BR112021022468A2 - Calibrador de espectrometria de massa - Google Patents
Calibrador de espectrometria de massaInfo
- Publication number
- BR112021022468A2 BR112021022468A2 BR112021022468A BR112021022468A BR112021022468A2 BR 112021022468 A2 BR112021022468 A2 BR 112021022468A2 BR 112021022468 A BR112021022468 A BR 112021022468A BR 112021022468 A BR112021022468 A BR 112021022468A BR 112021022468 A2 BR112021022468 A2 BR 112021022468A2
- Authority
- BR
- Brazil
- Prior art keywords
- light chain
- mass spectrometry
- calibrator
- amount
- mixture
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
calibrador de espectrometria de massa. a presente invenção fornece um método para quantificar a quantidade de cadeia leve de imunoglobulina kappa ou lambda em uma amostra de um indivíduo que compreende: i. fornecer uma amostra de um indivíduo; ii. misturar a amostra com uma quantidade predeterminada do calibrador de cadeia leve lambda ou calibrador de cadeia leve kappa para formar uma mistura; iii. realizar espectrometria de massa na mistura; e iv. quantificar uma ou as duas dentre o seguinte a) a quantidade da cadeia leve lambda na amostra comparando-se a quantidade da cadeia leve lambda relativa na mistura, conforme determinada pela espectrometria de massa, à quantidade relativa da cadeia leve kappa do calibrador na mistura, conforme determinado pela espectrometria de massa; e/ou b) a quantidade da cadeia leve kappa na amostra comparando-se a quantidade relativa da cadeia leve kappa na mistura, conforme determinada pela espectrometria de massa, à quantidade relativa da cadeia leve lambda do calibrador na mistura, conforme determinado pela espectrometria de massa, mais tipicamente, espectrometria maldi-tof ou cromatografia líquida-espectrometria de massa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1906599.4A GB201906599D0 (en) | 2019-05-10 | 2019-05-10 | Mass spectrometry calibrator |
GBGB1910708.5A GB201910708D0 (en) | 2019-07-26 | 2019-07-26 | Mass spectrometry calibrator |
PCT/GB2020/051040 WO2020229794A1 (en) | 2019-05-10 | 2020-04-29 | Mass spectrometry calibrator |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021022468A2 true BR112021022468A2 (pt) | 2022-01-04 |
Family
ID=70480304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021022468A BR112021022468A2 (pt) | 2019-05-10 | 2020-04-29 | Calibrador de espectrometria de massa |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220221469A1 (pt) |
EP (1) | EP3966570A1 (pt) |
JP (1) | JP7506093B2 (pt) |
KR (1) | KR20220007131A (pt) |
CN (1) | CN113811772A (pt) |
AU (1) | AU2020275921A1 (pt) |
BR (1) | BR112021022468A2 (pt) |
CA (1) | CA3139862A1 (pt) |
WO (1) | WO2020229794A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115684606B (zh) * | 2022-10-21 | 2023-11-28 | 南方医科大学珠江医院 | 一种m蛋白检测的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7320096A (en) | 1995-11-03 | 1997-05-29 | Binding Site Limited, The | Production of antibodies, and medical uses involving antibodies |
US10175242B2 (en) | 2014-02-28 | 2019-01-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Personalized myeloma detection |
ES2861600T3 (es) | 2014-04-04 | 2021-10-06 | Mayo Found Medical Education & Res | Isotipaje de inmunoglobulinas usando masa molecular precisa |
GB201603291D0 (en) | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
GB201708262D0 (en) | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
-
2020
- 2020-04-29 BR BR112021022468A patent/BR112021022468A2/pt unknown
- 2020-04-29 WO PCT/GB2020/051040 patent/WO2020229794A1/en unknown
- 2020-04-29 KR KR1020217040312A patent/KR20220007131A/ko unknown
- 2020-04-29 EP EP20723184.6A patent/EP3966570A1/en active Pending
- 2020-04-29 CN CN202080034628.7A patent/CN113811772A/zh active Pending
- 2020-04-29 US US17/610,036 patent/US20220221469A1/en active Pending
- 2020-04-29 CA CA3139862A patent/CA3139862A1/en active Pending
- 2020-04-29 JP JP2021566482A patent/JP7506093B2/ja active Active
- 2020-04-29 AU AU2020275921A patent/AU2020275921A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220007131A (ko) | 2022-01-18 |
JP7506093B2 (ja) | 2024-06-25 |
WO2020229794A1 (en) | 2020-11-19 |
AU2020275921A1 (en) | 2021-12-02 |
CN113811772A (zh) | 2021-12-17 |
EP3966570A1 (en) | 2022-03-16 |
US20220221469A1 (en) | 2022-07-14 |
JP2022532166A (ja) | 2022-07-13 |
CA3139862A1 (en) | 2020-11-19 |
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