BR112022001674A2 - Composição farmacêutica para administração por via otológica - Google Patents
Composição farmacêutica para administração por via otológicaInfo
- Publication number
- BR112022001674A2 BR112022001674A2 BR112022001674A BR112022001674A BR112022001674A2 BR 112022001674 A2 BR112022001674 A2 BR 112022001674A2 BR 112022001674 A BR112022001674 A BR 112022001674A BR 112022001674 A BR112022001674 A BR 112022001674A BR 112022001674 A2 BR112022001674 A2 BR 112022001674A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- otological
- administration
- mpa
- ear
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
composição farmacêutica para administração por via otológica. a presente invenção refere-se a uma composição farmacêutica que pode ser administrada no ouvido sem nenhuma operação complicada e tem a função de permitir que um fármaco seja retido e lentamente liberado no ouvido. a composição farmacêutica para administração por via otológica, compreende um, dois ou mais fármacos e um polímero, em que quando a viscosidade complexa da composição farmacêutica é medida usando um reômetro sob as condições de uma tensão de cisalhamento de 5% e uma frequência angular de 50 rad / s, enquanto aumenta a temperatura de 25º c para 37º c a uma taxa de aquecimento de 1º c / 10 s, a viscosidade complexa é inferior a 1.650 mpa.s a 25º c, e é de 1.650 mpa.s a 100.000 mpa.s em 10 minutos após atingir 37º c.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019140977 | 2019-07-31 | ||
PCT/JP2020/029342 WO2021020535A1 (ja) | 2019-07-31 | 2020-07-30 | 耳内投与用の医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022001674A2 true BR112022001674A2 (pt) | 2022-03-22 |
Family
ID=74228876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022001674A BR112022001674A2 (pt) | 2019-07-31 | 2020-07-30 | Composição farmacêutica para administração por via otológica |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230157946A1 (pt) |
EP (1) | EP4008353A4 (pt) |
JP (1) | JPWO2021020535A1 (pt) |
KR (1) | KR20220041143A (pt) |
CN (1) | CN114222589A (pt) |
AU (1) | AU2020319755A1 (pt) |
BR (1) | BR112022001674A2 (pt) |
CA (1) | CA3148042A1 (pt) |
MX (1) | MX2022001374A (pt) |
TW (1) | TW202120126A (pt) |
WO (1) | WO2021020535A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202107976D0 (en) * | 2021-06-03 | 2021-07-21 | Norbrook Lab Ltd | Sol-gel compositions for veterinary use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001247410B2 (en) | 2000-03-14 | 2005-05-12 | Alcon, Inc. | Viscoelastics for use in middle ear surgery |
WO2008124467A1 (en) | 2007-04-06 | 2008-10-16 | Macrocyclics | Bifunctional hydroxamic acid ligands and method of synthesis |
EP3508197A1 (en) * | 2009-10-21 | 2019-07-10 | Otonomy, Inc. | Modulation of gel temperature of poloxamer-containing formulations |
JP2013508381A (ja) * | 2009-10-21 | 2013-03-07 | オトノミ―,インク. | ポロクサマーを包含する製剤のゲル化温度の調節 |
PT2996709T (pt) | 2013-05-15 | 2020-07-14 | Univ Leland Stanford Junior | Modulação da atividade do fator de crescimento epidérmico de ligação à heparina para cicatrização da membrana timpânica |
US20180071209A1 (en) * | 2015-03-24 | 2018-03-15 | Dow Global Technologies Llc | Aqueous solution of polymers |
CN105769753B (zh) * | 2016-04-19 | 2019-10-29 | 浙江工业大学 | 一种温敏凝胶基质及其制备方法与应用 |
EP3554508A4 (en) * | 2016-12-19 | 2020-08-05 | Druggability Technologies IP Holdco Limited | SUVOREXANT PHARMACEUTICAL FORMULATIONS |
-
2020
- 2020-07-30 EP EP20846930.4A patent/EP4008353A4/en active Pending
- 2020-07-30 MX MX2022001374A patent/MX2022001374A/es unknown
- 2020-07-30 US US17/631,413 patent/US20230157946A1/en active Pending
- 2020-07-30 JP JP2021535442A patent/JPWO2021020535A1/ja active Pending
- 2020-07-30 CN CN202080054454.0A patent/CN114222589A/zh active Pending
- 2020-07-30 WO PCT/JP2020/029342 patent/WO2021020535A1/ja unknown
- 2020-07-30 AU AU2020319755A patent/AU2020319755A1/en active Pending
- 2020-07-30 KR KR1020227006050A patent/KR20220041143A/ko not_active Application Discontinuation
- 2020-07-30 TW TW109125750A patent/TW202120126A/zh unknown
- 2020-07-30 BR BR112022001674A patent/BR112022001674A2/pt unknown
- 2020-07-30 CA CA3148042A patent/CA3148042A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPWO2021020535A1 (pt) | 2021-02-04 |
MX2022001374A (es) | 2022-03-17 |
EP4008353A4 (en) | 2023-05-10 |
WO2021020535A1 (ja) | 2021-02-04 |
US20230157946A1 (en) | 2023-05-25 |
TW202120126A (zh) | 2021-06-01 |
KR20220041143A (ko) | 2022-03-31 |
CA3148042A1 (en) | 2021-02-04 |
EP4008353A1 (en) | 2022-06-08 |
CN114222589A (zh) | 2022-03-22 |
AU2020319755A1 (en) | 2022-03-10 |
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