BR112018001053A2 - compostos, composição farmacêutica e método para inibir, prevenir ou tratar um câncer em um indivíduo - Google Patents
compostos, composição farmacêutica e método para inibir, prevenir ou tratar um câncer em um indivíduoInfo
- Publication number
- BR112018001053A2 BR112018001053A2 BR112018001053A BR112018001053A BR112018001053A2 BR 112018001053 A2 BR112018001053 A2 BR 112018001053A2 BR 112018001053 A BR112018001053 A BR 112018001053A BR 112018001053 A BR112018001053 A BR 112018001053A BR 112018001053 A2 BR112018001053 A2 BR 112018001053A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- inhibiting
- preventing
- individual
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
Abstract
a invenção fornece uma série de compostos de azaarila substituídos com clorobenzeno tendo atividade na inibição do crescimento de células cancerosas e baixa toxicidade em células normais. particularmente, os compostos da invenção têm um efeito de inibição mais forte no câncer de bexiga e no câncer de fígado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562194705P | 2015-07-20 | 2015-07-20 | |
PCT/US2016/043203 WO2017015400A1 (en) | 2015-07-20 | 2016-07-20 | Chlorobenzene substituted azaaryl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018001053A2 true BR112018001053A2 (pt) | 2018-09-11 |
Family
ID=57834598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018001053A BR112018001053A2 (pt) | 2015-07-20 | 2016-07-20 | compostos, composição farmacêutica e método para inibir, prevenir ou tratar um câncer em um indivíduo |
Country Status (9)
Country | Link |
---|---|
US (1) | US10624897B2 (pt) |
EP (1) | EP3324970A4 (pt) |
JP (1) | JP2018527321A (pt) |
CN (1) | CN108348519A (pt) |
AU (1) | AU2016296997B2 (pt) |
BR (1) | BR112018001053A2 (pt) |
CA (1) | CA2993022A1 (pt) |
TW (1) | TWI694067B (pt) |
WO (1) | WO2017015400A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110283130B (zh) * | 2019-07-05 | 2023-12-19 | 温州医科大学 | 一种1-(2,5-二甲氧基苯基)-3-取代脲类结肠癌抑制剂及其制备和应用 |
CN114450277A (zh) * | 2019-09-30 | 2022-05-06 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的经取代的嘧啶 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
CN101336237B (zh) | 2005-12-21 | 2015-09-30 | 诺华股份有限公司 | 作为fgf抑制剂的嘧啶基芳基脲衍生物 |
KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
MX354783B (es) * | 2012-03-30 | 2018-03-21 | Novartis Ag | Inhibidor de fgfr para su uso en el tratamiento de trastornos hipofosfatemicos. |
WO2015057938A1 (en) * | 2013-10-18 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Pyrimidine fgfr4 inhibitors |
-
2016
- 2016-07-20 AU AU2016296997A patent/AU2016296997B2/en not_active Expired - Fee Related
- 2016-07-20 TW TW105122966A patent/TWI694067B/zh active
- 2016-07-20 WO PCT/US2016/043203 patent/WO2017015400A1/en unknown
- 2016-07-20 EP EP16828495.8A patent/EP3324970A4/en not_active Withdrawn
- 2016-07-20 JP JP2018502695A patent/JP2018527321A/ja active Pending
- 2016-07-20 CN CN201680043128.3A patent/CN108348519A/zh active Pending
- 2016-07-20 US US15/746,182 patent/US10624897B2/en active Active
- 2016-07-20 CA CA2993022A patent/CA2993022A1/en not_active Abandoned
- 2016-07-20 BR BR112018001053A patent/BR112018001053A2/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TWI694067B (zh) | 2020-05-21 |
CA2993022A1 (en) | 2017-01-26 |
WO2017015400A1 (en) | 2017-01-26 |
EP3324970A4 (en) | 2019-03-06 |
US10624897B2 (en) | 2020-04-21 |
EP3324970A1 (en) | 2018-05-30 |
AU2016296997B2 (en) | 2020-07-09 |
CN108348519A (zh) | 2018-07-31 |
JP2018527321A (ja) | 2018-09-20 |
TW201720800A (zh) | 2017-06-16 |
AU2016296997A1 (en) | 2018-03-08 |
US20190083499A1 (en) | 2019-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |