BR112023022788A2 - Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1 - Google Patents
Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1Info
- Publication number
- BR112023022788A2 BR112023022788A2 BR112023022788A BR112023022788A BR112023022788A2 BR 112023022788 A2 BR112023022788 A2 BR 112023022788A2 BR 112023022788 A BR112023022788 A BR 112023022788A BR 112023022788 A BR112023022788 A BR 112023022788A BR 112023022788 A2 BR112023022788 A2 BR 112023022788A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- drug
- drug conjugate
- cancer
- pharmaceutical composition
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 7
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 DRUG-LINKER Substances 0.000 title 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 title 1
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 title 1
- 102100039614 Nuclear receptor ROR-alpha Human genes 0.000 title 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 239000012625 DNA intercalator Substances 0.000 abstract 1
- 229940122277 RNA polymerase inhibitor Drugs 0.000 abstract 1
- 229940125644 antibody drug Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002147 killing effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 201000005249 lung adenocarcinoma Diseases 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 1
Classifications
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Mycology (AREA)
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1. são providos no presente pedido de patente um conjugado anticorpo-fármaco e um método de preparação do mesmo e seu uso. o conjugado anticorpo-fármaco tem uma estrutura representada pela fórmula ab-[m-l-e-d]x, e o fármaco é selecionado a partir de um agente anti-tubulina, um intercalador de dna, um inibidor de topoisomerase de dna e um inibidor de polimerase de rna. o conjugado anticorpo-fármaco preparado tem uma melhor relação anticorpo-fármaco e tem um bom efeito de morte direcionado no câncer de cólon e câncer de pulmão de células não pequenas (por exemplo, adenocarcinoma de pulmão).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN202110615214 | 2021-06-02 | ||
CN202110941134 | 2021-08-16 | ||
PCT/CN2022/094559 WO2022253035A1 (zh) | 2021-06-02 | 2022-05-23 | 抗体药物偶联物及其制备方法和用途 |
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BR112023022788A2 true BR112023022788A2 (pt) | 2024-01-02 |
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BR112023022788A BR112023022788A2 (pt) | 2021-06-02 | 2022-05-23 | Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1 |
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US (1) | US20240269312A1 (pt) |
EP (1) | EP4349372A1 (pt) |
JP (1) | JP2024521629A (pt) |
KR (1) | KR20240016249A (pt) |
CN (1) | CN117500527A (pt) |
AU (1) | AU2022287001A1 (pt) |
BR (1) | BR112023022788A2 (pt) |
CA (1) | CA3218527A1 (pt) |
MX (1) | MX2023012920A (pt) |
WO (1) | WO2022253035A1 (pt) |
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MX2024008640A (es) * | 2022-01-12 | 2024-07-24 | Regeneron Pharmaceuticals Inc | Analogos de camptotecina conjugados a un residuo de glutamina en una proteina y su uso. |
WO2023216956A1 (zh) | 2022-05-13 | 2023-11-16 | 四川科伦博泰生物医药股份有限公司 | 喜树碱类化合物及其制备方法和应用 |
WO2024109840A1 (zh) * | 2022-11-22 | 2024-05-30 | 康诺亚生物医药科技(成都)有限公司 | 稠环类化合物及其偶联物和用途 |
WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
WO2024179564A1 (zh) * | 2023-03-01 | 2024-09-06 | 江苏恒瑞医药股份有限公司 | 一种茚并[1,2-b]喹啉-10,13-二酮衍生物的制备方法 |
WO2024179561A1 (en) * | 2023-03-02 | 2024-09-06 | Multitude Therapeutics Inc. | Antibody-drug conjugates, pharmaceutical compositions and uses thereof |
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EP3252076B1 (en) | 2011-01-14 | 2019-09-04 | The Regents Of The University Of California | Diagnostic use of antibodies against ror-1 protein |
CN105263962B (zh) * | 2013-03-19 | 2019-12-31 | 北京盛诺基医药科技股份有限公司 | 抗体及用于治疗与雌激素受体相关疾病的方法 |
MX2019015057A (es) | 2017-06-23 | 2020-08-03 | Velosbio Inc | Inmunoconjugados de anticuerpos receptor huérfano similar al receptor tirosina cinasa 1 (ror1). |
CA3080236A1 (en) * | 2017-12-15 | 2019-06-20 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive molecule conjugate, preparation method and use thereof |
CN110903395A (zh) * | 2018-09-14 | 2020-03-24 | 四川科伦博泰生物医药股份有限公司 | 抗体、偶联物及其制备方法和用途 |
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CN117500527A (zh) | 2024-02-02 |
MX2023012920A (es) | 2023-11-13 |
EP4349372A1 (en) | 2024-04-10 |
WO2022253035A1 (zh) | 2022-12-08 |
AU2022287001A1 (en) | 2023-10-26 |
KR20240016249A (ko) | 2024-02-06 |
CA3218527A1 (en) | 2022-12-08 |
JP2024521629A (ja) | 2024-06-04 |
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