BR112021005952A2 - uso de um composto - Google Patents
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- BR112021005952A2 BR112021005952A2 BR112021005952-0A BR112021005952A BR112021005952A2 BR 112021005952 A2 BR112021005952 A2 BR 112021005952A2 BR 112021005952 A BR112021005952 A BR 112021005952A BR 112021005952 A2 BR112021005952 A2 BR 112021005952A2
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- donecopride
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- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000006403 short-term memory Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000005250 spinal neuron Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000007470 synaptic degeneration Effects 0.000 description 1
- 230000003956 synaptic plasticity Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306280.1A EP3628660A1 (en) | 2018-09-28 | 2018-09-28 | Donecopride and flucopride as neuroprotective agents in the treatment of neurodegenerative diseases |
| EP18306280.1 | 2018-09-28 | ||
| PCT/EP2019/076229 WO2020065028A1 (en) | 2018-09-28 | 2019-09-27 | Donecopride as neuroprotective agent in the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021005952A2 true BR112021005952A2 (pt) | 2021-06-29 |
Family
ID=63798921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021005952-0A BR112021005952A2 (pt) | 2018-09-28 | 2019-09-27 | uso de um composto |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220031680A1 (https=) |
| EP (2) | EP3628660A1 (https=) |
| JP (1) | JP2022511366A (https=) |
| KR (1) | KR20210098429A (https=) |
| CN (1) | CN113195452A (https=) |
| AU (1) | AU2019346024B2 (https=) |
| BR (1) | BR112021005952A2 (https=) |
| CA (1) | CA3115342A1 (https=) |
| SG (1) | SG11202103070VA (https=) |
| WO (1) | WO2020065028A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3166060A1 (fr) | 2024-09-12 | 2026-03-13 | Université De Caen Normandie | Composition pharmaceutique formulée pour être administrée par voie intranasale et utilisable pour le traitement d’une maladie neurodégénérative |
| FR3166146A1 (fr) | 2024-09-12 | 2026-03-13 | Université De Caen Normandie | Sel de fumarate de 1-(4-amino-5-chloro-2-méthoxyphényl)-3-[1-(cycloheptylméthyl)-4-pipéridinyl]propan-1-one –Composition pharmaceutique et utilisation associées |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| FR2904113A1 (fr) | 2006-07-21 | 2008-01-25 | Exonhit Therapeutics S A Sa | Procedes et outils pour la therapie de pathologies neurodegeneratives |
| CN102355902A (zh) * | 2009-01-24 | 2012-02-15 | 植物药物公共有限公司 | 神经营养因子介导的病症的处理 |
| FR3006686A1 (fr) | 2013-06-05 | 2014-12-12 | Univ Caen | Composes inhibiteurs de l'acetylcholinesterase et agonistes des recepteurs serotoninergiques 5ht4, a effet promnesiant, leurs procedes de preparation et compositions pharmaceutiques les contenant |
| MX368017B (es) * | 2013-12-16 | 2019-09-13 | Suven Life Sciences Ltd | Compuestos de indazol como agonistas del receptor de 5-ht4. |
-
2018
- 2018-09-28 EP EP18306280.1A patent/EP3628660A1/en not_active Withdrawn
-
2019
- 2019-09-27 KR KR1020217009149A patent/KR20210098429A/ko not_active Ceased
- 2019-09-27 US US17/280,217 patent/US20220031680A1/en not_active Abandoned
- 2019-09-27 EP EP19783459.1A patent/EP3856716A1/en active Pending
- 2019-09-27 AU AU2019346024A patent/AU2019346024B2/en not_active Ceased
- 2019-09-27 WO PCT/EP2019/076229 patent/WO2020065028A1/en not_active Ceased
- 2019-09-27 JP JP2021517453A patent/JP2022511366A/ja active Pending
- 2019-09-27 BR BR112021005952-0A patent/BR112021005952A2/pt unknown
- 2019-09-27 CN CN201980063618.3A patent/CN113195452A/zh active Pending
- 2019-09-27 SG SG11202103070VA patent/SG11202103070VA/en unknown
- 2019-09-27 CA CA3115342A patent/CA3115342A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019346024A1 (en) | 2021-04-29 |
| KR20210098429A (ko) | 2021-08-10 |
| JP2022511366A (ja) | 2022-01-31 |
| EP3856716A1 (en) | 2021-08-04 |
| US20220031680A1 (en) | 2022-02-03 |
| AU2019346024B2 (en) | 2024-07-18 |
| EP3628660A1 (en) | 2020-04-01 |
| SG11202103070VA (en) | 2021-04-29 |
| CN113195452A (zh) | 2021-07-30 |
| WO2020065028A1 (en) | 2020-04-02 |
| CA3115342A1 (en) | 2020-04-02 |
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Legal Events
| Date | Code | Title | Description |
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| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |