BR112022006523A2 - 2'-desóxi-2',2'-difluorotetraidrouridinas com alta pureza e métodos para produção da mesma - Google Patents

2'-desóxi-2',2'-difluorotetraidrouridinas com alta pureza e métodos para produção da mesma

Info

Publication number
BR112022006523A2
BR112022006523A2 BR112022006523A BR112022006523A BR112022006523A2 BR 112022006523 A2 BR112022006523 A2 BR 112022006523A2 BR 112022006523 A BR112022006523 A BR 112022006523A BR 112022006523 A BR112022006523 A BR 112022006523A BR 112022006523 A2 BR112022006523 A2 BR 112022006523A2
Authority
BR
Brazil
Prior art keywords
methods
difluorotetrahydrouridins
desoxy
production
high purity
Prior art date
Application number
BR112022006523A
Other languages
English (en)
Inventor
Zuend Gemma
Scott Ian
Davar Nipun
Annaka Kimiyoshi
Miyake Masahiro
Matsui Motoshi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BR112022006523A2 publication Critical patent/BR112022006523A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0245—Nitrogen containing compounds being derivatives of carboxylic or carbonic acids
    • B01J31/0247—Imides, amides or imidates (R-C=NR(OR))
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

2'-DESÓXI-2',2'-DIFLUOROTETRAIDROURIDINAS COM ALTA PUREZA E MÉTODOS PARA PRODUÇÃO DA MESMA. A presente invenção refere-se a métodos de síntese de 2'-desoxi-2',2'-difluorotetraidrouridina com maior pureza e distribuição uniforme de tamanho de partículas. Em particular, os métodos da invenção incluem procedimentos de cristalização e isolamento que suprem intermediários sintéticos de reação. A invenção inclui ainda composições compreendendo o composto final em forma altamente pura, incluindo menor número de impurezas e níveis mais baixos de impurezas individuais e totais.
BR112022006523A 2019-10-08 2020-10-07 2'-desóxi-2',2'-difluorotetraidrouridinas com alta pureza e métodos para produção da mesma BR112022006523A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962912317P 2019-10-08 2019-10-08
PCT/US2020/054500 WO2021071890A1 (en) 2019-10-08 2020-10-07 2'-deoxy-2',2'-difluorotetrahydrouridines with high purity and methods of making the same

Publications (1)

Publication Number Publication Date
BR112022006523A2 true BR112022006523A2 (pt) 2022-06-28

Family

ID=75437484

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022006523A BR112022006523A2 (pt) 2019-10-08 2020-10-07 2'-desóxi-2',2'-difluorotetraidrouridinas com alta pureza e métodos para produção da mesma

Country Status (10)

Country Link
US (2) US20220411457A1 (pt)
EP (1) EP4041743A4 (pt)
JP (1) JP2022552817A (pt)
KR (1) KR20220078619A (pt)
CN (1) CN114728997A (pt)
AU (1) AU2020363412A1 (pt)
BR (1) BR112022006523A2 (pt)
CA (1) CA3154754A1 (pt)
MX (1) MX2022004271A (pt)
WO (1) WO2021071890A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230271996A1 (en) * 2021-12-25 2023-08-31 Scinopharm Taiwan, Ltd. Process for preparing cedazuridine
TWI821074B (zh) * 2021-12-25 2023-11-01 台灣神隆股份有限公司 製備希達路里定（cedazuridine）的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388094B2 (en) * 2003-04-10 2008-06-17 Central Glass Company Limited Processing for producing 2′-deoxy-2′-fluorouridine
JO2778B1 (en) * 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
KR102272773B1 (ko) * 2013-10-29 2021-07-02 오츠카 세이야쿠 가부시키가이샤 2'-데옥시-2',2'-디플루오로테트라하이드로우리딘의 합성 경로
WO2017158396A1 (en) * 2016-03-16 2017-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Cytidine deaminase inhibitors for the treatment of pancreatic cancer
CN109999038A (zh) * 2019-04-15 2019-07-12 中山大学 一种基于阻断巨噬细胞效应的抗肿瘤药物组合物及其应用

Also Published As

Publication number Publication date
US20230303609A1 (en) 2023-09-28
KR20220078619A (ko) 2022-06-10
CN114728997A (zh) 2022-07-08
CA3154754A1 (en) 2021-04-15
US20220411457A1 (en) 2022-12-29
AU2020363412A1 (en) 2022-04-07
MX2022004271A (es) 2022-06-09
EP4041743A1 (en) 2022-08-17
EP4041743A4 (en) 2024-03-13
WO2021071890A1 (en) 2021-04-15
JP2022552817A (ja) 2022-12-20

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