BR112016021835A8 - análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, composição farmacêutica, e método para proporcionar um análogo da apelina - Google Patents

análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, composição farmacêutica, e método para proporcionar um análogo da apelina Download PDF

Info

Publication number
BR112016021835A8
BR112016021835A8 BR112016021835A BR112016021835A BR112016021835A8 BR 112016021835 A8 BR112016021835 A8 BR 112016021835A8 BR 112016021835 A BR112016021835 A BR 112016021835A BR 112016021835 A BR112016021835 A BR 112016021835A BR 112016021835 A8 BR112016021835 A8 BR 112016021835A8
Authority
BR
Brazil
Prior art keywords
apelin
analogue
providing
general formula
pharmaceutical composition
Prior art date
Application number
BR112016021835A
Other languages
English (en)
Inventor
Rink Rick
Original Assignee
Lanthiopep Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanthiopep Bv filed Critical Lanthiopep Bv
Publication of BR112016021835A8 publication Critical patent/BR112016021835A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

a invenção se refere ao campo da farmacologia. em particular, se refere a novos análogos de apelina, e às suas utilizações terapêuticas. é fornecido um análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, compreendendo uma ponte de lantionina com a estrutura ala-s-ala ou uma ponte metillantionina com a estrutura abu-s-ala ou ala-s-abu e em que a referida ponte (metil)lantionina é do tamanho i, i+3; i, i+4, i, i+5 ou i, i+6.
BR112016021835A 2014-03-25 2015-03-25 análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, composição farmacêutica, e método para proporcionar um análogo da apelina BR112016021835A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14161533 2014-03-25
PCT/NL2015/050191 WO2015147641A1 (en) 2014-03-25 2015-03-25 Cyclic apelin analogs

Publications (1)

Publication Number Publication Date
BR112016021835A8 true BR112016021835A8 (pt) 2018-08-28

Family

ID=50389830

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016021835A BR112016021835A8 (pt) 2014-03-25 2015-03-25 análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, composição farmacêutica, e método para proporcionar um análogo da apelina

Country Status (20)

Country Link
US (1) US20170107257A1 (pt)
EP (1) EP3122764B1 (pt)
JP (1) JP6740133B2 (pt)
KR (1) KR20160135742A (pt)
CN (1) CN106170492B (pt)
AU (1) AU2015237357B2 (pt)
BR (1) BR112016021835A8 (pt)
CA (1) CA2941080A1 (pt)
DK (1) DK3122764T3 (pt)
ES (1) ES2719137T3 (pt)
HR (1) HRP20190544T1 (pt)
HU (1) HUE042615T2 (pt)
IL (1) IL246487A0 (pt)
MX (1) MX2016012314A (pt)
PL (1) PL3122764T3 (pt)
PT (1) PT3122764T (pt)
RU (1) RU2697515C2 (pt)
SG (2) SG10201808383UA (pt)
WO (1) WO2015147641A1 (pt)
ZA (1) ZA201607177B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106366168B (zh) * 2016-08-26 2020-09-15 上海交通大学 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法
GB202016149D0 (en) * 2020-10-12 2020-11-25 Heptares Therapeutics Ltd Cyclic apelin receptor agonists
CN112851788B (zh) * 2021-02-03 2022-11-01 河北省科学院生物研究所 一种羊毛硫肽LichencinA3及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745583A1 (de) * 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US7101701B2 (en) * 2004-10-08 2006-09-05 The Trustees Of The University Of Pennsylvania Method to reduce contamination when culturing mycobacteria
AU2006279749B2 (en) * 2005-08-12 2012-12-20 Oragenics, Inc. Differentially protected orthogonal lanthionine technology
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
US20090233854A1 (en) * 2005-12-20 2009-09-17 Takeda Pharmaceutical Company Limited Novel application of apelin
EP2190859A1 (en) * 2007-08-03 2010-06-02 Sentinella Pharmaceuticals, Inc. ("Sentinella") Genes and proteins for the biosynthesis of the lantibiotic 107891
EP2405008A1 (en) * 2010-07-06 2012-01-11 LanthioPep B.V. Bacterial surface display of thioether-bridge-containing peptides
WO2012019928A1 (en) * 2010-08-13 2012-02-16 Guntram Christiansen Modified peptide display
LT3045183T (lt) 2011-03-11 2018-10-25 Genzyme Corporation Pegiliuotas apelinas ir jo panaudojimas
CN103483433B (zh) * 2013-09-10 2015-05-27 中国科学院微生物研究所 一种新型高效的羊毛硫细菌素cerecidin及其应用

Also Published As

Publication number Publication date
ES2719137T3 (es) 2019-07-08
US20170107257A1 (en) 2017-04-20
SG11201605195RA (en) 2016-10-28
DK3122764T3 (en) 2019-04-15
CN106170492A (zh) 2016-11-30
RU2016139223A3 (pt) 2018-10-12
CA2941080A1 (en) 2015-10-01
HRP20190544T1 (hr) 2019-05-31
MX2016012314A (es) 2016-11-30
EP3122764B1 (en) 2019-01-16
PL3122764T3 (pl) 2019-07-31
IL246487A0 (en) 2016-08-31
ZA201607177B (en) 2019-07-31
AU2015237357B2 (en) 2019-04-18
EP3122764A1 (en) 2017-02-01
RU2016139223A (ru) 2018-04-26
PT3122764T (pt) 2019-04-26
RU2697515C2 (ru) 2019-08-15
WO2015147641A1 (en) 2015-10-01
JP2017512760A (ja) 2017-05-25
HUE042615T2 (hu) 2019-07-29
AU2015237357A1 (en) 2016-07-07
KR20160135742A (ko) 2016-11-28
SG10201808383UA (en) 2018-10-30
JP6740133B2 (ja) 2020-08-12
CN106170492B (zh) 2020-08-21

Similar Documents

Publication Publication Date Title
BR112017022604A2 (pt) composto, composição farmacêutica, uso de um composto e de uma combinação, e, combinação
CO2017012995A2 (es) Derivados análogos de heteroarilos/arilo actvos como reguladores nrf2 y composiciones farmacéuticas de los mismos
CL2018000542A1 (es) Nuevos derivados de fenoximetilo.
BR112018010720A8 (pt) agonistas do receptor de apelina e métodos de uso
BR112018003026A2 (pt) composições compreendendo um inibidor de pi3k e um inibidor de hdac
DOP2015000245A (es) Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos
BR112013031268A2 (pt) "polipeptídeos análogos de pramlintida, uso dos mesmos, composição farmacêutica compreendendo os referidos polipeptídeos e método de preparação da referida composição".
BR112018071408A2 (pt) “composto inibidor de rip2 quinase, composição farmacêutica, usos de um composto e de uma combinação, e, combinação
BR112016013832A2 (pt) Uso de análogo e/ou derivado de insulina, formulação farmacêutica e processo para a preparação da mesma, kit e dispositivo médico
BR112018001755A2 (pt) composições de insulina de ação rápida
BR112016028845A2 (pt) composto, composição farmacêutica e uso de um composto
MA47816A (fr) Composition pharmaceutique comprenant du sélexipag
DOP2015000005A (es) Derivados de estra 1,3,5(10), 16 tetraeno 3 sustituidos, métodos para su preparación, preparaciones farmacéuticas que los contienen, así como su uso para la preparación de medicamentos
BR112016026660A2 (pt) ?produto extemporâneo para cuidados cosméticos e/ou dermatológicos, e, kit de preparação extemporânea de uma composição cosmética e/ou dermatológica?
BR112018014590A2 (pt) formulações/composições compreendendo um inibidor de btk
BR112017022158A2 (pt) compostos, composições farmacêuticas e uso de um composto
BR112017005821A2 (pt) formulação aquosa, método para a preparação de uma formulação aquosa, conjunto, método para a preparação de uma composição farmacêutica, composição farmacêutica e método para quimicamente estabilizar uma formulação aquosa
BR112018014540A2 (pt) formulações/composições compreendendo inibidor de btk
BR112016024235A2 (pt) composições farmacêuticas compreendendo agentes antibacterianos
UY37729A (es) NUEVOS COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE Nav1.7
SA520412289B1 (ar) مركبات مثبط الهدف الميكانيكي للراباميسين
BR112017026904A2 (pt) formulações farmacêuticas injetáveis de lefamulina
BR112016021835A8 (pt) análogo cíclico da apelina de fórmula geral x1-x2-x3-x4-x5-x6-x7-x8-x9-x10-x11-x12-x13-x14, composição farmacêutica, e método para proporcionar um análogo da apelina
BR112018076734A2 (pt) compostos heterocíclicos anti-infecciosos e usos dos mesmos
BR112017020053A2 (pt) novo composto heterocíclico, método para a preparação do mesmo e composição farmacêutica compreendendo o mesmo

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2663 DE 18-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.