BR112018005584A2 - composição, método para detecção de doença de lyme ou para monitoramento da eficácia de um tratamento para doença de lyme, e, célula hospedeira - Google Patents
composição, método para detecção de doença de lyme ou para monitoramento da eficácia de um tratamento para doença de lyme, e, célula hospedeiraInfo
- Publication number
- BR112018005584A2 BR112018005584A2 BR112018005584A BR112018005584A BR112018005584A2 BR 112018005584 A2 BR112018005584 A2 BR 112018005584A2 BR 112018005584 A BR112018005584 A BR 112018005584A BR 112018005584 A BR112018005584 A BR 112018005584A BR 112018005584 A2 BR112018005584 A2 BR 112018005584A2
- Authority
- BR
- Brazil
- Prior art keywords
- lyme disease
- borrelia
- treatment
- effectiveness
- monitoring
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
são providas composições e métodos para detecção, diagnóstico e prognóstico de doença de lyme (ld), incluindo um método para confirmação de infecção de borrelia spp. colocando-se em contato, in vitro, amostras de sangue total de indivíduos suspeitos de ter ld em contato com peptídeos sintéticos que compreendem regiões que contêm epítopo de células t derivadas de proteínas de borrelia que são expressadas em diferentes estágios da doença de lyme, e detecção, indireta, de células t ativadas específicas de ld determinando-se a produção de um indicador de resposta imune de células t (por exemplo, interferon-y) em resposta à estimulação pelos peptídeos. além disso, são descritos métodos para previsão de eliminação de espiroquetas de ld em pacientes com ld que passaram por tratamento de ld, expondo-se amostras de sangue total de tais indivíduos a peptídeos que compreendem regiões de epítopo de células t específicas de proteínas de borrelia que são expressadas em diferentes estágios da doença de lyme e confirmando-se uma falta de células t ativadas específicas de borrelia nas amostras pela ausência de um indicador de resposta imune de célula t detectável (por exemplo, interferon-y).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562233192P | 2015-09-25 | 2015-09-25 | |
| PCT/US2016/051896 WO2017053167A1 (en) | 2015-09-25 | 2016-09-15 | Compositions and methods for diagnosing lyme disease and for predicting lyme disease spirochete elimination after treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018005584A2 true BR112018005584A2 (pt) | 2018-10-16 |
Family
ID=57003597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018005584A BR112018005584A2 (pt) | 2015-09-25 | 2016-09-15 | composição, método para detecção de doença de lyme ou para monitoramento da eficácia de um tratamento para doença de lyme, e, célula hospedeira |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10983121B2 (pt) |
| EP (2) | EP3353551B1 (pt) |
| JP (2) | JP6936230B2 (pt) |
| KR (1) | KR102625783B1 (pt) |
| CN (2) | CN108139401B (pt) |
| AU (2) | AU2016328277B2 (pt) |
| BR (1) | BR112018005584A2 (pt) |
| CA (1) | CA2999078A1 (pt) |
| FI (1) | FI3353551T3 (pt) |
| LT (1) | LT3353551T (pt) |
| MX (1) | MX2018003454A (pt) |
| RU (1) | RU2750040C2 (pt) |
| SG (1) | SG10202110385UA (pt) |
| SI (1) | SI3353551T1 (pt) |
| WO (1) | WO2017053167A1 (pt) |
| ZA (1) | ZA201801716B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108139401B (zh) * | 2015-09-25 | 2022-02-18 | 凯杰科技有限公司 | 诊断莱姆病并用于预测治疗后莱姆病螺旋体消除的组合物和方法 |
| JP2021505560A (ja) * | 2017-12-04 | 2021-02-18 | インターベット インターナショナル ベー． フェー． | イヌライム病ワクチン |
| KR20210084485A (ko) * | 2018-10-01 | 2021-07-07 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 다중 항체 이소타입의 동시 분리능을 갖는 고 특이성 및 민감도 면역 흡착제 진단 분석 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054296A (en) * | 1988-10-24 | 2000-04-25 | Symbicom Ab | 66 kDa antigen from Borrelia |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
| BE1006728A3 (fr) | 1993-02-19 | 1994-11-29 | Wallone Region | Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi. |
| US7008625B2 (en) * | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
| US6214355B1 (en) * | 1995-04-24 | 2001-04-10 | Texas A & M University System | DbpA compositions |
