BR112022008137A2 - Processos para preparar um modulador de receptor s1p - Google Patents

Processos para preparar um modulador de receptor s1p

Info

Publication number
BR112022008137A2
BR112022008137A2 BR112022008137A BR112022008137A BR112022008137A2 BR 112022008137 A2 BR112022008137 A2 BR 112022008137A2 BR 112022008137 A BR112022008137 A BR 112022008137A BR 112022008137 A BR112022008137 A BR 112022008137A BR 112022008137 A2 BR112022008137 A2 BR 112022008137A2
Authority
BR
Brazil
Prior art keywords
processes
prepare
compound
receiver modulator
modulator
Prior art date
Application number
BR112022008137A
Other languages
English (en)
Inventor
De Lombaert Stéphane
Daryll Schwarz Holt Jonathon
Rosario Mollo Sarno Ana
Bradley Schwarz Jacob
A Christie Michael
L Ciolkowski Edward
Zhang Zenghong
Original Assignee
Escape Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Escape Bio Inc filed Critical Escape Bio Inc
Publication of BR112022008137A2 publication Critical patent/BR112022008137A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Filters And Equalizers (AREA)
  • Design And Manufacture Of Integrated Circuits (AREA)
  • Semiconductor Memories (AREA)

Abstract

PROCESSOS PARA PREPARAR UM MODULADOR DE RECEPTOR S1P. Este pedido refere-se a processos para preparar um modulador de receptor de S1P Composto 1, que é útil no tratamento de doenças ou distúrbios associados à atividade de S1P, incluindo distúrbios do SNC. O processo compreende a reação do composto 2 com o composto 3 na presença de um agente de redução.
BR112022008137A 2019-10-31 2020-10-30 Processos para preparar um modulador de receptor s1p BR112022008137A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962928422P 2019-10-31 2019-10-31
PCT/US2020/058259 WO2021087292A1 (en) 2019-10-31 2020-10-30 Processes for preparing an s1p-receptor modulator

Publications (1)

Publication Number Publication Date
BR112022008137A2 true BR112022008137A2 (pt) 2022-07-19

Family

ID=73598956

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022008137A BR112022008137A2 (pt) 2019-10-31 2020-10-30 Processos para preparar um modulador de receptor s1p

Country Status (12)

Country Link
US (1) US20210139503A1 (pt)
EP (1) EP4051684A1 (pt)
JP (1) JP2022553801A (pt)
KR (1) KR20220123633A (pt)
CN (1) CN114650996A (pt)
AU (1) AU2020372990A1 (pt)
BR (1) BR112022008137A2 (pt)
CA (1) CA3159193A1 (pt)
IL (1) IL292548A (pt)
MX (1) MX2022005085A (pt)
TW (1) TW202132312A (pt)
WO (1) WO2021087292A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI543984B (zh) 2010-07-09 2016-08-01 艾伯維公司 作為s1p調節劑的螺-哌啶衍生物
AU2020373047A1 (en) 2019-10-31 2022-05-19 ESCAPE Bio, Inc. Solid forms of an S1P-receptor modulator

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI522361B (zh) 2010-07-09 2016-02-21 艾伯維公司 作為s1p調節劑的稠合雜環衍生物
WO2017156177A1 (en) * 2016-03-09 2017-09-14 Raze Therapeutics, Inc. 3-phosphoglycerate dehydrogenase inhibitors and uses thereof

Also Published As

Publication number Publication date
MX2022005085A (es) 2022-05-26
TW202132312A (zh) 2021-09-01
JP2022553801A (ja) 2022-12-26
EP4051684A1 (en) 2022-09-07
KR20220123633A (ko) 2022-09-08
IL292548A (en) 2022-06-01
WO2021087292A1 (en) 2021-05-06
CA3159193A1 (en) 2021-05-06
CN114650996A (zh) 2022-06-21
US20210139503A1 (en) 2021-05-13
AU2020372990A1 (en) 2022-05-19

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