BR112021026660A2 - Funcionalidade de foco automático em análise de amostra óptica - Google Patents

Funcionalidade de foco automático em análise de amostra óptica

Info

Publication number
BR112021026660A2
BR112021026660A2 BR112021026660A BR112021026660A BR112021026660A2 BR 112021026660 A2 BR112021026660 A2 BR 112021026660A2 BR 112021026660 A BR112021026660 A BR 112021026660A BR 112021026660 A BR112021026660 A BR 112021026660A BR 112021026660 A2 BR112021026660 A2 BR 112021026660A2
Authority
BR
Brazil
Prior art keywords
sample analysis
automatic focus
optical sample
focus functionality
substrate
Prior art date
Application number
BR112021026660A
Other languages
English (en)
Inventor
Prince Simon
Condello Danilo
Hsieh Vincent
Phounsiri Krysada
O'shaughnessy John
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of BR112021026660A2 publication Critical patent/BR112021026660A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/42—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect
    • G02B27/4233—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application
    • G02B27/425—Diffraction optics, i.e. systems including a diffractive element being designed for providing a diffractive effect having a diffractive element [DOE] contributing to a non-imaging application in illumination systems
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/04—Prisms
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
    • G02B7/04—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification
    • G02B7/09—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification adapted for automatic focusing or varying magnification
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/28—Systems for automatic generation of focusing signals
    • G02B7/30—Systems for automatic generation of focusing signals using parallactic triangle with a base line
    • G02B7/32—Systems for automatic generation of focusing signals using parallactic triangle with a base line using active means, e.g. light emitter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Automatic Focus Adjustment (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

FUNCIONALIDADE DE FOCO AUTOMÁTICO EM ANÁLISE DE AMOSTRA ÓPTICA. É apresentado um método que compreende: direcionar, usando uma objetiva e uma primeira superfície reflexiva, a primeira luz de foco automático em direção a um sensor, sendo que a primeira luz de foco automático é refletida a partir de uma primeira superfície de um substrato; impedir que a segunda luz de foco automático atinja o sensor, sendo que a segunda luz de foco automático é refletida a partir de uma segunda superfície do substrato; e direcionar, usando a objetiva e uma segunda superfície reflexiva, a luz de emissão em direção ao sensor, sendo que a luz de emissão tem origem em uma amostra no substrato.
BR112021026660A 2019-12-31 2020-12-22 Funcionalidade de foco automático em análise de amostra óptica BR112021026660A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962956083P 2019-12-31 2019-12-31
US202062959681P 2020-01-10 2020-01-10
PCT/US2020/070951 WO2021138633A1 (en) 2019-12-31 2020-12-22 Autofocus functionality in optical sample analysis

Publications (1)

Publication Number Publication Date
BR112021026660A2 true BR112021026660A2 (pt) 2022-07-12

Family

ID=76546085

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026660A BR112021026660A2 (pt) 2019-12-31 2020-12-22 Funcionalidade de foco automático em análise de amostra óptica

Country Status (12)

Country Link
US (2) US11815458B2 (pt)
EP (1) EP3990891A4 (pt)
JP (1) JP2023510438A (pt)
KR (1) KR20220118301A (pt)
CN (3) CN113064266A (pt)
AU (1) AU2020418180A1 (pt)
BR (1) BR112021026660A2 (pt)
CA (1) CA3144819A1 (pt)
IL (1) IL289312A (pt)
MX (1) MX2021016073A (pt)
TW (2) TW202331329A (pt)
WO (1) WO2021138633A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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FR3128994B1 (fr) * 2021-11-08 2024-03-15 Inst De Radioprotection Et De Surete Nucleaire Module d’observation et dispositif associe de detection de la presence d’au moins une particule d’un aerosol

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Also Published As

Publication number Publication date
CN215953954U (zh) 2022-03-04
TW202331329A (zh) 2023-08-01
CN113064266A (zh) 2021-07-02
CA3144819A1 (en) 2021-07-08
MX2021016073A (es) 2022-03-25
US20240027349A1 (en) 2024-01-25
EP3990891A4 (en) 2023-07-26
AU2020418180A1 (en) 2022-01-06
WO2021138633A1 (en) 2021-07-08
US20210199587A1 (en) 2021-07-01
US11815458B2 (en) 2023-11-14
TWI794708B (zh) 2023-03-01
JP2023510438A (ja) 2023-03-14
IL289312A (en) 2022-02-01
KR20220118301A (ko) 2022-08-25
TW202127083A (zh) 2021-07-16
CN217561823U (zh) 2022-10-11
EP3990891A1 (en) 2022-05-04

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