MX2016001391A - Compuestos de urea y su uso como inhibidores de la enzima amida hidrolasa de acido graso (faah). - Google Patents

Compuestos de urea y su uso como inhibidores de la enzima amida hidrolasa de acido graso (faah).

Info

Publication number
MX2016001391A
MX2016001391A MX2016001391A MX2016001391A MX2016001391A MX 2016001391 A MX2016001391 A MX 2016001391A MX 2016001391 A MX2016001391 A MX 2016001391A MX 2016001391 A MX2016001391 A MX 2016001391A MX 2016001391 A MX2016001391 A MX 2016001391A
Authority
MX
Mexico
Prior art keywords
compound
enzyme inhibitors
urea compounds
faah enzyme
benzylpiperidin
Prior art date
Application number
MX2016001391A
Other languages
English (en)
Inventor
Erno Kiss Laszlo
Patrícia Da Costa Pereira Rosa Carla
Gusmão De Noronha Rita
Pinto Rui
Original Assignee
BIAL - PORTELA & Cª S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201313786A external-priority patent/GB201313786D0/en
Priority claimed from GB201409466A external-priority patent/GB201409466D0/en
Application filed by BIAL - PORTELA & Cª S A filed Critical BIAL - PORTELA & Cª S A
Publication of MX2016001391A publication Critical patent/MX2016001391A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto que tiene la Fórmula l: (ver Fórmula) Fórmula I donde: R1 se selecciona de hidrógeno, halógeno, hidroxilo y C1-4 alcoxi; R2 se selecciona de hidrógeno, halógeno, hidroxilo y C1-4 alcoxi; R3 es C1-4 alquilo; R4 es arilo que está sustituido con un grupo seleccionado de OSO2NH2, NHCONH2, NHSO2NH2, NHSO2C1-4 alquilo y CONH2 y n es 0 o 1; o una de sus sales farmacéuticamente aceptables; siempre que el compuesto no sea N-(1-bencilpiperidin-4-il)-N-metil-4-(4-(sulfamoilamino)fenil)-1H -imidazol-1-carboxamida o N-(1-bencilpiperidin-4-il)-N-metil-4-(3- (metilsulfonamido)fenil)-1H-imidazol-1-carboxamida. El compuesto puede usarse como un inhibidor de la amida hidrolasa de ácido graso.
MX2016001391A 2013-08-01 2014-08-01 Compuestos de urea y su uso como inhibidores de la enzima amida hidrolasa de acido graso (faah). MX2016001391A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201313786A GB201313786D0 (en) 2013-08-01 2013-08-01 Urea compounds and their use as enzyme inhibitors
GB201409466A GB201409466D0 (en) 2014-05-28 2014-05-28 Urea compounds and their use as enzyme inhibitors
PCT/PT2014/000051 WO2015016728A1 (en) 2013-08-01 2014-08-01 Urea compounds and their use as faah enzyme inhibitors

Publications (1)

Publication Number Publication Date
MX2016001391A true MX2016001391A (es) 2016-08-17

Family

ID=51493011

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001391A MX2016001391A (es) 2013-08-01 2014-08-01 Compuestos de urea y su uso como inhibidores de la enzima amida hidrolasa de acido graso (faah).

Country Status (12)

Country Link
US (1) US20160166560A1 (es)
EP (1) EP3027610A1 (es)
JP (1) JP2016528227A (es)
KR (1) KR20160038048A (es)
CN (1) CN105593226A (es)
AU (1) AU2014296894A1 (es)
BR (1) BR112016002196A2 (es)
CA (1) CA2919844A1 (es)
MX (1) MX2016001391A (es)
RU (1) RU2016105158A (es)
TW (1) TW201536769A (es)
WO (1) WO2015016728A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
MY186286A (en) 2017-09-05 2021-07-05 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of chronic kidney disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122013027950A2 (pt) 2008-12-24 2019-12-10 BIAL PORTELA & Cª S A compostos farmacêuticos
CA2806701A1 (en) * 2010-07-29 2012-02-02 Bial - Portela & Ca, S.A. Process for the synthesis of substituted urea compounds

Also Published As

Publication number Publication date
WO2015016728A1 (en) 2015-02-05
JP2016528227A (ja) 2016-09-15
AU2014296894A1 (en) 2016-02-25
EP3027610A1 (en) 2016-06-08
US20160166560A1 (en) 2016-06-16
CN105593226A (zh) 2016-05-18
KR20160038048A (ko) 2016-04-06
BR112016002196A2 (pt) 2017-08-01
TW201536769A (zh) 2015-10-01
CA2919844A1 (en) 2015-02-05
RU2016105158A (ru) 2017-09-06

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