BR112022020731A2 - Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos - Google Patents

Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos

Info

Publication number
BR112022020731A2
BR112022020731A2 BR112022020731A BR112022020731A BR112022020731A2 BR 112022020731 A2 BR112022020731 A2 BR 112022020731A2 BR 112022020731 A BR112022020731 A BR 112022020731A BR 112022020731 A BR112022020731 A BR 112022020731A BR 112022020731 A2 BR112022020731 A2 BR 112022020731A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
histone deacetylase
inhibitors
derivative compounds
oxadiazole derivative
Prior art date
Application number
BR112022020731A
Other languages
English (en)
Inventor
Kon Lee Chang
Sung Ko Moo
Hyoun Yun Seok
Michael Kim Hyunjin
Original Assignee
Chong Kun Dang Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Pharmaceutical Corp filed Critical Chong Kun Dang Pharmaceutical Corp
Publication of BR112022020731A2 publication Critical patent/BR112022020731A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS DE DERIVADO DE 1,3,4-OXADIAZOL COMO INIBIDOR DE HISTONA DESACETILASE 6 E A COMPOSIÇÃO FARMACÊUTICA QUE COMPREENDE OS MESMOS. A presente invenção se refere a um composto inovador que tem atividade inibidora de histona deacetilase 6 (HDAC6), um isômero óptico do mesmo ou um sal farmaceuticamente aceitável do mesmo, o uso do mesmo para preparar um medicamento terapêutico, uma composição farmacêutica que contém o mesmo e um método de tratamento que usa a composição e um método de preparação da mesma. O composto inovador, o isômero óptico do mesmo ou sal farmaceuticamente aceitável do mesmo de acordo com a presente invenção tem a atividade inibitória de HDAC6, que é eficaz na prevenção ou tratamento de doenças mediadas por HDAC6, incluindo câncer, doenças inflamatórias, doenças autoimunes, neurológicas ou doenças neurodegenerativas.
BR112022020731A 2020-04-13 2021-04-12 Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos BR112022020731A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200044730A KR102576148B1 (ko) 2020-04-13 2020-04-13 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
PCT/KR2021/004544 WO2021210857A1 (en) 2020-04-13 2021-04-12 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
BR112022020731A2 true BR112022020731A2 (pt) 2022-11-29

Family

ID=78084333

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022020731A BR112022020731A2 (pt) 2020-04-13 2021-04-12 Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos

Country Status (11)

Country Link
US (1) US20230278995A1 (pt)
EP (1) EP4136085A4 (pt)
JP (1) JP7492033B2 (pt)
KR (1) KR102576148B1 (pt)
CN (1) CN115427406A (pt)
AU (1) AU2021255176B2 (pt)
BR (1) BR112022020731A2 (pt)
CA (1) CA3174319A1 (pt)
MX (1) MX2022012844A (pt)
TW (1) TWI807300B (pt)
WO (1) WO2021210857A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI600638B (zh) * 2010-01-22 2017-10-01 艾斯特隆製藥公司 作爲蛋白質去乙醯酶抑制劑之反式醯胺化合物及其使用方法
EP2563787B1 (en) * 2010-04-30 2014-11-26 Boehringer Ingelheim International GmbH Azaindazole amide compounds as ccr1 receptor antagonists
US9278910B2 (en) * 2011-05-31 2016-03-08 Receptos, Inc. GLP-1 receptor stabilizers and modulators
WO2013134467A1 (en) 2012-03-07 2013-09-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Selective histone deactylase 6 inhibitors
RU2697665C1 (ru) * 2015-07-27 2019-08-16 Чонг Кун Данг Фармасьютикал Корп. Производные 1,3,4-оксадиазолсульфонамида в качестве ингибиторов деацетилазы гистонов 6 и фармацевтическая композиция, содержащая их
NZ739211A (en) * 2015-07-27 2019-05-31 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
CA2994688C (en) * 2015-08-04 2020-11-03 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
EP3475275B1 (en) * 2016-06-23 2024-04-10 Merck Sharp & Dohme LLC 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
AU2018379321B2 (en) * 2017-12-05 2024-05-16 Oryzon Genomics, S.A. 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors

Also Published As

Publication number Publication date
MX2022012844A (es) 2022-11-07
TW202200568A (zh) 2022-01-01
AU2021255176A1 (en) 2022-10-13
KR20210126970A (ko) 2021-10-21
US20230278995A1 (en) 2023-09-07
JP7492033B2 (ja) 2024-05-28
JP2023521836A (ja) 2023-05-25
KR102576148B1 (ko) 2023-09-07
EP4136085A1 (en) 2023-02-22
WO2021210857A1 (en) 2021-10-21
TWI807300B (zh) 2023-07-01
CA3174319A1 (en) 2021-10-21
AU2021255176B2 (en) 2024-01-18
CN115427406A (zh) 2022-12-02
EP4136085A4 (en) 2024-04-17

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