BR112023001842A2 - Fibras proteicas bacterianas - Google Patents

Fibras proteicas bacterianas

Info

Publication number
BR112023001842A2
BR112023001842A2 BR112023001842A BR112023001842A BR112023001842A2 BR 112023001842 A2 BR112023001842 A2 BR 112023001842A2 BR 112023001842 A BR112023001842 A BR 112023001842A BR 112023001842 A BR112023001842 A BR 112023001842A BR 112023001842 A2 BR112023001842 A2 BR 112023001842A2
Authority
BR
Brazil
Prior art keywords
fibers
protein
proteins
bacterial
multimers
Prior art date
Application number
BR112023001842A
Other languages
English (en)
Inventor
REMAUT Han
Sleutel Mike
Aspholm Marina
Pradhan Brajabandhu
Original Assignee
Vib Vzw
Univ Brussel Vrije
Norwegian Univ Of Life Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vib Vzw, Univ Brussel Vrije, Norwegian Univ Of Life Sciences filed Critical Vib Vzw
Publication of BR112023001842A2 publication Critical patent/BR112023001842A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Artificial Filaments (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

FIBRAS PROTEICAS BACTERIANAS. A presente invenção refere-se ao campo de apêndices de endósporos de Bacillus (Ena) e montagens multiméricas e fibrosas de proteínas para aplicações como bionanomateriais. Em particular, a invenção refere-se às proteínas de automontagem compostas por subunidades de proteínas contendo domínio DUF3992 bacteriano, contendo uma região conservada contendo cisteína N-terminal e proteínas projetadas, bem como multímeros e fibras dos mesmos. Além disso, a expressão recombinante das referidas subunidades de proteína de automontagem fornece métodos de produção de novas nanofibras de proteína e superfícies de exibição modificadas, tais como esporos de Bacillus. Finalmente, o uso dos referidos multímeros, fibras e superfícies em aplicações biomédicas e biotecnológicas é descrito aqui.
BR112023001842A 2020-08-07 2021-08-06 Fibras proteicas bacterianas BR112023001842A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20189961 2020-08-07
PCT/EP2021/072085 WO2022029325A2 (en) 2020-08-07 2021-08-06 Novel bacterial protein fibers

Publications (1)

Publication Number Publication Date
BR112023001842A2 true BR112023001842A2 (pt) 2023-02-23

Family

ID=71995804

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023001842A BR112023001842A2 (pt) 2020-08-07 2021-08-06 Fibras proteicas bacterianas

Country Status (8)

Country Link
US (1) US20230279059A1 (pt)
EP (1) EP4192846A2 (pt)
JP (1) JP2023537054A (pt)
KR (1) KR20230112606A (pt)
CN (1) CN116323645A (pt)
BR (1) BR112023001842A2 (pt)
CA (1) CA3189751A1 (pt)
WO (1) WO2022029325A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114480207B (zh) * 2022-02-22 2023-09-22 青岛蔚蓝赛德生物科技有限公司 一种太平洋芽孢杆菌及其降解污废水中硫化物的应用
WO2024079161A1 (en) 2022-10-12 2024-04-18 Vib Vzw Metal-binding bacterial protein fibers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2802351A1 (en) * 2010-06-17 2011-12-22 Research Development Foundation Clostridium taeniosporum spores and spore appendages as surface display hosts, drug delivery devices, and nanobiotechnological structures

Also Published As

Publication number Publication date
US20230279059A1 (en) 2023-09-07
CN116323645A (zh) 2023-06-23
EP4192846A2 (en) 2023-06-14
WO2022029325A2 (en) 2022-02-10
CA3189751A1 (en) 2022-02-10
JP2023537054A (ja) 2023-08-30
KR20230112606A (ko) 2023-07-27
WO2022029325A3 (en) 2022-03-31

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