BR112021026317A2 - Análogos de teta-defensina - Google Patents

Análogos de teta-defensina

Info

Publication number
BR112021026317A2
BR112021026317A2 BR112021026317A BR112021026317A BR112021026317A2 BR 112021026317 A2 BR112021026317 A2 BR 112021026317A2 BR 112021026317 A BR112021026317 A BR 112021026317A BR 112021026317 A BR112021026317 A BR 112021026317A BR 112021026317 A2 BR112021026317 A2 BR 112021026317A2
Authority
BR
Brazil
Prior art keywords
theta
defensin
analogues
sepsis
effect
Prior art date
Application number
BR112021026317A
Other languages
English (en)
Other versions
BR112021026317A8 (pt
Inventor
Dat Tran
B Schaal Justin
E Selsted Michael
Original Assignee
Dat Tran
B Schaal Justin
E Selsted Michael
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dat Tran, B Schaal Justin, E Selsted Michael filed Critical Dat Tran
Publication of BR112021026317A2 publication Critical patent/BR112021026317A2/pt
Publication of BR112021026317A8 publication Critical patent/BR112021026317A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

análogos de teta-defensina. a presente invenção refere-se a análogos de peptídeo de uma teta-defensina que foram desenvolvidos para fornecer um efeito bifásico no tratamento de infecção e/ou sepse. esses análogos são ativos em concentrações abaixo das necessárias para fornecer um efeito bactericida ou bacteriostático e funcionam recrutando inicialmente células efetoras do sistema imunológico para abordar o organismo infeccioso seguido pela regulação do sistema imunológico para regular negativamente a resposta inflamatória característica da sepse e choque séptico. estes análogos de teta-defensina são protetores em concentrações onde as teta-defensinas de ocorrência natural não têm efeito aparente e incluem um conjunto central de características estruturais e de sequência não encontradas na teta-defensina nativa.
BR112021026317A 2019-06-26 2020-06-26 Análogos de teta-defensina BR112021026317A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962867000P 2019-06-26 2019-06-26
PCT/US2020/039945 WO2020264389A1 (en) 2019-06-26 2020-06-26 Novel theta defensin analogs

Publications (2)

Publication Number Publication Date
BR112021026317A2 true BR112021026317A2 (pt) 2022-04-12
BR112021026317A8 BR112021026317A8 (pt) 2022-12-13

Family

ID=74042848

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112021026317A BR112021026317A8 (pt) 2019-06-26 2020-06-26 Análogos de teta-defensina
BR112021026216A BR112021026216A8 (pt) 2019-06-26 2020-06-26 Composições e métodos para o tratamento de infecções fúngicas

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112021026216A BR112021026216A8 (pt) 2019-06-26 2020-06-26 Composições e métodos para o tratamento de infecções fúngicas

Country Status (11)

Country Link
US (4) US11021518B2 (pt)
EP (2) EP3990472A4 (pt)
JP (2) JP2022552925A (pt)
KR (2) KR20220042129A (pt)
CN (2) CN114080394A (pt)
AU (2) AU2020302077C1 (pt)
BR (2) BR112021026317A8 (pt)
CA (2) CA3143032A1 (pt)
IL (2) IL289236A (pt)
MX (2) MX2021015534A (pt)
WO (2) WO2020264328A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022552925A (ja) * 2019-06-26 2022-12-21 イー． セルステッド、マイケル 真菌感染症の治療のための組成物及び方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
AU5153598A (en) * 1997-10-27 1999-05-17 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
US6335318B1 (en) * 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US20030022829A1 (en) 2001-03-30 2003-01-30 Wendy Maury Novel antiviral activities primate theta defensins and mammalian cathelicidins
US7119070B2 (en) * 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
DE10226216A1 (de) * 2002-06-13 2003-12-24 Bayer Ag Behandlung von schweren Infektionen und septischem Schock
GB0300718D0 (en) 2003-01-13 2003-02-12 Ares Trading Sa Proteins
US20080255052A1 (en) * 2004-12-23 2008-10-16 The Regents Of The University Of California Immunologic regulation by theta defensins
WO2007044998A1 (en) 2005-10-12 2007-04-19 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US7521535B2 (en) 2006-09-20 2009-04-21 The Board Of Regents For Oklahoma State University Anti-microbial defensin-related peptides and methods of use
CA2745499A1 (en) 2008-12-05 2010-06-10 Angiochem Inc. Peptide therapeutic conjugates and uses thereof
BR112013030874B8 (pt) * 2011-06-02 2021-09-14 Univ California Uso de uma theta-defensina ou análogo da mesma para tratar uma condição inflamatória crônica
US9394561B2 (en) 2011-12-07 2016-07-19 National Research Council Of Canada Cyclic peptide production
WO2013130767A1 (en) 2012-02-29 2013-09-06 Pulmatrix, Inc. Inhalable dry powders
US10329550B2 (en) 2014-02-14 2019-06-25 Lysando Ag Antimicrobial agents
EP3180431A1 (en) 2014-08-11 2017-06-21 Miti Biosystems GmbH Cyclic peptides expressed by a genetic package
ES2710973T3 (es) 2014-08-29 2019-04-29 Ceinge Biotecnologie Avanzate S C A R L Análogos de las defensinas beta cíclicas para el tratamiento de infecciones
JP2022552925A (ja) * 2019-06-26 2022-12-21 イー． セルステッド、マイケル 真菌感染症の治療のための組成物及び方法

Also Published As

Publication number Publication date
JP2022552925A (ja) 2022-12-21
EP3990472A1 (en) 2022-05-04
BR112021026216A8 (pt) 2022-12-13
WO2020264328A1 (en) 2020-12-30
AU2020302077A1 (en) 2022-01-20
CA3144279A1 (en) 2020-12-30
BR112021026216A2 (pt) 2022-07-19
EP3990471A1 (en) 2022-05-04
KR20220044947A (ko) 2022-04-12
US20200407400A1 (en) 2020-12-31
AU2020302913A1 (en) 2022-01-27
MX2021015816A (es) 2022-04-18
CN114080394A (zh) 2022-02-22
US20230072433A1 (en) 2023-03-09
WO2020264389A1 (en) 2020-12-30
AU2020302913B2 (en) 2023-02-23
US20200407399A1 (en) 2020-12-31
IL289236A (en) 2022-02-01
EP3990471A4 (en) 2023-07-12
AU2020302077C1 (en) 2023-11-30
AU2020302077B2 (en) 2023-08-31
AU2020302077A8 (en) 2022-05-12
US11021518B2 (en) 2021-06-01
CN114072415A (zh) 2022-02-18
EP3990472A4 (en) 2023-07-12
US11427617B2 (en) 2022-08-30
BR112021026317A8 (pt) 2022-12-13
JP2022538854A (ja) 2022-09-06
KR20220042129A (ko) 2022-04-04
US20210261623A1 (en) 2021-08-26
MX2021015534A (es) 2022-04-20
CA3143032A1 (en) 2020-12-30
IL289238A (en) 2022-02-01

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: THE UNIVERSITY OF SOUTHERN CALIFORNIA (US)

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]