BR112023022788A2 - Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1 - Google Patents

Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1

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Publication number
BR112023022788A2
BR112023022788A2 BR112023022788A BR112023022788A BR112023022788A2 BR 112023022788 A2 BR112023022788 A2 BR 112023022788A2 BR 112023022788 A BR112023022788 A BR 112023022788A BR 112023022788 A BR112023022788 A BR 112023022788A BR 112023022788 A2 BR112023022788 A2 BR 112023022788A2
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BR
Brazil
Prior art keywords
antibody
drug
drug conjugate
cancer
pharmaceutical composition
Prior art date
Application number
BR112023022788A
Other languages
English (en)
Inventor
Bingqiang Kang
Bo Wang
Deliang Li
Fen Li
Haijun Tian
Hanwen Deng
Hongmei Song
Jian Ye
Jiangjiang Hu
Jingyi Wang
Junyou Ge
Qiang Tian
Xiaobei Wang
Xiaoxi Yuan
Ying-Hua Chang
Yitao Zhang
Yong Zheng
Yu Miao
Zujian Tang
Original Assignee
Klus Pharma Inc
Sichuan Kelun Biotech Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klus Pharma Inc, Sichuan Kelun Biotech Biopharmaceutical Co Ltd filed Critical Klus Pharma Inc
Publication of BR112023022788A2 publication Critical patent/BR112023022788A2/pt

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Abstract

conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1. são providos no presente pedido de patente um conjugado anticorpo-fármaco e um método de preparação do mesmo e seu uso. o conjugado anticorpo-fármaco tem uma estrutura representada pela fórmula ab-[m-l-e-d]x, e o fármaco é selecionado a partir de um agente anti-tubulina, um intercalador de dna, um inibidor de topoisomerase de dna e um inibidor de polimerase de rna. o conjugado anticorpo-fármaco preparado tem uma melhor relação anticorpo-fármaco e tem um bom efeito de morte direcionado no câncer de cólon e câncer de pulmão de células não pequenas (por exemplo, adenocarcinoma de pulmão).
BR112023022788A 2021-06-02 2022-05-23 Conjugado anticorpo-fármaco, fármaco-ligante, composição farmacêutica, uso do conjugado anticorpo-fármaco e método para tratar um câncer com alta expressão de ror1 BR112023022788A2 (pt)

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CN202110615214 2021-06-02
CN202110941134 2021-08-16
PCT/CN2022/094559 WO2022253035A1 (zh) 2021-06-02 2022-05-23 抗体药物偶联物及其制备方法和用途

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BR112023022788A2 true BR112023022788A2 (pt) 2024-01-02

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WO2023216956A1 (zh) 2022-05-13 2023-11-16 四川科伦博泰生物医药股份有限公司 喜树碱类化合物及其制备方法和应用
WO2024109840A1 (zh) * 2022-11-22 2024-05-30 康诺亚生物医药科技（成都）有限公司 稠环类化合物及其偶联物和用途
WO2024114318A1 (zh) * 2022-11-29 2024-06-06 四川科伦博泰生物医药股份有限公司 药物连接子化合物及其制备方法和用途
WO2024179564A1 (zh) * 2023-03-01 2024-09-06 江苏恒瑞医药股份有限公司 一种茚并[1,2-b]喹啉-10,13-二酮衍生物的制备方法
WO2024179561A1 (en) * 2023-03-02 2024-09-06 Multitude Therapeutics Inc. Antibody-drug conjugates, pharmaceutical compositions and uses thereof

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EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
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