CA3104887A1 - T cell-antigen coupler with various construct optimizations - Google Patents
T cell-antigen coupler with various construct optimizations Download PDFInfo
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C—CHEMISTRY; METALLURGY
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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| US201862699173P | 2018-07-17 | 2018-07-17 | |
| US62/699,173 | 2018-07-17 | ||
| US201862703037P | 2018-07-25 | 2018-07-25 | |
| US62/703,037 | 2018-07-25 | ||
| US201862773120P | 2018-11-29 | 2018-11-29 | |
| US62/773,120 | 2018-11-29 | ||
| US201962826853P | 2019-03-29 | 2019-03-29 | |
| US62/826,853 | 2019-03-29 | ||
| US201962828879P | 2019-04-03 | 2019-04-03 | |
| US62/828,879 | 2019-04-03 | ||
| US201962839235P | 2019-04-26 | 2019-04-26 | |
| US62/839,235 | 2019-04-26 | ||
| US16/442,274 | 2019-06-14 | ||
| US16/442,274 US10640562B2 (en) | 2018-07-17 | 2019-06-14 | T cell-antigen coupler with various construct optimizations |
| US201962874426P | 2019-07-15 | 2019-07-15 | |
| US62/874,426 | 2019-07-15 | ||
| PCT/US2019/042297 WO2020018727A1 (en) | 2018-07-17 | 2019-07-17 | T cell-antigen coupler with various construct optimizations |
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| CA3104887A1 true CA3104887A1 (en) | 2020-01-23 |
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| EP (1) | EP3823984A4 (he) |
| JP (1) | JP7404279B2 (he) |
| KR (1) | KR20210021593A (he) |
| CN (1) | CN112689642A (he) |
| AU (1) | AU2019307905B2 (he) |
| BR (1) | BR112021000735A2 (he) |
| CA (1) | CA3104887A1 (he) |
| IL (1) | IL280049A (he) |
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| BR112016018100A2 (pt) | 2014-02-07 | 2018-02-20 | Univ Mcmaster | acoplador antigênico de células t trifuncional, métodos e usos do mesmo |
| CN111479925B (zh) | 2017-10-12 | 2024-03-08 | 麦克马斯特大学 | 具有y182t突变的t细胞-抗原偶联物及其方法和用途 |
| US11110123B2 (en) | 2018-07-17 | 2021-09-07 | Triumvira Immunologics Usa, Inc. | T cell-antigen coupler with various construct optimizations |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| WO2022226065A2 (en) | 2021-04-21 | 2022-10-27 | Conagen Inc. | Biosynthetic production of delta-lactones using cytochrome p450 hydroxylase enzymes or mutants thereof |
| US12016923B2 (en) | 2021-06-01 | 2024-06-25 | Triumvira Immunologics Usa, Inc. | Claudin 18.2 T cell-antigen couplers and uses thereof |
| US11453723B1 (en) * | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
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| HUE033245T2 (hu) * | 2011-12-19 | 2017-11-28 | Synimmune Gmbh | Bispecifikus ellenanyag molekula |
| CA2876730A1 (en) * | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
| BR112016018100A2 (pt) * | 2014-02-07 | 2018-02-20 | Univ Mcmaster | acoplador antigênico de células t trifuncional, métodos e usos do mesmo |
| DK3280729T3 (da) * | 2015-04-08 | 2022-07-25 | Novartis Ag | Cd20-behandlinger, cd22-behandlinger og kombinationsbehandlinger med en cd19-kimær antigenreceptor (car)-udtrykkende celle |
| WO2016166139A1 (en) * | 2015-04-14 | 2016-10-20 | Eberhard Karls Universität Tübingen | Bispecific fusion proteins for enhancing immune responses of lymphocytes against tumor cells |
| CN109563507B (zh) * | 2016-07-08 | 2024-03-05 | 埃克苏马生物技术公司 | 用于转导淋巴细胞及调节其活性的方法及组合物 |
| EP3493827A4 (en) | 2016-08-04 | 2020-02-26 | Memorial Sloan-Kettering Cancer Center | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY |
| CN108250302A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多功能蛋白质 |
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Also Published As
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| CN112689642A (zh) | 2021-04-20 |
| PH12021550114A1 (en) | 2021-10-04 |
| IL280049A (he) | 2021-03-01 |
| AU2019307905A1 (en) | 2021-03-04 |
| JP7404279B2 (ja) | 2023-12-25 |
| SG11202100307WA (en) | 2021-02-25 |
| EP3823984A4 (en) | 2022-04-06 |
| EP3823984A1 (en) | 2021-05-26 |
| BR112021000735A2 (pt) | 2021-07-13 |
| AU2019307905B2 (en) | 2024-09-12 |
| MX2021000541A (es) | 2021-08-16 |
| WO2020018727A1 (en) | 2020-01-23 |
| JP2021530971A (ja) | 2021-11-18 |
| KR20210021593A (ko) | 2021-02-26 |
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