BR112017021120A2 - forma de dosagem de combinação de um antagonista de receptor mu opioide e um agente opioide - Google Patents
forma de dosagem de combinação de um antagonista de receptor mu opioide e um agente opioideInfo
- Publication number
- BR112017021120A2 BR112017021120A2 BR112017021120-3A BR112017021120A BR112017021120A2 BR 112017021120 A2 BR112017021120 A2 BR 112017021120A2 BR 112017021120 A BR112017021120 A BR 112017021120A BR 112017021120 A2 BR112017021120 A2 BR 112017021120A2
- Authority
- BR
- Brazil
- Prior art keywords
- opioid
- dosage form
- combination dosage
- receptor antagonist
- release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
a invenção proporciona uma composição sólida do axelopran antagonista de opioides mu periféricos e uma forma de dosagem de combinação do sulfato de axelopran antagonista de opioides mu em uma forma de liberação imediata e um agente analgésico de opioide que pode estar em uma liberação prolongada, liberação contínua, liberação modificada ou forma de liberação controlada e métodos de preparação dessa forma de dosagem de combinação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562141981P | 2015-04-02 | 2015-04-02 | |
US62/141,981 | 2015-04-02 | ||
PCT/US2016/025176 WO2016161069A1 (en) | 2015-04-02 | 2016-03-31 | Combination dosage form of a mu opioid receptor antagonist and an opioid agent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017021120A2 true BR112017021120A2 (pt) | 2018-07-03 |
Family
ID=55806767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017021120-3A BR112017021120A2 (pt) | 2015-04-02 | 2016-03-31 | forma de dosagem de combinação de um antagonista de receptor mu opioide e um agente opioide |
Country Status (26)
Country | Link |
---|---|
US (4) | US20160287573A1 (pt) |
EP (1) | EP3277278B1 (pt) |
JP (2) | JP6713483B2 (pt) |
KR (1) | KR20170132325A (pt) |
CN (1) | CN107820424B (pt) |
AU (1) | AU2016243691A1 (pt) |
BR (1) | BR112017021120A2 (pt) |
CA (1) | CA2980328A1 (pt) |
CY (1) | CY1122828T1 (pt) |
DK (1) | DK3277278T3 (pt) |
ES (1) | ES2774473T3 (pt) |
HK (1) | HK1247105A1 (pt) |
HR (1) | HRP20200432T1 (pt) |
HU (1) | HUE048785T2 (pt) |
IL (1) | IL254593A0 (pt) |
LT (1) | LT3277278T (pt) |
ME (1) | ME03671B (pt) |
MX (1) | MX2017012474A (pt) |
PH (1) | PH12017501767A1 (pt) |
PL (1) | PL3277278T3 (pt) |
PT (1) | PT3277278T (pt) |
RS (1) | RS60074B1 (pt) |
RU (1) | RU2017134794A (pt) |
SI (1) | SI3277278T1 (pt) |
TW (1) | TW201642856A (pt) |
WO (1) | WO2016161069A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2017012474A (es) | 2015-04-02 | 2018-01-11 | Theravance Biopharma R&D Ip Llc | Forma farmaceutica combinada de un antagonista de los receptores opioides mu y un agente opioide. |
JP7222244B2 (ja) * | 2017-08-08 | 2023-02-15 | 三菱ケミカル株式会社 | 医薬錠剤、およびその製造方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1685839E (pt) | 1997-12-22 | 2013-07-08 | Euro Celtique Sa | Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide |
US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
AR029538A1 (es) * | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
RU2004106619A (ru) | 2001-08-06 | 2005-07-10 | Эро-Селтик С.А. (Lu) | Композиции опиоидного агониста, содержащие высвобождаемый и изолированный антагонист |
US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
CA2510465A1 (en) * | 2002-12-18 | 2004-07-08 | Pain Therapeutics | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
