BR112022017736A2 - Métodos e composições aprimorados para modular um genoma - Google Patents
Métodos e composições aprimorados para modular um genomaInfo
- Publication number
- BR112022017736A2 BR112022017736A2 BR112022017736A BR112022017736A BR112022017736A2 BR 112022017736 A2 BR112022017736 A2 BR 112022017736A2 BR 112022017736 A BR112022017736 A BR 112022017736A BR 112022017736 A BR112022017736 A BR 112022017736A BR 112022017736 A2 BR112022017736 A2 BR 112022017736A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- genome
- modulate
- improved methods
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Toys (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062985264P | 2020-03-04 | 2020-03-04 | |
| US202063035674P | 2020-06-05 | 2020-06-05 | |
| PCT/US2021/020943 WO2021178717A2 (en) | 2020-03-04 | 2021-03-04 | Improved methods and compositions for modulating a genome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022017736A2 true BR112022017736A2 (pt) | 2022-11-29 |
Family
ID=77613826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022017736A BR112022017736A2 (pt) | 2020-03-04 | 2021-03-04 | Métodos e composições aprimorados para modular um genoma |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US12565666B2 (enExample) |
| EP (1) | EP4114941A4 (enExample) |
| JP (2) | JP7863508B2 (enExample) |
| KR (1) | KR20230053735A (enExample) |
| CN (1) | CN116209770A (enExample) |
| AU (1) | AU2021230545A1 (enExample) |
| BR (1) | BR112022017736A2 (enExample) |
| CA (1) | CA3174483A1 (enExample) |
| IL (1) | IL296095A (enExample) |
| WO (1) | WO2021178717A2 (enExample) |
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| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| AU2019327449B2 (en) | 2018-08-28 | 2026-04-09 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| KR20210055733A (ko) | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021046243A2 (en) | 2019-09-03 | 2021-03-11 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| BR112022017715A2 (pt) | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| IL296095A (en) | 2020-03-04 | 2022-11-01 | Flagship Pioneering Innovations Vi Llc | Improved methods and compositions for genome modulation |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| WO2022241029A1 (en) | 2021-05-11 | 2022-11-17 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| KR20260037664A (ko) | 2021-09-08 | 2026-03-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈을 조절하기 위한 방법 및 조성물 |
| CN113755627B (zh) * | 2021-09-24 | 2023-06-16 | 广西大学 | 一种基于顺式调控元件的引物及其设计方法和在分子标记中的应用 |
| CN114277119B (zh) * | 2021-12-09 | 2023-05-16 | 浙江大学医学院附属邵逸夫医院 | 一种环状RNA circ-Arsb在制备防治骨质疏松产品中的应用 |
| EP4444362A4 (en) | 2021-12-10 | 2026-04-01 | Flagship Pioneering Innovations Vi Llc | CFTR COMPOSITIONS AND MODULATION METHODS |
| CA3256516A1 (en) * | 2022-04-28 | 2023-11-02 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for modulating a genome in T lymphocytes, induced pluripotent stem cells, and respiratory epithelial cells |
| WO2023215727A2 (en) * | 2022-05-02 | 2023-11-09 | The Regents Of The University Of California | Multicomponent systems for site-specific genome modifications |
| CN116334141B (zh) * | 2022-08-04 | 2026-04-24 | 北京中因科技股份有限公司 | 基于基因编辑的RHO-R135W-adRP基因编辑药物 |
| CN116064797B (zh) * | 2022-08-29 | 2023-10-20 | 广州达健生物科技有限公司 | 一种子宫内膜癌基因甲基化水平检测试剂及其应用 |
| AU2023364078A1 (en) * | 2022-10-19 | 2025-05-01 | Metagenomi Therapeutics, Inc. | Gene editing systems comprising reverse transcriptases |
| WO2024131786A1 (zh) * | 2022-12-19 | 2024-06-27 | 北京干细胞与再生医学研究院 | 一种在基因组插入大片段dna的系统 |
| US12565665B2 (en) | 2022-12-21 | 2026-03-03 | Trustees Of Boston University | Compositions and methods for controlled mRNA translation and stability |
| CN116179513B (zh) * | 2023-03-10 | 2023-12-22 | 之江实验室 | 一种Cpf1蛋白及其在基因编辑中的应用 |
| WO2024196963A2 (en) * | 2023-03-21 | 2024-09-26 | The Regents Of The University Of California | Compositions and methods for genome editing |
| WO2024220741A1 (en) | 2023-04-19 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for the production of libraries |
| CN121889499A (zh) * | 2023-06-15 | 2026-04-17 | 比姆医疗股份有限公司 | 用于治疗α1-抗胰蛋白酶缺乏症的方法和组合物 |
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| BR112022017715A2 (pt) | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
| AU2021232005A1 (en) | 2020-03-04 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| BR112022017735A2 (pt) | 2020-03-05 | 2022-11-29 | Flagship Pioneering Innovations Vi Llc | Métodos e composições de supressão de defesa de hospedeiro para modular um genoma |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| WO2021248102A1 (en) | 2020-06-05 | 2021-12-09 | Flagship Pioneering Innovations Vi, Llc | Template guide rna molecules |
| AU2022206476A1 (en) | 2021-01-11 | 2023-07-20 | President And Fellows Of Harvard College | Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision |
| US20240132916A1 (en) | 2021-02-09 | 2024-04-25 | The Broad Institute, Inc. | Nuclease-guided non-ltr retrotransposons and uses thereof |
| WO2022183210A1 (en) | 2021-02-26 | 2022-09-01 | Flagship Pioneering Innovations Vi, Llc | Tissue-specific methods and compositions for modulating a genome |
| AU2022240747A1 (en) | 2021-03-19 | 2023-10-05 | Flagship Pioneering Innovations Vi, Llc | Ltr transposon compositions and methods |
| EP4314257A4 (en) | 2021-04-01 | 2025-07-09 | Prime Medicine Inc | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES |
| EP4347859A4 (en) | 2021-05-26 | 2025-07-02 | Flagship Pioneering Innovations Vi Llc | INTEGRASE COMPOSITIONS AND METHODS |
| EP4352230A4 (en) | 2021-06-03 | 2025-06-11 | Prime Medicine, Inc. | Genome editing compositions and methods for treating Wilson's disease |
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| KR20260037664A (ko) | 2021-09-08 | 2026-03-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈을 조절하기 위한 방법 및 조성물 |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| WO2023039447A2 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Serpina-modulating compositions and methods |
| MX2024002930A (es) | 2021-09-08 | 2024-05-29 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
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| CA3235826A1 (en) | 2021-10-21 | 2023-04-27 | Wei Hsi Yeh | Genome editing compositions and methods for treatment of usher syndrome type 3 |
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| US20250297248A1 (en) | 2021-11-24 | 2025-09-25 | Prime Medicine, Inc. | Methods and compositions for inhibiting mismatch repair |
| AU2022398241A1 (en) | 2021-11-24 | 2024-06-06 | Prime Medicine, Inc. | Modified prime editing guide rnas |
| EP4444362A4 (en) | 2021-12-10 | 2026-04-01 | Flagship Pioneering Innovations Vi Llc | CFTR COMPOSITIONS AND MODULATION METHODS |
| WO2023192655A2 (en) | 2022-04-01 | 2023-10-05 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
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2021
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- 2021-03-04 CN CN202180035530.8A patent/CN116209770A/zh active Pending
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- 2021-03-04 WO PCT/US2021/020943 patent/WO2021178717A2/en not_active Ceased
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| US12037602B2 (en) | 2024-07-16 |
| WO2021178717A9 (en) | 2022-03-17 |
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| JP7863508B2 (ja) | 2026-05-21 |
| US20240076698A1 (en) | 2024-03-07 |
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| US12065669B2 (en) | 2024-08-20 |
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| US20240018551A1 (en) | 2024-01-18 |
| US20240084333A1 (en) | 2024-03-14 |
| JP2023517294A (ja) | 2023-04-25 |
| US12565666B2 (en) | 2026-03-03 |
| IL296095A (en) | 2022-11-01 |
| CA3174483A1 (en) | 2021-09-10 |
| KR20230053735A (ko) | 2023-04-21 |
| CN116209770A (zh) | 2023-06-02 |
| EP4114941A2 (en) | 2023-01-11 |
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