294 c = ςρ - 4 '-'next c. = ςρ - ζ '-'means ^J ^ distant θ

Φ error Φΐ — 1 <Pinst

Φΐ Φΐ — 1 C <P _error

If ΙφβΓΓοΙ> 3, C Cdistant

Else If | <Perrol>1> C with _half

FIsp C = C '-'next· [00824] Upon completion of filtering, the 9123 processor uses

the amplitude and phase estimations to estimate the current error between the rotary position estimation and a current position of the lead screw mechanism. This is done using the following equation:

θι = Current Lead Thread Angle

Aj = Current Position Correction

Δΐ = aicos ^ i + 0 _f ) η = Position Based on Current Rotation x _t = Adjusted Target Position

Xi = n + Aj.

[00825] Once the error between the rotary position estimation and the actual output of the lead screw mechanism has been determined, this data is sent to the 9125 controller. The 9125 controller incorporates this data with the assumed direction relation between the lead screw speeds and lead screw outlet distance to increase output accuracy. This algorithm used to detect the phase and amplitude of the error can be used with any sensor input sufficient to detect, estimate and / or compensate the lead thread eccentricity.

[00826] Figure 107 shows a flow chart of a 9100 method to attenuate the eccentricity error of the advance thread, according to one embodiment of the present disclosure. The 9100 method includes a

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Rotation tracking act 9103, distance tracking act 9101, conversion act 9105, normalization act 9107, error creating act 9109, filtering act 9111, storage act 9113, act 9115 and a Control Act 9117.

[00827] Act 9103 of rotation tracking involves tracking the rotations of the threaded drive shaft of a lead screw mechanism using a rotary position sensor. A Hall effect sensor can be used as the rotating position sensor, as described in this document. Distance tracking act 9101 tracks the exit distance from the lead screw mechanism using a linear position sensor. An optical mouse sensor can be used for the linear position sensor; however, in some modalities, any sensor capable of tracking linear position can be used. In some modalities, acts 9101 and 9103 can occur simultaneously, in the direction of the stage or in any order or variation.

[00828] The Act 9105 converts the rotation data into the estimated output distance data of the lead screw mechanism. Method 9100 can proceed with Act 9107 when or after the rotation data has been converted.

[00829] Standardization Act 9107 normalizes distance sensor data to create a data set with reduced sensor deviation. The sensor can be recalibrated every ten degrees of advance thread rotation, by normalizing the data, in some specific modalities. The 9100 method can move to Act 9109 when or after the data has been normalized, in some modalities.

[00830] The Error Creation Act 9109 creates error data that compares the distance sensor data to the output of the rotation data.

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Filtering Act 9111 filters normalized data. Storage Act 9113 stores data as a value for each degree of rotation of the lead thread. Estimation Act 9115 uses the stored data as the value for each degree of rotation of the lead thread to determine the amplitude and phase of the error. The phase and amplitude estimation can be performed by correlating a sine and cosine wave with the data by comparison. The Pet Act 9115 can also be responsible for the position of the half nut on the lead thread and be responsible for a decrease in amplitude when the half nut approaches an end of the lead thread. Once the amplitude and phase of the error have been determined, the 9100 method moves to Act 9117.

[00831] Control Act 9117 controls the lead screw speeds with the estimated amplitude and phase deviations incorporated in the assumed direction relation between the lead screw speeds and the output.

[00832] Figures 108 to 111 show several views of an infusion pump with a modular power supply attached to it, according to one embodiment of the present disclosure. Figure 108 shows a side view of a pump with a modular power supply attached to the rear of the pump. Figure 109 shows a side view of a pump with an external power supply. Figure 110 shows a side view of a pump with a power supply attached to the bottom of the pump. Figure 111 shows a side view of a pump with a power supply attached to the top of the pump.

[00833] As shown in figures 108 to 111, the various modalities show an infusion pump 9202 with a power input module 9204, a power supply 9205 and an output adapter 9209. In some embodiments, the input module of

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276/294 energy 9204 is attached to a housing 9203 of an infusion pump 9202 and has a port configured to receive DC current to supply the pump 9202 with energy. The 9205 power supply has the ability to be removably attached to the 9204 power input module. The 9204 power input module can be an electrical connector that has conductive contacts. The 9205 power supply can be attached to a 9209 AC plug configured to receive an AC signal. The 9205 power supply may include an AC to DC conversion module, within the 9205 power supply, to convert the AC signal received via a 9207 power cable to a DC current. A 9211 non-DC connection supplies DC current to the 9204 power input module.

[00834] Figure 108 shows a mode that has the 9205 power supply attached to the rear of the 9202 pump, by the 9204 power input module. The 9204 power input module can hold the 9205 power supply in place. The 9205 power supply receives AC power through a 9207 power cord connected to the 9209 AC plug.

[00835] Figure 109 depicts a 9205 power supply mode in which a 9211 power cable connects the DC output socket of the 9205 power supply to the 9204 power input module. The 9202 pump can be configured to fix the 9205 power supply outside your 9203 housing.

[00836] Figure 110 shows a mode of pump 9202 that shows the power supply 9205 affixed to the bottom of pump 9202.

Figure 111 shows a mode in which the power supply

9205 is affixed to the top side of the 9202 pump.

[00837] Figure 112 shows a modality in which a power supply (hereinafter also referred to as a power source)

9205 which has a 9213 frame for wrapping the power cord

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9207 of figures 108 to 111. In some embodiments, a mechanism that automatically wraps the 9207 cable can be used.

[00838] Figure 113 shows an embodiment in which a 9219 power supply supplies power to multiple 9215 pumps, according to another embodiment of the present disclosure. That is, a single 9219 power supply can be configured to supply power (for example, DC power) to multiple 9215 pumps. In figure 113, power supply 9219 is attached to a pole 9221 on which the 9215 pumps are mounted. The 9219 power supply can have multiple 9217 power cables in electrical communication with the 9219 power supply power outlet plug that is connected to the 9218 power input modules of the 9215 pumps attached to pole 9221.

[00839] The 9205 power supply may also include a battery that is charged by the power supply and that has the capacity to power the pump when the power supply is not receiving AC power. In most cases, this battery will supplement a battery inside the 9203 housing pump. This could be used to extend the operating time of the 9202 pump, when no AC current is available, for example, when the patient is being moved to a different location . You can also allow the 9202 pump to have a smaller internal battery.

[00840] A 9202 pump can be attached to a support that powers the 9202 pump and allows the 9202 pump to communicate with other pumps in the support. When attached to the bracket, the 9202 pump will not need the 9205 power supply. The 9204 power input module can be designed, so the bracket and 9205 power supply connect in the same way, making the two interchangeable.

[00841] Figures 114A to 114J show several views of a con

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278/294 near a 9502 syringe pump, according to one embodiment of the present disclosure. Referring to Figure 114A, the syringe pump assembly 9502 is shown and includes a body 9580, a syringe holder 9514 and a plunger head assembly 9516. The plunger head assembly 9516 includes a plunger head 9581, a 9562 half-nut assembly and a 9561 plunger tube (refer to figure 124). A syringe (for example, see figure 114E for syringe 9518) can be placed on syringe holder 9514, which is attached by retaining member 9504 and a retaining clip 9506 (described below). A dial 9505 opens the pivotable jaw members 9508, 9510 and allows the plunger head assembly 9516 to move away from or towards the syringe holder 9514.

[00842] Referring now to figure 114B, a top view of the 9502 syringe pump assembly is shown, which provides a clean view of a 9512 sensor. The 9512 sensor can detect the presence or absence of a syringe seated inside the 9514 syringe holder. The 9512 sensor is coupled to one of the syringe pump processor to which the 9502 syringe pump assembly is attached, so that the processor can detect the presence or absence of a loaded syringe in the syringe holder 9514.

[00843] Figure 114C shows the syringe pump assembly 9502 in a configuration ready to receive a syringe inside the syringe holder 9514. That is, the retaining member 9504 is in an upward position and the dial 9505 is rotated in one open position, which is 90 degrees clockwise, from the closed position. The rotation of the dial 9505 also rotates the articulating jaw members 9508, 9510 apart from each other. Display 9505 can be held in the open position, as shown in figure 114C,

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279/294 by an internal mechanism (described below) that allows the user to stop applying torque to the 9505 display and remove his hand from the 9505 display, all while the 9505 display remains in the open position. This allows a user to easily load a syringe, optionally with the use of both hands, and slide the 9516 plunger head assembly, so that the 9508, 9510 articulating claw members can operatively engage the syringe flange. Retaining member 9504 is spring oriented towards the syringe holder 9514; however, when retaining member 9504 is in a fully open position, an internal mechanism can retain retaining member 9514 in an open position, without any required torque applied by a user.

[00844] Figure 114D shows the syringe pump assembly 9502 in a configuration where the retaining member 9504 is in a downward position and the dial 9505 is rotated in a closed position. The rotation of the dial 9505 also guides the articulating jaw members 9508, 9510, towards each other. The 9505 display can be held in the closed position, as shown in figure 114D, by an internal bias mechanism (described below) that allows the user to stop torqueing the 9505 display and remove his hand from the 9505 display, all while the display 9505 remains in the closed position. When dial 9505 is rotated away from the open position (see figure 114C) by a predetermined amount, towards the closed position, the 9516 piston head assembly is locked in position and cannot move freely in or out of the rest of the 9502 syringe pump assembly (described below).

[00845] Referring to Figures 114E to 115B, an overview of the loading operation of a 9518 syringe, on the 9502 syringe pump assembly, is illustrated. After the 9504 retaining member is in the

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280/294 open position (as shown in figure 114C), syringe 9518 can be placed on syringe holder 9514 and retaining member 9504 rotated on syringe 9518, as shown in figure 114E. The syringe 9518 can be retained by a retaining clip 9506 that secures a flange 9525 of a barrel 9523 of the syringe 9518 between the syringe holder 9514 and the retaining clip 9506.

[00846] When syringe 9518 is sufficiently placed in syringe holder 9514, syringe 9519 can trigger sensor 9512 when syringe 9518 is loaded into syringe holder 9514. Sensor 9512 is most easily seen in figure 114F. A processor can be attached to the 9512 sensor and is configured to receive this notification. In addition, a radial angle sensor (described below) can be coupled to the processor to measure the radial angle of the retaining member 9504 (refer again to figure 114E) to estimate the size of the 9518 syringe.

[00847] As shown in figure 114G, after syringe 9518 is placed inside syringe holder 9514, retaining member 9504 can be rotated towards the syringe and plunger head assembly 9516 can be moved towards syringe 9518 , until a force sensor 9520 contacts an end 9517 (which may be a flange) of a plunger 9519 of syringe 9518. Dial 9505 can be rotated causing the pivotable jaw members 9508, 9510 to rotate towards flange 9517 plunger 9519 of syringe 9518 and hold flange 9517 of plunger 9519 of syringe 9518, as shown in figure 114H. Figure 1141 shows this configuration from an aerial view.

[00848] Figure 114J shows a close view of the operation of retaining clip 9506 and sensor 9512 of the syringe pump assembly of figures 114A to 114J. As is easily seen in figure 114J, flange 9525 of barrel 9523 of syringe 9518 is arranged between

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281/294 the syringe holder 9514 and the retaining clip 9506. The resilience of the retaining clip 9506 can, through friction, lock the 9523 barrel of the 9518 syringe in place. Also shown is sensor 9512, which can be a sensor-type button that is operable on syringe holder 9514, when syringe 9518 is placed inside syringe holder 9514.

[00849] Figures 115A and 115B show two sides of retaining clip 9506. Retaining clip 9506 includes three holes 9521, so that retaining clip 9506 can be attached to syringe holder 9514. Retaining clip 9506 includes an internal recess 9522, for receiving smaller syringes, and an external recess 9524, for receiving larger syringes. It can be seen from figure 115B that retaining clip 9506 includes a support structure 9526 to provide additional resilience to apply greater forces to flange 9525 of barrel 9523 of syringe 9518 (see figure 114J).

[00850] As shown in figure 116A, sensor 9512 is easily visible, due to the fact that the syringe holder 9514 has been removed. Also shown in figure 116A is a bottom cover 9503 which is affixed to the bottom of the syringe holder 9514 to cover the sensor 9512 and optionally allow the retaining clip 9506 a place to be fixed. That is, the retaining clip 9506 can optionally be fixed to the bottom cover 9503, by means of fasteners 9527 (for example, screws), in some embodiments.

[00851] Figure 116B shows a side view of the syringe pump assembly 9502, with syringe holder 9514 and bottom cover 9503 removed. As is easily seen in figure 116B, sensor 9512 includes a plunger head 9507, a plunger shaft

9509, a 9511 spring and a 9513 sensor board. The sensor board

9513 includes a 9515 switch that has a 9526 paddle. The 9511 spring is

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282/294 coupled to the plunger shaft 9509 to orient the plunger shaft 9509 and plunger head 9507 towards the location on the syringe holder 9514, where a syringe 9518 can be placed (refer again to figure 114E).

[00852] When a syringe (for example, syringe 9518 of figure 114J) presses against plunger head 9507 of sensor 9512, plunger head 9507 retracts into syringe holder 9514 (see figure 114E for a view of the syringe holder 9514). Referring again to figure 116B, when a syringe presses against the sensor plunger head 9507, the plunger head 9507 moves the plunger shaft 9509. The plunger shaft 9509 is coupled to a spring 9511, so that the shaft piston 9509 can overcome the propensity of spring 9511 to engage switch 9515 of sensor plate 9513. That is, when the piston shaft 9509 is sufficiently acted against the propensity of spring 9511, the piston shaft 9509 presses against a 9526 paddle of a switch 9515 on the sensor board 9513 (refer to figure 116C). Fig. 116C shows a close view of the interaction of plunger shaft 9509 and blade 9526 of switch 9515. When switch 9515 detects movement by a predetermined amount, sensor plate 9513 provides a signal from sensor 9512 to the processor to notify it that a 9518 syringe was loaded onto the 9514 syringe holder (as shown in figure 114E).

[00853] Referring again to figure 116C, although the switch

9515 can be a separate switch (for example, only two separate states), in some embodiments, switch 9515 provides an analog position of paddle 9526 for sensor plate 9513, which is supplied to the processor as the signal from sensor 9512.

[00854] Figures 117A to 117C show various views of syringe holder 9514 of syringe pump assembly 9502 shown

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283/294 in figures 114A to 114J, according to an embodiment of the present disclosure. As is easily seen in figure 117A, syringe holder 9514 includes a hole 9528 for sensor 9512 (for example, see figure 114A). The syringe holder 9514 also includes a surface 9532 that has several wedge-shaped surfaces that approach an end 9533 of surface 9532. Surface 9532 slopes downward as it approaches end 9533. Figure 117B shows the head positioned at the end with the 9532 inclined surface.

[00855] Referring to figure 117C, the syringe holder 9514 also includes a surface 9530 having holes 9531, in which the screws 9527 of the retaining clip 9506 can be used to secure the retaining clip 9506 to it. A hole 9529 is also visible in figure 117C, in which retaining member 9504 (see figure 114A) can be partially positioned therein.

[00856] Figures 118A to 118B show various views of the syringe pump assembly 9502 shown in figures 114A to 114J, with syringe holder 9514 removed, in accordance with an embodiment of the present disclosure. Figures 118A to 118B will now be described in relation to the 9518 syringe diameter estimation.

[00857] As shown in figure 118A, the retaining member 9504 is in a fully open position. Retaining member 9504 is coupled to a 9535 shaft. An O-ring helps to seal the internal parts of the 9502 syringe pump assembly that prevents contamination through bore 9529 (see figure 117a). As shown in figure 118A, a fixed cam 9536 is positioned at the distal end of the axis 9534, while a movable cam 9537 is positioned at the proximal end of the axis 9534. A spring 9535 guides the movable cam 9537 out of the fixed cam 9536.

[00858] The retaining member 9504 is coupled to the 9534 axis, in

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284/294 so that the rotation of the retaining member 9504 also rotates the axis 9534. A rotating cam 9545 is also coupled to the 9534 axis. The rotating cam 9545 rotates as the retaining member 9504 is actuated (for example, rotated between open and closed positions). When the retaining member 9504 is in the fully open position, the rotating cam 9545 and the movable cam 9537 can engage with each other, so that the retaining member 9504 remains in the fully open position, even when a user hand is removed from the holding member 9504 (that is, holding member 9504 is in a resident position). That is, the rotating cam 9545 and the movable cam 9537 can engage with each other with opposite surfaces that are perpendicular to a geometric axis defined by axis 9534.

[00859] As the retaining member 9504 is rotated, the rotating cam 9545 rotates so that the movable cam 9537 and the rotating cam 9545 engage with each other, by means of opposite surfaces that are not perpendicular to a geometric axis defined by the axis 9534. This causes the force of the spring 9535 to translate from the movable cam 9537 to the rotating cam 9545, so that the rotating cam 9545 rotates, thus rotating the retaining member 9504 towards its closed position. That is, the 9535 spring, finally, can cause a rotational bias force on the retaining member, while the retaining member 9504 is not in the resident position. Figure 118B shows the holding member 9504 in the holding position, for example, when the holding member is rotated towards any loaded syringe. Guide rods 9538 prevent movable cam 9537 from rotating with shaft 9534, or due to spring 9535, and guide movable cam 9537 away from and toward attached cam 9536. A loaded syringe 9518 on syringe holder 9514 can stop the retaining member 9504 from turning completely to the closed position

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285/294 (see figure 114E). Figure 118B shows the retaining member 9504 fully rotated to the closed position.

[00860] A 9539 gear is also attached to the 9534 shaft and rotates with it. The 9539 gear engages a 9543 gear assembly. The 9543 gear assembly can increase or decrease the gear to rotate a 9540 magnet. A 9542 sensor plate includes a 9541 Hall effect sensor (for example, a rotary encoder) that can determine the rotational angle of the magnet 9540 and then determines the position of the retaining member 9504. The sensor plate 9542 can transmit a signal encoding the position of the retaining member 9504 to the processor where the processor correlates the position of the limb position retainer 9504 with a barrel diameter 9523 of the syringe (refer to figure 114E).

[00861] Figures 119A to 119B show various views of the syringe pump assembly shown in figures 114A to 114J to illustrate the action of the claw member 9508, 9510 to hold a 9517 flange of a syringe plunger 9517 (for example , syringe 9518, as shown in figure 114E), according to an embodiment of the present disclosure. Figure 119A shows the pivotable claw members 9508, 9510 in an open position, and figure 119B shows the pivotable claw members 9508, 9510 that hold the flange 9517 of the plunger 9519. As is easily seen in figure 119A, ramps 9546 are used, so that as the pivotable claw members 9508, 9510 hold onto the flange 9517 of the plunger 9519 (as in figure 119B), flange 9517 is held against the plunger head assembly 9516 (see figure 114A) more more fixedly.

[00862] Figure 120 shows the plunger head of the 9516 plunger head assembly (from the syringe pump assembly shown in figures 114A to 114J) with the cover removed to illustrate the mechanical rotation effects of the 9505 display, according to an

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286/294 modality of the present disclosure. As shown in figure 120, dial 9505 is coupled to a 9547 shaft, a cam 9548 and a stem actuator 9554. A spring 9557 is operatively coupled to shaft 9547 to orient dial 9505 and the shaft to rotate toward a position closed (as shown in figure 120).

[00863] A 9553 gear is operatively coupled to a 9559 potentiometer. Potentiometer 9559 is coupled to a 9558 circuit board that is configured to provide the processor with the rotational position of gear 9553 (described below). Refer now to Figures 121A to 121C, where circuit board 9558 and potentiometer 9559 have been removed to assist in viewing the internal parts of 9516 piston head assembly. That is, figures 121A through 121C show various views of the plunger head with the cover and a circuit board removed to illustrate the mechanical rotation effects of the dial, in accordance with an embodiment of the present disclosure;

[00864] As shown in figure 121 A, the display 9505 is coupled to the cam 9548, so that rotation of the display 9505 in an open position causes the cam 9548 to rotate, so that the swing arm 9549 rotates as a cam follower 9550 of swing arm 9549 engages with cam 9548. Swing arm 9549 is coupled to a gear 9552. A gear 9553 is attached to gear 9552 which is attached to swing arm 9549. Gear 9552 and swing arm 9549 they are coupled to a spring 9551, so that the swing arm 9549 is oriented so that the cam follower 9550 is oriented towards the cam 9548. Figure 121B shows the configuration in which the display 9505 is in the fully open position. It is observed that the swing arm 9549 rotated from its position in figure 121 A, and it is also observed that gear 9553 rotated by a corresponding amount. Referin

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287/294 now referring to figures 114C and 121B, gear 9552 is coupled to articulating claw member 9510 and gear 9553 is coupled to articulating claw member 9508. Figure 121B and figure 114C show the configuration in that the 9505 dial has been turned to the open position.

[00865] When dial 9505 has rotated to a fully open position, cam 9548 engages a holder 9560 of cam 9548. Figure 121C shows a close view to illustrate holder 9560. As is easily seen in figure 121C, the follower cam 9550 can fit on holder 9560, which holds dial 9505 in a residence position. That is, although a user may remove their hand from the 9505 display, the 9505 display remains in the fully open position, as shown in figure 121C. In some embodiments, the 9557 spring does not provide enough torque on the 9547 shaft to overcome the 9560 holder without user assistance. [00866] When the dial 9505 is rotated from the open position, as in figure 121B, back to the closed position, the articulating claw members 9508, 9510 will rotate towards a 9517 flange of a 9519 plunger of a 9518 syringe (see 114G and 114H). However, the articulating claw members 9508, 9510 will stop rotating towards each other when they contact flange 9517 of plunger 9519, as shown in figure 114H. Referring again to figures 121A to 121B, this will cause the cam follower 9550 to leave the cam 9548, due to the fact that the surface of the cam 9548 will continue to move out of the cam follower 9550. The swing arm 9549 has no ability to rotate further, due to the fact that it is coupled to the claw member 9510 (see figure 114H), whose movement is limited by flange 9517 of plunger 9519 of syringe 9518. The position of the articulating claw members 9508, 9510 can be determined by one or more

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288/294 potentiometers 9559 and communicated to a processor. The processor can use this position to estimate a 9518 syringe size characteristic.

[00867] Figures 122A to 122B show two views of a cam 9548 (for example, a dial shaft cam) that can, for example, be used within the plunger head assembly 9516 of the syringe pump assembly 9502 shown in figures 114A to 114J, according to an embodiment of the present disclosure. Holder 9560 is easily seen in figures 121A to 121B.

[00868] Figures 123A to 123B show two views close to the internal cavity of the plunger head assembly of the syringe pump assembly shown in figures 114A to 114J, according to an embodiment of the present disclosure. As the 9547 shaft is rotated, the 9554 stem actuator rotates. When dial 9505 (see figure 120) is close to the fully open position, stem actuator 9554 engages link 9555 to extract stem 9556, as shown in figure 123B. The 9556 stem is spring oriented in the 9516 plunger head assembly.

[00869] Figure 124 shows the plunger head assembly 9516 of the syringe pump assembly shown in figures 114A to 114J, according to an embodiment of the present disclosure. As seen in figure 124, the plunger head assembly 9516 includes a half-nut assembly 9562 that has a linear cam 9566 coupled to stem 9556. A plunger tube 9561 connects to half-nut assembly 9562 with the rest of the plunger head 9516. Plunger tube 9561 shown in figure 124 is removed in figures 125A to 125B showing a 9563 guide rod. As is easily seen in figures 125A to 125B, guide 9563 guides rod 9556. Observe a spring 9564 is attached to a collar 9565 to guide stem 9556 towards the half nut assembly 9562.

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289/294 Figures 126A to 1261 show several additional views of the syringe pump assembly 9502 of figures 114A to 114J, according to an embodiment of the present disclosure. Referring to figure 126A, the half-nut assembly 9562 is easily visible, due to the fact that the syringe holder 9514 (see figure 114A) is removed and a cover of the syringe pump assembly 9502 is also removed.

[00871] The 9562 half nut assembly can be coupled to the 9572 lead thread, so that the rotation of the 9572 lead thread acts linearly on the 9562 half nut assembly. The 9562 half nut assembly includes a 9575 linear bearing that can travel on a 9574 trail. As the 9562 half nut assembly travels, a 9578 sensor engages with a 9579 linear resistor to form a linear potentiometer, which is used to estimate the linear position of the 9562 half nut assembly , which is communicated to the processor to estimate the fluid discharge from a syringe (for example, syringe 9518 in figure 114E).

[00872] The half-nut assembly 9562 also includes a linear cam 9566 coupled to stem 9556 (see also figure 124), the first and second half-nut arms 9567, 9568 and a pivot pin 9569. When the linear cam 9566 moves towards the first ends 9576 of the first and second half-nut arms 9567, 9568, the first and second half-nut arms 9567, 9568 pivot along the pivot pin 9569, so that the second ends 9577 of the first and second half-nut arms 9567, 9568 engage with the lead thread. Each of the second ends 9577 of the first and second half nut arm 9567, 9568 includes threads to engage with the 9572 lead thread. A spacer 9571 ensures that the distance between the first and second end 9577 of the first and second half arm -nut

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9567, 9568, so that they are sufficiently spaced apart, so that the half-nut assembly 9562 fully engages the lead thread 9572.

[00873] Figure 126B shows a side view, in perspective, of the 9502 syringe pump assembly. Note that the first and second half-nut arms 9567, 9568, include internal threads to engage with the 9572 lead thread A 9573 bearing is attached to the 9572 lead thread to allow it to turn. Fig. 126C shows the plunger head assembly 9516 with the cover of the half-nut assembly 9562 outside. It can be seen that a spring 9570 opens the first ends 9577 of the first half-nut arms 9567, 9568, out of the lead thread 9572. Figure 126D shows an angled view, in perspective, to illustrate how the first ends 9576 of the first and second half nut arm 9567, 9568, engage with linear cam 9566. Figure 126E shows a side view of half nut assembly 9562. Linear cam 9566 is in a stowed position, which occurs when dial 9505 is in a fully open position. Note that stem 9556 is retracted by a 9564 spring (see figure 125B). Fig. 126F shows that the linear cam 9566 is in an engaged position. As shown in figure 126G, the linear cam surface 9566 acted on the first ends 9576 of the half-nut arms 9567, 9568. When in that position, the linear cam surface 9566 engages with the first ends 9576 of half-nut arms 9567, 9568, as if a force was applied to open the first ends 9576 of half-nut arms 9567, 9568, out of each other, no force translation will be experienced by the rod 9556. That is, the linear cam surface 9566 engages with the first ends 9576 of half-nut arms 9567, 9568, so that the contacting surfaces are parallel

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291/294 to each other and parallel to a geometric axis of the rod 9556. Figures 126H and 1261 show two views in which the half nut assembly 9562 is fully engaged with the lead thread 9572, in which the rotation of the lead thread 9572 linear actuation of the 9562 half-nut assembly (and then the entire 9516 plunger head assembly in relation to the 9502 syringe pump assembly).

[00874] Figure 127 shows a side view, in perspective, of the 9601 syringe pump assembly attached to a 9690 monitor. It is observed that the 9601 syringe pump assembly is shown and includes a 9680 body, a syringe holder 9614 and a 9616 plunger head assembly. The 9616 plunger head assembly includes a 9681 plunger head, a 9562 half-nut assembly (refer to figure 114A) and a 9661 plunger tube. example, see figure 114E for syringe 9518) can be placed on syringe holder 9614, which is attached by retaining member 9604 and a retaining clip 9606. A dial 9605 opens the articulating claw members 9508, 9510 (refer to Fig. 114A) and allows the plunger head assembly 9616 to move outward or towards the syringe holder 9614. Monitor 9690 includes a screen 9691, a power button 9692, an alarm silence button 9693 and a 9694 menu button. Pump 9601 is configured to display a plurality of monitors on screen 9691, related to pump operation and patient data.

[00875] Figure 128 shows a flow chart of a 9302 method for discharging fluid from a syringe and for providing mitigation for an obstruction condition, according to one embodiment of the present disclosure. The 9302 method can be implanted by a syringe pump, such as the syringe pump shown in figure 127. The acts can be implanted by or with the use of one or more processesPetition 870160077500, from 12/20/2016, p. 308/484

292/294 pain in a syringe pump.

[00876] Method 9302 will be described, as it is implanted by the syringe pump shown in figure 127; however, such a description should not be construed as limiting. Method 9302 can be implanted in any pump that discharges fluid, for example, any syringe pump described in this document. Method 9302 includes acts 9304 to 9316. Act 9304 loads a syringe into a syringe pump. For example, a syringe can be loaded onto the 9614 syringe holder. Act 9306 determines the diameter of a syringe barrel. The syringe barrel diameter drum can be determined by the position of the 9604 holding finger. Act 9308 acts on the syringe using the syringe pump. The 9616 plunger head assembly can actuate a syringe plunger. Act 9310 estimates the fluid pressure inside the syringe barrel. Does Act 9312 make a decision based on whether the pressure inside the syringe barrel is below a predetermined limit? If the decision is yes, then acts 9308 to 9312 can continue, to achieve a target flow rate until a discharged dose of target fluid is reached.

[00877] If the decision is not in Act 9312, in Act 9314: the syringe pump retracts the syringe plunger from the syringe barrel by a predetermined amount (which can be an actuation distance or an actuation volume of the syringe. Act 9316, the syringe pump acts on the plunger in the barrel, until the fluid pressure inside the syringe barrel exceeds another predetermined limit.One or more processors may sound an alarm or alert that notifies a health professional of the obstruction.

[00878] Various alternatives and modifications can be planned by people versed in the technique, without departing from the revelation. Consequently, the present disclosure is intended to encompass all the

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293/294 such alternatives, modifications and variations. Additionally, although various modalities of the present disclosure have been shown in the drawings and / or discussed in this document, the disclosure is not intended to be limited to them, as the disclosure is intended to be as broad in scope as the technique will allow and that the specification be read in the same way. Therefore, the above description should not be interpreted as limiting, but merely as exemplifications of particular modalities. And, people skilled in the art will foresee other changes within the scope and spirit of the claims attached to it. Other elements, steps, methods and techniques that are substantially different from those described above and / or in the appended claims are also intended to be within the scope of the disclosure.

[00879] The modalities shown in the drawings are presented only to demonstrate certain examples of the disclosure. And, the drawings described are illustrative only and are not limiting. In the drawings, for illustrative purposes, the size of some of the elements may be exaggerated and not plotted on a particular scale. Additionally, the elements shown within the drawings that have the same numbers can be identical elements or they can be similar elements, depending on the context.

[00880] Where the term it comprises is used in the present description and claims, other elements or steps are not excluded. Where a definite or indefinite article is used, when referring to a singular noun, for example, one, one, or the, they include a plural of that noun, unless something is otherwise stated specifically. So, the term you understand should not be interpreted as being restricted to the items listed from then on; other elements or steps are not excluded, and, therefore, the scope of the expression a device comprising items A and B

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294/294 should not be limited to devices consisting only of components A and B. This expression means that, in relation to the present disclosure, the only relevant components of the device are A and B.

[00881] Additionally, the terms first, second, third and the like, if used in the description or in the claims, are provided to distinguish between similar elements and not necessarily to describe a sequential or chronological order. It should be understood that the terms then used are interchangeable under appropriate circumstances (unless clearly disclosed otherwise) and that the disclosure modalities described in this document are capable of operation in other sequences and / or arrangements that are described or illustrated in this document.

Claims (20)

1. Syringe pump to deliver an agent to a patient, where the syringe pump is characterized by the fact that it comprises: an accommodation; a lead thread; a sliding block assembly, wherein said sliding block assembly comprises a threaded section configured to engage and disengage the lead thread; a plunger head assembly coupled to said sliding and operative block for driving a syringe plunger inside a barrel of said syringe; a gripping means configured to hold any of a range of plunger flange sizes, wherein said means is gripping to any of a range of plunger flange sizes comprising at least one first flange gripper piston and a second piston flange gripper, wherein the first and second piston flange grippers are configured to be actuated from a first position to a position in which at least one point of each between the first and the second piston flange grips are in contact with an edge of the piston flange which forces the piston flange against the piston head assembly and acts as an anti-siphon mechanism. 2. Syringe pump, according to claim 1, characterized by the fact that the means configured to hold any one of a range of piston flange sizes comprises; a cam; at least one cam follower; at least one propensity member, where the member Petition 870160077500, of 12/20/2016, p. 312/484 2/5 propensity propose said means configured to hold any one of a range of piston flange sizes towards a first position; and wherein the movement of at least one cam follower along the cam overcomes the bias member and allows the configured means to secure any of a range of piston flange sizes to move towards a second position. 3. Syringe pump according to claim 2, characterized by the fact that the cam, at least one cam follower and at least one bias member are coupled to a rotary axis, wherein said cam is not rotatable with said axis, however, is displaceable along an axial dimension of said axis, wherein said at least one cam follower is fixedly coupled to said axis and rotatable with said axis, and in which the rotation of said axis causes the movement of at least one cam follower along said cam, thereby displacing the cam along the axial dimension of said axis. 4. Syringe pump according to claim 2, characterized by the fact that the propensity member automatically returns the medium configured to hold any range of piston flange sizes in the first position in the absence of sufficient force to overcome the member of propensity. 5. Syringe pump according to claim 2, characterized by the fact that the cam comprises at least one holder, each of which at least one holder is reached by one of at least one cam follower when the configured medium to attach any range of piston flange sizes has been allowed to move to the second position. 6. Syringe pump, according to claim 1, caPetition 870160077500, from 12/20/2016, p. 313/484 3/5 characterized by the fact that the plunger head assembly additionally comprises a pressure sensor to monitor the pressure of the agent that is dispensed from the syringe. 7. Syringe pump according to claim 6, characterized in that the syringe plunger flange is held against the pressure sensor by the means configured to secure any range of plunger flange sizes. Syringe pump according to claim 1, wherein the syringe pump is characterized by the fact that it additionally comprises a barrel flange clamp, wherein said barrel flange clamp is configured to retain a flange of syringe barrel. Syringe pump according to claim 8, characterized in that the drum flange clamp comprises a means of detecting the presence of a drum flange, wherein said means of detecting the presence of a drum flange The drum comprises an optical sensor and a light source, wherein said light source is obscured in the presence of said drum flange. 10. Syringe pump to administer an agent to a patient, in which the syringe pump is characterized by the fact that it comprises; an accommodation; a lead thread; a sliding block assembly, wherein said sliding block assembly comprises a threaded section configured for engagement and disengagement with said lead thread and movable along said lead thread; a plunger head assembly coupled to said sliding and operative block assembly for driving a syringe plunger inside a barrel of said syringe; Petition 870160077500, of 12/20/2016, p. 314/484 4/5 a gripping means configured to hold any of a range of piston flange sizes; a means of monitoring the gripping means, wherein the gripping means monitoring means is capable of generating data to determine at least one characteristic of the attached syringe. 11. Syringe pump, according to claim 10, characterized by the fact that the means of monitoring the gripping means is a potentiometer. 12. Syringe pump, according to claim 10, characterized by the fact that the data generated by the means of monitoring the gripping means are evaluated through the reference of said data against a database. 13. Syringe pump, according to claim 10, characterized by the fact that the data generated by the means of monitoring the gripping means are evaluated through the reference of said data against a database and the data generated by at least one another sensor. 14. Syringe pump, according to claim 10, characterized by the fact that the gripping means comprises; a cam; at least one cam follower; at least one bias member, wherein said bias member tends said means of grasping towards a first position; and wherein the movement of at least one cam follower along the cam overcomes the bias member and allows the gripping means to move towards a second position. 15. Syringe pump, according to claim 14, characterized by the fact that the cam, at least one follower of Petition 870160077500, of 12/20/2016, p. 315/484 5/5 cam and at least one biasing member are coupled to a rotating axis, wherein said cam is rotatable with said axis, however, it is displaceable along an axial dimension of said axis, where said at least a cam follower is fixedly coupled to said axis and rotatable with said axis, and the rotation of said axis causes the movement of at least one cam follower along said cam to move the cam along the axial dimension of said axis. 16. Syringe pump according to claim 14, characterized by the fact that the biasing member automatically returns the gripping means to the first position in the absence of sufficient force to overcome the biasing member. 17. Syringe pump according to claim 14, characterized by the fact that the cam comprises at least one holder, each of said at least one holder being reached by one of at least one cam follower when the means to stop hold any range of piston flange sizes allowed to be moved to the second position. 18. Syringe pump according to claim 10, characterized in that the piston head assembly additionally comprises a pressure sensor to monitor the pressure of the agent that is dispensed from the syringe. 19. Syringe pump according to claim 18, characterized in that a syringe plunger flange is held against the pressure sensor by the gripping means. 20. Syringe pump according to claim 19, characterized in that the drum flange clamp comprises a means of detecting the presence of a drum flange, wherein said means of detecting the presence of said drum flange The drum comprises an optical sensor and a light source, wherein said light source is obscured in the presence of said drum flange.