BR112021000735A2 - acoplador de antígeno de células t com várias otimizações de construto - Google Patents
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201862773120P | 2018-11-29 | 2018-11-29 | |
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| US201962826853P | 2019-03-29 | 2019-03-29 | |
| US62/826,853 | 2019-03-29 | ||
| US201962828879P | 2019-04-03 | 2019-04-03 | |
| US62/828,879 | 2019-04-03 | ||
| US201962839235P | 2019-04-26 | 2019-04-26 | |
| US62/839,235 | 2019-04-26 | ||
| US16/442,274 | 2019-06-14 | ||
| US16/442,274 US10640562B2 (en) | 2018-07-17 | 2019-06-14 | T cell-antigen coupler with various construct optimizations |
| US201962874426P | 2019-07-15 | 2019-07-15 | |
| US62/874,426 | 2019-07-15 | ||
| PCT/US2019/042297 WO2020018727A1 (en) | 2018-07-17 | 2019-07-17 | T cell-antigen coupler with various construct optimizations |
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| JP (1) | JP7404279B2 (he) |
| KR (1) | KR20210021593A (he) |
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| CA3078637A1 (en) | 2017-10-12 | 2019-04-18 | Mcmaster University | T cell-antigen coupler with y182t mutation and methods and uses thereof |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| US11110123B2 (en) | 2018-07-17 | 2021-09-07 | Triumvira Immunologics Usa, Inc. | T cell-antigen coupler with various construct optimizations |
| EP4326888A1 (en) | 2021-04-21 | 2024-02-28 | Conagen Inc. | Biosynthetic production of gamma-or delta-lactones using cytochrome p450 hydroxylase enzymes or mutants thereof |
| US12016923B2 (en) | 2021-06-01 | 2024-06-25 | Triumvira Immunologics Usa, Inc. | Claudin 18.2 T cell-antigen couplers and uses thereof |
| US11453723B1 (en) * | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
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| US9718893B2 (en) * | 2011-12-19 | 2017-08-01 | Synimmune Gmbh | Bispecific antibody molecule |
| EP2872526B1 (en) * | 2012-07-13 | 2020-04-01 | The Trustees of the University of Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
| KR102480433B1 (ko) * | 2014-02-07 | 2022-12-21 | 맥마스터 유니버시티 | 3기능성 t 세포-항원 커플러 및 이의 제조 방법 및 용도 |
| SI3280729T1 (sl) * | 2015-04-08 | 2022-09-30 | Novartis Ag | Terapije CD20, terapije CD22 in kombinacija terapij s celico, ki izraža himerni antigenski receptor CD19 (CAR) |
| WO2016166139A1 (en) * | 2015-04-14 | 2016-10-20 | Eberhard Karls Universität Tübingen | Bispecific fusion proteins for enhancing immune responses of lymphocytes against tumor cells |
| CN109563507B (zh) * | 2016-07-08 | 2024-03-05 | 埃克苏马生物技术公司 | 用于转导淋巴细胞及调节其活性的方法及组合物 |
| AU2017305524A1 (en) * | 2016-08-04 | 2019-02-28 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| CN108250302A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多功能蛋白质 |
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| CA3104887A1 (en) | 2020-01-23 |
| IL280049A (he) | 2021-03-01 |
| JP7404279B2 (ja) | 2023-12-25 |
| EP3823984A4 (en) | 2022-04-06 |
| MX2021000541A (es) | 2021-08-16 |
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| JP2021530971A (ja) | 2021-11-18 |
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| PH12021550114A1 (en) | 2021-10-04 |
| EP3823984A1 (en) | 2021-05-26 |
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