BR112022017736A2 - Métodos e composições aprimorados para modular um genoma - Google Patents
Métodos e composições aprimorados para modular um genomaInfo
- Publication number
- BR112022017736A2 BR112022017736A2 BR112022017736A BR112022017736A BR112022017736A2 BR 112022017736 A2 BR112022017736 A2 BR 112022017736A2 BR 112022017736 A BR112022017736 A BR 112022017736A BR 112022017736 A BR112022017736 A BR 112022017736A BR 112022017736 A2 BR112022017736 A2 BR 112022017736A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- genome
- modulate
- improved methods
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cosmetics (AREA)
- Toys (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062985264P | 2020-03-04 | 2020-03-04 | |
| US202063035674P | 2020-06-05 | 2020-06-05 | |
| PCT/US2021/020943 WO2021178717A2 (en) | 2020-03-04 | 2021-03-04 | Improved methods and compositions for modulating a genome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022017736A2 true BR112022017736A2 (pt) | 2022-11-29 |
Family
ID=77613826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022017736A BR112022017736A2 (pt) | 2020-03-04 | 2021-03-04 | Métodos e composições aprimorados para modular um genoma |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US12565666B2 (https=) |
| EP (1) | EP4114941A4 (https=) |
| JP (2) | JP2023517294A (https=) |
| KR (1) | KR20230053735A (https=) |
| CN (1) | CN116209770A (https=) |
| AU (1) | AU2021230545A1 (https=) |
| BR (1) | BR112022017736A2 (https=) |
| CA (1) | CA3174483A1 (https=) |
| IL (1) | IL296095A (https=) |
| WO (1) | WO2021178717A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| EP3844272A1 (en) | 2018-08-28 | 2021-07-07 | Flagship Pioneering Innovations VI, LLC | Methods and compositions for modulating a genome |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| CN113755627B (zh) * | 2021-09-24 | 2023-06-16 | 广西大学 | 一种基于顺式调控元件的引物及其设计方法和在分子标记中的应用 |
| CN114277119B (zh) * | 2021-12-09 | 2023-05-16 | 浙江大学医学院附属邵逸夫医院 | 一种环状RNA circ-Arsb在制备防治骨质疏松产品中的应用 |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
| WO2023212724A2 (en) * | 2022-04-28 | 2023-11-02 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for modulating a genome in t cells, induced pluripotent stem cells, and respiratory epithelial cells |
| KR20250006975A (ko) * | 2022-05-02 | 2025-01-13 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 부위 특이적 게놈 변형을 위한 다성분 시스템 |
| CN116334141B (zh) * | 2022-08-04 | 2026-04-24 | 北京中因科技股份有限公司 | 基于基因编辑的RHO-R135W-adRP基因编辑药物 |
| CN116064797B (zh) * | 2022-08-29 | 2023-10-20 | 广州达健生物科技有限公司 | 一种子宫内膜癌基因甲基化水平检测试剂及其应用 |
| AU2023364078A1 (en) * | 2022-10-19 | 2025-05-01 | Metagenomi Therapeutics, Inc. | Gene editing systems comprising reverse transcriptases |
| CN120418275A (zh) * | 2022-12-19 | 2025-08-01 | 北京干细胞与再生医学研究院 | 一种在基因组插入大片段dna的系统 |
| US12565665B2 (en) | 2022-12-21 | 2026-03-03 | Trustees Of Boston University | Compositions and methods for controlled mRNA translation and stability |
| CN116179513B (zh) * | 2023-03-10 | 2023-12-22 | 之江实验室 | 一种Cpf1蛋白及其在基因编辑中的应用 |
| WO2024196963A2 (en) * | 2023-03-21 | 2024-09-26 | The Regents Of The University Of California | Compositions and methods for genome editing |
| TW202449159A (zh) | 2023-04-19 | 2024-12-16 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於產生文庫之組合物及方法 |
| CN116523902B (zh) * | 2023-06-21 | 2023-09-26 | 湖南盛鼎科技发展有限责任公司 | 基于改进yolov5的电子粉涂敷均匀检测方法及设备 |
| WO2025006419A1 (en) | 2023-06-26 | 2025-01-02 | Flagship Pioneering Innovations Vii, Llc | Engineered plasmodia and related methods |
| CN119286819A (zh) * | 2023-07-10 | 2025-01-10 | 北京干细胞与再生医学研究院 | 工程化的哺乳动物基因写入系统 |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030121063A1 (en) | 1995-11-16 | 2003-06-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods of use of mammalian retrotransposons |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US20060183226A1 (en) | 2002-01-31 | 2006-08-17 | Haruhiko Fujiwara | Methods for retrotransposing long interspersed elements (lines) |
| WO2004072290A1 (en) | 2003-02-07 | 2004-08-26 | The Administrators Of The Tulane Educational Fund | Mammalian retrotransposable elements |
| JPWO2005054463A1 (ja) | 2003-11-21 | 2007-12-06 | 財団法人大阪産業振興機構 | レトロトランスポゾンを用いた哺乳動物のゲノム改変技術の開発 |
| US20110171729A1 (en) | 2006-05-04 | 2011-07-14 | Ab Maxis Inc. | Method for Producing Stable Mammalian Cell Lines Producing High Levels of Recombinant Proteins |
| EP2055784A1 (en) | 2007-10-31 | 2009-05-06 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Controlled activation of non-LTR retrotransposons in mammals |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| US20140113375A1 (en) | 2012-10-21 | 2014-04-24 | Lixin Liu | Transient Expression And Reverse Transcription Aided Genome Alteration System |
| US20140186843A1 (en) | 2012-12-12 | 2014-07-03 | Massachusetts Institute Of Technology | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| CN113355357B (zh) | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| RU2662932C2 (ru) | 2013-03-14 | 2018-07-31 | Карибо Биосайенсиз, Инк. | Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| EP3155116A4 (en) | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| EP3183358B1 (en) | 2014-08-19 | 2020-10-07 | President and Fellows of Harvard College | Rna-guided systems for probing and mapping of nucleic acids |
| EP3188763B1 (en) | 2014-09-02 | 2020-05-13 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification |
| WO2016065364A1 (en) | 2014-10-24 | 2016-04-28 | Life Technologies Corporation | Compositions and methods for enhancing homologous recombination |
| CN108026526B (zh) | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| WO2016205728A1 (en) | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Crispr mediated recording of cellular events |
| EP3356520B1 (en) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| US11427837B2 (en) | 2016-01-12 | 2022-08-30 | The Regents Of The University Of California | Compositions and methods for enhanced genome editing |
| US20170275665A1 (en) * | 2016-02-24 | 2017-09-28 | Board Of Regents, The University Of Texas System | Direct crispr spacer acquisition from rna by a reverse-transcriptase-cas1 fusion protein |
| US11447768B2 (en) | 2016-03-01 | 2022-09-20 | University Of Florida Research Foundation, Incorporated | Molecular cell diary system |
| WO2017173004A1 (en) | 2016-03-30 | 2017-10-05 | Mikuni Takayasu | A method for in vivo precise genome editing |
| EP3443088B1 (en) | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| EP4166660A1 (en) | 2016-04-29 | 2023-04-19 | BASF Plant Science Company GmbH | Improved methods for modification of target nucleic acids using fused guide rna - donor molecules |
| US20190345483A1 (en) | 2016-05-12 | 2019-11-14 | President And Fellows Of Harvard College | AAV Split Cas9 Genome Editing and Transcriptional Regulation |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018045321A1 (en) | 2016-09-02 | 2018-03-08 | North Carolina State University | Methods and compositions for modification of plastid genomes |
| ES2985812T3 (es) | 2016-09-09 | 2024-11-07 | The Board Of Trustees Of The Leland Stanfordjunior Univ | Edición genómica de precisión de alto rendimiento |
| US20190330620A1 (en) | 2016-10-14 | 2019-10-31 | Emendobio Inc. | Rna compositions for genome editing |
| EP4545649A3 (en) | 2016-11-11 | 2025-06-04 | Bio-Rad Laboratories, Inc. | Methods for processing nucleic acid samples |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| EP3630849A4 (en) | 2017-05-25 | 2021-01-13 | The General Hospital Corporation | BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| JP2021530212A (ja) | 2018-07-13 | 2021-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | レトロトランスポゾンベースの送達媒体及びその使用方法 |
| EP3844272A1 (en) | 2018-08-28 | 2021-07-07 | Flagship Pioneering Innovations VI, LLC | Methods and compositions for modulating a genome |
| JP7658579B2 (ja) | 2018-10-19 | 2025-04-08 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 操作された長鎖散在反復エレメント（ｌｉｎｅ）トランスポゾンおよびそれらの使用方法 |
| WO2020186262A1 (en) | 2019-03-14 | 2020-09-17 | Cornell University | Compositions and methods for gene targeting using crispr-cas and transposons |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20220298495A1 (en) | 2019-06-12 | 2022-09-22 | Emendobio Inc. | Novel genome editing tool |
| JP7759311B2 (ja) | 2019-07-19 | 2025-10-23 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | リコンビナーゼ組成物及び使用方法 |
| EP4034659A4 (en) | 2019-09-27 | 2024-10-16 | The Broad Institute, Inc. | PROGRAMMABLE POLYNUCLEOTIDE EDITORS FOR AMPLIFIED HOMOLOGOUS RECOMBINATION |
| US20220411768A1 (en) | 2019-10-21 | 2022-12-29 | The Trustees Of Columbia University In The City Of New York | Methods of performing rna templated genome editing |
| CA3162499A1 (en) | 2019-11-22 | 2021-05-27 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| EP4085141A4 (en) | 2019-12-30 | 2024-03-06 | The Broad Institute, Inc. | GENOME EDITING USING REVERSE TRANSCRIPTASE FOR FULLY ACTIVE CRISPR COMPLEXES |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| US20230348939A1 (en) | 2020-03-04 | 2023-11-02 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| BR112022017713A2 (pt) | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| CA3174553A1 (en) | 2020-03-05 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Host defense suppressing methods and compositions for modulating a genome |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| WO2021248102A1 (en) | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| EP4274894A2 (en) | 2021-01-11 | 2023-11-15 | The Broad Institute, Inc. | Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision |
| US20240132916A1 (en) | 2021-02-09 | 2024-04-25 | The Broad Institute, Inc. | Nuclease-guided non-ltr retrotransposons and uses thereof |
| WO2022183210A1 (en) | 2021-02-26 | 2022-09-01 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| AU2022240747A1 (en) | 2021-03-19 | 2023-10-05 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| EP4314257A4 (en) | 2021-04-01 | 2025-07-09 | Prime Medicine Inc | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES |
| EP4347859A4 (en) | 2021-05-26 | 2025-07-02 | Flagship Pioneering Innovations Vi Llc | INTEGRASE COMPOSITIONS AND METHODS |
| EP4352230A4 (en) | 2021-06-03 | 2025-06-11 | Prime Medicine, Inc. | Genome editing compositions and methods for treating Wilson's disease |
| WO2023283092A1 (en) | 2021-07-06 | 2023-01-12 | Prime Medicine, Inc. | Compositions and methods for efficient genome editing |
| EP4373939A4 (en) | 2021-07-23 | 2025-11-19 | Prime Medicine Inc | Genome editing compositions and treatment methods for chronic granulomatous disease |
| WO2023015318A2 (en) | 2021-08-05 | 2023-02-09 | Prime Medicine, Inc. | Genome editing compositions and methods for treatment of cystic fibrosis |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| IL311219A (en) | 2021-09-08 | 2024-05-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for genome modulation |
| MX2024002988A (es) | 2021-09-08 | 2024-06-11 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos moduladores de la serpina. |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| CA3231679A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Hbb-modulating compositions and methods |
| EP4419688A2 (en) | 2021-10-21 | 2024-08-28 | Prime Medicine, Inc. | Genome editing compositions and methods for treatment of usher syndrome type 3 |
| EP4430185A1 (en) | 2021-11-09 | 2024-09-18 | Prime Medicine, Inc. | Genome editing compositions and methods for treatment of fuchs endothelial corneal dystrophy |
| EP4430188A1 (en) | 2021-11-09 | 2024-09-18 | Prime Medicine, Inc. | Genome editing compositions and methods for treatment of amyotrophic lateral sclerosis |
| EP4430189A1 (en) | 2021-11-11 | 2024-09-18 | Prime Medicine, Inc. | Genome editing compositions and methods for treatment of fragile x syndrome |
| IL313027A (en) | 2021-11-24 | 2024-07-01 | Prime Medicine Inc | Modified prime editing guide rnas |
| EP4437106A2 (en) | 2021-11-24 | 2024-10-02 | Prime Medicine, Inc. | Methods and compositions for inhibiting mismatch repair |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
| EP4504921A4 (en) | 2022-04-01 | 2026-04-15 | Prime Medicine Inc | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTID SEQUENCES |
-
2021
- 2021-03-04 KR KR1020227034440A patent/KR20230053735A/ko active Pending
- 2021-03-04 CN CN202180035530.8A patent/CN116209770A/zh active Pending
- 2021-03-04 IL IL296095A patent/IL296095A/en unknown
- 2021-03-04 BR BR112022017736A patent/BR112022017736A2/pt unknown
- 2021-03-04 CA CA3174483A patent/CA3174483A1/en active Pending
- 2021-03-04 WO PCT/US2021/020943 patent/WO2021178717A2/en not_active Ceased
- 2021-03-04 JP JP2022552817A patent/JP2023517294A/ja active Pending
- 2021-03-04 AU AU2021230545A patent/AU2021230545A1/en active Pending
- 2021-03-04 EP EP21764647.0A patent/EP4114941A4/en active Pending
-
2022
- 2022-09-02 US US17/929,455 patent/US12565666B2/en active Active
-
2023
- 2023-09-14 US US18/467,392 patent/US12065669B2/en active Active
- 2023-09-14 US US18/467,428 patent/US12037602B2/en active Active
-
2025
- 2025-08-27 JP JP2025141096A patent/JP2025172847A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN116209770A (zh) | 2023-06-02 |
| CA3174483A1 (en) | 2021-09-10 |
| EP4114941A4 (en) | 2024-10-16 |
| AU2021230545A1 (en) | 2022-09-29 |
| JP2025172847A (ja) | 2025-11-26 |
| IL296095A (en) | 2022-11-01 |
| US12565666B2 (en) | 2026-03-03 |
| US20240076698A1 (en) | 2024-03-07 |
| US20240018551A1 (en) | 2024-01-18 |
| JP2023517294A (ja) | 2023-04-25 |
| KR20230053735A (ko) | 2023-04-21 |
| US12037602B2 (en) | 2024-07-16 |
| US20240084333A1 (en) | 2024-03-14 |
| WO2021178717A2 (en) | 2021-09-10 |
| US12065669B2 (en) | 2024-08-20 |
| WO2021178717A9 (en) | 2022-03-17 |
| EP4114941A2 (en) | 2023-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112022017736A2 (pt) | Métodos e composições aprimorados para modular um genoma | |
| BR112022017715A2 (pt) | Métodos e composições para modular um genoma | |
| BR112022017713A2 (pt) | Métodos e composições para modular um genoma | |
| WO2021102390A8 (en) | Recombinase compositions and methods of use | |
| BR112022003970A2 (pt) | Métodos e composições para integração genômica | |
| MX2024002930A (es) | Metodos y composiciones para modular un genoma. | |
| CO2021006098A2 (es) | Moduladores de profármacos de la vía de estrés integrada | |
| MX2020006072A (es) | Métodos y composiciones relacionados con cpf1 para la edición genica. | |
| BR112022017735A2 (pt) | Métodos e composições de supressão de defesa de hospedeiro para modular um genoma | |
| BR112021021703A2 (pt) | Cicloalquilas substituídas como moduladores da via de estresse integrada | |
| BR112021024224A2 (pt) | Inibidores de tead e usos dos mesmos | |
| UY38685A (es) | Moduladores de la vía de tensión integrada | |
| MX2020004538A (es) | Moduladores de la vía de estrés integrada. | |
| MX2020004555A (es) | Moduladores de la vía de estrés integrada. | |
| MX2020004551A (es) | Moduladores de la vía de estrés integrada. | |
| MX2020004557A (es) | Moduladores de la vía de estrés integrada. | |
| BR112019016635A2 (pt) | aminotriazolopiridinas como inibidores da cinase | |
| BR112023023642A2 (pt) | Métodos e composições para integração genômica | |
| EP3934688A4 (en) | COMPOSITIONS AND METHODS FOR MODULATION OF VIRAL INFECTION THROUGH REGULATION OF GLUCOSYLCERAMIDS | |
| BR112023022315A2 (pt) | Quimeras direcionadas à desubiquitinase e métodos relacionados | |
| BR112022001913A2 (pt) | Métodos e composições para cultivar bactérias dependentes de hemoglobina | |
| BR112021023144A2 (pt) | Compostos de oxatiazina para inibir gapdh | |
| BR112024001188A2 (pt) | Moduladores de canais de potássio | |
| BR112021017159A2 (pt) | Supressão da expressão de gene alvo através da edição de genoma de mirnas nativos | |
| MX2021013081A (es) | Métodos y composiciones para modular el corte y empalme de intrones alternativos. |