BR112019002462A2 - método de produção de ácido lático - Google Patents
método de produção de ácido láticoInfo
- Publication number
- BR112019002462A2 BR112019002462A2 BR112019002462-0A BR112019002462A BR112019002462A2 BR 112019002462 A2 BR112019002462 A2 BR 112019002462A2 BR 112019002462 A BR112019002462 A BR 112019002462A BR 112019002462 A2 BR112019002462 A2 BR 112019002462A2
- Authority
- BR
- Brazil
- Prior art keywords
- lactic acid
- whey
- fermentation broth
- lactose
- byproduct
- Prior art date
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title abstract 14
- 235000014655 lactic acid Nutrition 0.000 title abstract 6
- 239000004310 lactic acid Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000005862 Whey Substances 0.000 abstract 7
- 102000007544 Whey Proteins Human genes 0.000 abstract 7
- 108010046377 Whey Proteins Proteins 0.000 abstract 7
- 239000006227 byproduct Substances 0.000 abstract 5
- 238000000855 fermentation Methods 0.000 abstract 5
- 230000004151 fermentation Effects 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 5
- 239000012466 permeate Substances 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 3
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
- 239000008101 lactose Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011144 upstream manufacturing Methods 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000010953 base metal Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000009388 chemical precipitation Methods 0.000 abstract 1
- 238000011143 downstream manufacturing Methods 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 229910000000 metal hydroxide Inorganic materials 0.000 abstract 1
- 150000004692 metal hydroxides Chemical class 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
- A23C21/026—Whey; Whey preparations containing, or treated with, microorganisms or enzymes containing, or treated only with, lactic acid producing bacteria, bifidobacteria or propionic acid bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C2210/00—Physical treatment of dairy products
- A23C2210/20—Treatment using membranes, including sterile filtration
- A23C2210/206—Membrane filtration of a permeate obtained by ultrafiltration, nanofiltration or microfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/06—Specific process operations in the permeate stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2623—Ion-Exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2642—Aggregation, sedimentation, flocculation, precipitation or coagulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2673—Evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2688—Biological processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/025—Reverse osmosis; Hyperfiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Dairy Products (AREA)
Abstract
a presente invenção refere-se a um processo para a produção de ácido láctico puro a partir de um subproduto de soro de leite rico em lactose e minerais, por exemplo, permeado de soro de leite sem lactose ou permeado de soro de leite concentrado. o método compreende etapas a montante de neutralizar o subproduto de soro de leite com um hidróxido de metal básico para formar um precipitado que compreende cálcio e fosfato e separar o precipitado do subproduto de soro de leite para fornecer um subproduto de soro de leite clarificado. o subproduto de soro de leite clarificado é fermentado por uma bactéria capaz de bioconversão da lactose em ácido láctico para fornecer um caldo de fermentação que contém um sal de ácido láctico. nas etapas a jusante, o caldo de fermentação é acidificado para liberar ácido láctico do sal de ácido láctico, o precipitado do caldo produzido através de acidificação é removido e o caldo de fermentação acidificado é tratado para recuperar ácido láctico puro ao remover os sais residuais e água e, opcionalmente, proteínas. o processo da invenção produz ácido láctico com uma pureza de 80-98 % e uma pureza isomérica > 98 % de ácido l-láctico usando um processo que emprega a remoção a montante de sais divalentes por meio de precipitação química, fermentação bacteriana do substrato desmineralizado e processamento a jusante mínimo do caldo de fermentação. os métodos da invenção também podem ser usados com permeados de leite.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183196.1 | 2016-08-08 | ||
| EP16183196.1A EP3282018A1 (en) | 2016-08-08 | 2016-08-08 | A method of producing lactic acid |
| PCT/EP2017/070120 WO2018029219A1 (en) | 2016-08-08 | 2017-08-08 | A method of producing lactic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019002462A2 true BR112019002462A2 (pt) | 2019-05-14 |
Family
ID=56681979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019002462-0A BR112019002462A2 (pt) | 2016-08-08 | 2017-08-08 | método de produção de ácido lático |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11382335B2 (pt) |
| EP (2) | EP3282018A1 (pt) |
| AU (1) | AU2017309957B2 (pt) |
| BR (1) | BR112019002462A2 (pt) |
| CL (1) | CL2019000312A1 (pt) |
| DK (1) | DK3497225T3 (pt) |
| ES (1) | ES2883329T3 (pt) |
| MX (1) | MX2019001560A (pt) |
| PL (1) | PL3497225T3 (pt) |
| PT (1) | PT3497225T (pt) |
| RU (1) | RU2763351C2 (pt) |
| WO (1) | WO2018029219A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10927390B2 (en) | 2015-10-30 | 2021-02-23 | Glanbia Ireland Designated Activity Company | Method for producing lactic acid by bacterial fermentation |
| EP3282018A1 (en) | 2016-08-08 | 2018-02-14 | Glanbia Ingredients Ireland Designated Activity Company | A method of producing lactic acid |
| AU2020224691B2 (en) * | 2019-02-24 | 2022-10-20 | Capro-X, Inc. | Microbial conversion of lactose-containing feedstocks to carboxylic acids |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3131717A1 (de) * | 1981-08-11 | 1983-03-03 | Hoechst Ag, 6000 Frankfurt | Lactobacillus bulgaricus dsm 2129 und seine verwendung zur herstellung von d-milchsaeure |
| US4698303A (en) * | 1985-02-15 | 1987-10-06 | Engenics, Inc. | Production of lactic acid by continuous fermentation using an inexpensive raw material and a simplified method of lactic acid purification |
| US5322781A (en) * | 1985-11-18 | 1994-06-21 | Cooperatieve Weiproduktenfabriek "Borculo" W.A. | Procedure for the preparation of D-(-)-lactic acid with Lactobacillus bulgaricus |
| US5416020A (en) * | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US5801025A (en) | 1995-10-27 | 1998-09-01 | Shimadzu Corporation | Method for producing L-lactic acid with high optical purity using bacillus strains |
| AUPO821397A0 (en) * | 1997-07-24 | 1997-08-14 | Commonwealth Scientific And Industrial Research Organisation | Process for the purification of nutrients from food process streams |
| NZ523459A (en) * | 2000-05-30 | 2004-08-27 | Lactascan Aps | Method for producing lactic acid |
| WO2010103548A2 (en) | 2009-03-13 | 2010-09-16 | Godavari Biorefineries Ltd. | Improved method for producing lactic acid and derivative thereof |
| EP2580315A4 (en) * | 2010-06-14 | 2013-11-27 | Cobalt Technologies Inc | SALT SELECTION OF MICROBIAL MUTATIONS TO INCREASE TOLERANCE TO BIOPRODUCTS, TITLE, OR TOLERANCE TO OSMOTIC SHOCKS |
| US10927390B2 (en) | 2015-10-30 | 2021-02-23 | Glanbia Ireland Designated Activity Company | Method for producing lactic acid by bacterial fermentation |
| EP3282018A1 (en) | 2016-08-08 | 2018-02-14 | Glanbia Ingredients Ireland Designated Activity Company | A method of producing lactic acid |
-
2016
- 2016-08-08 EP EP16183196.1A patent/EP3282018A1/en not_active Withdrawn
-
2017
- 2017-08-08 AU AU2017309957A patent/AU2017309957B2/en active Active
- 2017-08-08 ES ES17761447T patent/ES2883329T3/es active Active
- 2017-08-08 WO PCT/EP2017/070120 patent/WO2018029219A1/en unknown
- 2017-08-08 US US16/324,117 patent/US11382335B2/en active Active
- 2017-08-08 BR BR112019002462-0A patent/BR112019002462A2/pt unknown
- 2017-08-08 PT PT177614476T patent/PT3497225T/pt unknown
- 2017-08-08 DK DK17761447.6T patent/DK3497225T3/da active
- 2017-08-08 EP EP17761447.6A patent/EP3497225B1/en active Active
- 2017-08-08 MX MX2019001560A patent/MX2019001560A/es unknown
- 2017-08-08 RU RU2019102326A patent/RU2763351C2/ru active
- 2017-08-08 PL PL17761447T patent/PL3497225T3/pl unknown
-
2019
- 2019-02-06 CL CL2019000312A patent/CL2019000312A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3497225B1 (en) | 2021-05-05 |
| EP3497225A1 (en) | 2019-06-19 |
| AU2017309957B2 (en) | 2022-01-27 |
| WO2018029219A1 (en) | 2018-02-15 |
| MX2019001560A (es) | 2019-09-18 |
| CL2019000312A1 (es) | 2019-06-21 |
| US20190166865A1 (en) | 2019-06-06 |
| PT3497225T (pt) | 2021-08-11 |
| EP3282018A1 (en) | 2018-02-14 |
| RU2763351C2 (ru) | 2021-12-28 |
| RU2019102326A (ru) | 2020-09-11 |
| AU2017309957A1 (en) | 2019-02-21 |
| ES2883329T3 (es) | 2021-12-07 |
| DK3497225T3 (da) | 2021-08-09 |
| RU2019102326A3 (pt) | 2021-02-08 |
| PL3497225T3 (pl) | 2022-03-21 |
| US11382335B2 (en) | 2022-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |