BR112022014093A2 - Reagente de diagnóstico para determinação quantitativa de procalcitonina em uma amostra - Google Patents

Reagente de diagnóstico para determinação quantitativa de procalcitonina em uma amostra

Info

Publication number
BR112022014093A2
BR112022014093A2 BR112022014093A BR112022014093A BR112022014093A2 BR 112022014093 A2 BR112022014093 A2 BR 112022014093A2 BR 112022014093 A BR112022014093 A BR 112022014093A BR 112022014093 A BR112022014093 A BR 112022014093A BR 112022014093 A2 BR112022014093 A2 BR 112022014093A2
Authority
BR
Brazil
Prior art keywords
procalcitonin
sample
quantitative determination
suspension
diagnostic reagent
Prior art date
Application number
BR112022014093A
Other languages
English (en)
Inventor
Grimmler Matthias
Masetto Thomas
Original Assignee
Diasys Diagnostic Systems Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diasys Diagnostic Systems Gmbh filed Critical Diasys Diagnostic Systems Gmbh
Publication of BR112022014093A2 publication Critical patent/BR112022014093A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/585—Calcitonins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

REAGENTE DE DIAGNÓSTICO PARA DETERMINAÇÃO QUANTITATIVA DE PROCALCITONINA EM UMA AMOSTRA. De modo a fornecer um reagente de diagnóstico adequado para análise turbidimétrica com um fotômetro simples e com alta sensibilidade para determinação quantitativa da procalcitonina em uma amostra, em que o reagente é uma suspensão aquosa de partículas de polímero com anticorpos contra a procalcitonina covalentemente ligada a essas partículas de polímero, no qual não é detectável nenhuma ou apenas uma tendência extremamente leve à aglutinação/sedimentação, mesmo após tempos mais longos e a reatividade específica das partículas permanece em grande parte inalterada, propõe-se, de acordo com a invenção, que as partículas de polímero em suspensão tenham um tamanho médio de partícula na faixa de 150 a 450 nm, a suspensão compreende uma proporção de açúcar ou álcool de açúcar dissolvido na faixa de 25 a 250 g/l e a suspensão tem um pH na faixa de 8 a 10.
BR112022014093A 2020-01-28 2021-01-25 Reagente de diagnóstico para determinação quantitativa de procalcitonina em uma amostra BR112022014093A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020102038 2020-01-28
PCT/EP2021/051577 WO2021151820A1 (de) 2020-01-28 2021-01-25 Diagnostisches reagenz zur quantitativen bestimmung von procalcitonin in einer probe

Publications (1)

Publication Number Publication Date
BR112022014093A2 true BR112022014093A2 (pt) 2022-09-13

Family

ID=74550606

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022014093A BR112022014093A2 (pt) 2020-01-28 2021-01-25 Reagente de diagnóstico para determinação quantitativa de procalcitonina em uma amostra

Country Status (7)

Country Link
US (1) US20230083766A1 (pt)
EP (1) EP4097476A1 (pt)
JP (1) JP2023514969A (pt)
KR (1) KR20220133225A (pt)
CN (1) CN115210569A (pt)
BR (1) BR112022014093A2 (pt)
WO (1) WO2021151820A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE356874T1 (de) 1999-12-22 2007-04-15 Dade Behring Marburg Gmbh Lösungen von humanem procalcitonin
CN103558400A (zh) * 2013-11-25 2014-02-05 重庆中元生物技术有限公司 一种降钙素原乳胶增强免疫比浊法检测试剂盒
CN105891497A (zh) * 2014-12-19 2016-08-24 北京科美生物技术有限公司 一种降钙素原胶体金免疫比色法定量检测试剂盒及其制备方法
CN109725160B (zh) * 2018-12-30 2021-03-23 山东博科生物产业有限公司 一种降钙素原(pct)检测试剂盒
CN109959797A (zh) * 2019-03-28 2019-07-02 曾宪亮 一种降钙素原检测试剂盒及其制备方法

Also Published As

Publication number Publication date
EP4097476A1 (de) 2022-12-07
WO2021151820A1 (de) 2021-08-05
KR20220133225A (ko) 2022-10-04
US20230083766A1 (en) 2023-03-16
CN115210569A (zh) 2022-10-18
JP2023514969A (ja) 2023-04-12

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