BR112022008023A2 - Dispositivos de seleção e/ou estimulação de células e métodos de uso - Google Patents
Dispositivos de seleção e/ou estimulação de células e métodos de usoInfo
- Publication number
- BR112022008023A2 BR112022008023A2 BR112022008023A BR112022008023A BR112022008023A2 BR 112022008023 A2 BR112022008023 A2 BR 112022008023A2 BR 112022008023 A BR112022008023 A BR 112022008023A BR 112022008023 A BR112022008023 A BR 112022008023A BR 112022008023 A2 BR112022008023 A2 BR 112022008023A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- devices
- cell selection
- stimulation devices
- aspects
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/606—Construction of the column body with fluid access or exit ports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/161—Temperature conditioning
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N30/54—Temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962928303P | 2019-10-30 | 2019-10-30 | |
| PCT/EP2020/080476 WO2021084050A1 (en) | 2019-10-30 | 2020-10-29 | Cell selection and/or stimulation devices and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022008023A2 true BR112022008023A2 (pt) | 2022-07-12 |
Family
ID=73172649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022008023A BR112022008023A2 (pt) | 2019-10-30 | 2020-10-29 | Dispositivos de seleção e/ou estimulação de células e métodos de uso |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250237628A1 (https=) |
| EP (1) | EP4051402B1 (https=) |
| JP (1) | JP7746263B2 (https=) |
| KR (1) | KR20220101641A (https=) |
| CN (1) | CN114929360A (https=) |
| AU (1) | AU2020377043B2 (https=) |
| BR (1) | BR112022008023A2 (https=) |
| CA (1) | CA3159380A1 (https=) |
| IL (1) | IL292319B2 (https=) |
| MX (1) | MX2022005145A (https=) |
| WO (1) | WO2021084050A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| JP7738826B2 (ja) * | 2021-10-29 | 2025-09-16 | 東ソー株式会社 | 遺伝子改変t細胞の製造方法 |
| ES3024941T3 (en) * | 2022-02-02 | 2025-06-05 | Sartorius Bia Separations D O O | Method of purifying or removing a target component from full plasma |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| JP2026504491A (ja) | 2023-02-03 | 2026-02-05 | ツェー3エス2 ゲーエムベーハー | 操作された免疫細胞の非ウイルス的製造のための方法 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| EP0198015B2 (en) | 1984-10-02 | 1995-07-19 | Biogen, Inc. | Production of streptavidin-like polypeptides |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| IN165717B (https=) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| DE3729002A1 (de) * | 1987-08-31 | 1989-04-20 | Merck Patent Gmbh | Chromatographiesaeulen-kartuschensystem |
| US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| IE913929A1 (en) | 1990-11-13 | 1992-05-20 | Immunex Corp | Bifunctional selectable fusion genes |
| DE4228458A1 (de) | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| ATE293686T1 (de) | 1993-06-04 | 2005-05-15 | Us Navy | Verfahren zur selektiven stimulierung der t- zellproliferation. |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| WO1996013593A2 (en) | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| AU708375B2 (en) | 1995-02-09 | 1999-08-05 | University Of Washington | Modified-affinity streptavidin |
| US6022951A (en) | 1995-04-11 | 2000-02-08 | Univ Boston | Streptavidin mutants |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
| US6123655A (en) | 1996-04-24 | 2000-09-26 | Fell; Claude | Cell separation system with variable size chamber for the processing of biological fluids |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| EP0977770A4 (en) | 1997-03-14 | 2000-04-05 | Univ Boston | DIFFERENTLY FLAVORED STREPTAVIDINE |
| ATE533784T1 (de) | 1997-10-02 | 2011-12-15 | Altor Bioscience Corp | Lösliche, einzelkettige proteine des t- zellrezeptors |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| WO1999060120A2 (en) | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| ATE304375T1 (de) | 1998-05-23 | 2005-09-15 | Univ Leiden Medical Ct | Cd40 bindende antikörper und ctl peptide zur behandlung von tumoren |
| EP1109921A4 (en) | 1998-09-04 | 2002-08-28 | Sloan Kettering Inst Cancer | FUSION RECEPTORS SPECIFIC TO MEMBRANE SPECIFIC PROSTATIC ANTIGEN AND USES THEREOF |
| US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| HK1041454B (en) | 1998-12-24 | 2004-12-31 | 生物安全股份有限公司 | Blood separation system particularly for concentrating hematopoietic stem cells |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| WO2001056603A1 (en) | 2000-02-01 | 2001-08-09 | Tanox, Inc. | Cd40-binding apc-activating molecules |
| US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| IL160359A0 (en) | 2001-08-31 | 2004-07-25 | Avidex Ltd | Soluble t cell receptor |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US7939059B2 (en) | 2001-12-10 | 2011-05-10 | California Institute Of Technology | Method for the generation of antigen-specific lymphocytes |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| CA2501870C (en) | 2002-10-09 | 2013-07-02 | Avidex Limited | Single chain recombinant t cell receptors |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| ATE475669T1 (de) | 2004-06-29 | 2010-08-15 | Immunocore Ltd | Einen modifizierten t-zellen-rezeptor exprimierende zellen |
| JP5008568B2 (ja) * | 2004-10-07 | 2012-08-22 | ウオーターズ・テクノロジーズ・コーポレイシヨン | Hplcキャピラリーカラム装置 |
| WO2006054961A2 (en) | 2004-11-12 | 2006-05-26 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| US8188232B1 (en) | 2004-11-15 | 2012-05-29 | Washington University In St. Louis | Compositions and methods for modulating lymphocyte activity |
| ES2345837T3 (es) | 2005-03-23 | 2010-10-04 | Biosafe S.A. | Sistema integrado para la recogida, el procesamiento y el trasplante de subgrupos de celulas, incluyendo celulas madre adultas, para medicina regenerativa. |
| WO2008009311A1 (en) * | 2006-07-17 | 2008-01-24 | Agilent Technologies, Inc. | Temperature adjustment of a fluidic sample within a fluidic device |
| GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| SI2856876T1 (en) | 2007-03-30 | 2018-04-30 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| AU2008247382B2 (en) | 2007-05-07 | 2014-06-05 | Medimmune, Llc | Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| EP2331566B1 (en) | 2008-08-26 | 2015-10-07 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
| TR201904484T4 (tr) | 2009-11-03 | 2019-05-21 | Hope City | Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt). |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| US9023604B2 (en) | 2011-07-18 | 2015-05-05 | Iba Gmbh | Method of reversibly staining a target cell |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| CN104080797A (zh) | 2011-11-11 | 2014-10-01 | 弗雷德哈钦森癌症研究中心 | 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法 |
| CA2861491C (en) | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP2844743B1 (en) | 2012-05-03 | 2021-01-13 | Fred Hutchinson Cancer Research Center | Enhanced affinity t cell receptors and methods for making the same |
| US11185795B2 (en) * | 2012-07-06 | 2021-11-30 | Waters Technologies Corporation | Techniques for thermally insulating a chromatographic column |
| DE112013003410T5 (de) * | 2012-07-06 | 2015-04-23 | Waters Technologies Corporation | Verfahren zur Isolierung einer Flüssigkeitschromatographiesäule |
| BR122020002986A8 (pt) | 2012-08-20 | 2023-04-18 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapia celular |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| CN105073770B (zh) | 2012-11-16 | 2019-08-06 | Iba股份有限公司 | 链霉亲和素突变蛋白及其使用方法 |
| US10220332B2 (en) * | 2013-02-15 | 2019-03-05 | Douglas T. Gjerde | Columns for isolation, detection and use of biological cells |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| SI3132247T1 (sl) | 2014-04-16 | 2021-12-31 | Juno Therapeutics Gmbh | Postopki, kompleti in naprava za povečanje populacije celic |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CN113604491A (zh) | 2014-05-02 | 2021-11-05 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| ES2987570T3 (es) | 2014-11-05 | 2024-11-15 | Juno Therapeutics Inc | Métodos para la transducción y el procesamiento de células |
| BR112017011932A8 (pt) | 2014-12-05 | 2022-11-08 | Memorial Sloan Kettering Cancer Center | Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso |
| SI3226897T1 (sl) | 2014-12-05 | 2021-08-31 | Memorial Sloan Kettering Cancer Center | Protitelesa, ki ciljajo na B-celični maturacijski antigen, in postopki uporabe |
| CN118271463A (zh) | 2014-12-05 | 2024-07-02 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的嵌合抗原受体及其用途 |
| MY191537A (en) | 2014-12-05 | 2022-06-30 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
| AU2016341529B2 (en) | 2015-10-22 | 2023-03-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| US20180325964A1 (en) * | 2015-11-20 | 2018-11-15 | Advaxis, Inc. | Manufacturing device and method of an immunotherapeutic formulation comprising a recombinant listeria strain |
| JP6967011B2 (ja) * | 2016-04-15 | 2021-11-17 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフィカラムを熱的に絶縁するための技術 |
| JP7062640B2 (ja) | 2016-07-29 | 2022-05-06 | ジュノー セラピューティクス インコーポレイテッド | 抗cd19抗体に対する抗イディオタイプ抗体 |
| MX2019010906A (es) | 2017-03-14 | 2020-02-12 | Juno Therapeutics Inc | Metodos para almacenamiento criogenico. |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| ES2968737T3 (es) | 2018-11-06 | 2024-05-13 | Juno Therapeutics Inc | Proceso para producir células T manipuladas genéticamente |
-
2020
- 2020-10-29 KR KR1020227017393A patent/KR20220101641A/ko active Pending
- 2020-10-29 EP EP20803451.2A patent/EP4051402B1/en active Active
- 2020-10-29 IL IL292319A patent/IL292319B2/en unknown
- 2020-10-29 CN CN202080090115.8A patent/CN114929360A/zh active Pending
- 2020-10-29 WO PCT/EP2020/080476 patent/WO2021084050A1/en not_active Ceased
- 2020-10-29 BR BR112022008023A patent/BR112022008023A2/pt unknown
- 2020-10-29 AU AU2020377043A patent/AU2020377043B2/en active Active
- 2020-10-29 CA CA3159380A patent/CA3159380A1/en active Pending
- 2020-10-29 MX MX2022005145A patent/MX2022005145A/es unknown
- 2020-10-29 JP JP2022525641A patent/JP7746263B2/ja active Active
- 2020-10-29 US US17/772,981 patent/US20250237628A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3159380A1 (en) | 2021-05-06 |
| KR20220101641A (ko) | 2022-07-19 |
| CN114929360A (zh) | 2022-08-19 |
| EP4051402B1 (en) | 2026-04-29 |
| AU2020377043A1 (en) | 2022-06-02 |
| IL292319B1 (en) | 2025-09-01 |
| AU2020377043B2 (en) | 2026-02-26 |
| IL292319A (en) | 2022-06-01 |
| EP4051402A1 (en) | 2022-09-07 |
| WO2021084050A1 (en) | 2021-05-06 |
| JP7746263B2 (ja) | 2025-09-30 |
| IL292319B2 (en) | 2026-01-01 |
| JP2023500318A (ja) | 2023-01-05 |
| US20250237628A1 (en) | 2025-07-24 |
| MX2022005145A (es) | 2022-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112022008023A2 (pt) | Dispositivos de seleção e/ou estimulação de células e métodos de uso | |
| Burnstock et al. | Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death | |
| Kondratov et al. | Circadian proteins in the regulation of cell cycle and genotoxic stress responses | |
| Schoenhard et al. | Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2 | |
| Michel et al. | Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response | |
| MX2020009514A (es) | Anticuerpos anti-claudina 18.2 (cldn18.2). | |
| Whitehead et al. | N-terminal phosphorylation of p60 katanin directly regulates microtubule severing | |
| Solagna et al. | Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling | |
| BR112023022594A2 (pt) | Sistemas cirúrgicos configurados para controlar a aplicação de energia terapêutica ao tecido com base em parâmetros do cartucho e do tecido | |
| Eelen et al. | 1, 25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts | |
| PY2219816A (es) | Moduladores de sting (estimulador de genes de interferón) | |
| Dippold et al. | Myosin phosphatase isoforms as determinants of smooth muscle contractile function and calcium sensitivity of force production | |
| CO2021018066A2 (es) | Terapia con linfocitos de infiltración tumoral y sus usos | |
| Liu et al. | β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression | |
| Hocking et al. | Papaverine prevents vasospasm by regulation of myosin light chain phosphorylation and actin polymerization in human saphenous vein | |
| CL2025001720A1 (es) | Productos terapéuticos dirigidos al receptor de somatostatina subtipo 2 (sst2r) y usos de la misma | |
| Tian et al. | High expression of PP2A-Aα is associated with diapause induction during the photoperiod-sensitive stage of the cotton bollworm, Helicoverpa armigera | |
| BR112017027726A2 (pt) | controlador e fonte de alimentação universais de plataforma de fototerapia | |
| CO2022011813A2 (es) | Elementos y métodos de regulación de ácidos nucleicos específicos de músculo y uso de los mismos | |
| Krakowiak et al. | Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5′-O-monophosphorothioate and their derivatives—Implication for desulfuration process in the cell | |
| CO2024014842A2 (es) | Elementos para desdireccionamiento de la expresión génica en el hígado | |
| Johnson et al. | Phosphatases driving mitosis: pushing the gas and lifting the brakes | |
| Xiong et al. | Cloning of cytidine triphosphate: phosphocholine cytidylyltransferase mRNA upregulated by a neuropeptide arginine-vasopressin (4–8) in rat hippocampus | |
| Dupré et al. | ARPP19 phosphorylations by PKA and greatwall: the Yin and the Yang of the cell decision to divide | |
| Guo et al. | Homeostatic mechanisms by alternative forms of tRNA synthetases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |