BR112016012840A2 - Derivado de pirimidina e fonte de ácido graxo para uso no tratamento de prisão de ventre - Google Patents
Derivado de pirimidina e fonte de ácido graxo para uso no tratamento de prisão de ventreInfo
- Publication number
- BR112016012840A2 BR112016012840A2 BR112016012840A BR112016012840A BR112016012840A2 BR 112016012840 A2 BR112016012840 A2 BR 112016012840A2 BR 112016012840 A BR112016012840 A BR 112016012840A BR 112016012840 A BR112016012840 A BR 112016012840A BR 112016012840 A2 BR112016012840 A2 BR 112016012840A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- fatty acid
- acid source
- pyrimidine derivative
- consaidation
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 3
- 229930195729 fatty acid Natural products 0.000 title abstract 3
- 239000000194 fatty acid Substances 0.000 title abstract 3
- 150000004665 fatty acids Chemical class 0.000 title abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 2
- 206010010774 Constipation Diseases 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/175—Amino acids
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Psychology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
DERIVADO DE PIRIMIDINA E FONTE DE ÁCIDO GRAXO PARA O USO NO TRATAMENTO DE PRISÃO DE VENTRE. A invenção se relaciona a uma combinação de um derivado de pirimidina e uma fonte de ácido graxo para uso no tratamento de prisão de ventre, em particular, no tratamento de prisão de ventre em pacientes que sofrem de distúrbios GI, distúrbios neurológicos, ou distúrbios psiquiátricos. Vantajosamente, a combinação compreende uma ou mais vitaminas ou fibras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/NL2013/050879 WO2015084158A1 (en) | 2013-12-06 | 2013-12-06 | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
PCT/NL2014/050671 WO2015084160A1 (en) | 2013-12-06 | 2014-09-30 | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016012840A2 true BR112016012840A2 (pt) | 2017-08-08 |
Family
ID=49880906
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016012857-5A BR112016012857B1 (pt) | 2013-12-06 | 2014-09-30 | Usos de uma combinação de uma fonte de uridina e um ômega-3-ácido graxo poli- insaturado tendo 18-24 átomos de carbono |
BR112016012840A BR112016012840A2 (pt) | 2013-12-06 | 2014-09-30 | Derivado de pirimidina e fonte de ácido graxo para uso no tratamento de prisão de ventre |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016012857-5A BR112016012857B1 (pt) | 2013-12-06 | 2014-09-30 | Usos de uma combinação de uma fonte de uridina e um ômega-3-ácido graxo poli- insaturado tendo 18-24 átomos de carbono |
Country Status (6)
Country | Link |
---|---|
US (2) | US10517885B2 (pt) |
EP (3) | EP3077005B1 (pt) |
CN (2) | CN106170211A (pt) |
BR (2) | BR112016012857B1 (pt) |
ES (1) | ES2883650T3 (pt) |
WO (3) | WO2015084158A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2015084158A1 (en) | 2013-12-06 | 2015-06-11 | N.V. Nutricia | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
WO2017069613A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients |
WO2017069610A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving equilibrioception in healthy individuals and nutritional composition |
CN106377533A (zh) * | 2016-09-08 | 2017-02-08 | 中国海洋大学 | 一种海参磷脂及其在提高机体运动协调能力制品中的应用 |
CN111500636B (zh) * | 2017-04-01 | 2024-04-26 | 广州华真医药科技有限公司 | 治疗自身免疫性相关疾病的病毒载体及其构建方法和应用 |
AU2017417888B9 (en) * | 2017-06-09 | 2023-09-28 | N.V. Nutricia | Composition for improving efficacy of L-DOPA treatment |
EP3737384B1 (en) * | 2018-03-08 | 2023-10-25 | Purepharm Inc. | Methods and compositions for preventing and treating conditions related to alpha-synuclein |
CN108813453A (zh) * | 2018-05-23 | 2018-11-16 | 青岛大学 | 一种防治帕金森病的食用组合物 |
CN108813628A (zh) * | 2018-05-23 | 2018-11-16 | 青岛大学 | 一种防治帕金森病食用组合物的制备方法 |
US11464789B2 (en) | 2018-08-03 | 2022-10-11 | Enterin, Inc. | Aminosterol compositions and methods of using the same for treating schizophrenia |
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WO2012125020A1 (en) * | 2011-03-14 | 2012-09-20 | N.V. Nutricia | Method for treating neurotrauma |
MX2011007872A (es) * | 2011-07-26 | 2013-01-29 | Nucitec Sa De Cv | Composicion nutrimental para niños que presentan reflujo, colico y/o estreñimiento. |
WO2014032108A1 (en) * | 2012-08-29 | 2014-03-06 | Borody Thomas J | Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions |
WO2015084158A1 (en) | 2013-12-06 | 2015-06-11 | N.V. Nutricia | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
-
2013
- 2013-12-06 WO PCT/NL2013/050879 patent/WO2015084158A1/en active Application Filing
-
2014
- 2014-09-30 WO PCT/NL2014/050673 patent/WO2015084161A1/en active Application Filing
- 2014-09-30 EP EP14815077.4A patent/EP3077005B1/en active Active
- 2014-09-30 CN CN201480075062.7A patent/CN106170211A/zh active Pending
- 2014-09-30 CN CN201480075054.2A patent/CN105979939B/zh active Active
- 2014-09-30 BR BR112016012857-5A patent/BR112016012857B1/pt active IP Right Grant
- 2014-09-30 BR BR112016012840A patent/BR112016012840A2/pt not_active Application Discontinuation
- 2014-09-30 EP EP14815076.6A patent/EP3076960B1/en active Active
- 2014-09-30 ES ES14815077T patent/ES2883650T3/es active Active
- 2014-09-30 EP EP21180324.2A patent/EP3919053A1/en active Pending
- 2014-09-30 US US15/102,136 patent/US10517885B2/en active Active
- 2014-09-30 WO PCT/NL2014/050671 patent/WO2015084160A1/en active Application Filing
- 2014-09-30 US US15/102,152 patent/US20160331772A1/en not_active Abandoned
Also Published As
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WO2015084160A1 (en) | 2015-06-11 |
BR112016012857B1 (pt) | 2021-10-05 |
CN106170211A (zh) | 2016-11-30 |
EP3919053A1 (en) | 2021-12-08 |
WO2015084161A1 (en) | 2015-06-11 |
EP3077005B1 (en) | 2021-08-04 |
BR112016012857A2 (pt) | 2017-08-08 |
ES2883650T3 (es) | 2021-12-09 |
CN105979939A (zh) | 2016-09-28 |
EP3076960A1 (en) | 2016-10-12 |
WO2015084158A1 (en) | 2015-06-11 |
EP3076960B1 (en) | 2020-11-25 |
EP3077005A1 (en) | 2016-10-12 |
US20160331772A1 (en) | 2016-11-17 |
US20160303159A1 (en) | 2016-10-20 |
CN105979939B (zh) | 2021-09-10 |
US10517885B2 (en) | 2019-12-31 |
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