BR112016002196A2 - compostos de ureia e sua utilização como inibidores enzimáticos - Google Patents

compostos de ureia e sua utilização como inibidores enzimáticos

Info

Publication number
BR112016002196A2
BR112016002196A2 BR112016002196A BR112016002196A BR112016002196A2 BR 112016002196 A2 BR112016002196 A2 BR 112016002196A2 BR 112016002196 A BR112016002196 A BR 112016002196A BR 112016002196 A BR112016002196 A BR 112016002196A BR 112016002196 A2 BR112016002196 A2 BR 112016002196A2
Authority
BR
Brazil
Prior art keywords
compound
enzyme inhibitors
urea compounds
benzylpiperidin
carboxamide
Prior art date
Application number
BR112016002196A
Other languages
English (en)
Inventor
Patrícia Da Costa Pereira Rosa Carla
Erno Kiss Laszlo
Gusmão De Noronha Rita
Pinto Rui
Original Assignee
BIAL PORTELA & Cª S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201313786A external-priority patent/GB201313786D0/en
Priority claimed from GB201409466A external-priority patent/GB201409466D0/en
Application filed by BIAL PORTELA & Cª S A filed Critical BIAL PORTELA & Cª S A
Publication of BR112016002196A2 publication Critical patent/BR112016002196A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

resumo da patente de invenã§ã£o para: “compostos de ureia e sua utilizaã‡ãƒo como inibidores enzimãticos”. um composto possuindo a fã³rmula i: fã³rmula i em que: r1 ã© seleccionado de hidrogã©nio, halogã©neo, hidroxilo e alcoxilo c1-4; r2 ã© seleccionado de hidrogã©nio, halogã©neo, hidroxilo e alcoxilo c1-4; r3 ã© alquilo c1-4; r4 ã© arilo, o qual estã¡ substituã­do com um grupo seleccionado de oso2nh2, nhconh2, nhso2nh2, nhso2alquilo c1-4 e conh2; e n ã© 0 ou 1; ou um seu sal farmaceuticamente aceitã¡vel; na condiã§ã£o de que o composto nã£o seja n-(1-benzilpiperidin-4-il)-n-metil-4-(4-(sulfamoilamino)-fenil)-1h-imidazole-1-carboxamida ou n-(1-benzilpiperidin-4-il)-n-metil-4-(3-(metilsulfonamido)fenil)-1h-imidazole-1-carboxamida. o composto pode ser utilizado como um inibidor da hidrolase de amidas de ã¡cidos gordo.
BR112016002196A 2013-08-01 2014-08-01 compostos de ureia e sua utilização como inibidores enzimáticos BR112016002196A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201313786A GB201313786D0 (en) 2013-08-01 2013-08-01 Urea compounds and their use as enzyme inhibitors
GB201409466A GB201409466D0 (en) 2014-05-28 2014-05-28 Urea compounds and their use as enzyme inhibitors
PCT/PT2014/000051 WO2015016728A1 (en) 2013-08-01 2014-08-01 Urea compounds and their use as faah enzyme inhibitors

Publications (1)

Publication Number Publication Date
BR112016002196A2 true BR112016002196A2 (pt) 2017-08-01

Family

ID=51493011

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002196A BR112016002196A2 (pt) 2013-08-01 2014-08-01 compostos de ureia e sua utilização como inibidores enzimáticos

Country Status (12)

Country Link
US (1) US20160166560A1 (pt)
EP (1) EP3027610A1 (pt)
JP (1) JP2016528227A (pt)
KR (1) KR20160038048A (pt)
CN (1) CN105593226A (pt)
AU (1) AU2014296894A1 (pt)
BR (1) BR112016002196A2 (pt)
CA (1) CA2919844A1 (pt)
MX (1) MX2016001391A (pt)
RU (1) RU2016105158A (pt)
TW (1) TW201536769A (pt)
WO (1) WO2015016728A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
PH12018000227A1 (en) 2017-09-05 2019-03-11 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of chronic kidney disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009330821B2 (en) 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
US9458111B2 (en) * 2010-07-29 2016-10-04 Bial—Portela & Ca, S.A. Process for the synthesis of substituted urea compounds

Also Published As

Publication number Publication date
CA2919844A1 (en) 2015-02-05
TW201536769A (zh) 2015-10-01
RU2016105158A (ru) 2017-09-06
JP2016528227A (ja) 2016-09-15
KR20160038048A (ko) 2016-04-06
AU2014296894A1 (en) 2016-02-25
EP3027610A1 (en) 2016-06-08
WO2015016728A1 (en) 2015-02-05
CN105593226A (zh) 2016-05-18
MX2016001391A (es) 2016-08-17
US20160166560A1 (en) 2016-06-16

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)