BR112021020907A2 - Antígenos de influenza recombinantes - Google Patents
Antígenos de influenza recombinantesInfo
- Publication number
- BR112021020907A2 BR112021020907A2 BR112021020907A BR112021020907A BR112021020907A2 BR 112021020907 A2 BR112021020907 A2 BR 112021020907A2 BR 112021020907 A BR112021020907 A BR 112021020907A BR 112021020907 A BR112021020907 A BR 112021020907A BR 112021020907 A2 BR112021020907 A2 BR 112021020907A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- recombinant influenza
- influenza
- acid sequence
- influenza antigens
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 7
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 241000712431 Influenza A virus Species 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
antígenos de influenza recombinantes. a presente invenção refere-se a polipeptídeos de hemaglutinina (ha) de influenza a recombinantes, compreendendo um domínio ha1 e um domínio ha2 de uma ha do vírus influenza a, e compreendendo uma sequência de aminoácidos na qual: (a) o aminoácido na posição 355 é w; e (b) o aminoácido na posição 432 é i e/ou o aminoácido na posição 380 é i; e na qual a numeração das posições de aminoácidos na sequência de aminoácidos do polipeptídeo de ha está de acordo com a numeração dos aminoácidos na sequência de aminoácidos de ha de uma cepa de influenza h3n2 de referência, em particular a cepa de referência h3n2 a/aichi/2/68 (seq id no: 1), fragmentos imunogênicos dos mesmos, moléculas de ácido nucleico que codificam os referidos polipeptídeos ou fragmentos imunogênicos e seus usos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962838690P | 2019-04-25 | 2019-04-25 | |
PCT/EP2020/061335 WO2020216844A1 (en) | 2019-04-25 | 2020-04-23 | Recombinant influenza antigens |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021020907A2 true BR112021020907A2 (pt) | 2022-04-19 |
Family
ID=70476193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021020907A BR112021020907A2 (pt) | 2019-04-25 | 2020-04-23 | Antígenos de influenza recombinantes |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220204567A1 (pt) |
EP (1) | EP3959228A1 (pt) |
JP (1) | JP2022530439A (pt) |
KR (1) | KR20220005002A (pt) |
CN (1) | CN113597428A (pt) |
AU (1) | AU2020263900A1 (pt) |
BR (1) | BR112021020907A2 (pt) |
CA (1) | CA3137448A1 (pt) |
EA (1) | EA202192921A1 (pt) |
MX (1) | MX2021012991A (pt) |
WO (1) | WO2020216844A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3319633T3 (pl) | 2015-07-07 | 2021-04-19 | Janssen Vaccines & Prevention B.V. | Szczepionka przeciwko rsv |
MA43762A (fr) | 2016-04-05 | 2021-04-21 | Janssen Vaccines & Prevention Bv | Vaccin contre le rsv |
EA039124B1 (ru) | 2016-05-30 | 2021-12-08 | Янссен Вэксинс Энд Превеншн Б.В. | Стабилизированные f-белки rsv до слияния |
WO2022261297A2 (en) * | 2021-06-10 | 2022-12-15 | University Of Georgia Research Foundation, Inc. | Broadly reactive viral antigens as immunogens, compositions and methods of use thereof |
WO2023126982A1 (en) * | 2021-12-31 | 2023-07-06 | Mynvax Private Limited | Polypeptide fragments, immunogenic composition against influenza virus, and implementations thereof |
TW202408567A (zh) * | 2022-05-06 | 2024-03-01 | 法商賽諾菲公司 | 用於核酸疫苗之訊息序列 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
ATE336587T1 (de) | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
US5851806A (en) | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
IL122614A0 (en) | 1995-06-15 | 1998-08-16 | Introgene Bv | Packaging systems for human recombinant adenovirus to be used in gene therapy |
US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
US6020191A (en) | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
US5981225A (en) | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
WO2011056802A1 (en) * | 2009-11-03 | 2011-05-12 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Influenza virus recombinant proteins |
WO2013079473A1 (en) * | 2011-11-28 | 2013-06-06 | Crucell Holland B.V. | Influenza virus vaccines and uses thereof |
-
2020
- 2020-04-23 MX MX2021012991A patent/MX2021012991A/es unknown
- 2020-04-23 US US17/594,576 patent/US20220204567A1/en active Pending
- 2020-04-23 CA CA3137448A patent/CA3137448A1/en active Pending
- 2020-04-23 EA EA202192921A patent/EA202192921A1/ru unknown
- 2020-04-23 JP JP2021563156A patent/JP2022530439A/ja active Pending
- 2020-04-23 CN CN202080019855.2A patent/CN113597428A/zh active Pending
- 2020-04-23 BR BR112021020907A patent/BR112021020907A2/pt unknown
- 2020-04-23 KR KR1020217036388A patent/KR20220005002A/ko active Search and Examination
- 2020-04-23 WO PCT/EP2020/061335 patent/WO2020216844A1/en unknown
- 2020-04-23 AU AU2020263900A patent/AU2020263900A1/en active Pending
- 2020-04-23 EP EP20720893.5A patent/EP3959228A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN113597428A (zh) | 2021-11-02 |
JP2022530439A (ja) | 2022-06-29 |
EA202192921A1 (ru) | 2022-02-03 |
KR20220005002A (ko) | 2022-01-12 |
CA3137448A1 (en) | 2020-10-29 |
MX2021012991A (es) | 2021-12-10 |
WO2020216844A1 (en) | 2020-10-29 |
US20220204567A1 (en) | 2022-06-30 |
AU2020263900A1 (en) | 2021-10-14 |
EP3959228A1 (en) | 2022-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112021020907A2 (pt) | Antígenos de influenza recombinantes | |
EP1725581B1 (en) | Novel assay for the separation and quantification of hemagglutinin antigens | |
Byrd-Leotis et al. | Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes | |
Zhao et al. | An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses | |
US20220288189A1 (en) | Influenza hemagglutinin proteins and methods of use thereof | |
Brett et al. | Site-specific S-acylation of influenza virus hemagglutinin: the location of the acylation site relative to the membrane border is the decisive factor for attachment of stearate | |
EA033386B1 (ru) | Рекомбинантные иммуногенные полипептиды стеблевого домена гемагглютинина вируса гриппа а и их применение | |
BR112017027448A2 (pt) | vacina contra rsv | |
BR112015029635A2 (pt) | polipeptídeo do domínio de haste da hemaglutinina da gripe, molécula de ácido nucleico, vetor, e, composição | |
Nakowitsch et al. | Egg‐or cell culture‐derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines | |
Chae et al. | Universal monoclonal antibody-based influenza hemagglutinin quantitative enzyme-linked immunosorbent assay | |
Zhang et al. | Role of stem glycans attached to haemagglutinin in the biological characteristics of H5N1 avian influenza virus | |
HRP20220980T1 (hr) | Cjepiva protiv virusa influence i njihova uporaba | |
MX2022012251A (es) | Vacuna universal contra la influenza usando arnm modificado con nucleósidos. | |
Li et al. | A recombinant protein containing highly conserved hemagglutinin residues 81-122 of influenza H5N1 induces strong humoral and mucosal immune responses | |
CN102612559B (zh) | 源自流感m2的修饰的肽疫苗 | |
BR112022006578A2 (pt) | Polipeptídeos de fusão e de hemaglutinina do vírus da cinomose canina | |
Ni et al. | Development of a novel dual-domain nanoparticle antigen construct for universal influenza vaccine | |
ES2728433T3 (es) | Procedimientos para aislar y cuantificar un antígeno de vacunas | |
He et al. | Putative suppressing effect of IgG Fc-conjugated haemagglutinin (HA) stalk of influenza virus H7N9 on the neutralizing immunogenicity of Fc-conjugated HA head: implication for rational design of HA-based influenza vaccines | |
EP2780365A1 (en) | Lactoferrin derived peptides for use as broad- spectrum inhibitors of influenza virus infection | |
Tsai et al. | Monoclonal antibodies targeting the synthetic peptide corresponding to the polybasic cleavage site on H5N1 influenza hemagglutinin | |
KR102061658B1 (ko) | 뉴라미니다제 억제제에 대해 저항성을 나타내는 인플루엔자 바이러스의 스크리닝 방법 | |
BR112023004433A2 (pt) | Ácido nucleico, vetor, segmento genômico viral, vírus, composição farmacêutica, método para induzir ou aumentar uma resposta imune contra o vírus influenza, vírus recombinante, método para induzir uma resposta imune em um sujeito em necessidade e polipeptídeo | |
Tao et al. | Enhanced protective efficacy of H5 subtype influenza vaccine with modification of the multibasic cleavage site of hemagglutinin in retroviral pseudotypes |