BR112022022764A2 - Composições de polipeptídeo de fusão de il-2 e métodos para fazer e usar as mesmas - Google Patents
Composições de polipeptídeo de fusão de il-2 e métodos para fazer e usar as mesmasInfo
- Publication number
- BR112022022764A2 BR112022022764A2 BR112022022764A BR112022022764A BR112022022764A2 BR 112022022764 A2 BR112022022764 A2 BR 112022022764A2 BR 112022022764 A BR112022022764 A BR 112022022764A BR 112022022764 A BR112022022764 A BR 112022022764A BR 112022022764 A2 BR112022022764 A2 BR 112022022764A2
- Authority
- BR
- Brazil
- Prior art keywords
- making
- methods
- fusion polypeptide
- polypeptide compositions
- compositions
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 230000004927 fusion Effects 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063022853P | 2020-05-11 | 2020-05-11 | |
| PCT/US2021/031611 WO2021231316A1 (en) | 2020-05-11 | 2021-05-10 | Il-2 fusion polypeptide compositions and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022022764A2 true BR112022022764A2 (pt) | 2023-01-17 |
Family
ID=78524918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022022764A BR112022022764A2 (pt) | 2020-05-11 | 2021-05-10 | Composições de polipeptídeo de fusão de il-2 e métodos para fazer e usar as mesmas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210371486A1 (enExample) |
| EP (1) | EP4149515A4 (enExample) |
| JP (1) | JP2023525565A (enExample) |
| KR (1) | KR20230009446A (enExample) |
| CN (1) | CN115916242A (enExample) |
| AU (1) | AU2021270745A1 (enExample) |
| BR (1) | BR112022022764A2 (enExample) |
| CA (1) | CA3172871A1 (enExample) |
| IL (1) | IL298065A (enExample) |
| MX (1) | MX2022014164A (enExample) |
| TW (1) | TW202207970A (enExample) |
| WO (1) | WO2021231316A1 (enExample) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1292686C (en) * | 1986-10-27 | 1991-12-03 | Ze'ev Shaked | Pharmaceutical compositions of recombinant interleukin-2 and formulation process |
| SK11142002A3 (sk) * | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
| CN1816356A (zh) * | 2003-05-14 | 2006-08-09 | 免疫原公司 | 药物缀合物组合物 |
| JP2006137678A (ja) * | 2004-11-10 | 2006-06-01 | Shionogi & Co Ltd | インターロイキン−２組成物 |
| US9156897B2 (en) * | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| US10016415B2 (en) * | 2014-08-18 | 2018-07-10 | Alkermes Pharma Ireland Limited | Aripiprazole prodrug compositions |
| AU2015364396B2 (en) * | 2014-12-19 | 2018-08-09 | Alkermes, Inc. | Single chain Fc fusion proteins |
| WO2019019998A1 (zh) * | 2017-07-25 | 2019-01-31 | 江苏恒瑞医药股份有限公司 | 一种il-15蛋白复合物药物组合物及其用途 |
| US20210038684A1 (en) * | 2019-06-11 | 2021-02-11 | Alkermes Pharma Ireland Limited | Compositions and Methods for Cancer Immunotherapy |
| BR112022007158A2 (pt) * | 2019-10-18 | 2022-07-05 | Alkermes Pharma Ireland Ltd | Agentes imunomodulatórios de il-2 em combinação com inibidores do ponto de verificação imunológico |
| EP4093755A4 (en) * | 2020-01-24 | 2024-07-31 | Alkermes Pharma Ireland Limited | PURIFICATION PROCESSES |
-
2021
- 2021-05-10 KR KR1020227043013A patent/KR20230009446A/ko not_active Withdrawn
- 2021-05-10 CA CA3172871A patent/CA3172871A1/en active Pending
- 2021-05-10 JP JP2022568912A patent/JP2023525565A/ja active Pending
- 2021-05-10 CN CN202180042991.8A patent/CN115916242A/zh active Pending
- 2021-05-10 EP EP21804863.5A patent/EP4149515A4/en not_active Withdrawn
- 2021-05-10 IL IL298065A patent/IL298065A/en unknown
- 2021-05-10 WO PCT/US2021/031611 patent/WO2021231316A1/en not_active Ceased
- 2021-05-10 MX MX2022014164A patent/MX2022014164A/es unknown
- 2021-05-10 BR BR112022022764A patent/BR112022022764A2/pt not_active Application Discontinuation
- 2021-05-10 US US17/315,973 patent/US20210371486A1/en not_active Abandoned
- 2021-05-10 AU AU2021270745A patent/AU2021270745A1/en not_active Abandoned
- 2021-05-11 TW TW110116903A patent/TW202207970A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230009446A (ko) | 2023-01-17 |
| CA3172871A1 (en) | 2021-11-18 |
| CN115916242A (zh) | 2023-04-04 |
| EP4149515A4 (en) | 2023-12-06 |
| JP2023525565A (ja) | 2023-06-16 |
| IL298065A (en) | 2023-01-01 |
| MX2022014164A (es) | 2023-02-22 |
| TW202207970A (zh) | 2022-03-01 |
| AU2021270745A1 (en) | 2022-12-15 |
| WO2021231316A1 (en) | 2021-11-18 |
| US20210371486A1 (en) | 2021-12-02 |
| EP4149515A1 (en) | 2023-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR115024A1 (es) | PROTEÍNAS DE FUSIÓN INTERLEUCINA-2 / RECEPTOR a DE INTERLEUCINA-2 Y MÉTODOS DE USO | |
| CL2021001779A1 (es) | Polipéptidos que comprenden polipéptidos con il-2 modificada y usos de los mismos | |
| AR114445A1 (es) | Conjugados de il-15, y sus usos | |
| AR122863A1 (es) | Polipéptidos que comprenden polipéptidos con il-2 modificada y usos de los mismos | |
| MX2023005068A (es) | Variantes de interleucina-18 y métodos de uso. | |
| CY1122494T1 (el) | Πρωτεϊνες συντηξης οι οποιες περιλαμβανουν μια πρωτεϊνη δεσμευσης και ενα πολυπεπτιδιο ιντερλευκινης-15 το οποιο εχει μια μειωμενη συγγενεια για il15ra και θεραπευτικες χρησεις αυτων | |
| MX2021009259A (es) | Conjugados de il-2 y metodos de uso del mismo. | |
| CL2017000284A1 (es) | Proteínas de fusión de interleucina 2/receptor de interleucina-2 alfa y métodos de uso | |
| ES2723774T3 (es) | Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal | |
| PH12022550326A1 (en) | Interleukin-2 muteins for the expansion of t-regulatory cells | |
| EP4460512A4 (en) | NEW INTERLEUKIN-2 POLYPEPTIDES | |
| MX2024003535A (es) | Proteina mutante de interleucina-2 y fusion de la misma. | |
| MX2021005759A (es) | Plataformas, productos y metodos para la expresion en endosporas. | |
| MX2022014082A (es) | Secuencias de interleucina (il-2) y usos de las mismas. | |
| AR121713A1 (es) | Nuevos análogos de il-2 inmunoestimulantes | |
| BR112018013071A2 (pt) | uso de derivados de triptofano para formulações de proteínas | |
| WO2021188374A3 (en) | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides | |
| CO2022008004A2 (es) | Polipéptidos xten con código de barras y composiciones de estos, y métodos para preparar y usar los mismos | |
| BR112021022755A2 (pt) | Sequências de alvos para plataforma de visualização de endosporos à base de paenibacillus | |
| BR112022022764A2 (pt) | Composições de polipeptídeo de fusão de il-2 e métodos para fazer e usar as mesmas | |
| CO2023000048A2 (es) | Conjugados de citoquina | |
| BR112022020937A2 (pt) | Composições cosméticas compreendendo seda de aranha dragon sintética. | |
| MX2023011262A (es) | Composiciones que comprenden polipeptidos de fusion nkg2d, cxcr2 y dap10/dap12 y metodos de uso de los mismos. | |
| BR112022022869A2 (pt) | Composições de polipeptídeo de fusão de il-2 e métodos de fabricação e uso destas | |
| PE20180162A1 (es) | Polipeptidos dirigidos a la fusion de vih |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |