BR112022018043A2 - Composições farmacêuticas de sais de éster de colina de ácido lipoico e métodos de tratamento usando as mesmas - Google Patents
Composições farmacêuticas de sais de éster de colina de ácido lipoico e métodos de tratamento usando as mesmasInfo
- Publication number
- BR112022018043A2 BR112022018043A2 BR112022018043A BR112022018043A BR112022018043A2 BR 112022018043 A2 BR112022018043 A2 BR 112022018043A2 BR 112022018043 A BR112022018043 A BR 112022018043A BR 112022018043 A BR112022018043 A BR 112022018043A BR 112022018043 A2 BR112022018043 A2 BR 112022018043A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- same
- lipoic acid
- ester salts
- choline ester
- Prior art date
Links
- 229960001231 choline Drugs 0.000 title abstract 2
- 235000019136 lipoic acid Nutrition 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229960002663 thioctic acid Drugs 0.000 title abstract 2
- AGBQKNBQESQNJD-ZETCQYMHSA-N (S)-lipoic acid Chemical class OC(=O)CCCC[C@H]1CCSS1 AGBQKNBQESQNJD-ZETCQYMHSA-N 0.000 title 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical group C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title 1
- -1 choline ester salts Chemical class 0.000 abstract 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020079271 | 2020-03-13 | ||
| US202063013836P | 2020-04-22 | 2020-04-22 | |
| PCT/IB2021/052092 WO2021181361A1 (en) | 2020-03-13 | 2021-03-12 | Pharmaceutical compositions of lipoic acid choline ester salts and methods of treatment using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022018043A2 true BR112022018043A2 (pt) | 2022-10-18 |
Family
ID=75108681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022018043A BR112022018043A2 (pt) | 2020-03-13 | 2021-03-12 | Composições farmacêuticas de sais de éster de colina de ácido lipoico e métodos de tratamento usando as mesmas |
Country Status (18)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2026518762A (ja) | 2023-05-24 | 2026-06-09 | 温州医科大学附属眼視光医院 | 効果的に近視を先送りにし治療する医薬組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5520920A (en) | 1978-07-31 | 1980-02-14 | Honda Motor Co Ltd | Device for absorbing twisting vibration of drive system |
| US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| AR050902A1 (es) * | 2004-04-27 | 2006-12-06 | Glaxo Group Ltd | Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion |
| DE102006062599B4 (de) | 2006-12-29 | 2018-03-08 | Endress + Hauser Gmbh + Co. Kg | Opto-elektronische Vorrichtung zur Übertragung eines elektrischen Signals und deren Verwendung |
| WO2009038656A1 (en) | 2007-09-17 | 2009-03-26 | Kosta Steliou | Mitochondria-targeting antioxidant therapeutics |
| US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
| WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
| EP3069612A3 (en) | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| ES2579173T3 (es) | 2009-06-15 | 2016-08-05 | Encore Health, Llc | Ésteres de colina para tratar presbicia y cataratas |
| EP3113613A4 (en) * | 2014-03-03 | 2019-03-13 | Encore Vision, Inc. | LIPOIC ACID CHOLINESTER COMPOSITIONS AND METHOD OF USE THEREOF |
| WO2016126662A1 (en) | 2015-02-03 | 2016-08-11 | Kardiatonos, Inc. | Compounds for the prevention and treatment of vascular disease |
| WO2016164534A1 (en) | 2015-04-09 | 2016-10-13 | Kardiatonos, Inc. | Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage |
| WO2016176089A1 (en) | 2015-04-29 | 2016-11-03 | Kardiatonos, Inc. | Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage |
| ES2904580T3 (es) * | 2015-09-24 | 2022-04-05 | Novartis Ag | Composiciones de éster de colina del ácido lipoico y métodos para generar formulaciones oftálmicas biocompatibles. |
| JOP20190057A1 (ar) * | 2016-09-23 | 2019-03-24 | Encore Vision Inc | تركيبات استر كولين حمض الليبويك وطرق تثبيتها إلى منتجات عقار ذات صلة دوائية |
| CN106967044B (zh) * | 2017-05-12 | 2019-02-22 | 苏州富士莱医药股份有限公司 | 制备r-硫辛酸胆碱酯卤化物的方法 |
| CN107089967A (zh) * | 2017-05-12 | 2017-08-25 | 苏州富士莱医药股份有限公司 | 一种r‑硫辛酸胆碱酯卤化物的制备方法 |
| EP3749303A4 (en) * | 2018-02-05 | 2022-01-26 | Cellixbio Private Limited | COMBINATION OF AN ANTIMUSCARINE OR ANTICCHOLINERGIC AGENT AND LIPOIC ACID AND USES THEREOF |
| US11158871B2 (en) | 2018-07-18 | 2021-10-26 | GM Global Technology Operations LLC | Fuel cell assembly and a vehicle that utilizes the fuel cell assembly |
| US11985964B2 (en) | 2018-08-03 | 2024-05-21 | Kevin F Lohmeier | Fishing rod holder |
| CN108822077A (zh) | 2018-08-07 | 2018-11-16 | 苏州富士莱医药股份有限公司 | 一种r-硫辛酸胆碱酯卤化物的精制方法 |
| CN108586429A (zh) | 2018-08-07 | 2018-09-28 | 苏州富士莱医药股份有限公司 | R-硫辛酸胆碱酯卤化物的纯化精制方法 |
-
2021
- 2021-03-03 CN CN202110237490.7A patent/CN113387923A/zh active Pending
- 2021-03-08 JP JP2021035929A patent/JP7041298B2/ja not_active Expired - Fee Related
- 2021-03-11 TW TW110108635A patent/TWI768760B/zh not_active IP Right Cessation
- 2021-03-12 WO PCT/IB2021/052092 patent/WO2021181361A1/en not_active Ceased
- 2021-03-12 EP EP21713132.5A patent/EP4118079A1/en not_active Withdrawn
- 2021-03-12 PE PE2022001926A patent/PE20230242A1/es unknown
- 2021-03-12 BR BR112022018043A patent/BR112022018043A2/pt not_active Application Discontinuation
- 2021-03-12 KR KR1020227033130A patent/KR20220146561A/ko not_active Ceased
- 2021-03-12 CR CR20220449A patent/CR20220449A/es unknown
- 2021-03-12 MX MX2022011206A patent/MX2022011206A/es unknown
- 2021-03-12 CN CN202180020651.5A patent/CN115279745A/zh active Pending
- 2021-03-12 US US17/199,736 patent/US11135239B1/en active Active
- 2021-03-12 CA CA3175077A patent/CA3175077A1/en active Pending
- 2021-03-12 AU AU2021235563A patent/AU2021235563A1/en not_active Abandoned
- 2021-03-12 IL IL295378A patent/IL295378A/en unknown
- 2021-08-31 US US17/463,391 patent/US11590158B2/en active Active
- 2021-12-20 JP JP2021206074A patent/JP2022058376A/ja active Pending
-
2022
- 2022-09-06 CO CONC2022/0012653A patent/CO2022012653A2/es unknown
- 2022-09-06 EC ECSENADI202269611A patent/ECSP22069611A/es unknown
- 2022-09-07 DO DO2022000179A patent/DOP2022000179A/es unknown
- 2022-09-08 JO JOP/2022/0211A patent/JOP20220211A1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113387923A (zh) | 2021-09-14 |
| EP4118079A1 (en) | 2023-01-18 |
| US11590158B2 (en) | 2023-02-28 |
| ECSP22069611A (es) | 2022-10-31 |
| DOP2022000179A (es) | 2022-09-30 |
| CR20220449A (es) | 2022-10-12 |
| TW202140435A (zh) | 2021-11-01 |
| WO2021181361A1 (en) | 2021-09-16 |
| US20210283171A1 (en) | 2021-09-16 |
| CO2022012653A2 (es) | 2022-09-09 |
| PE20230242A1 (es) | 2023-02-07 |
| JP2022058376A (ja) | 2022-04-12 |
| CA3175077A1 (en) | 2021-09-16 |
| TWI768760B (zh) | 2022-06-21 |
| IL295378A (en) | 2022-10-01 |
| US20210393671A1 (en) | 2021-12-23 |
| MX2022011206A (es) | 2022-09-19 |
| US11135239B1 (en) | 2021-10-05 |
| JOP20220211A1 (ar) | 2022-09-08 |
| JP2021147392A (ja) | 2021-09-27 |
| KR20220146561A (ko) | 2022-11-01 |
| JP7041298B2 (ja) | 2022-03-23 |
| AU2021235563A1 (en) | 2022-09-22 |
| CN115279745A (zh) | 2022-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2022000603A1 (es) | Inhibidores prmt5 cooperativos de mta | |
| BR112021024108A2 (pt) | Inibidores de tead e usos dos mesmos | |
| BR112022018678A2 (pt) | Degradadores de mdm2 e usos dos mesmos | |
| BR112021002267A8 (pt) | Inibidores de prmt5 | |
| CY1120805T1 (el) | Κρυσταλλικες μορφες αναστολεα προλυλο υδροξυλασης | |
| BR112022006279A2 (pt) | Heteroaril-bifenil aminas para o tratamento de doenças pd-l1 | |
| BR112017012197A2 (pt) | composto, composição herbicida, mistura herbicida e método para controlar o crescimento de vegetação indesejada | |
| BR112022026896A2 (pt) | Método para a preparação de aminofuranos | |
| BR112018013251A2 (pt) | compostos heterocílicos tricíclicos fundidos como inibidores da hiv integrase | |
| BR112017026406A2 (pt) | formas sólidas de ácido (z)-4-(5-((3-benzil-4-oxo-2-tioxotiazolidin-5-ilideno)metil)furan-2-il)benzoico | |
| MX2021009806A (es) | Ésteres de ácidos grasos de cadena media de beta-hidroxibutirato y butanodiol y composiciones y métodos para usar los mismos. | |
| MX2022007275A (es) | Composiciones de acidos biliares y compuestos de fenilbutirato. | |
| BR112022022608A2 (pt) | Compostos como inibidores de bcl-2 | |
| BR112017023959A2 (pt) | novos compostos de sulfonimidoilpurinona e derivados para o tratamento e profilaxia de infecção por vírus | |
| MX2019014411A (es) | Compuestos que contienen nitrogeno sustituido. | |
| CL2021001640A1 (es) | Formas de sal y cristalinas de un compuesto orgánico y composiciones farmacéuticas del mismo | |
| BR112018004234A2 (pt) | método para produçao de ésteres de cianidrina contendo fósforo | |
| MX2019012967A (es) | Cristal de base libre de derivados benzofurano y metodo de preparacion. | |
| CO2021011042A2 (es) | Sales de sulcardina | |
| BR112018004247A2 (pt) | método para produção de ésteres de cianidrina contendo fósforo. | |
| BR112018076734A2 (pt) | compostos heterocíclicos anti-infecciosos e usos dos mesmos | |
| BR112020026507A8 (pt) | Composto de isotiazolo[5,4-d]pirimidinas como inibidor de irak4 | |
| DOP2022000179A (es) | Composiciones farmacéuticas de sales de éster de colina de ácido lipoico y métodos de tratamiento usando las mismas | |
| BR112022012368A2 (pt) | Composto, e, composição farmacêutica para o tratamento de doenças associadas a diacilglicerol aciltransferase 2 | |
| BR112023022298A2 (pt) | Moduladores de trex1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |