BR112019000216A2 - uso de removedores de gama-cetoaldeídos reativos para prolongar a vida útil de célula e tempo de saúde - Google Patents

uso de removedores de gama-cetoaldeídos reativos para prolongar a vida útil de célula e tempo de saúde

Info

Publication number
BR112019000216A2
BR112019000216A2 BR112019000216A BR112019000216A BR112019000216A2 BR 112019000216 A2 BR112019000216 A2 BR 112019000216A2 BR 112019000216 A BR112019000216 A BR 112019000216A BR 112019000216 A BR112019000216 A BR 112019000216A BR 112019000216 A2 BR112019000216 A2 BR 112019000216A2
Authority
BR
Brazil
Prior art keywords
ketoaldehyde
removers
cell life
extend cell
health time
Prior art date
Application number
BR112019000216A
Other languages
English (en)
Other versions
BR112019000216B1 (pt
Inventor
L Roberts Ii Jackson
T Nguyen Thuy
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of BR112019000216A2 publication Critical patent/BR112019000216A2/pt
Publication of BR112019000216B1 publication Critical patent/BR112019000216B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

métodos e compostos para uso na promoção de sobrevivência de pelo menos uma célula eucariótica, em que os compostos são eficazes como removedores de gama-cetoaldeído.
BR112019000216-2A 2016-07-06 2017-07-06 Usos de removedores de gama-cetoaldeídos reativos para tratar dano oxidante celular relacionado à idade por deficiência de sirtuína, para preservar a sirtuína e para promover a sobrevivência de pelo menos uma célula eucariótica pela preservação da atividade de desacetilação mediada por sirtuína BR112019000216B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359183P 2016-07-06 2016-07-06
US62/359,183 2016-07-06
PCT/US2017/040982 WO2018009720A1 (en) 2016-07-06 2017-07-06 Use of scavengers of reactive gamma-ketoaldehydes to extend cell lifespan and healthspan

Publications (2)

Publication Number Publication Date
BR112019000216A2 true BR112019000216A2 (pt) 2019-04-16
BR112019000216B1 BR112019000216B1 (pt) 2023-04-18

Family

ID=60912291

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019000216-2A BR112019000216B1 (pt) 2016-07-06 2017-07-06 Usos de removedores de gama-cetoaldeídos reativos para tratar dano oxidante celular relacionado à idade por deficiência de sirtuína, para preservar a sirtuína e para promover a sobrevivência de pelo menos uma célula eucariótica pela preservação da atividade de desacetilação mediada por sirtuína

Country Status (9)

Country Link
US (1) US11633370B2 (pt)
EP (1) EP3481798A4 (pt)
JP (2) JP2019524703A (pt)
CN (1) CN109689619A (pt)
AU (1) AU2017293846B2 (pt)
BR (1) BR112019000216B1 (pt)
CA (1) CA3030036A1 (pt)
MX (1) MX2019000114A (pt)
WO (1) WO2018009720A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615015B1 (en) * 2017-04-27 2024-03-13 Vanderbilt University Gamma-ketoaldehyde scavengers for treating atherosclerosis
JP2023545304A (ja) * 2020-10-13 2023-10-27 ヴァンダービルト ユニバーシティー 腎傷害による腸リンパ管の乱れを予防する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7705054B1 (en) * 2004-10-20 2010-04-27 Vanderbilt University Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases
US8822542B2 (en) * 2004-10-20 2014-09-02 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury
PL2731597T3 (pl) * 2011-07-12 2024-04-29 Vanderbilt University Sposoby leczenia stanu zapalnego i nadciśnienia tętniczego za pomocą wychwytywaczy gamma-ketoaldehydowych

Also Published As

Publication number Publication date
CN109689619A (zh) 2019-04-26
US20190240170A1 (en) 2019-08-08
CA3030036A1 (en) 2018-01-11
WO2018009720A1 (en) 2018-01-11
EP3481798A1 (en) 2019-05-15
AU2017293846A1 (en) 2019-01-31
BR112019000216B1 (pt) 2023-04-18
MX2019000114A (es) 2019-04-01
JP2023113705A (ja) 2023-08-16
JP2019524703A (ja) 2019-09-05
US11633370B2 (en) 2023-04-25
EP3481798A4 (en) 2020-03-11
AU2017293846B2 (en) 2022-03-17

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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