BR112019008374A2 - inibidor seletivo de egfr mutante por inserção do éxon 20 - Google Patents
inibidor seletivo de egfr mutante por inserção do éxon 20Info
- Publication number
- BR112019008374A2 BR112019008374A2 BR112019008374A BR112019008374A BR112019008374A2 BR 112019008374 A2 BR112019008374 A2 BR 112019008374A2 BR 112019008374 A BR112019008374 A BR 112019008374A BR 112019008374 A BR112019008374 A BR 112019008374A BR 112019008374 A2 BR112019008374 A2 BR 112019008374A2
- Authority
- BR
- Brazil
- Prior art keywords
- egfr inhibitor
- mutant egfr
- selective exon
- insert mutant
- exon insert
- Prior art date
Links
- 229940121647 egfr inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
agente antitumoral compreendendo um composto selecionado do grupo consistindo nos compostos a a d descritos na descrição, ou um sal dos mesmos, para tratar um paciente com tumor maligno que expressa egfr tendo mutação por inserção do éxon 20.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016213072 | 2016-10-31 | ||
PCT/JP2017/037186 WO2018079310A1 (ja) | 2016-10-31 | 2017-10-13 | エクソン20挿入変異型egfr選択的阻害剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019008374A2 true BR112019008374A2 (pt) | 2019-10-01 |
Family
ID=62024991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019008374A BR112019008374A2 (pt) | 2016-10-31 | 2017-10-13 | inibidor seletivo de egfr mutante por inserção do éxon 20 |
Country Status (22)
Country | Link |
---|---|
US (2) | US11857513B2 (pt) |
EP (1) | EP3533449B1 (pt) |
JP (1) | JP6896755B2 (pt) |
KR (1) | KR102639585B1 (pt) |
CN (1) | CN110191711B (pt) |
AU (1) | AU2017350440B2 (pt) |
BR (1) | BR112019008374A2 (pt) |
CA (1) | CA3041015A1 (pt) |
DK (1) | DK3533449T3 (pt) |
ES (1) | ES2955832T3 (pt) |
FI (1) | FI3533449T3 (pt) |
HU (1) | HUE063712T2 (pt) |
IL (1) | IL266239B2 (pt) |
JO (1) | JOP20190073A1 (pt) |
MX (1) | MX2019004969A (pt) |
PH (1) | PH12019500957A1 (pt) |
PL (1) | PL3533449T3 (pt) |
PT (1) | PT3533449T (pt) |
SG (1) | SG11201903875QA (pt) |
TW (1) | TWI774699B (pt) |
WO (1) | WO2018079310A1 (pt) |
ZA (1) | ZA201902629B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108101905A (zh) * | 2016-11-24 | 2018-06-01 | 中国科学院上海药物研究所 | 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途 |
US20220072000A1 (en) * | 2018-12-28 | 2022-03-10 | Taiho Pharmaceutical Co., Ltd. | L718 and/or l792 mutant treatment-resistant egfr inhibitor |
CN113453764B (zh) | 2019-02-15 | 2024-04-16 | 大鹏药品工业株式会社 | 7H-吡咯并[2,3-d]嘧啶-4-胺衍生物 |
WO2021057796A1 (zh) * | 2019-09-29 | 2021-04-01 | 深圳市塔吉瑞生物医药有限公司 | 取代的稠合三环衍生物及其组合物及用途 |
CN113861195B (zh) * | 2020-06-30 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种多稠环egfr抑制剂及其制备方法和应用 |
WO2022007841A1 (zh) * | 2020-07-09 | 2022-01-13 | 上海和誉生物医药科技有限公司 | 一种egfr抑制剂、其制备方法和在药学上的应用 |
WO2022055895A1 (en) * | 2020-09-08 | 2022-03-17 | Cullinan Pearl Corp. | Treatment regimens for exon-20 insertion mutant egfr cancers |
WO2022121967A1 (zh) * | 2020-12-09 | 2022-06-16 | 南京药石科技股份有限公司 | Egfr酪氨酸激酶抑制剂及其用途 |
CN115785107A (zh) * | 2022-12-15 | 2023-03-14 | 南京雷正医药科技有限公司 | 一种取代8,9-二氢嘧啶并[5,4-b]吲嗪类化合物、药物组合物及其用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW440562B (en) | 1994-05-20 | 2001-06-16 | Taiho Pharmaceutical Co Ltd | Condensed-indan derivative and pharmaceutically acceptable salts thereof |
CA2601766A1 (en) | 2005-03-17 | 2006-09-28 | Novartis Ag | N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase |
DK1800675T3 (da) | 2005-12-23 | 2011-09-05 | Nutricia Nv | Sammensætninger omfattende polyumættede fedtsyrer, proteiner og mangan og/eller molybdæn og nucleosider/nucleotider til behandling af demens |
MY152972A (en) | 2009-07-10 | 2014-12-15 | Taiho Pharmaceutical Co Ltd | Azabicyclo compound and salt thereof |
US7741330B1 (en) | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
MX2013007938A (es) | 2011-01-07 | 2013-11-01 | Taiho Pharmaceutical Co Ltd | Compuesto biciclico novedoso o sal del mismo. |
WO2013047813A1 (ja) | 2011-09-30 | 2013-04-04 | 大鵬薬品工業株式会社 | 1,2,4-トリアジン-6-カルボキサミド誘導体 |
TWI594986B (zh) | 2011-12-28 | 2017-08-11 | Taiho Pharmaceutical Co Ltd | Antineoplastic agent effect enhancer |
TW201336847A (zh) | 2012-02-07 | 2013-09-16 | Taiho Pharmaceutical Co Ltd | 喹啉基吡咯并嘧啶化合物或其鹽 |
JP5557963B2 (ja) * | 2012-02-23 | 2014-07-23 | 大鵬薬品工業株式会社 | キノリルピロロピリミジル縮合環化合物又はその塩 |
MX2015010934A (es) | 2013-02-22 | 2015-10-29 | Taiho Pharmaceutical Co Ltd | Metodo para producir un compuesto triciclico, y un compuesto triciclico capaz de producirse por dicho metodo de produccion. |
CA2922077C (en) * | 2013-08-22 | 2018-06-26 | Taiho Pharmaceutical Co., Ltd. | Quinoline-substituted compound |
EP3143015B1 (en) | 2014-05-13 | 2019-02-20 | ARIAD Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
CN110526912B (zh) | 2014-06-19 | 2023-02-14 | 武田药品工业株式会社 | 用于激酶抑制的杂芳基化合物 |
JP6583614B2 (ja) | 2015-05-11 | 2019-10-02 | 大同特殊鋼株式会社 | アーク炉の電極折損防止装置 |
PT3677266T (pt) | 2017-09-01 | 2024-03-04 | Taiho Pharmaceutical Co Ltd | Inibidor seletivo de egfr com mutação no exão 18 e/ou exão 21 |
-
2017
- 2017-06-16 JO JOP/2019/0073A patent/JOP20190073A1/ar unknown
- 2017-10-13 HU HUE17864975A patent/HUE063712T2/hu unknown
- 2017-10-13 IL IL266239A patent/IL266239B2/en unknown
- 2017-10-13 TW TW106135203A patent/TWI774699B/zh active
- 2017-10-13 DK DK17864975.2T patent/DK3533449T3/da active
- 2017-10-13 AU AU2017350440A patent/AU2017350440B2/en active Active
- 2017-10-13 PL PL17864975.2T patent/PL3533449T3/pl unknown
- 2017-10-13 CA CA3041015A patent/CA3041015A1/en active Pending
- 2017-10-13 PT PT178649752T patent/PT3533449T/pt unknown
- 2017-10-13 EP EP17864975.2A patent/EP3533449B1/en active Active
- 2017-10-13 JP JP2018547565A patent/JP6896755B2/ja active Active
- 2017-10-13 BR BR112019008374A patent/BR112019008374A2/pt unknown
- 2017-10-13 KR KR1020197015270A patent/KR102639585B1/ko active IP Right Grant
- 2017-10-13 ES ES17864975T patent/ES2955832T3/es active Active
- 2017-10-13 FI FIEP17864975.2T patent/FI3533449T3/fi active
- 2017-10-13 SG SG11201903875QA patent/SG11201903875QA/en unknown
- 2017-10-13 WO PCT/JP2017/037186 patent/WO2018079310A1/ja unknown
- 2017-10-13 MX MX2019004969A patent/MX2019004969A/es unknown
- 2017-10-13 CN CN201780067762.5A patent/CN110191711B/zh active Active
- 2017-10-31 US US16/345,792 patent/US11857513B2/en active Active
-
2019
- 2019-04-25 ZA ZA2019/02629A patent/ZA201902629B/en unknown
- 2019-04-29 PH PH12019500957A patent/PH12019500957A1/en unknown
-
2023
- 2023-11-17 US US18/512,528 patent/US20240148734A1/en active Pending
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