BR112021019241A8 - Flavivírus vivos e atenuados, ácidos nucleicos de rna e de cdna, células recombinantes, clones de cdna, composições imunogênicas e vírus do nilo ocidental (wnv) vivo e atenuado - Google Patents
Flavivírus vivos e atenuados, ácidos nucleicos de rna e de cdna, células recombinantes, clones de cdna, composições imunogênicas e vírus do nilo ocidental (wnv) vivo e atenuadoInfo
- Publication number
- BR112021019241A8 BR112021019241A8 BR112021019241A BR112021019241A BR112021019241A8 BR 112021019241 A8 BR112021019241 A8 BR 112021019241A8 BR 112021019241 A BR112021019241 A BR 112021019241A BR 112021019241 A BR112021019241 A BR 112021019241A BR 112021019241 A8 BR112021019241 A8 BR 112021019241A8
- Authority
- BR
- Brazil
- Prior art keywords
- live
- atenuated
- wnv
- cdna
- nucleic acids
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24171—Demonstrated in vivo effect
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
FLAVIVÍRUS VIVOS E ATENUADOS, ÁCIDOS NUCLEICOS DE RNA E DE CDNA, CÉLULAS RECOMBINANTES, CLONES DE CDNA, COMPOSIÇÕES IMUNOGÊNICAS E VÍRUS DO NILO OCIDENTAL (WNV) VIVO E ATENUADO. O presente pedido diz respeito à atenuação de um flavivírus, tal como um Vírus do Nilo Ocidental (WNV), Vírus Zika (ZIKV), Vírus da Encefalite Japonesa (JEV), Vírus da dengue (DV), particularmente o DV4, ou Vírus Usutu. O pedido fornece particularmente um flavivírus vivo e atenuado, como um WNV ou ZIKV vivo e atenuado, compreendendo uma proteína M mutada. A referida proteína M mutada compreende, ou consiste em, uma sequência na qual, pelo menos, os aminoácidos nas posições 36 e 43 da referida sequência estão mutados. O presente pedido também fornece exemplos de realização derivados do referido flavivírus vivo e atenuado, como um WNV ou ZIKV, tais como ácidos nucleicos, células, clones de cDNA, composições imunogênicas, bem como usos e métodos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962825734P | 2019-03-28 | 2019-03-28 | |
PCT/IB2020/000302 WO2020194063A1 (en) | 2019-03-28 | 2020-03-27 | A live and attenuated flavivirus comprising a mutated m protein |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112021019241A2 BR112021019241A2 (pt) | 2022-01-18 |
BR112021019241A8 true BR112021019241A8 (pt) | 2022-12-06 |
Family
ID=70736788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021019241A BR112021019241A8 (pt) | 2019-03-28 | 2020-03-27 | Flavivírus vivos e atenuados, ácidos nucleicos de rna e de cdna, células recombinantes, clones de cdna, composições imunogênicas e vírus do nilo ocidental (wnv) vivo e atenuado |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230167415A1 (pt) |
EP (1) | EP3947655A1 (pt) |
BR (1) | BR112021019241A8 (pt) |
CA (1) | CA3129482A1 (pt) |
IL (1) | IL286658A (pt) |
WO (1) | WO2020194063A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022101463A1 (en) * | 2020-11-16 | 2022-05-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of the last c-terminal residues m31/41 of zikv m ectodomain for triggering apoptotic cell death |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189403B2 (en) | 2003-06-30 | 2007-03-13 | Institut Pasteur | Attenuated flavivirus strains containing a mutated M-ectodomain and their applications |
CA2584228C (en) * | 2004-10-20 | 2015-05-05 | Acambis Inc. | Vaccines against japanese encephalitis virus and west nile virus |
WO2016079560A1 (en) * | 2014-11-21 | 2016-05-26 | Institut Pasteur | A live and attenuated japanese encephalitis virus comprising a mutated m protein |
-
2020
- 2020-03-27 BR BR112021019241A patent/BR112021019241A8/pt not_active Application Discontinuation
- 2020-03-27 CA CA3129482A patent/CA3129482A1/en active Pending
- 2020-03-27 EP EP20725898.9A patent/EP3947655A1/en not_active Withdrawn
- 2020-03-27 US US17/593,446 patent/US20230167415A1/en active Pending
- 2020-03-27 WO PCT/IB2020/000302 patent/WO2020194063A1/en unknown
-
2021
- 2021-09-23 IL IL286658A patent/IL286658A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20230167415A1 (en) | 2023-06-01 |
BR112021019241A2 (pt) | 2022-01-18 |
WO2020194063A1 (en) | 2020-10-01 |
IL286658A (en) | 2021-12-01 |
CA3129482A1 (en) | 2020-10-01 |
EP3947655A1 (en) | 2022-02-09 |
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