BR112021020779A8 - Métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos - Google Patents

Métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos

Info

Publication number
BR112021020779A8
BR112021020779A8 BR112021020779A BR112021020779A BR112021020779A8 BR 112021020779 A8 BR112021020779 A8 BR 112021020779A8 BR 112021020779 A BR112021020779 A BR 112021020779A BR 112021020779 A BR112021020779 A BR 112021020779A BR 112021020779 A8 BR112021020779 A8 BR 112021020779A8
Authority
BR
Brazil
Prior art keywords
uterine
leiomyosarcomas
improved methods
early diagnosis
subject
Prior art date
Application number
BR112021020779A
Other languages
English (en)
Other versions
BR112021020779A2 (pt
Inventor
Mas Perucho Aymara
Simón Vallés Carlos
Alonso Valero Roberto
Original Assignee
Igenomix S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igenomix S L filed Critical Igenomix S L
Publication of BR112021020779A2 publication Critical patent/BR112021020779A2/pt
Publication of BR112021020779A8 publication Critical patent/BR112021020779A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B17/32002—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B17/32002—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments
    • A61B2017/320024—Morcellators, e.g. having a hollow cutting tube with an annular cutter for morcellating and removing tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos. a presente invenção proporciona um método para a diferenciação de tumores miometicos/neoplasmas uterinos tais como lm, lms e imt. além disso, a descrição proporciona um método para o tratamento de um leiomioma uterino em um indivíduo, compreendendo: (a) realizar um ensaio de genotipagem sobre uma amostra biológica do indivíduo para determinar se o indivíduo tem um genótipo de leiomiossarcoma uterino, e (b) remover cirurgicamente o leiomioma uterino se o indivíduo não tem um genótipo de leiomiossarcoma uterino.
BR112021020779A 2019-04-17 2020-04-17 Métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos BR112021020779A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382307 2019-04-17
EP19382322 2019-04-29
PCT/EP2020/060878 WO2020212580A1 (en) 2019-04-17 2020-04-17 Improved methods for the early diagnosis of uterine leiomyomas and leiomyosarcomas

Publications (2)

Publication Number Publication Date
BR112021020779A2 BR112021020779A2 (pt) 2022-01-04
BR112021020779A8 true BR112021020779A8 (pt) 2022-01-25

Family

ID=70554002

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021020779A BR112021020779A8 (pt) 2019-04-17 2020-04-17 Métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos

Country Status (6)

Country Link
US (1) US20220220564A1 (pt)
EP (1) EP3956476A1 (pt)
JP (1) JP2022529294A (pt)
CN (1) CN114051537A (pt)
BR (1) BR112021020779A8 (pt)
WO (1) WO2020212580A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110408677A (zh) * 2019-07-27 2019-11-05 苏州丽纳芯生物科技有限公司 一种基于固态纳米孔结肠癌kras基因突变检测方法
WO2023061914A2 (en) * 2021-10-11 2023-04-20 Igenomix, S.L. Methods and reagents for the differential diagnosis of uterine tumors

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1359808A (en) 1916-03-20 1920-11-23 Martin R Jacobus Poultry-feeder
US4437975A (en) 1977-07-20 1984-03-20 Mobil Oil Corporation Manufacture of lube base stock oil
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
IE72468B1 (en) 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
JP2650159B2 (ja) 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
BR8907830A (pt) 1988-12-16 1991-10-22 Siska Diagnostics Inc Processo para preparar uma dna de filamento duplo que codifica uma sequencia que corresponde a uma sequencia objetivada de acido nucleico e processo util para deteccao de pelo menos uma sequencia de acido nucleico objetivada especifica
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5037379A (en) 1990-06-22 1991-08-06 Vance Products Incorporated Surgical tissue bag and method for percutaneously debulking tissue
EP0561796B1 (en) 1990-08-24 1997-12-29 The University Of Tennessee Research Corporation Dna amplification fingerprinting
WO1992007095A1 (en) 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5550215A (en) 1991-11-22 1996-08-27 Holmes; Christopher P. Polymer reversal on solid surfaces
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
ATE241426T1 (de) 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung von polymerarrays
US5403276A (en) 1993-02-16 1995-04-04 Danek Medical, Inc. Apparatus for minimally invasive tissue removal
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
CA2121861A1 (en) 1993-04-23 1994-10-24 William D. Fox Mechanical morcellator
US5449370A (en) 1993-05-12 1995-09-12 Ethicon, Inc. Blunt tipped ultrasonic trocar
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5327896A (en) 1993-06-30 1994-07-12 Arthrex, Inc. Suction downbiter
US5443472A (en) 1993-10-08 1995-08-22 Li Medical Technologies, Inc. Morcellator system
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE69503126T2 (de) 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
JP2000512744A (ja) 1996-05-16 2000-09-26 アフィメトリックス，インコーポレイテッド 標識材料を検出するシステムおよび方法
US6586806B1 (en) 1997-06-20 2003-07-01 Cypress Semiconductor Corporation Method and structure for a single-sided non-self-aligned transistor
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
WO1999005591A2 (en) 1997-07-25 1999-02-04 Affymetrix, Inc. Method and apparatus for providing a bioinformatics database
JP2001514907A (ja) 1997-08-15 2001-09-18 アフィメトリックス・インコーポレーテッド クラスタ解析を利用した多形検出
US6033860A (en) 1997-10-31 2000-03-07 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6269846B1 (en) 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US5936324A (en) 1998-03-30 1999-08-10 Genetic Microsystems Inc. Moving magnet scanner
US6162235A (en) 1998-05-18 2000-12-19 Ethicon Endo-Surgery, Inc. Method of tissue morcellation using an ultrasonic surgical instrument with a ballistic specimen bag
JP3565025B2 (ja) 1998-07-07 2004-09-15 日産自動車株式会社 治具交換装置および治具交換方法
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
DE69929542T2 (de) 1998-10-27 2006-09-14 Affymetrix, Inc., Santa Clara Komplexitätsmanagement und analyse genomischer dna
CA2366459A1 (en) 1999-03-26 2000-10-05 Affymetrix, Inc. Universal arrays
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
US6391592B1 (en) 2000-12-14 2002-05-21 Affymetrix, Inc. Blocker-aided target amplification of nucleic acids
US20020183936A1 (en) 2001-01-24 2002-12-05 Affymetrix, Inc. Method, system, and computer software for providing a genomic web portal
US6585606B2 (en) 2001-07-16 2003-07-01 Thomas S. Penrose Golf club accessory
US6632611B2 (en) 2001-07-20 2003-10-14 Affymetrix, Inc. Method of target enrichment and amplification
CA2445204C (en) 2002-10-16 2014-08-12 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
US8206896B2 (en) * 2005-11-30 2012-06-26 Shinshu University Detection of uterine leiomyosarcoma using LMP2
WO2008128186A1 (en) 2007-04-12 2008-10-23 Applied Medical Resources Corporation Method and apparatus for tissue morcellation
US9513300B2 (en) 2008-05-05 2016-12-06 Cornell University Determination of serum anti-mullerian hormone as a diagnostic test for spay in companion animals
EP2539450B1 (en) 2010-02-25 2016-02-17 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
US9955922B2 (en) 2012-11-16 2018-05-01 Lowell Zane Shuck Capsule device and methodology for discovery of gut microbe roles in diseases with origin in gut
US9913653B2 (en) 2013-07-11 2018-03-13 Covidien Lp Devices, systems, and methods for tissue morcellation
US9044210B1 (en) 2014-04-24 2015-06-02 University Of South Florida Power morcellation in a protected environment
TWI585937B (zh) 2014-08-01 2017-06-01 乾坤科技股份有限公司 具有順形電磁屏蔽結構的半導體封裝件及其製作方法
EP3064594A1 (en) * 2015-03-06 2016-09-07 Université de Bordeaux Signature of clinical outcome in uterine smooth muscle tumor analysis, and method of diagnosis thereof
CN106252749B (zh) 2015-06-04 2020-12-29 松下知识产权经营株式会社 蓄电池包的控制方法以及蓄电池包
JP6583817B2 (ja) * 2015-09-04 2019-10-02 国立大学法人山口大学 子宮平滑筋における腫瘍の診断マーカー
CN105506169B (zh) * 2016-02-29 2018-11-06 北京泱深生物信息技术有限公司 子宫肌瘤诊治标志物

Also Published As

Publication number Publication date
WO2020212580A1 (en) 2020-10-22
US20220220564A1 (en) 2022-07-14
CN114051537A (zh) 2022-02-15
JP2022529294A (ja) 2022-06-20
EP3956476A1 (en) 2022-02-23
BR112021020779A2 (pt) 2022-01-04

Similar Documents

Publication Publication Date Title
Jones et al. mTOR has distinct functions in generating versus sustaining humoral immunity
Maresca et al. Enzootic bovine leukosis: report of eradication and surveillance measures in Italy over an 8-year period (2005–2012)
Morris et al. Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways
MY180473A (en) Imaging and evaluating embryos, oocytes, and stem cells
BR112021020779A8 (pt) Métodos aperfeiçoados para diagnóstico precoce de leiomiomas e leiomiossarcomas uterinos
Arai et al. Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples
BR112014000965B8 (pt) Método, aparelho e meio de armazenamento não transitório
EA201892489A1 (ru) Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma)
Rahman et al. Altered chromatin condensation of heat-stressed spermatozoa perturbs the dynamics of DNA methylation reprogramming in the paternal genome after in vitro fertilisation in cattle
EA201100120A1 (ru) Способы и системы для оценки клинического бесплодия
Surani Human germline: a new research frontier
CY1115640T1 (el) Διαγνωση και αγωγη εναντι της σχιζοφρενειας
BR112014014307A2 (pt) métodos e kits para detecção in situ à temperatura ambiente de um ácido nucleico alvo em uma amostra biológica
EA201892490A1 (ru) Пцр с мультиплексной оптимизированной амплификацией неправильно спаренных оснований (moma) в реальном времени для анализа состояния плода
Baker Recognizing paradigm instability in theories of carcinogenesis.
Naumova et al. Dynamics of response to asynapsis and meiotic silencing in spermatocytes from Robertsonian translocation carriers
Hetzel et al. Reply to “updated phylogenetic analysis of arenaviruses detected in boid snakes”
Spade et al. Xenotransplantation models to study the effects of toxicants on human fetal tissues
Sun et al. Effects of scriptaid on the histone acetylation of buffalo oocytes and their ability to support the development of somatic cell nuclear transfer embryos
EA201892117A1 (ru) Неразрушающее генотипирование семян
Wollenberg et al. Staphylococcus aureus killing assay of Caenorhabditis elegans
Raoofi et al. Serological survey in camels (Camelus dromedarius) to detect antibodies against bovine herpesvirus type-1 and Mycobacterium avium paratuberculosis in Iran
Hunter et al. Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN
Yu et al. Successful reprogramming of differentiated cells by somatic cell nuclear transfer, using in vitro‐matured oocytes with a modified activation method
KR20190048618A (ko) 초파리를 통한 저선량 방사선의 항산화 효과 분석 방법 및 항산화 증진 방법