BR112019014691A2 - muteínas de lipocalina com afinidade de ligação para lag-3 - Google Patents
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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Landscapes
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| EP17151945 | 2017-01-18 | ||
| PCT/EP2018/051139 WO2018134274A1 (en) | 2017-01-18 | 2018-01-18 | Lipocalin muteins with binding affinity for lag-3 |
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| BR112019014691A BR112019014691A2 (pt) | 2017-01-18 | 2018-01-18 | muteínas de lipocalina com afinidade de ligação para lag-3 |
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| Country | Link |
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| US (2) | US11168119B2 (https=) |
| EP (1) | EP3571219A1 (https=) |
| JP (1) | JP7225116B2 (https=) |
| KR (1) | KR20190104409A (https=) |
| CN (1) | CN110402252A (https=) |
| AU (1) | AU2018209178B2 (https=) |
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| CA (1) | CA3050194A1 (https=) |
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| RU (1) | RU2019122482A (https=) |
| SG (1) | SG11201906509WA (https=) |
| WO (1) | WO2018134274A1 (https=) |
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| KR20180029238A (ko) | 2015-07-15 | 2018-03-20 | 피어이스 파마슈티컬즈 게엠베하 | Lag-3에 특이적인 신규 단백질 |
| WO2018134274A1 (en) | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding affinity for lag-3 |
| AU2020253034A1 (en) | 2019-03-29 | 2021-08-19 | Pieris Pharmaceuticals Gmbh | Inhaled administration of lipocalin muteins |
| AU2021285201A1 (en) | 2020-06-05 | 2022-11-24 | Pieris Pharmaceuticals Gmbh | Multimeric immunomodulator targeting 4-1BB |
| EP4320141A1 (en) * | 2021-04-08 | 2024-02-14 | Pieris Pharmaceuticals GmbH | Novel lipocalin muteins specific for connective tissue growth factor (ctgf) |
| CN113480667B (zh) * | 2021-08-17 | 2023-03-28 | 长春萤火虫生物科技有限公司 | 一种人粒细胞集落刺激因子突变体重组融合蛋白及其制备方法和应用 |
| CN113754743B (zh) * | 2021-10-12 | 2024-02-02 | 成都齐碳科技有限公司 | 孔蛋白单体的突变体、蛋白孔及其应用 |
| WO2023118497A1 (en) | 2021-12-22 | 2023-06-29 | Pieris Pharmaceuticals Gmbh | Novel il-18 variants |
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| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| CZ298681B6 (cs) | 1998-06-08 | 2007-12-19 | F. Hoffmann-La Roche Ag | Lécivo pro lécení infekcí chronické hepatitis C |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| AU4505399A (en) | 1999-06-02 | 2000-12-28 | Abb Research Ltd | Coating composition for high temperature protection |
| US7211395B2 (en) | 2001-03-09 | 2007-05-01 | Dyax Corp. | Serum albumin binding moieties |
| CA2464690A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of apolipoprotein d |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| FI1897548T4 (fi) | 2003-02-28 | 2024-09-03 | The Johns Hopkins University | T-solujen säätely |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| WO2006056464A2 (en) | 2004-11-26 | 2006-06-01 | Pieris Ag | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
| EP1929073A4 (en) | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
| WO2007107563A2 (en) * | 2006-03-20 | 2007-09-27 | Technische Universität München | Muteins of tear lipocalin with affinity for the t-cell coreceptor cd4 |
| CN106986926A (zh) | 2008-01-30 | 2017-07-28 | 皮里斯股份公司 | 具有对人c‑met受体酪氨酸激酶的亲和性的泪脂质运载蛋白的突变蛋白及其获得方法 |
| ES2710384T3 (es) | 2011-12-13 | 2019-04-24 | Pieris Pharmaceuticals Gmbh | Procedimientos para la prevención o el tratamiento de determinados trastornos mediante la inhibición de la unión de IL-4 y/o IL-13 a sus respectivos receptores |
| WO2013174783A1 (en) | 2012-05-23 | 2013-11-28 | Pieris Ag | Lipocalin muteins with binding-affinity for glypican-3 (gpc-3) and use of lipocalin muteins for target-specific delivery to cells expressing gpc-3 |
| WO2014076321A1 (en) | 2012-11-19 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| EP3094650A2 (en) * | 2014-01-13 | 2016-11-23 | Pieris Pharmaceuticals GmbH | Multi-specific polypeptide useful for localized tumor immunomodulation |
| MX390894B (es) * | 2015-05-18 | 2025-03-21 | Pieris Pharmaceuticals Gmbh | Polipéptido de fusión anti-cáncer. |
| KR20180029238A (ko) | 2015-07-15 | 2018-03-20 | 피어이스 파마슈티컬즈 게엠베하 | Lag-3에 특이적인 신규 단백질 |
| WO2018134274A1 (en) | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Lipocalin muteins with binding affinity for lag-3 |
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- 2018-01-18 BR BR112019014691A patent/BR112019014691A2/pt not_active IP Right Cessation
- 2018-01-18 RU RU2019122482A patent/RU2019122482A/ru not_active Application Discontinuation
- 2018-01-18 US US16/478,465 patent/US11168119B2/en not_active Expired - Fee Related
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| CA3050194A1 (en) | 2018-07-26 |
| US11168119B2 (en) | 2021-11-09 |
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| US11773147B2 (en) | 2023-10-03 |
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| KR20190104409A (ko) | 2019-09-09 |
| JP7225116B2 (ja) | 2023-02-20 |
| MX2019008434A (es) | 2019-11-11 |
| AU2018209178B2 (en) | 2021-07-29 |
| EP3571219A1 (en) | 2019-11-27 |
| RU2019122482A (ru) | 2021-02-19 |
| US20190345207A1 (en) | 2019-11-14 |
| CN110402252A (zh) | 2019-11-01 |
| WO2018134274A1 (en) | 2018-07-26 |
| RU2019122482A3 (https=) | 2021-05-26 |
| SG11201906509WA (en) | 2019-08-27 |
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