BR112017004652A2 - composição cosmética ou farmacêutica, e, uso de um derivado de benzotriazol. - Google Patents
composição cosmética ou farmacêutica, e, uso de um derivado de benzotriazol.Info
- Publication number
- BR112017004652A2 BR112017004652A2 BR112017004652A BR112017004652A BR112017004652A2 BR 112017004652 A2 BR112017004652 A2 BR 112017004652A2 BR 112017004652 A BR112017004652 A BR 112017004652A BR 112017004652 A BR112017004652 A BR 112017004652A BR 112017004652 A2 BR112017004652 A2 BR 112017004652A2
- Authority
- BR
- Brazil
- Prior art keywords
- bis
- alkyl
- triazine
- micronized
- alkoxy
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 title 1
- 239000004904 UV filter Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 2-methylphenyl ester Chemical class 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- CENPSTJGQOQKKW-UHFFFAOYSA-N 2,4,6-tris(4-phenylphenyl)-1,3,5-triazine Chemical compound C1=CC=CC=C1C1=CC=C(C=2N=C(N=C(N=2)C=2C=CC(=CC=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC=CC=2)C=C1 CENPSTJGQOQKKW-UHFFFAOYSA-N 0.000 abstract 1
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 abstract 1
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 abstract 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 abstract 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 abstract 1
- ISDGWTZFJKFKMO-UHFFFAOYSA-N 2-phenyl-1,3-dioxane-4,6-dione Chemical compound O1C(=O)CC(=O)OC1C1=CC=CC=C1 ISDGWTZFJKFKMO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 125000003860 C1-C20 alkoxy group Chemical group 0.000 abstract 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 abstract 1
- IVQLSQJMQLZYJE-UHFFFAOYSA-N [2-[4-[2-[4-(diethylamino)-2-hydroxybenzoyl]benzoyl]piperazine-1-carbonyl]phenyl]-[4-(diethylamino)-2-hydroxyphenyl]methanone Chemical compound OC1=CC(N(CC)CC)=CC=C1C(=O)C1=CC=CC=C1C(=O)N1CCN(C(=O)C=2C(=CC=CC=2)C(=O)C=2C(=CC(=CC=2)N(CC)CC)O)CC1 IVQLSQJMQLZYJE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229960005193 avobenzone Drugs 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 abstract 1
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 abstract 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 abstract 1
- 229960000655 ensulizole Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940068171 ethyl hexyl salicylate Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960004881 homosalate Drugs 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical class [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 abstract 1
- 229960001679 octinoxate Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000004408 titanium dioxide Substances 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
é descrita uma composição cosmética ou farmacêutica que compreende uma combinação de filtro uv de (a) pelo menos um derivado de benzo¬triazol que corresponde à fórmula (i), em que r1 é hidrogênio; alquila c1-c5; alcóxi c1-c5; ou halogênio; r2 é hidrogênio; alquila c1-c20; alcóxi c1-c5; alcóxi carbonila c1-c5; cicloalquila c5-c10; arila c5-c10; ou aralquila c5-c10; r3 é alquila c1-c20; cicloalquila c5-c10; alcóxi c1-c20 ou cicloalcóxi c5-c10 e r4 é hidrogênio; ou alquila c1-c5; (b) pelo menos um filtro uv selecionado de (b1) filtros uv de malonato de benzilideno; (b2) 5,6,5?,6?-tetrafenil-3,3?-(1,4-fenileno)bis(1,2,4-triazina) micronizado que corresponde à fórmula (b3) ácido benzoico, 4,4'-[[6-[[3-[1,3,3,3-tetrametil-1-[(trimetilsilil)óxi]-1 disiloxanil]propil]amino]-1,3,5-triazino-2,4-diil]diimino]bis-, éster dibutílico e (b4) ácido 2-propenoico, 3-(4-metoxifenil)-, éster 2-metilfenílico e opcionalmente (c) pelo menos um filtro uv selecionado de (c1) bis-etil-hexiloxifenol metoxifenil triazina; (c2) butil metoxidibenzoilmetano; (c3) dietil-hexil butamido triazona; (c4) etil-hexil triazona; (c5) benzoato de dietilamino hidróxi benzoil hexila; (c6) metoxicinamato de etil-hexila; (c7) salicilato de etil-hexila; (c8) homossalato; (c9) octocrileno; (c10) metileno bis-benzotriazolil tetrametilbutilfenol micronizado; (c11) ácido fenilbenzimidazol sulfônico; (c12) dióxido de titânio; (c13) tris-bifenil triazina; (c14) (2-{4-[2-(4-dietilamino-2-hidróxi-benzoil)-benzoil]-piperazino-1-carbonil}-fenil)-(4-dietilamino-2-hidróxi-fenil)-metanona micronizado (c15) derivados de merocianina; (c16) bis(butilbenzoato) diaminotriazina aminopropilsiloxano e (c17) bis-etil-hexiloxifenol metoxifenil triazina, encapsulado em uma matriz polimérica.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14184028.0 | 2014-09-09 | ||
| EP14184028 | 2014-09-09 | ||
| PCT/EP2015/070257 WO2016037942A1 (en) | 2014-09-09 | 2015-09-04 | Mixtures of cosmetic uv absorbers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017004652A2 true BR112017004652A2 (pt) | 2018-01-30 |
| BR112017004652B1 BR112017004652B1 (pt) | 2020-12-08 |
Family
ID=51492860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017004652-0A BR112017004652B1 (pt) | 2014-09-09 | 2015-09-04 | uso de um derivado de benzotriazol |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170290756A1 (pt) |
| EP (1) | EP3191075B1 (pt) |
| JP (1) | JP6821555B2 (pt) |
| BR (1) | BR112017004652B1 (pt) |
| WO (1) | WO2016037942A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3095757B1 (fr) * | 2019-05-10 | 2021-05-21 | Fabre Pierre Dermo Cosmetique | Système photoprotecteur constitué de 4 filtres solaires |
| CN114504521A (zh) * | 2022-03-16 | 2022-05-17 | 上海家化联合股份有限公司 | 水分散型防晒剂的乳化组合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457911A (en) * | 1981-01-28 | 1984-07-03 | Van Dyk & Company Inc. | Dialkyl malonates as organic sunscreen adjuvants |
| EP1308084A1 (en) * | 2002-10-02 | 2003-05-07 | Ciba SC Holding AG | Synergistic UV absorber combination |
| WO2006114381A1 (en) * | 2005-04-28 | 2006-11-02 | Ciba Specialty Chemicals Holding Inc. | Use of benzotriazole derivatives for photostabilisation |
| EP2078521A1 (de) * | 2008-01-08 | 2009-07-15 | Stada Arzneimittel Ag | Kosmetische Zusammensetzung, enthaltend ein Benzotriazolderivat und einen AHR-Antagonisten |
| WO2011003774A2 (en) * | 2009-07-07 | 2011-01-13 | Basf Se | Uv filter combinations comprising benzylidene malonates |
| US8895754B2 (en) * | 2010-01-15 | 2014-11-25 | Dsm Ip Assets B.V. | Process to make UV radiation absorbing 2-phenyl-1,2,3,-benzotriazoles |
| US11419804B2 (en) * | 2014-07-25 | 2022-08-23 | Basf Se | Sunscreen formulations optimized for the formation of vitamin D |
-
2015
- 2015-09-04 BR BR112017004652-0A patent/BR112017004652B1/pt active IP Right Grant
- 2015-09-04 JP JP2017513234A patent/JP6821555B2/ja active Active
- 2015-09-04 US US15/509,668 patent/US20170290756A1/en not_active Abandoned
- 2015-09-04 EP EP15759455.7A patent/EP3191075B1/en active Active
- 2015-09-04 WO PCT/EP2015/070257 patent/WO2016037942A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP3191075B1 (en) | 2023-02-15 |
| US20170290756A1 (en) | 2017-10-12 |
| WO2016037942A1 (en) | 2016-03-17 |
| JP2017526707A (ja) | 2017-09-14 |
| JP6821555B2 (ja) | 2021-01-27 |
| EP3191075A1 (en) | 2017-07-19 |
| BR112017004652B1 (pt) | 2020-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/09/2015, OBSERVADAS AS CONDICOES LEGAIS. |