BR112022022003A2 - Método para aprimorar imunogenicidade de antígeno de proteína/peptídeo - Google Patents

Método para aprimorar imunogenicidade de antígeno de proteína/peptídeo

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Publication number
BR112022022003A2
BR112022022003A2 BR112022022003A BR112022022003A BR112022022003A2 BR 112022022003 A2 BR112022022003 A2 BR 112022022003A2 BR 112022022003 A BR112022022003 A BR 112022022003A BR 112022022003 A BR112022022003 A BR 112022022003A BR 112022022003 A2 BR112022022003 A2 BR 112022022003A2
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Brazil
Prior art keywords
peptide antigen
protein
immunogenicity
enhance protein
antigen
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BR112022022003A
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English (en)
Inventor
Xie Liangzhi
Zhang Yanjing
Zhang Jiandong
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Sinocelltech Ltd
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Publication date
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Publication of BR112022022003A2 publication Critical patent/BR112022022003A2/pt

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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
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    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

MÉTODO PARA APRIMORAR IMUNOGENICIDADE DE ANTÍGENO DE PROTEÍNA/PEPTÍDEO. Trata-se de um método para aprimorar a imunogenicidade de um antígeno de proteína/peptídeo, em que o método compreende conjugar um antígeno de proteína/peptídeo com um açúcar para formar um conjugado de antígeno de glicoproteína/peptídeo, que aprimorou a imunogenicidade em comparação com um antígeno de proteína/peptídeo não conjugado. Em particular, o método envolve conjugar um patógeno, tal como um antígeno de proteína de superfície viral ou um fragmento do mesmo, com um polissacarídeo, em particular um polissacarídeo capsular de Streptococcus pneumoniae. O conjugado com imunogenicidade aprimorada pode ser usado para prevenir ou tratar doenças causadas por patógenos, em particular doenças causadas por coronavírus.
BR112022022003A 2020-05-01 2021-04-29 Método para aprimorar imunogenicidade de antígeno de proteína/peptídeo BR112022022003A2 (pt)

Applications Claiming Priority (2)

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CN202010369100 2020-05-01
PCT/CN2021/090809 WO2021219047A1 (zh) 2020-05-01 2021-04-29 一种增强蛋白/肽抗原免疫原性的方法

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BR112022022003A BR112022022003A2 (pt) 2020-05-01 2021-04-29 Método para aprimorar imunogenicidade de antígeno de proteína/peptídeo

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US (1) US20230330220A1 (pt)
EP (1) EP4144365A1 (pt)
JP (1) JP2023526780A (pt)
KR (1) KR20230005313A (pt)
CN (1) CN115484977A (pt)
AU (1) AU2021262999A1 (pt)
BR (1) BR112022022003A2 (pt)
CA (1) CA3176745A1 (pt)
MX (1) MX2022013456A (pt)
WO (1) WO2021219047A1 (pt)

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NL2023863B1 (en) * 2019-09-20 2021-05-25 Univ Griffith Protein particles and uses thereof
CN114699521B (zh) * 2022-06-07 2023-02-24 中国人民解放军军事科学院军事医学研究院 基于金属硫蛋白家族的免疫佐剂及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192540A (en) 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
JP2002513028A (ja) * 1998-04-28 2002-05-08 ガレニカ ファーマシューティカルズ， インコーポレイテッド ポリサッカリド抗原結合体
AU2004220590B2 (en) 2003-03-07 2010-02-18 Inhibitex, Inc. Polysaccharide - Staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
NZ567164A (en) 2005-10-18 2012-06-29 Novavax Inc Functional influenza virus like particles (VLPS)
WO2013022808A2 (en) * 2011-08-05 2013-02-14 The University Of Chicago Immunogenic protein conjugates and methods for making and using the same
CN106075428A (zh) * 2015-07-01 2016-11-09 北京科兴中维生物技术有限公司 一种免疫原性组合物及其制备方法
EP3347042A4 (en) * 2015-09-10 2019-02-20 Inventprise, LLC. MULTIVALENT CONJUGATES WITH VIRUSUAL PARTICLES
JP2020500007A (ja) 2016-10-13 2020-01-09 マサチューセッツ インスティテュート オブ テクノロジー ジカウイルスエンベロープタンパク質に結合する抗体およびその使用
CN108619502A (zh) * 2017-03-22 2018-10-09 武汉博沃生物科技有限公司 一种基于重组载体蛋白的季节流感-rsv-流脑联合疫苗
CA3061709A1 (en) * 2017-03-28 2018-10-04 The Children's Medical Center Corporation A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
GB201802339D0 (en) * 2018-02-13 2018-03-28 Glaxosmithkline Biologicals Sa Immunogenic composition

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US20230330220A1 (en) 2023-10-19
AU2021262999A1 (en) 2023-01-19
WO2021219047A1 (zh) 2021-11-04
MX2022013456A (es) 2022-11-16
CA3176745A1 (en) 2021-11-04
EP4144365A1 (en) 2023-03-08
JP2023526780A (ja) 2023-06-23
CN115484977A (zh) 2022-12-16
KR20230005313A (ko) 2023-01-09

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