BR112023005807A2 - Sistema de liberação de polímero biodegradável para liberação prolongada de testosterona - Google Patents

Sistema de liberação de polímero biodegradável para liberação prolongada de testosterona

Info

Publication number
BR112023005807A2
BR112023005807A2 BR112023005807A BR112023005807A BR112023005807A2 BR 112023005807 A2 BR112023005807 A2 BR 112023005807A2 BR 112023005807 A BR112023005807 A BR 112023005807A BR 112023005807 A BR112023005807 A BR 112023005807A BR 112023005807 A2 BR112023005807 A2 BR 112023005807A2
Authority
BR
Brazil
Prior art keywords
release
testosterone
prolonged
biodegradable polymer
release system
Prior art date
Application number
BR112023005807A
Other languages
English (en)
Inventor
Van Hove Amy
Janagam Dileep
Fieldson Gregory
Original Assignee
Tolmar International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tolmar International Ltd filed Critical Tolmar International Ltd
Publication of BR112023005807A2 publication Critical patent/BR112023005807A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SISTEMA DE LIBERAÇÃO DE POLÍMERO BIODEGRADÁVEL PARA LIBERAÇÃO PROLONGADA DE TESTOSTERONA. A presente invenção refere-se a composições poliméricas de poli(lactídeo-co-glicolídeo) (PLG) biodegradáveis que são administradas dentro do corpo com seringas ou agulhas e que são utilizadas para liberar uma testosterona dentro do corpo durante um período de tempo prolongado.
BR112023005807A 2020-09-30 2021-09-24 Sistema de liberação de polímero biodegradável para liberação prolongada de testosterona BR112023005807A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063085868P 2020-09-30 2020-09-30
PCT/IB2021/058743 WO2022070010A1 (en) 2020-09-30 2021-09-24 Biodegradable polymer delivery system for extended delivery of testosterone

Publications (1)

Publication Number Publication Date
BR112023005807A2 true BR112023005807A2 (pt) 2023-05-02

Family

ID=78179467

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023005807A BR112023005807A2 (pt) 2020-09-30 2021-09-24 Sistema de liberação de polímero biodegradável para liberação prolongada de testosterona

Country Status (12)

Country Link
US (1) US20240000797A1 (pt)
EP (1) EP4221684A1 (pt)
JP (1) JP2023544311A (pt)
KR (1) KR20230079071A (pt)
CN (1) CN116528876A (pt)
AR (1) AR123663A1 (pt)
AU (1) AU2021351927A1 (pt)
BR (1) BR112023005807A2 (pt)
CA (1) CA3197318A1 (pt)
MX (1) MX2023003800A (pt)
TW (1) TW202228707A (pt)
WO (1) WO2022070010A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3708916A1 (de) 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
DE19701912C1 (de) * 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
WO2002012369A1 (fr) 2000-08-07 2002-02-14 Wako Pure Chemical Industries, Ltd. Polymere d'acide lactique et son procede de preparation
ES2755374T3 (es) 2007-02-15 2020-04-22 Tolmar Therapeutics Inc Poli(lactida/glicolida) de descarga lenta y métodos para producir polímeros
US20220040201A1 (en) * 2018-09-25 2022-02-10 Tolmar International, Ltd. Liquid polymer delivery system for extended administration of drugs

Also Published As

Publication number Publication date
AU2021351927A9 (en) 2024-09-26
AR123663A1 (es) 2022-12-28
CN116528876A (zh) 2023-08-01
TW202228707A (zh) 2022-08-01
JP2023544311A (ja) 2023-10-23
MX2023003800A (es) 2023-04-13
AU2021351927A1 (en) 2023-05-11
US20240000797A1 (en) 2024-01-04
WO2022070010A1 (en) 2022-04-07
KR20230079071A (ko) 2023-06-05
CA3197318A1 (en) 2022-04-07
EP4221684A1 (en) 2023-08-09

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