BR112017005474A2 - normalização da resposta de um instrumento de fluorescência com o uso de resposta espectral - Google Patents
normalização da resposta de um instrumento de fluorescência com o uso de resposta espectralInfo
- Publication number
- BR112017005474A2 BR112017005474A2 BR112017005474A BR112017005474A BR112017005474A2 BR 112017005474 A2 BR112017005474 A2 BR 112017005474A2 BR 112017005474 A BR112017005474 A BR 112017005474A BR 112017005474 A BR112017005474 A BR 112017005474A BR 112017005474 A2 BR112017005474 A2 BR 112017005474A2
- Authority
- BR
- Brazil
- Prior art keywords
- clinical diagnostic
- response
- analyzer
- diagnostic analyzer
- master
- Prior art date
Links
- 230000003595 spectral effect Effects 0.000 title abstract 2
- 238000010606 normalization Methods 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
- G01N2201/12746—Calibration values determination
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Quality & Reliability (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
"normalização da resposta de um instrumento de fluorescência com o uso de resposta espectral", a presente invenção refere-se a um método para normalizar ao menos um dentre uma população de analisador de diagnóstico clínico para um analisador de diagnóstico clínico mestre, de modo que um resultado de ensaio de um analisador de diagnóstico clínico subordinado possa ser convertido para o resultado equivalente do analisador de diagnóstico clínico mestre, utilizando-se um fator multiplicativo simples quando o ensaio executado em cada analisador usar um corante comum identificado de forma fluorescente. refere-se, ainda, a um método para renormalizar um resultado de ensaio de diagnóstico clínico subordinado para um resultado de ensaio de diagnóstico clínico mestre, com o uso de um fator multiplicativo simples quando o ensaio executado no analisador de diagnóstico clínico subordinado usar um corante identificado de forma fluorescente diferente do que o ensaio executado no analisador de diagnóstico clínico mestre.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052132P | 2014-09-18 | 2014-09-18 | |
| PCT/US2015/050576 WO2016044523A1 (en) | 2014-09-18 | 2015-09-17 | Normalizing the response of a fluorescence instrument using spectral response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017005474A2 true BR112017005474A2 (pt) | 2017-12-05 |
Family
ID=55533825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017005474A BR112017005474A2 (pt) | 2014-09-18 | 2015-09-17 | normalização da resposta de um instrumento de fluorescência com o uso de resposta espectral |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20170276600A1 (pt) |
| EP (1) | EP3194914B1 (pt) |
| JP (1) | JP6250870B2 (pt) |
| CN (1) | CN107076609B (pt) |
| BR (1) | BR112017005474A2 (pt) |
| CA (1) | CA2961211C (pt) |
| ES (1) | ES2929726T3 (pt) |
| RU (1) | RU2017112093A (pt) |
| WO (1) | WO2016044523A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107076609B (zh) | 2014-09-18 | 2018-07-13 | 奥索临床诊断有限公司 | 使用光谱响应来归一化荧光仪器的响应 |
| CN109030321B (zh) * | 2018-05-23 | 2020-09-15 | 中国科学院苏州生物医学工程技术研究所 | 用于流式细胞仪的数据处理方法 |
| CN108841939B (zh) * | 2018-06-21 | 2020-09-22 | 北京致雨生物科技有限公司 | 多重数字pcr浓度测量方法及微滴式数字pcr系统 |
| CN114279566B (zh) * | 2021-12-30 | 2023-01-24 | 中国科学院长春光学精密机械与物理研究所 | 光谱仪辐亮度响应非线性度的校正方法、装置及校正系统 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472671B1 (en) * | 2000-02-09 | 2002-10-29 | Jean I. Montagu | Quantified fluorescence microscopy |
| JP2002036373A (ja) * | 2000-07-25 | 2002-02-05 | Sanyo Electric Co Ltd | 光造形装置 |
| JP2003032408A (ja) * | 2001-07-13 | 2003-01-31 | Konica Corp | ホワイトボード装置、画像データ処理システム及び画像データ蓄積媒体 |
| US8084260B2 (en) * | 2004-11-24 | 2011-12-27 | Applied Biosystems, Llc | Spectral calibration method and system for multiple instruments |
| DE102005049364B4 (de) * | 2005-03-18 | 2023-05-25 | BAM Bundesanstalt für Materialforschung und -prüfung | Multifunktionelle Kalibriereinrichtung und Kit sowie ihre Verwendungen zur Charakterisierung von Lumineszenzmesssystemen |
| US7649611B2 (en) * | 2005-12-30 | 2010-01-19 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
| EP1998155A1 (de) * | 2007-05-30 | 2008-12-03 | Roche Diagnostics GmbH | Verfahren zur Wellenlängenkalibration eines Spektrometers |
| US8760645B2 (en) * | 2011-05-24 | 2014-06-24 | Idexx Laboratories Inc. | Method of normalizing a fluorescence analyzer |
| CN107076609B (zh) | 2014-09-18 | 2018-07-13 | 奥索临床诊断有限公司 | 使用光谱响应来归一化荧光仪器的响应 |
-
2015
- 2015-09-17 CN CN201580050217.6A patent/CN107076609B/zh active Active
- 2015-09-17 JP JP2017515072A patent/JP6250870B2/ja active Active
- 2015-09-17 RU RU2017112093A patent/RU2017112093A/ru unknown
- 2015-09-17 CA CA2961211A patent/CA2961211C/en active Active
- 2015-09-17 ES ES15841304T patent/ES2929726T3/es active Active
- 2015-09-17 WO PCT/US2015/050576 patent/WO2016044523A1/en active Application Filing
- 2015-09-17 US US15/512,343 patent/US20170276600A1/en not_active Abandoned
- 2015-09-17 BR BR112017005474A patent/BR112017005474A2/pt not_active Application Discontinuation
- 2015-09-17 EP EP15841304.7A patent/EP3194914B1/en active Active
-
2018
- 2018-02-06 US US15/889,765 patent/US11035783B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2961211A1 (en) | 2016-03-24 |
| US20170276600A1 (en) | 2017-09-28 |
| US20180231458A1 (en) | 2018-08-16 |
| ES2929726T3 (es) | 2022-12-01 |
| EP3194914B1 (en) | 2022-08-10 |
| RU2017112093A3 (pt) | 2018-10-18 |
| EP3194914A4 (en) | 2017-08-16 |
| CA2961211C (en) | 2017-12-19 |
| JP2017528720A (ja) | 2017-09-28 |
| US11035783B2 (en) | 2021-06-15 |
| RU2017112093A (ru) | 2018-10-18 |
| EP3194914A1 (en) | 2017-07-26 |
| JP6250870B2 (ja) | 2017-12-20 |
| CN107076609A (zh) | 2017-08-18 |
| WO2016044523A1 (en) | 2016-03-24 |
| CN107076609B (zh) | 2018-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |