BR112023025408A2 - Vetor de dna linear fechado adequado para uso como um vetor de transferência lentiviral, e, método para melhorar o título infeccioso de partículas lentivirais quando o vetor de transferência é um vetor de dna linear fechado - Google Patents
Vetor de dna linear fechado adequado para uso como um vetor de transferência lentiviral, e, método para melhorar o título infeccioso de partículas lentivirais quando o vetor de transferência é um vetor de dna linear fechadoInfo
- Publication number
- BR112023025408A2 BR112023025408A2 BR112023025408A BR112023025408A BR112023025408A2 BR 112023025408 A2 BR112023025408 A2 BR 112023025408A2 BR 112023025408 A BR112023025408 A BR 112023025408A BR 112023025408 A BR112023025408 A BR 112023025408A BR 112023025408 A2 BR112023025408 A2 BR 112023025408A2
- Authority
- BR
- Brazil
- Prior art keywords
- vector
- linear dna
- closed linear
- lentiviral
- lentiviral particles
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 14
- 239000002245 particle Substances 0.000 title abstract 6
- 208000015181 infectious disease Diseases 0.000 title abstract 4
- 230000002458 infectious effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 108700019146 Transgenes Proteins 0.000 abstract 2
- 238000010276 construction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15061—Methods of inactivation or attenuation
- C12N2740/15062—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/50—Vectors for producing vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Control Of Eletrric Generators (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Detail Structures Of Washing Machines And Dryers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2108176.5A GB202108176D0 (en) | 2021-06-08 | 2021-06-08 | Vector |
| GBGB2207077.5A GB202207077D0 (en) | 2022-05-14 | 2022-05-14 | Vector |
| PCT/GB2022/051437 WO2022258967A1 (en) | 2021-06-08 | 2022-06-08 | Lentiviral vector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023025408A2 true BR112023025408A2 (pt) | 2024-02-27 |
Family
ID=82067426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023025408A BR112023025408A2 (pt) | 2021-06-08 | 2022-06-08 | Vetor de dna linear fechado adequado para uso como um vetor de transferência lentiviral, e, método para melhorar o título infeccioso de partículas lentivirais quando o vetor de transferência é um vetor de dna linear fechado |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250122528A1 (https=) |
| EP (1) | EP4352238A1 (https=) |
| JP (1) | JP2024520797A (https=) |
| KR (1) | KR20240024807A (https=) |
| AU (1) | AU2022289260A1 (https=) |
| BR (1) | BR112023025408A2 (https=) |
| CA (1) | CA3222751A1 (https=) |
| IL (1) | IL308705A (https=) |
| MX (1) | MX2023014228A (https=) |
| WO (1) | WO2022258967A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025076341A1 (en) * | 2023-10-05 | 2025-04-10 | Janssen Biotech, Inc. | Improved methods in lentiviral manufacturing for production of car-t cell drug products |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| FR2722506B1 (fr) | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
| GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| GB201502645D0 (en) | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| DK3500682T3 (da) | 2016-08-16 | 2020-08-24 | Touchlight Ip Ltd | Fremstilling af lukket, lineært dna |
| KR20190089988A (ko) * | 2016-12-06 | 2019-07-31 | 블루버드 바이오, 인코포레이티드. | I형 점액다당류증에 대한 유전자 요법 |
-
2022
- 2022-06-08 US US18/567,499 patent/US20250122528A1/en active Pending
- 2022-06-08 AU AU2022289260A patent/AU2022289260A1/en active Pending
- 2022-06-08 CA CA3222751A patent/CA3222751A1/en active Pending
- 2022-06-08 EP EP22730967.1A patent/EP4352238A1/en active Pending
- 2022-06-08 WO PCT/GB2022/051437 patent/WO2022258967A1/en not_active Ceased
- 2022-06-08 KR KR1020237042463A patent/KR20240024807A/ko active Pending
