BR112016002598A2 - método para tratamento da diabetes mellitus, método para atualizar o regime de dosagem de insulina de um paciente, dispositivo e sistema para aliviar glicotoxicidade e/ou restabelecer a função das células beta pancreáticas em um paciente - Google Patents

método para tratamento da diabetes mellitus, método para atualizar o regime de dosagem de insulina de um paciente, dispositivo e sistema para aliviar glicotoxicidade e/ou restabelecer a função das células beta pancreáticas em um paciente

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Publication number
BR112016002598A2
BR112016002598A2 BR112016002598A BR112016002598A BR112016002598A2 BR 112016002598 A2 BR112016002598 A2 BR 112016002598A2 BR 112016002598 A BR112016002598 A BR 112016002598A BR 112016002598 A BR112016002598 A BR 112016002598A BR 112016002598 A2 BR112016002598 A2 BR 112016002598A2
Authority
BR
Brazil
Prior art keywords
patient
glycotoxicity
cell function
beta cell
pancreatic beta
Prior art date
Application number
BR112016002598A
Other languages
English (en)
Other versions
BR112016002598B1 (pt
Inventor
Bashan Eran
Hodish Israel
Original Assignee
Hygieia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hygieia Inc filed Critical Hygieia Inc
Publication of BR112016002598A2 publication Critical patent/BR112016002598A2/pt
Publication of BR112016002598B1 publication Critical patent/BR112016002598B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14288—Infusion or injection simulation
    • A61M2005/14292—Computer-based infusion planning or simulation of spatio-temporal infusate distribution

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Primary Health Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

sistemas, métodos e /ou dispositivos para tratamento da diabetes mellitus por meio do alívio da glicotoxicidade e restabelecimento da função das células beta pancreáticas, compreendendo pelo menos uma memória para armazenar entrada de dados correspondentes a pelo menos um ou mais componentes do presente regime de dosagem de insulina de um paciente, e entrada de dados correspondentes pelo menos às medições de nível de glicose do sangue do paciente determinadas em uma pluralidade de vezes e um processador operacionalmente ligado à pelo menos primeira memória. o processador é programado pelo menos para determinar a partir das entradas de dados correspondentes às medições de nível de glicose do sangue do paciente determinadas em uma pluralidade de vezes se e por quanto variar pelo menos um dos componentes do presente regime de dosagem de insulina do paciente. são também descritos sistemas, métodos e/ou dispositivos para aliviar a glicotoxicidade e restabelecer a função das células beta pancreáticas, compreendendo estabelecer o atual estado glicêmico do paciente em relação a uma faixa glicêmica desejada e determinar a partir de pelo menos um de uma pluralidade dos dados correspondentes às medições de nível de glicose do sangue do paciente se e por quanto ajustar pelo menos um dos componentes no presente regime de dosagem de insulina do paciente.
BR112016002598-9A 2013-08-05 2014-08-05 Dispositivo e sistema para aliviar glicotoxicidade e/ou restabelecer a função das células beta pancreáticas em um paciente BR112016002598B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361862327P 2013-08-05 2013-08-05
US61/862,327 2013-08-05
PCT/US2014/049771 WO2015021041A2 (en) 2013-08-05 2014-08-05 Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus

Publications (2)

Publication Number Publication Date
BR112016002598A2 true BR112016002598A2 (pt) 2017-08-01
BR112016002598B1 BR112016002598B1 (pt) 2022-06-21

Family

ID=52462031

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002598-9A BR112016002598B1 (pt) 2013-08-05 2014-08-05 Dispositivo e sistema para aliviar glicotoxicidade e/ou restabelecer a função das células beta pancreáticas em um paciente

Country Status (4)

Country Link
EP (1) EP3030140B1 (pt)
CN (2) CN113940627A (pt)
BR (1) BR112016002598B1 (pt)
WO (1) WO2015021041A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018525093A (ja) 2015-08-07 2018-09-06 トラスティーズ オブ ボストン ユニバーシティ グルコース目標の自動適合を備えたグルコース制御システム
EP3481274B1 (en) * 2016-07-08 2023-01-25 Novo Nordisk A/S Basal titration with adaptive target glucose level
US11957876B2 (en) 2019-07-16 2024-04-16 Beta Bionics, Inc. Glucose control system with automated backup therapy protocol generation
EP4000075A4 (en) 2019-07-16 2023-10-04 Beta Bionics, Inc. BLOOD GLUCOSE CONTROL SYSTEM
WO2021011738A1 (en) 2019-07-16 2021-01-21 Beta Bionics, Inc. Blood glucose control system
US20220189603A1 (en) 2020-12-07 2022-06-16 Beta Bionics, Inc. Medicament pumps and control systems for managing glucose control therapy data of a subject

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7651845B2 (en) * 2004-05-13 2010-01-26 The Regents Of The University Of California Method and apparatus for glucose control and insulin dosing for diabetics
US20070078314A1 (en) * 2005-09-30 2007-04-05 Grounsell Richard L System and method for measuring and predicting insulin dosing rates
US8454510B2 (en) * 2007-06-20 2013-06-04 Medingo Ltd. Method and device for assessing carbohydrate-to-insulin ratio
US9220456B2 (en) * 2008-04-04 2015-12-29 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
PT2260423T (pt) * 2008-04-04 2018-05-30 Hygieia Inc Aparelho para optimizar o regime de dosagem de insulina a um paciente
CN102265279B (zh) * 2008-12-23 2019-08-23 霍夫曼-拉罗奇有限公司 用于慢性病患者的诊断或者治疗支持的结构化测试方法及其设备
US9918635B2 (en) * 2008-12-23 2018-03-20 Roche Diabetes Care, Inc. Systems and methods for optimizing insulin dosage
WO2010097796A1 (en) * 2009-02-26 2010-09-02 Mor Research Applications Ltd. Method and system for automatic monitoring of diabetes related treatments
CA2957595C (en) * 2009-09-29 2020-06-02 Lifescan Scotland Limited Analyte testing method and device for diabetes management
WO2011039741A1 (en) * 2009-09-30 2011-04-07 Mor Research Applications Ltd. Monitoring device for mangement of insulin delivery
TW201333870A (zh) * 2011-12-21 2013-08-16 艾登工具股份有限公司 決定病人胰島素療法的系統及方法

Also Published As

Publication number Publication date
EP3030140A4 (en) 2017-02-08
WO2015021041A2 (en) 2015-02-12
CN105592779A (zh) 2016-05-18
EP3030140B1 (en) 2019-06-19
EP3030140A2 (en) 2016-06-15
CN113940627A (zh) 2022-01-18
WO2015021041A3 (en) 2015-04-09
BR112016002598B1 (pt) 2022-06-21

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