| CA2244147A1 (en) | 1996-01-22 | 1997-07-31 | Medimmune Incorporated | Decorin binding protein compositions and methods of use |
| KR20000076072A (ko) | 1998-01-08 | 2000-12-26 | 바이오메리욱스,인코포레이티드 | 진단 시약으로서의 재조합 Р37/ＦｌａＡ |
| US8129165B2 (en) | 2006-09-15 | 2012-03-06 | Intercell Ag | Borrelia antigens |
| WO2009131665A1 (en) | 2008-04-22 | 2009-10-29 | Research Foundation Of State University Of New York | Borrelia burgdorferi cell envelope protein array |
| EP2619584B1 (en) | 2010-09-21 | 2016-10-12 | Stichting Katholieke Universiteit | Novel method for diagnosing lyme disease using a cellular immunological test |
| MX2013003609A (es) | 2010-09-27 | 2013-10-17 | Univ Cornell | Metodos para diagnosticar la enfermedad de lyme. |
| US20120142023A1 (en) * | 2010-12-02 | 2012-06-07 | Ascoli Carl A | Proteins and method for detection of lyme disease |
| RU133313U1 (ru) | 2012-01-27 | 2013-10-10 | Федеральное бюджетное учреждение науки "Центральный научно-исследовательский институт эпидемиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ЦНИИ Эпидемиологии Роспотребнадзора) | Диагностическая тест-система в формате иммуночипа и способ серологической диагностики иксодового клещевого боррелиоза |
| EP2809348B1 (en) * | 2012-02-01 | 2018-11-07 | Biopeptides Corporation | Diagnostic peptides for lyme disease |
| CN108139401B (zh) | 2015-09-25 | 2022-02-18 | 凯杰科技有限公司 | 诊断莱姆病并用于预测治疗后莱姆病螺旋体消除的组合物和方法 |
| WO2017139715A1 (en) | 2016-02-11 | 2017-08-17 | The Translational Genomics Research Institute | Systems and methods for the detection of infectious diseases |
-
2016
- 2016-09-15 CN CN201680056129.1A patent/CN108139401B/zh active Active
- 2016-09-15 EP EP16771056.5A patent/EP3353551B1/en active Active
- 2016-09-15 WO PCT/US2016/051896 patent/WO2017053167A1/en active Application Filing
- 2016-09-15 FI FIEP16771056.5T patent/FI3353551T3/fi active
- 2016-09-15 JP JP2018535813A patent/JP6936230B2/ja active Active
- 2016-09-15 SI SI201631660T patent/SI3353551T1/sl unknown
- 2016-09-15 CN CN202111067721.0A patent/CN113866423A/zh active Pending
- 2016-09-15 KR KR1020187011154A patent/KR102625783B1/ko active IP Right Grant
- 2016-09-15 BR BR112018005584A patent/BR112018005584A2/pt active Search and Examination
- 2016-09-15 EP EP22169501.8A patent/EP4071477A1/en active Pending
- 2016-09-15 CA CA2999078A patent/CA2999078A1/en active Pending
- 2016-09-15 US US15/763,032 patent/US10983121B2/en active Active
- 2016-09-15 LT LTEPPCT/US2016/051896T patent/LT3353551T/lt unknown
- 2016-09-15 SG SG10202110385UA patent/SG10202110385UA/en unknown
- 2016-09-15 RU RU2018111268A patent/RU2750040C2/ru active
- 2016-09-15 MX MX2018003454A patent/MX2018003454A/es unknown
- 2016-09-15 AU AU2016328277A patent/AU2016328277B2/en active Active
-
2018
- 2018-03-13 ZA ZA2018/01716A patent/ZA201801716B/en unknown
-
2021
- 2021-03-12 US US17/200,553 patent/US20220057397A1/en active Pending
- 2021-04-13 JP JP2021067752A patent/JP7231665B2/ja active Active
-
2023
- 2023-02-23 AU AU2023201072A patent/AU2023201072A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7231665B2 (ja) | 2023-03-01 |
| ZA201801716B (en) | 2022-08-31 |
| LT3353551T (lt) | 2023-02-10 |
| CA2999078A1 (en) | 2017-03-30 |
| CN113866423A (zh) | 2021-12-31 |
| CN108139401B (zh) | 2022-02-18 |
| US20220057397A1 (en) | 2022-02-24 |
| JP2021118705A (ja) | 2021-08-12 |
| US10983121B2 (en) | 2021-04-20 |
| AU2023201072A1 (en) | 2023-03-30 |
| AU2016328277B2 (en) | 2022-11-24 |
| KR20180066106A (ko) | 2018-06-18 |
| SI3353551T1 (sl) | 2023-03-31 |
| MX2018003454A (es) | 2018-08-15 |
| FI3353551T3 (fi) | 2023-01-31 |
| CN108139401A (zh) | 2018-06-08 |
| EP4071477A1 (en) | 2022-10-12 |
| WO2017053167A1 (en) | 2017-03-30 |
| AU2016328277A1 (en) | 2018-05-10 |
| KR102625783B1 (ko) | 2024-01-15 |
| JP6936230B2 (ja) | 2021-09-15 |
| EP3353551B1 (en) | 2022-11-02 |
| RU2018111268A (ru) | 2019-10-28 |
| RU2750040C2 (ru) | 2021-06-21 |
| SG10202110385UA (en) | 2021-11-29 |
| JP2018536429A (ja) | 2018-12-13 |
| US20190285630A1 (en) | 2019-09-19 |
| RU2018111268A3 (pt) | 2020-01-22 |
| EP3353551A1 (en) | 2018-08-01 |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] |