- 2022-06-08 BR BR112023025408A patent/BR112023025408A2/pt unknown
- 2022-06-08 MX MX2023014228A patent/MX2023014228A/es unknown
- 2022-06-08 JP JP2023575790A patent/JP2024520797A/ja active Pending
- 2022-06-08 IL IL308705A patent/IL308705A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023014228A (es) | 2024-01-25 |
| WO2022258967A1 (en) | 2022-12-15 |
| JP2024520797A (ja) | 2024-05-24 |
| IL308705A (en) | 2024-01-01 |
| CA3222751A1 (en) | 2022-12-15 |
| KR20240024807A (ko) | 2024-02-26 |
| AU2022289260A1 (en) | 2023-12-07 |
| EP4352238A1 (en) | 2024-04-17 |
| WO2022258967A9 (en) | 2023-03-02 |
| WO2022258967A8 (en) | 2023-11-23 |
| US20250122528A1 (en) | 2025-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20210022A1 (ar) | بنيات جسم مضاد لـ cldn18.2وcd3 | |
| BR112023025408A2 (pt) | Vetor de dna linear fechado adequado para uso como um vetor de transferência lentiviral, e, método para melhorar o título infeccioso de partículas lentivirais quando o vetor de transferência é um vetor de dna linear fechado | |
| BR112013009583A2 (pt) | ácido nucleico, vetor, célula hospedeira, métodos de preparação de uma linhagem bacteriana variante de tipificação, de marcação, de geração e de controle de populações bacterianas, linhagem e célula bacteriana variante, kit, uso de um ácido nucleico, cultivo celular, produto, processo de preparação de produtos, mutantes de fago e mutante de escape de fago | |
| ECSP14004893A (es) | Moléculas de unión para bcma y cd3 | |
| BR112017012910A2 (pt) | proteína de fusão que compreende três domínios de ligação a 5t4 e cd3 | |
| BR112016002743A2 (pt) | novo anticorpo de receptor de tslp anti-humana | |
| CL2016001256A1 (es) | Composiciones y métodos para anticuerpos dirigidos factor de p (divisional de sol. n° 1640-14). | |
| BR112018077375A2 (pt) | kits, moléculas de anticorpo biespecífico trivalente, composição farmacêutica, vetor de expressão, célula hospedeira e método para a produção de uma molécula de anticorpo biespecífico trivalente | |
| BR112018001042A2 (pt) | construtos de anticorpo para flt3 e cd3 | |
| PE20151920A1 (es) | Moleculas de union para bcma y cd3 | |
| BR112016026337A2 (pt) | formato biespecífico adequado para o uso na triagem de alto rendimento | |
| MX2014007256A (es) | Metodo rapido para la clonacion y expresion de segmentos genicos consanguineos de regiones variables de anticuerpos. | |
| CO2021013699A2 (es) | Líneas celulares productoras diseñadas genéticamente y métodos de elaboración y uso de las mismas | |
| BR112013017370A2 (pt) | massa de chocolate com um teor de massa de cacau e um teor de açúcares adicionados, uso de uma massa de chocolate e produtos de chocolate fabricados a partir de uma massa de chocolate | |
| PH12023552784A1 (en) | Anti-CD122 Antibodies And Uses Thereof | |
| PL439808A1 (pl) | Sposoby i kompozycje hodowli komórkowych do produkcji przeciwciał | |
| BR112023008629A2 (pt) | Construtos de polipeptídeos que se ligam seletivamente a cldn6 e cd3 | |
| BRPI0909267B8 (pt) | composição farmacêutica e processo para a preparação de uma composição farmacêutica | |
| BR112012019534A2 (pt) | composição, métodos para preparar uma composição, e para selecionar anticorpos, e, kit | |
| BR112018000690A2 (pt) | micro-organismo recombinante, e, métodos para preparar um micro-organismo de metabolização de xilose e para produzir óleo. | |
| BR112016016586A2 (pt) | Polipeptídeo de citocromo p450 com atividade enzimática aumentada | |
| NZ735485A (en) | Method for obtaining high-yield, stable-expression cell clones and antibody molecules obtained thereby | |
| BR112018006542A2 (pt) | ?vetor, mistura de vetores e kit? | |
| Xu et al. | Growth-promoting effect and triptolide production regulation of endophytic bacteria from Tripterygium wilfordii | |
| Wong et al. | Engraftment and SDF-1/CXCR4 Signaling in Human CD34+ Hematopoietic Stem/Progenitor Cells Are Regulated By R4 Rgs Subfamily Proteins |