BR112022021931A2 - Métodos de tratamento do mieloma múltiplo com uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente cd38 - Google Patents

Métodos de tratamento do mieloma múltiplo com uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente cd38

Info

Publication number
BR112022021931A2
BR112022021931A2 BR112022021931A BR112022021931A BR112022021931A2 BR 112022021931 A2 BR112022021931 A2 BR 112022021931A2 BR 112022021931 A BR112022021931 A BR 112022021931A BR 112022021931 A BR112022021931 A BR 112022021931A BR 112022021931 A2 BR112022021931 A2 BR 112022021931A2
Authority
BR
Brazil
Prior art keywords
carfilzomib
dexamethasone
antibody
methods
multiple myeloma
Prior art date
Application number
BR112022021931A
Other languages
English (en)
Inventor
Klippel Zandra
Original Assignee
Onyx Pharma Inc
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Pharma Inc, Janssen Biotech Inc filed Critical Onyx Pharma Inc
Publication of BR112022021931A2 publication Critical patent/BR112022021931A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MÉTODOS DE TRATAMENTO DO MIELOMA MÚLTIPLO COM UMA TERAPIA TRIPLA DE CARFILZOMIBE, DEXAMETASONA E UM ANTICORPO QUE RECONHECE ESPECIFICAMENTE CD38. A presente invenção se refere a métodos de tratamento de um indivíduo que sofre de mieloma múltiplo pela administração de uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente CD38.
BR112022021931A 2020-04-29 2021-04-29 Métodos de tratamento do mieloma múltiplo com uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente cd38 BR112022021931A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063017336P 2020-04-29 2020-04-29
PCT/US2021/029830 WO2021222524A1 (en) 2020-04-29 2021-04-29 Methods of treating multiple myeloma with a triplet therapy of carfilzomib, dexamethasone, and an antibody that specifically recognizes cd38.

Publications (1)

Publication Number Publication Date
BR112022021931A2 true BR112022021931A2 (pt) 2023-02-14

Family

ID=76217902

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022021931A BR112022021931A2 (pt) 2020-04-29 2021-04-29 Métodos de tratamento do mieloma múltiplo com uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente cd38

Country Status (4)

Country Link
US (1) US20210338766A1 (pt)
EP (1) EP4143232A1 (pt)
BR (1) BR112022021931A2 (pt)
WO (1) WO2021222524A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9603927B2 (en) * 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US10781261B2 (en) * 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
CN108472369A (zh) * 2015-11-03 2018-08-31 詹森生物科技公司 抗cd38抗体的皮下制剂及其用途
US20180117150A1 (en) * 2016-11-01 2018-05-03 Janssen Biotech, Inc. Combination Therapies for CD38-Positive Hematological Malignances with ANTI-CD38 Antibodies and Cyclophosphamide
MA50514A (fr) * 2017-10-31 2020-09-09 Janssen Biotech Inc Méthodes de traitement du myélome multiple à haut risque

Also Published As

Publication number Publication date
EP4143232A1 (en) 2023-03-08
WO2021222524A1 (en) 2021-11-04
US20210338766A1 (en) 2021-11-04

Similar Documents

Publication Publication Date Title
EP4302835A3 (en) Methods of treating ovarian cancer
BR112021020409A2 (pt) Terapia de combinação com anticorpo anti-bcma e inibidor de gama-secretase
WO2018022668A3 (en) NEUROMODULATORY COMPOSITIONS AND ASSOCIATED METHODS OF TREATING CANCER
MX2022013163A (es) Anticuerpo contra nectin-4 y aplicacion del mismo.
BR112018014222A2 (pt) método de tratamento da glomerulopatia c3
BR112021019135A2 (pt) Anticorpo anticlaudina 18.2 e aplicação do mesmo
EA202090510A1 (ru) Способ лечения бокового амиотрофического склероза придопидином
MX2022007968A (es) Dosificacion de gamma-hidroxibutirato (ghb).
NZ767902A (en) Methods of treating ulcerative colitis
MX2021000847A (es) Procedimientos para el tratamiento del cancer con el inhibidor de pi3k, gdc 0077.
EP4345110A3 (en) Methods for treating severe atopic dermatitis by administering an il-4r inhibitor
PH12020552059A1 (en) Dosing regimen for the treatment of pi3k related disorders
MX2017014396A (es) Tratamiento de mieloma multiple.
BR112018003836A2 (pt) combinações de inibidor de btk para tratar mieloma múltiplo
MX2023008193A (es) Procedimientos para tratar el cáncer.
MX2021007330A (es) Composiciones y métodos terapéuticos para tratar cáncer usando ácido 6, 8-bis-benciltio-octanoico y un inhibidor de autofagia.
MX2023001296A (es) Composiciones y metodos para tratar enfermedades y trastornos.
MX2022013557A (es) Tratamiento combinado con anticuerpo anti-cd40 contra el cáncer.
BR112022003659A2 (pt) Composições e métodos de tratamento de doenças vasculares
EA202193276A1 (ru) Способы лечения холангиокарциномы
MX2023005591A (es) Metodos de tratamiento de enfermedades y trastornos.
MX2022004910A (es) Metodos de tratamiento de los sintomas del trastorno del espectro autista.
BR112022021931A2 (pt) Métodos de tratamento do mieloma múltiplo com uma terapia tripla de carfilzomibe, dexametasona e um anticorpo que reconhece especificamente cd38
PH12020551331A1 (en) Treatment and prevention of pre-eclampsia
BR112018002763A2 (pt) método para cicatrização de ferimentos