CA2540308C (en) | 2003-09-26 | 2013-08-06 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
TWI415635B (zh) | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
BRPI0608392A2 (pt) * | 2005-03-02 | 2009-12-29 | Theravance Inc | compostos de quinolinona como agonistas do receptor 5-ht4 |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
ES2366058T3 (es) * | 2006-03-01 | 2011-10-14 | Theravance, Inc. | Compuestos de 8-azabiciclo[3.2.1]octano como antagonistas de los receptores opioides mu. |
CN101500542A (zh) * | 2006-07-11 | 2009-08-05 | 共有药物有限公司 | 控释制剂 |
TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | 8-氮雜雙環〔3.2.1〕辛烷化合物之結晶型 |
TWI415850B (zh) | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備mu類鴉片受體拮抗劑之中間物的方法 |
EP2294012B1 (en) * | 2008-05-07 | 2014-07-09 | Salix Pharmaceuticals, Ltd. | Administration of a bowel cleanser and an antibiotic for the treatment of bowel disease |
EP2210595A1 (en) | 2009-01-14 | 2010-07-28 | LEK Pharmaceuticals d.d. | Active coating of pharmaceutical dosage forms |
EP2429505B1 (en) * | 2009-05-12 | 2015-11-04 | BPSI Holdings, LLC. | Enhanced moisture barrier immediate release film coating systems and substrates coated therewith |
IT1398930B1 (it) * | 2010-03-24 | 2013-03-28 | Molteni & C | Formulazioni farmaceutiche bistrato contenenti agonisti ed antagonisti oppioidi. |
US20130224296A1 (en) | 2010-09-03 | 2013-08-29 | Bristol-Myers Squibb Company | Drug Formulations Using Water Soluble Antioxidants |
EP2670397B1 (en) | 2011-02-01 | 2020-05-13 | Bristol-Myers Squibb Company | Pharmaceutical formulations including an amine compound |
US9339489B2 (en) * | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
MX2017012474A (es) | 2015-04-02 | 2018-01-11 | Theravance Biopharma R&D Ip Llc | Forma farmaceutica combinada de un antagonista de los receptores opioides mu y un agente opioide. |
-
2016
- 2016-03-31 MX MX2017012474A patent/MX2017012474A/es unknown
- 2016-03-31 US US15/086,816 patent/US20160287573A1/en not_active Abandoned
- 2016-03-31 RU RU2017134794A patent/RU2017134794A/ru not_active Application Discontinuation
- 2016-03-31 KR KR1020177031800A patent/KR20170132325A/ko unknown
- 2016-03-31 HU HUE16718062A patent/HUE048785T2/hu unknown
- 2016-03-31 ES ES16718062T patent/ES2774473T3/es active Active
- 2016-03-31 JP JP2017550832A patent/JP6713483B2/ja active Active
- 2016-03-31 ME MEP-2020-48A patent/ME03671B/me unknown
- 2016-03-31 PT PT167180629T patent/PT3277278T/pt unknown
- 2016-03-31 SI SI201630671T patent/SI3277278T1/sl unknown
- 2016-03-31 TW TW105110406A patent/TW201642856A/zh unknown
- 2016-03-31 DK DK16718062.9T patent/DK3277278T3/da active
- 2016-03-31 WO PCT/US2016/025176 patent/WO2016161069A1/en active Application Filing
- 2016-03-31 RS RS20200315A patent/RS60074B1/sr unknown
- 2016-03-31 BR BR112017021120-3A patent/BR112017021120A2/pt not_active Application Discontinuation
- 2016-03-31 CA CA2980328A patent/CA2980328A1/en not_active Abandoned
- 2016-03-31 AU AU2016243691A patent/AU2016243691A1/en not_active Abandoned
- 2016-03-31 EP EP16718062.9A patent/EP3277278B1/en active Active
- 2016-03-31 CN CN201680019821.7A patent/CN107820424B/zh active Active
- 2016-03-31 LT LTEP16718062.9T patent/LT3277278T/lt unknown
- 2016-03-31 PL PL16718062T patent/PL3277278T3/pl unknown
-
2017
- 2017-09-19 IL IL254593A patent/IL254593A0/en unknown
- 2017-09-26 PH PH12017501767A patent/PH12017501767A1/en unknown
- 2017-10-31 US US15/798,647 patent/US10369142B2/en active Active
-
2018
- 2018-05-24 HK HK18106740.0A patent/HK1247105A1/zh unknown
-
2019
- 2019-06-27 US US16/454,353 patent/US10946009B2/en active Active
-
2020
- 2020-02-04 JP JP2020016858A patent/JP2020073583A/ja not_active Withdrawn
- 2020-03-17 HR HRP20200432TT patent/HRP20200432T1/hr unknown
- 2020-03-17 CY CY20201100246T patent/CY1122828T1/el unknown
-
2021
- 2021-02-08 US US17/248,787 patent/US11452723B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SV2017005426A (es) | Derivados de feniltriazol sustituido con hidroxialquilo y sus usos | |
BR112017005693A2 (pt) | método para tratar e/ou prevenir uma doença hepática, e, composição farmacêutica. | |
HK1248218A1 (zh) | 作為毒蕈碱m1受體和/或m4受體的激動劑的螺環化合物 | |
BR112017018715A2 (pt) | agonista de receptor de angiotensina ii para tratar fibrose pulmonar | |
CL2016002169A1 (es) | Inhibidores de diacilglicerol aciltransferasa 2 para uso en el tratamiento de trastornos metabólicos y relacionados. | |
BR112015006019A2 (pt) | composto selecionado, composição farmacêutica, método para tratar uma doença ou distúrbio, uso de um composto, kit para tratar uma condição mediada por pim quinase e invenção. | |
IL247854B (en) | Muscarinic receptor antagonists, preparations containing them and their uses | |
BR112015009948A2 (pt) | antagonistas de ativina-actriia e usos para tratamento ósseos e outros disturbios | |
EP3515420C0 (en) | PHARMACEUTICAL COMPOSITIONS FOR USE IN BLEPHARITIS THERAPY | |
BR112016018062A8 (pt) | compostos terapêuticos, composição farmacêutica e usos | |
MA40998A (fr) | Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés | |
WO2016066634A3 (en) | Use of ccr5 antagonists alone or in combination therapy for the treatment of cancer | |
IL261982B (en) | A prophylactic and therapeutic preparation based on peroxaphthalate, especially a pharmaceutical preparation | |
CL2016002151A1 (es) | Derivados de piridazina para uso en la prevención o el tratamiento de un trastorno atáxico | |
PH12019500326A1 (en) | Combination of fxr agonists | |
BR112015022513A2 (pt) | produto e método para tratamento de diarreia | |
IT201700025666A1 (it) | Composizione per l’uso nel trattamento dell’ipercolesterolemia e nella prevenzione di patologie cardiovascolari. | |
EP3332764A4 (en) | BIOFILM TRAINING PREVENTION AGENT AND COMPOSITION FOR ORAL USE | |
BR112017021120A2 (pt) | forma de dosagem de combinação de um antagonista de receptor mu opioide e um agente opioide | |
BR112017011685A2 (pt) | composições compreendendo 15-hepe e métodos de tratamento ou prevenção da fibrose usando as mesmas | |
MX2016016667A (es) | Métodos para tratar el cáncer y prevenir la resistencia a fármacos contra el cáncer. | |
BR112016005589B8 (pt) | Composição farmacêutica líquida, e, uso da mesma | |
CL2008000092A1 (es) | Compuestos derivados de 3-cianopiridina, inhibidores del receptor p2y12; composicion farmaceutica que comprende a dichos compustos; y su uso en el tratamiento del transtorno de la agregacion plaquetaria. | |
IL265560A (en) | Preparations containing a mineralocorticoid receptor antagonist and their uses | |
CR20170125A (es) | Composición farmacéutica sólica que comprende amlodipina y losartán |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |