BR112017025519A2 - ?cristal do composto (6s,9as)-n-benzil-6-[(4- hidroxifenil)metil]-4,7-dioxo-8-({6-[3-(piperazina-1-il) azetidin-1-il]piridin-2-il}metil)-2-(prop-2-en-1-il)- octaidro-1h-pirazino[2,1-c] [1,2,4]triazina-1- carboxamida? - Google Patents

?cristal do composto (6s,9as)-n-benzil-6-[(4- hidroxifenil)metil]-4,7-dioxo-8-({6-[3-(piperazina-1-il) azetidin-1-il]piridin-2-il}metil)-2-(prop-2-en-1-il)- octaidro-1h-pirazino[2,1-c] [1,2,4]triazina-1- carboxamida?

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Publication number
BR112017025519A2
BR112017025519A2 BR112017025519-7A BR112017025519A BR112017025519A2 BR 112017025519 A2 BR112017025519 A2 BR 112017025519A2 BR 112017025519 A BR112017025519 A BR 112017025519A BR 112017025519 A2 BR112017025519 A2 BR 112017025519A2
Authority
BR
Brazil
Prior art keywords
methil
azetidin
dioxo
carboxamide
prop
Prior art date
Application number
BR112017025519-7A
Other languages
English (en)
Japanese (ja)
Other versions
BR112017025519B1 (pt
Inventor
Kushida Ikuo
Ito Yoko
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of BR112017025519A2 publication Critical patent/BR112017025519A2/pt
Publication of BR112017025519B1 publication Critical patent/BR112017025519B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção proporciona um cristal de (6s,9as)-n-benzil-8-({6-[3-(4-etilpiperazin-1-il)azetidin-1-il]piridin-2-il} metil)-6-(2-fluoro-4-hidroxibenzil)-4,7-dioxo-2-(prop-2-en-1-il) hexaidro-2h-pirazino [2,1-c][1,2,4] triazina-1(6h)-carboxamida.
BR112017025519-7A 2015-06-23 2016-06-21 Cristal do composto (6s,9as)-n-benzil-6-[(4-hidroxifenil)metil]-4,7-dioxo-8-({6-[3-(piperazina-1-il) azetidin-1-il]piridin-2-il}metil)-2-(prop-2-en-1-il)-octaidro-1hpirazino[2,1-c] [1,2,4]triazina-1-carboxamida BR112017025519B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562183577P 2015-06-23 2015-06-23
US62/183.577 2015-06-23
US62/183,577 2015-06-23
PCT/JP2016/068381 WO2016208576A1 (ja) 2015-06-23 2016-06-21 （６Ｓ，９ａＳ）－Ｎ－ベンジル－６－［（４－ヒドロキシフェニル）メチル］－４，７－ジオキソ－８－（｛６－［３－（ピペラジン－１－イル）アゼチジン－１－イル］ピリジン－２－イル｝メチル）－２－（プロプ－２－エン－１－イル）－オクタヒドロ－１Ｈ－ピラジノ［２，１－ｃ］［１，２，４］トリアジン－１－カルボキサミド化合物の結晶

Publications (2)

Publication Number Publication Date
BR112017025519A2 true BR112017025519A2 (pt) 2018-08-07
BR112017025519B1 BR112017025519B1 (pt) 2023-08-01

Family

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Also Published As

Publication number Publication date
CA2986999A1 (en) 2016-12-29
RU2723551C2 (ru) 2020-06-16
RU2017141763A3 (pt) 2019-08-23
IL255901B (en) 2020-07-30
AU2016284383A1 (en) 2017-12-14
CA2986999C (en) 2023-08-08
CN107614504B (zh) 2019-12-24
WO2016208576A1 (ja) 2016-12-29
KR102559211B1 (ko) 2023-07-25
MX2017015257A (es) 2018-02-19
SG11201709593VA (en) 2017-12-28
CN107614504A (zh) 2018-01-19
ES2870013T3 (es) 2021-10-26
JP6126319B1 (ja) 2017-05-10
EP3315499A1 (en) 2018-05-02
JPWO2016208576A1 (ja) 2017-06-29
IL255901A (en) 2018-01-31
RU2017141763A (ru) 2019-07-23
EP3315499A4 (en) 2018-12-19
EP3315499B1 (en) 2021-04-07
US10259817B2 (en) 2019-04-16
KR20180019083A (ko) 2018-02-23
US20180141950A1 (en) 2018-05-24
AU2016284383B2 (en) 2020-08-20

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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