BR112021000768A2 - uso de pró-medicamentos de riluzol para tratar a doença de alzheimer - Google Patents
uso de pró-medicamentos de riluzol para tratar a doença de alzheimer Download PDFInfo
- Publication number
- BR112021000768A2 BR112021000768A2 BR112021000768-7A BR112021000768A BR112021000768A2 BR 112021000768 A2 BR112021000768 A2 BR 112021000768A2 BR 112021000768 A BR112021000768 A BR 112021000768A BR 112021000768 A2 BR112021000768 A2 BR 112021000768A2
- Authority
- BR
- Brazil
- Prior art keywords
- riluzole
- patient
- prodrug
- administered
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862701814P | 2018-07-22 | 2018-07-22 | |
| US62/701,814 | 2018-07-22 | ||
| PCT/US2019/042718 WO2020023324A1 (en) | 2018-07-22 | 2019-07-20 | Use of riluzole prodrugs to treat alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021000768A2 true BR112021000768A2 (pt) | 2021-05-11 |
Family
ID=69181140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021000768-7A BR112021000768A2 (pt) | 2018-07-22 | 2019-07-20 | uso de pró-medicamentos de riluzol para tratar a doença de alzheimer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12161633B2 (https=) |
| EP (1) | EP3823616A4 (https=) |
| JP (2) | JP2021530543A (https=) |
| KR (1) | KR20210034621A (https=) |
| CN (1) | CN112469408A (https=) |
| AU (1) | AU2019310013B2 (https=) |
| BR (1) | BR112021000768A2 (https=) |
| CA (1) | CA3107215A1 (https=) |
| EA (1) | EA202190308A1 (https=) |
| IL (1) | IL280177B2 (https=) |
| MX (2) | MX2021000515A (https=) |
| NZ (1) | NZ772009A (https=) |
| PH (1) | PH12021550043A1 (https=) |
| SG (1) | SG11202100385YA (https=) |
| WO (1) | WO2020023324A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230027189A (ko) * | 2020-06-24 | 2023-02-27 | 바이오하벤 테라퓨틱스 리미티드 | 강박 장애를 치료하기 위한 조성물 및 방법 |
| EP4240308A4 (en) * | 2020-10-05 | 2024-10-30 | Icahn School of Medicine at Mount Sinai | Riluzole for the treatment of alzheimer's disease |
| EP4277624B1 (en) * | 2021-01-18 | 2026-01-14 | Biohaven Therapeutics Ltd. | Troriluzole for use in the treatment of alzheimer's disease of mild severity |
| WO2022178425A1 (en) * | 2021-02-22 | 2022-08-25 | Yale University | Targeted bifunctional degraders |
| CN114344297B (zh) * | 2022-03-01 | 2024-05-14 | 暨南大学 | 利鲁唑在治疗少精症中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214663B2 (en) * | 2000-06-14 | 2007-05-08 | Medarex, Inc. | Tripeptide prodrug compounds |
| JP2008518935A (ja) * | 2004-11-01 | 2008-06-05 | セオ ホン ユー | 筋萎縮性側索硬化症の神経退行を減少させるための方法及び組成物 |
| FR2957077B1 (fr) * | 2010-03-02 | 2012-04-13 | Univ Dauvergne Clermont I | Utilisation du riluzole pour traiter ou prevenir les effets indesirables d'agents anti-cancereux |
| EP3079692A4 (en) | 2013-12-09 | 2017-10-18 | Thomas Jefferson University | Novel methods of treating a neurodegenerative disease in a mammal in need thereof |
| WO2016085998A1 (en) * | 2014-11-26 | 2016-06-02 | Medicinova, Inc. | Combination of ibudilast and riluzole and methods of using same |
| RS62915B1 (sr) * | 2015-03-03 | 2022-03-31 | Biohaven Therapeutics Ltd | Prolekovi riluzola i njihova primena |
| WO2017201502A1 (en) * | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
| WO2018031707A1 (en) * | 2016-08-10 | 2018-02-15 | Biohaven Pharmaceutical Holding Company Ltd. | Acyl benzo[d]thiazol-2-amine and their methods of use |
| AU2019223014B2 (en) * | 2018-02-21 | 2024-10-17 | Orphai Therapeutics Inc. | Combination therapy with apilimod and glutamatergic agents |
| EP4277624B1 (en) * | 2021-01-18 | 2026-01-14 | Biohaven Therapeutics Ltd. | Troriluzole for use in the treatment of alzheimer's disease of mild severity |
-
2019
- 2019-07-20 WO PCT/US2019/042718 patent/WO2020023324A1/en not_active Ceased
- 2019-07-20 CA CA3107215A patent/CA3107215A1/en active Pending
- 2019-07-20 JP JP2021503571A patent/JP2021530543A/ja active Pending
- 2019-07-20 US US17/261,057 patent/US12161633B2/en active Active
- 2019-07-20 EA EA202190308A patent/EA202190308A1/ru unknown
- 2019-07-20 KR KR1020217004639A patent/KR20210034621A/ko not_active Ceased
- 2019-07-20 IL IL280177A patent/IL280177B2/en unknown
- 2019-07-20 EP EP19841953.3A patent/EP3823616A4/en active Pending
- 2019-07-20 NZ NZ772009A patent/NZ772009A/en unknown
- 2019-07-20 AU AU2019310013A patent/AU2019310013B2/en active Active
- 2019-07-20 BR BR112021000768-7A patent/BR112021000768A2/pt unknown
- 2019-07-20 CN CN201980048687.7A patent/CN112469408A/zh active Pending
- 2019-07-20 SG SG11202100385YA patent/SG11202100385YA/en unknown
- 2019-07-20 MX MX2021000515A patent/MX2021000515A/es unknown
-
2021
- 2021-01-07 PH PH12021550043A patent/PH12021550043A1/en unknown
- 2021-01-14 MX MX2024010655A patent/MX2024010655A/es unknown
-
2025
- 2025-02-21 JP JP2025026643A patent/JP2025093952A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN112469408A (zh) | 2021-03-09 |
| EP3823616A1 (en) | 2021-05-26 |
| US20210290599A1 (en) | 2021-09-23 |
| SG11202100385YA (en) | 2021-02-25 |
| EA202190308A1 (ru) | 2021-05-19 |
| NZ772009A (en) | 2026-02-27 |
| WO2020023324A1 (en) | 2020-01-30 |
| IL280177A (en) | 2021-03-01 |
| EP3823616A4 (en) | 2022-05-04 |
| IL280177B1 (en) | 2024-09-01 |
| IL280177B2 (en) | 2025-01-01 |
| MX2021000515A (es) | 2021-06-08 |
| US12161633B2 (en) | 2024-12-10 |
| KR20210034621A (ko) | 2021-03-30 |
| CA3107215A1 (en) | 2020-01-30 |
| PH12021550043A1 (en) | 2021-09-20 |
| JP2021530543A (ja) | 2021-11-11 |
| AU2019310013A1 (en) | 2021-02-11 |
| AU2019310013B2 (en) | 2025-01-02 |
| JP2025093952A (ja) | 2025-06-24 |
| MX2024010655A (es) | 2024-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12161633B2 (en) | Use of riluzole prodrugs to treat alzheimer's disease | |
| Kiernan et al. | Amyotrophic lateral sclerosis | |
| TWI595875B (zh) | 用於治療阿茲海默症之方法及藥物產品 | |
| US20200155522A1 (en) | Gaboxadol for reducing risk of suicide and rapid relief of depression | |
| EP4277624B1 (en) | Troriluzole for use in the treatment of alzheimer's disease of mild severity | |
| von Leden et al. | 18F-FDG-PET imaging of rat spinal cord demonstrates altered glucose uptake acutely after contusion injury | |
| BR112021002692A2 (pt) | uso de comprimidos desintegrantes orais de riluzol para o tratamento de doenças | |
| TW202339763A (zh) | 用於治療多種疾病之組成物及方法 | |
| Tobita et al. | A case of Marchiafava-Bignami disease with complete recovery: sequential imaging documenting improvement of callosal lesions | |
| US12201618B2 (en) | Use of riluzole prodrugs to treat Alzheimer's disease | |
| EA049330B1 (ru) | Применение пролекарств рилузола для лечения болезни альцгеймера | |
| Ochoa-Orozco et al. | “Chasing the Dragon”: A Fatal Case Report of Toxic Leucoencéphalopathie Due to Inhaled Heroin | |
| Jackson | The case against the stimulants | |
| US20250375459A1 (en) | Methods for ameliorating cognitive impairment using bile acid derivatives | |
| US20240016783A1 (en) | Riluzole for the treatment of alzheimer's disease | |
| TR2023000415A2 (tr) | İrri̇table barsak sendromu medi̇kal tedavi̇si̇nde kullanilmak üzere geli̇şti̇ri̇len kompozi̇syon | |
| Nakajima et al. | Associations of Neuromelanin in the Substantia Nigra with Antipsychotic Response in Schizophrenia | |
| Besson et al. | PET imaging in Alzheimer's disease | |
| US20200038417A1 (en) | Methods and compositions for treating cognitive impairment | |
| JP2024538513A (ja) | バイオマーカーとして抱合胆汁酸を使用して気分障害及び／又は気分障害の状態の改善を検出及び／又は定量する方法、並びにその改善された方法及び組成物 | |
| Coit et al. | A Placebo-Controlled Trial of Acetyl-L-Carnitine and α-Lipoic Acid in the Treatment of Bipolar Depression | |
| JP2024535008A (ja) | バイオマーカーとしてｎ－アセチル－ｌ－トリプトファンを使用して気分障害及び／又は気分障害の状態の改善を検出及び／又は定量する方法、並びにその改善された方法及び組成物 | |
| Inokuchi et al. | Adult-onset seizures in a patient with Down syndrome and portosystemic shunt | |
| Aronson | Rif S. El-Mallakh and Yonglin Gao | |
| Schweinsburg et al. | imaging of substance abuse |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |