BR112017025705A2 - método de liberação de glicosídeos de esteviol de uma célula hospedeira, método de recuperação de glicosídeos de esteviol de uma composição e composição - Google Patents

método de liberação de glicosídeos de esteviol de uma célula hospedeira, método de recuperação de glicosídeos de esteviol de uma composição e composição

Info

Publication number
BR112017025705A2
BR112017025705A2 BR112017025705A BR112017025705A BR112017025705A2 BR 112017025705 A2 BR112017025705 A2 BR 112017025705A2 BR 112017025705 A BR112017025705 A BR 112017025705A BR 112017025705 A BR112017025705 A BR 112017025705A BR 112017025705 A2 BR112017025705 A2 BR 112017025705A2
Authority
BR
Brazil
Prior art keywords
composition
releasing
steviol
host cell
steviol glycosides
Prior art date
Application number
BR112017025705A
Other languages
English (en)
Other versions
BR112017025705B1 (pt
Inventor
Flores Belit
S Gaspard Dan
C Anderson James
T Mortenson Kristopher
Rasmussen Maribeth
Paulson Nicole
Nygaard Richard
j brower Robert iii
Liu Carlson Ting
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of BR112017025705A2 publication Critical patent/BR112017025705A2/pt
Publication of BR112017025705B1 publication Critical patent/BR112017025705B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

são divulgados métodos de liberação ou enriquecimento de glicosídeos de esteviol produzidos por levedura. os métodos divulgados acentuam ou aprimoram a liberação ou o enriquecimento dos glicosídeos de esteviol.
BR112017025705-0A 2015-05-29 2016-05-27 Método de liberação de glicosídeos de esteviol de uma célula hospedeira BR112017025705B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562168142P 2015-05-29 2015-05-29
US62/168142 2015-05-29
PCT/US2016/034781 WO2016196345A1 (en) 2015-05-29 2016-05-27 Heat treatment to produce glycosides

Publications (2)

Publication Number Publication Date
BR112017025705A2 true BR112017025705A2 (pt) 2018-08-14
BR112017025705B1 BR112017025705B1 (pt) 2022-05-10

Family

ID=57442146

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025705-0A BR112017025705B1 (pt) 2015-05-29 2016-05-27 Método de liberação de glicosídeos de esteviol de uma célula hospedeira

Country Status (8)

Country Link
US (3) US10612065B2 (pt)
EP (2) EP4063513A1 (pt)
JP (1) JP2018516081A (pt)
CN (1) CN107613786A (pt)
AU (2) AU2016271125A1 (pt)
BR (1) BR112017025705B1 (pt)
CA (1) CA2987587C (pt)
WO (1) WO2016196345A1 (pt)

Families Citing this family (14)

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CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
CN107614677A (zh) 2015-05-29 2018-01-19 嘉吉公司 用于使用多阶段进料生产甜菊醇糖苷的发酵方法
BR112017025614A2 (pt) 2015-05-29 2018-09-11 Cargill, Incorporated método para produzir glicosídeo de esteviol e composição
AU2016271125A1 (en) * 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
US10844414B2 (en) 2015-08-06 2020-11-24 Cargill, Incorporated Methods for producing steviol glycosides in engineered yeast
US11091743B2 (en) 2016-08-12 2021-08-17 Amyris, Inc. UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides
CN117051063A (zh) 2016-10-21 2023-11-14 百事可乐公司 一种酶法制备瑞鲍迪甙c的方法
EP3530745A4 (en) 2016-10-21 2020-07-22 Pepsico, Inc. PROCESS FOR PREPARING REBAUDIOSIDE N USING AN ENZYMATIC PROCESS
JP6842800B2 (ja) 2016-10-21 2021-03-17 ペプシコ・インク 酵素的方法を使用してレバウディオサイドｊを調製するための方法
CA3175100A1 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
SG10202111903TA (en) * 2017-03-31 2021-12-30 Suntory Holdings Ltd Novel steviol glycoside and production method therefor, and sweetener composition containing same
EP3765627A4 (en) 2018-03-12 2021-10-13 Conagen Inc. BIOSYNTHETIC PRODUCTION OF STEVIOL GLYCOSIDES REBAUDIOSIDE J AND REBAUDIOSIDE N
US20220389043A1 (en) * 2019-10-17 2022-12-08 Dsm Ip Assets B.V. Improved isolation of steviol glycosides
CN117015611A (zh) 2021-03-01 2023-11-07 嘉吉公司 木糖基化甜菊醇糖苷和用于生产的酶促方法

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WO2002040697A2 (en) 2000-11-03 2002-05-23 Genentech, Inc. Metabolic rate shifts in fermentations expressing recombinant proteins
US7923552B2 (en) * 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
US7923231B2 (en) 2004-12-17 2011-04-12 Cargill, Incorporated Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
ES2464282T3 (es) 2006-09-27 2014-06-02 Novo Nordisk A/S Método para preparar polipéptidos de insulina madura
WO2009043012A1 (en) 2007-09-27 2009-04-02 Mascoma Corporation Progressive fermentation of lignocellulosis biomass
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
EP2499257A1 (en) 2009-11-10 2012-09-19 Massachusetts Institute of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
US8981081B2 (en) 2010-03-12 2015-03-17 Purecircle Usa Inc. High-purity steviol glycosides
MY180803A (en) 2010-06-02 2020-12-09 Evolva Inc Recombinant production of steviol glycosides
WO2012075030A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
PL2655612T3 (pl) 2010-12-23 2017-12-29 Shell Internationale Research Maatschappij B.V. Czynniki uszkadzające geny produkujące pochodne tłuszczowego acylo-coa
WO2013022989A2 (en) * 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
CN104684414A (zh) 2011-12-19 2015-06-03 可口可乐公司 纯化甜叶菊醇糖苷的方法和其用途
DK2806754T3 (en) * 2012-01-23 2019-02-18 Dsm Ip Assets Bv Diterpene PREPARATION
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
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WO2014191580A1 (en) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Extracellular diterpene production
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WO2015014969A1 (en) 2013-07-31 2015-02-05 Dsm Ip Assets B.V. Steviol glycosides
DK3027632T3 (da) 2013-07-31 2019-06-17 Dsm Ip Assets Bv Indvinding af steviolglycosider fra et fermenteringsmedium
EP2902481A1 (en) 2014-01-31 2015-08-05 Danstar Ferment AG Method for obtaining low ethanol-producing yeast strains, yeast strains obtained therefrom and their use
US20160068870A1 (en) 2015-03-03 2016-03-10 Edward Brian HAMRICK Methods for fermenting carbohydrate-rich crops
BR112017025614A2 (pt) 2015-05-29 2018-09-11 Cargill, Incorporated método para produzir glicosídeo de esteviol e composição
AU2016271125A1 (en) * 2015-05-29 2017-12-21 Cargill, Incorporated Heat treatment to produce glycosides
CN107614677A (zh) 2015-05-29 2018-01-19 嘉吉公司 用于使用多阶段进料生产甜菊醇糖苷的发酵方法
US10844414B2 (en) 2015-08-06 2020-11-24 Cargill, Incorporated Methods for producing steviol glycosides in engineered yeast

Also Published As

Publication number Publication date
CA2987587C (en) 2022-05-03
CN107613786A (zh) 2018-01-19
US10612065B2 (en) 2020-04-07
BR112017025705B1 (pt) 2022-05-10
US20200283814A1 (en) 2020-09-10
AU2016271125A1 (en) 2017-12-21
EP3302097B1 (en) 2022-03-23
US20220081699A1 (en) 2022-03-17
WO2016196345A1 (en) 2016-12-08
US11761022B2 (en) 2023-09-19
EP3302097A4 (en) 2018-12-05
AU2019264515A1 (en) 2019-12-05
EP3302097A1 (en) 2018-04-11
EP4063513A1 (en) 2022-09-28
JP2018516081A (ja) 2018-06-21
CA2987587A1 (en) 2016-12-08
AU2019264515B2 (en) 2021-03-04
US20180163244A1 (en) 2018-06-14
US11028423B2 (en) 2021-06-08

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Legal Events

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/05/2016, OBSERVADAS AS CONDICOES LEGAIS