BR112021023519A2 - Mediadores de silenciamento genético - Google Patents

Mediadores de silenciamento genético

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Publication number
BR112021023519A2
BR112021023519A2 BR112021023519A BR112021023519A BR112021023519A2 BR 112021023519 A2 BR112021023519 A2 BR 112021023519A2 BR 112021023519 A BR112021023519 A BR 112021023519A BR 112021023519 A BR112021023519 A BR 112021023519A BR 112021023519 A2 BR112021023519 A2 BR 112021023519A2
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BR
Brazil
Prior art keywords
present
genetic silencing
silencing mediators
trna
mediators
Prior art date
Application number
BR112021023519A
Other languages
English (en)
Inventor
Monika Gullerova
Original Assignee
Cancer Research Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Tech Ltd filed Critical Cancer Research Tech Ltd
Publication of BR112021023519A2 publication Critical patent/BR112021023519A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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Abstract

mediadores de silenciamento genético. a presente invenção refere-se a um método para inibir a expressão de um gene em um sistema biológico. o método da presente invenção compreende introduzir um polinucleotídeo derivado de trna no sistema biológico. o polinucleotídeo derivado de trna da presente invenção compreende uma sequência que seja complementar a uma região intrônica do gene cuja expressão deve ser inibida.
BR112021023519A 2019-05-24 2020-05-22 Mediadores de silenciamento genético BR112021023519A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1907380.8A GB201907380D0 (en) 2019-05-24 2019-05-24 Mediators of gene silencing
PCT/GB2020/051257 WO2020240162A1 (en) 2019-05-24 2020-05-22 Mediators of gene silencing

Publications (1)

Publication Number Publication Date
BR112021023519A2 true BR112021023519A2 (pt) 2022-01-25

Family

ID=66867557

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023519A BR112021023519A2 (pt) 2019-05-24 2020-05-22 Mediadores de silenciamento genético

Country Status (9)

Country Link
US (1) US20220220476A1 (pt)
EP (1) EP3976784A1 (pt)
JP (1) JP2022533236A (pt)
CN (1) CN113924366A (pt)
AU (1) AU2020284492A1 (pt)
BR (1) BR112021023519A2 (pt)
CA (1) CA3140501A1 (pt)
GB (1) GB201907380D0 (pt)
WO (1) WO2020240162A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202018570D0 (en) * 2020-11-25 2021-01-06 Cancer Research Tech Ltd Mediators of gene silencing
CN114836538B (zh) * 2022-04-14 2023-04-07 南昌大学第一附属医院 生物标志物在hbv相关肝癌诊断及预后中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005086896A2 (en) * 2004-03-10 2005-09-22 Ulrich Thomann Delivery vectors for short interfering rna, micro-rna and antisense rna
WO2012006551A2 (en) * 2010-07-08 2012-01-12 The Brigham And Women's Hospital, Inc. Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules
WO2012018881A2 (en) * 2010-08-03 2012-02-09 Alnylam Pharmaceuticals, Inc. Methods and compositions for the regulation of rna
US20160024575A1 (en) * 2013-05-02 2016-01-28 The Regents Of The University Of California Circulating small noncoding rna markers
WO2016069641A1 (en) * 2014-10-28 2016-05-06 Thomas Jefferson University COMPOSITIONS AND METHODS OF USING TRANSFER RNAS (tRNAs)
WO2018009547A1 (en) * 2016-07-05 2018-01-11 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Diagnosing col6-related disorders and methods for treating same
WO2018204412A1 (en) * 2017-05-01 2018-11-08 Thomas Jefferson University Systems-level analysis of tcga cancers reveals disease trna fragmentation patterns and associations with messenger rnas and repeat

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Publication number Publication date
US20220220476A1 (en) 2022-07-14
AU2020284492A1 (en) 2021-12-23
JP2022533236A (ja) 2022-07-21
CA3140501A1 (en) 2020-12-03
CN113924366A (zh) 2022-01-11
WO2020240162A1 (en) 2020-12-03
EP3976784A1 (en) 2022-04-06
GB201907380D0 (en) 2019-07-10

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